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The map label for this gene is nat [H]

Identifier: 108797191

GI number: 108797191

Start: 231717

End: 232562

Strand: Direct

Name: nat [H]

Synonym: Mmcs_0211

Alternate gene names: 108797191

Gene position: 231717-232562 (Clockwise)

Preceding gene: 108797189

Following gene: 108797194

Centisome position: 4.06

GC content: 69.03

Gene sequence:

>846_bases
ATGGGACACATGACCGAGACCGCTGTCGACACCCCGGCGTACTTCACCAGGATCGGCTATCGGGGTGCGGGCGATCCCAC
GCTCGCCACACTGCGGGCGCTGATCGCCGCGCACAACCGGTCGATCCCGTTCGAGAACCTCGACCCGCTGCTGGGCACGC
CGGTCGCCGACCTCAGCGCGGCCGCCCTGACCGACAAGCTCGTGTACCGGCGACGCGGCGGCTACTGCTACGAACACAAC
GGGCTGATGGGATACGTGCTCGAGGATCTGGGCTTCGGCGTCGAGCGGATCGCCGGGCGGGTGGTGTGGATGCGCCGCGA
TGACACGCTGCCCGCGCAGACCCATCAACTGCTGACGGTGACGGTGCCGGAGGTGGCCGGCCGCTACCTGGTCGACGTCG
GCTTCGGCGGGCAGACGCTGTCCTCGCCGATCCGCTTCGAGACGGGTGTCGAACAGCCCACCAGACACGAGCCGTACCGG
ATTCGCGACCACGGCGAGGGGCACGTCCTGGAATCCCTCATCCGGGGTGAGTGGCGTCCGCTGTACCTGTTCGCCGACCG
GCCGCAGCCGCTGATCGACCTCGAGGTCGGCAGCTGGTACGTCTCGACCCATCCCGCGTCGGTGTTCGCGGTCGGCCTGA
CCGCCGCGCTGGTGACCGACGAGGCCCGGGTCAACATGCGGGGCCGCCACCTCACGGTGCATCGCGCCGAGGGCAGTGAG
CAGATCCGGTTCGACACCGCGGCACAGGTACTCGACGCACTCGACGAACGGTTCGGCATCGACCTGACAGACCTCGGCGA
CCGGGCCGCCGTGGAGCAGCGCATCCACGAGGTGCTCGACAATTAG

Upstream 100 bases:

>100_bases
CCCGGTAGTCGAGACGCTCACGGAGGGATTACCCGTTCCGCCGGGATGACACCGCCGAAAGTGCACCGAGGTTGACCTCA
ACCGCGCTTGAGGTCACACC

Downstream 100 bases:

>100_bases
CGGTGCGGCTCGGCGAAGCTACGGTCCGACGAGCACATCCCACGGGTCGGCGGCGGACAACGCCAACCGGCCCAGCACCC
CGGCGTGCTGCGCGGTGGTG

Product: arylamine N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MGHMTETAVDTPAYFTRIGYRGAGDPTLATLRALIAAHNRSIPFENLDPLLGTPVADLSAAALTDKLVYRRRGGYCYEHN
GLMGYVLEDLGFGVERIAGRVVWMRRDDTLPAQTHQLLTVTVPEVAGRYLVDVGFGGQTLSSPIRFETGVEQPTRHEPYR
IRDHGEGHVLESLIRGEWRPLYLFADRPQPLIDLEVGSWYVSTHPASVFAVGLTAALVTDEARVNMRGRHLTVHRAEGSE
QIRFDTAAQVLDALDERFGIDLTDLGDRAAVEQRIHEVLDN

Sequences:

>Translated_281_residues
MGHMTETAVDTPAYFTRIGYRGAGDPTLATLRALIAAHNRSIPFENLDPLLGTPVADLSAAALTDKLVYRRRGGYCYEHN
GLMGYVLEDLGFGVERIAGRVVWMRRDDTLPAQTHQLLTVTVPEVAGRYLVDVGFGGQTLSSPIRFETGVEQPTRHEPYR
IRDHGEGHVLESLIRGEWRPLYLFADRPQPLIDLEVGSWYVSTHPASVFAVGLTAALVTDEARVNMRGRHLTVHRAEGSE
QIRFDTAAQVLDALDERFGIDLTDLGDRAAVEQRIHEVLDN
>Mature_280_residues
GHMTETAVDTPAYFTRIGYRGAGDPTLATLRALIAAHNRSIPFENLDPLLGTPVADLSAAALTDKLVYRRRGGYCYEHNG
LMGYVLEDLGFGVERIAGRVVWMRRDDTLPAQTHQLLTVTVPEVAGRYLVDVGFGGQTLSSPIRFETGVEQPTRHEPYRI
RDHGEGHVLESLIRGEWRPLYLFADRPQPLIDLEVGSWYVSTHPASVFAVGLTAALVTDEARVNMRGRHLTVHRAEGSEQ
IRFDTAAQVLDALDERFGIDLTDLGDRAAVEQRIHEVLDN

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649128, Length=279, Percent_Identity=28.3154121863799, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI237649126, Length=279, Percent_Identity=28.3154121863799, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI237649124, Length=279, Percent_Identity=28.3154121863799, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI237649122, Length=279, Percent_Identity=28.3154121863799, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI237649119, Length=279, Percent_Identity=28.3154121863799, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI42741671, Length=279, Percent_Identity=28.3154121863799, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI237649009, Length=279, Percent_Identity=28.3154121863799, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI237649132, Length=279, Percent_Identity=28.3154121863799, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI237649130, Length=279, Percent_Identity=28.3154121863799, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI116295260, Length=250, Percent_Identity=28.4, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1787736, Length=254, Percent_Identity=37.007874015748, Blast_Score=139, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 31227; Mature: 31095

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHMTETAVDTPAYFTRIGYRGAGDPTLATLRALIAAHNRSIPFENLDPLLGTPVADLSA
CCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHH
AALTDKLVYRRRGGYCYEHNGLMGYVLEDLGFGVERIAGRVVWMRRDDTLPAQTHQLLTV
HHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCHHHHCCEEEEEECCCCCCCCCCEEEEE
TVPEVAGRYLVDVGFGGQTLSSPIRFETGVEQPTRHEPYRIRDHGEGHVLESLIRGEWRP
ECHHHCCCEEEEECCCCHHHCCCCEECCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCCE
LYLFADRPQPLIDLEVGSWYVSTHPASVFAVGLTAALVTDEARVNMRGRHLTVHRAEGSE
EEEEECCCCCEEEEEECCEEEECCCCHHHHHHHHHHEEECCHHCCCCCCEEEEEECCCCC
QIRFDTAAQVLDALDERFGIDLTDLGDRAAVEQRIHEVLDN
EEEHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GHMTETAVDTPAYFTRIGYRGAGDPTLATLRALIAAHNRSIPFENLDPLLGTPVADLSA
CCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHH
AALTDKLVYRRRGGYCYEHNGLMGYVLEDLGFGVERIAGRVVWMRRDDTLPAQTHQLLTV
HHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCHHHHCCEEEEEECCCCCCCCCCEEEEE
TVPEVAGRYLVDVGFGGQTLSSPIRFETGVEQPTRHEPYRIRDHGEGHVLESLIRGEWRP
ECHHHCCCEEEEECCCCHHHCCCCEECCCCCCCCCCCCEEECCCCCHHHHHHHHCCCCCE
LYLFADRPQPLIDLEVGSWYVSTHPASVFAVGLTAALVTDEARVNMRGRHLTVHRAEGSE
EEEEECCCCCEEEEEECCEEEECCCCHHHHHHHHHHEEECCHHCCCCCCEEEEEECCCCC
QIRFDTAAQVLDALDERFGIDLTDLGDRAAVEQRIHEVLDN
EEEHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]