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The map label for this gene is php [C]

Identifier: 108797204

GI number: 108797204

Start: 246426

End: 247403

Strand: Reverse

Name: php [C]

Synonym: Mmcs_0224

Alternate gene names: 108797204

Gene position: 247403-246426 (Counterclockwise)

Preceding gene: 108797206

Following gene: 108797203

Centisome position: 4.34

GC content: 68.71

Gene sequence:

>978_bases
GTGCCACAGTTGAATACCGCGGCGGGAACCATCGACACCGCCGACCTCGGCGTCACGCTCATGCATGAGCATGTGTTCAT
CATGACCACGGAGATCCTGCTCAACTACCCGGACGCGTGGGGTGACGAGGCCAAGCGCGAGGCCGACGCGATCGCCCGGC
TCGACGAGCTGAAGGCACGCGGGGTCGACACCATCGTCGACCTGACCGTGGTGGGGCTGGGCCGCTACATCCCGCGCATC
GCGCGTATCGCCGCGGCCACCGACCTCAACATCGTCGTGGCCACCGGGCTGTACACCTACAACGACGTCCCGTTCTTCTT
CCACTTCACCGGCCCCGGCACCGCGCTGGGCGGGCCGGAGGTGATGGTCGACATGTTCGTGCGCGACATCGAGCACGGTA
TCGCCGACACCGGGGTCAAGGCCGCGATCCTCAAGTGCGCCACCGACGAACCCGGGCTCACCCCCGGTGTGGAGCGGGTG
CTGCGCGCGGTCGCGCAGGCGCACCGCCGGACCGGCGTGCCGATCTCGACCCACACCCATGCCGCCACCCGGCGGGGGCT
GGACCAGCAGCGCATCTTCGCCGAGGAGGGCGTCGACCTGTCGCGGGTGGTGATCGGGCACTCCGGCGACACCACCGACC
TGGACTACCTCGAAGCGCTGATGGCGGCCGGCTCCTACATCGGCATGGACCGTTTCGGGGTCGATGCGTTCCTCGGGTTC
GAGGACCGGGTGGCGACCGTGGCGGCGCTGTGCGAGCGCGGCCACGCCGATCAGATGGTCCTGTCCCACGACGCCTCGTG
CTACTTCGACGCGCTGCCGGAGGAGACCGTCGCGCACACGATGCCGAACTGGCACTATCTGCACATCCACAACGACGTGC
TGCCCGCGCTGCGCGCCCGTGGCGTCACCGACGAACAGCTCACCACGATGCTCGTCGACAATCCCCGGCGGATCTTCGAG
CACTCGGGCGGGTACTGA

Upstream 100 bases:

>100_bases
ATGCGGCGTTCCTCCCTCGGGTCCGCTAGCGGGTACCCGCTGCAGCGCCGATCCCCGCAAACCACGCCCCCGCAGCACAC
CGCGCCCTAGCATCGGGCCT

Downstream 100 bases:

>100_bases
GATGGTCGACGGCGTACCCCCGATCGGGACGCAGTTCTCGGCCCTGGCCGCCCGGGATCCCGACGCACCGGCGCTGACGT
GCGCCGGGCGCACCGTCACC

Product: aryldialkylphosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MPQLNTAAGTIDTADLGVTLMHEHVFIMTTEILLNYPDAWGDEAKREADAIARLDELKARGVDTIVDLTVVGLGRYIPRI
ARIAAATDLNIVVATGLYTYNDVPFFFHFTGPGTALGGPEVMVDMFVRDIEHGIADTGVKAAILKCATDEPGLTPGVERV
LRAVAQAHRRTGVPISTHTHAATRRGLDQQRIFAEEGVDLSRVVIGHSGDTTDLDYLEALMAAGSYIGMDRFGVDAFLGF
EDRVATVAALCERGHADQMVLSHDASCYFDALPEETVAHTMPNWHYLHIHNDVLPALRARGVTDEQLTTMLVDNPRRIFE
HSGGY

Sequences:

>Translated_325_residues
MPQLNTAAGTIDTADLGVTLMHEHVFIMTTEILLNYPDAWGDEAKREADAIARLDELKARGVDTIVDLTVVGLGRYIPRI
ARIAAATDLNIVVATGLYTYNDVPFFFHFTGPGTALGGPEVMVDMFVRDIEHGIADTGVKAAILKCATDEPGLTPGVERV
LRAVAQAHRRTGVPISTHTHAATRRGLDQQRIFAEEGVDLSRVVIGHSGDTTDLDYLEALMAAGSYIGMDRFGVDAFLGF
EDRVATVAALCERGHADQMVLSHDASCYFDALPEETVAHTMPNWHYLHIHNDVLPALRARGVTDEQLTTMLVDNPRRIFE
HSGGY
>Mature_324_residues
PQLNTAAGTIDTADLGVTLMHEHVFIMTTEILLNYPDAWGDEAKREADAIARLDELKARGVDTIVDLTVVGLGRYIPRIA
RIAAATDLNIVVATGLYTYNDVPFFFHFTGPGTALGGPEVMVDMFVRDIEHGIADTGVKAAILKCATDEPGLTPGVERVL
RAVAQAHRRTGVPISTHTHAATRRGLDQQRIFAEEGVDLSRVVIGHSGDTTDLDYLEALMAAGSYIGMDRFGVDAFLGFE
DRVATVAALCERGHADQMVLSHDASCYFDALPEETVAHTMPNWHYLHIHNDVLPALRARGVTDEQLTTMLVDNPRRIFEH
SGGY

Specific function: Its Real Enzymatic Activity Is Not Yet Known. It Was Tested For General Esterase, Aminopeptidase, Sulfatase, Phosphatase, Carbonic Anhydrase, Phosphodiesterase, And Phosphotriesterase Activities With The Following Substrates: P- Nitrophenyl Acetate, L-Ala

COG id: COG1735

COG function: function code R; Predicted metal-dependent hydrolase with the TIM-barrel fold

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphotriesterase family [H]

Homologues:

Organism=Homo sapiens, GI20070186, Length=353, Percent_Identity=26.3456090651558, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI47933341, Length=353, Percent_Identity=26.3456090651558, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1789780, Length=307, Percent_Identity=30.6188925081433, Blast_Score=125, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24645325, Length=365, Percent_Identity=25.2054794520548, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017947
- InterPro:   IPR001559 [H]

Pfam domain/function: PF02126 PTE [H]

EC number: NA

Molecular weight: Translated: 35463; Mature: 35331

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00962 RIBOSOMAL_S2_1 ; PS01322 PHOSPHOTRIESTERASE_1 ; PS01323 PHOSPHOTRIESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQLNTAAGTIDTADLGVTLMHEHVFIMTTEILLNYPDAWGDEAKREADAIARLDELKAR
CCCCCCCCCCCCHHHCCEEHHHCEEHEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC
GVDTIVDLTVVGLGRYIPRIARIAAATDLNIVVATGLYTYNDVPFFFHFTGPGTALGGPE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECEEEECCCCEEEEECCCCCCCCCHH
VMVDMFVRDIEHGIADTGVKAAILKCATDEPGLTPGVERVLRAVAQAHRRTGVPISTHTH
HHHHHHHHHHHHHHHHCCHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCH
AATRRGLDQQRIFAEEGVDLSRVVIGHSGDTTDLDYLEALMAAGSYIGMDRFGVDAFLGF
HHHHHCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHCCHHHCCC
EDRVATVAALCERGHADQMVLSHDASCYFDALPEETVAHTMPNWHYLHIHNDVLPALRAR
HHHHHHHHHHHHCCCCCCCHHHCCCCCEECCCCHHHHHHCCCCEEEEEEECHHHHHHHHC
GVTDEQLTTMLVDNPRRIFEHSGGY
CCCHHHHHHHHHCCCHHHHHCCCCC
>Mature Secondary Structure 
PQLNTAAGTIDTADLGVTLMHEHVFIMTTEILLNYPDAWGDEAKREADAIARLDELKAR
CCCCCCCCCCCHHHCCEEHHHCEEHEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC
GVDTIVDLTVVGLGRYIPRIARIAAATDLNIVVATGLYTYNDVPFFFHFTGPGTALGGPE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECEEEECCCCEEEEECCCCCCCCCHH
VMVDMFVRDIEHGIADTGVKAAILKCATDEPGLTPGVERVLRAVAQAHRRTGVPISTHTH
HHHHHHHHHHHHHHHHCCHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCH
AATRRGLDQQRIFAEEGVDLSRVVIGHSGDTTDLDYLEALMAAGSYIGMDRFGVDAFLGF
HHHHHCCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHCCHHHCCC
EDRVATVAALCERGHADQMVLSHDASCYFDALPEETVAHTMPNWHYLHIHNDVLPALRAR
HHHHHHHHHHHHCCCCCCCHHHCCCCCEECCCCHHHHHHCCCCEEEEEEECHHHHHHHHC
GVTDEQLTTMLVDNPRRIFEHSGGY
CCCHHHHHHHHHCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]