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The map label for this gene is prrA [H]

Identifier: 108797145

GI number: 108797145

Start: 180346

End: 181077

Strand: Direct

Name: prrA [H]

Synonym: Mmcs_0165

Alternate gene names: 108797145

Gene position: 180346-181077 (Clockwise)

Preceding gene: 108797144

Following gene: 108797146

Centisome position: 3.16

GC content: 68.72

Gene sequence:

>732_bases
GTGCGGGCTGAAACCGGGGAGCCCGAACCCGCAGCGCAGGACACCCCCGGTCGCACGGTGCTGATGGTCGACGACGATCC
CGATGTCCGCACGTCCGTCGCGCGCGGACTGCGGCATTCGGGGTTCGACGTACGCGTCGCCGCGAACGGTAAGGAAGCGC
TACGGCTGCTGTCTGCCGAATCGCACGACGCGCTGGTGCTCGACGTGCAGATGCCGGAACTCGACGGTGTCGCCGTGGTG
ACCGCGCTGCGCGCGCTCGGCAACGACATCCCCATCTGCGTACTCTCGGCGCGCGATACCGTCAACGACCGCATCGCCGG
GCTCGAGGCGGGCGCCGACGACTACCTCACCAAACCGTTCGACCTCGGTGAGCTGGTGGCCCGGCTGCATGCGCTGCTGC
GCCGGGCCCACCACTCCGACCGTCCGTCGGACACCATGACGGTCGGGCCGTTGACCATCGACACCGCCCGGCGGCTGGTG
TTCGTCGACGGAGAACGGGTGGATCTGACCAAACGCGAGTTCGACCTGCTCGCCGTCCTCGCCGAGAACAACGGCGTGGT
GCTGTCGCGCCAGCGGCTGCTCGAGCTGGTCTGGGGCTACGACTTCGACGTCGACACCAACGTCGCCGACGTGTTCATCT
CCTACCTGCGGCGCAAACTCGAGCGCGACGGTCTGCCGCGGGTGATCCACACCGTGCGCGGGATCGGATACGTGCTGCGG
GACGAGCCCTGA

Upstream 100 bases:

>100_bases
AAGCCGATCTGACCGGCATCCGCCAGCCGCTGGTCGACCTGAAGACCCGGTGCGGGACGGCGACGCCGCCTGAAGACGAC
GTCGACACGCCGTAACCGGC

Downstream 100 bases:

>100_bases
CGTCGTGTGGTTGCCCCGCCTCTTCCGCTCGACGTCGTTGCGCACCCGGGTCGCCGTGGCGTCGGCGGCCGCCGCGTCGG
CCGTCGTGGCGGCGTTCACG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MRAETGEPEPAAQDTPGRTVLMVDDDPDVRTSVARGLRHSGFDVRVAANGKEALRLLSAESHDALVLDVQMPELDGVAVV
TALRALGNDIPICVLSARDTVNDRIAGLEAGADDYLTKPFDLGELVARLHALLRRAHHSDRPSDTMTVGPLTIDTARRLV
FVDGERVDLTKREFDLLAVLAENNGVVLSRQRLLELVWGYDFDVDTNVADVFISYLRRKLERDGLPRVIHTVRGIGYVLR
DEP

Sequences:

>Translated_243_residues
MRAETGEPEPAAQDTPGRTVLMVDDDPDVRTSVARGLRHSGFDVRVAANGKEALRLLSAESHDALVLDVQMPELDGVAVV
TALRALGNDIPICVLSARDTVNDRIAGLEAGADDYLTKPFDLGELVARLHALLRRAHHSDRPSDTMTVGPLTIDTARRLV
FVDGERVDLTKREFDLLAVLAENNGVVLSRQRLLELVWGYDFDVDTNVADVFISYLRRKLERDGLPRVIHTVRGIGYVLR
DEP
>Mature_243_residues
MRAETGEPEPAAQDTPGRTVLMVDDDPDVRTSVARGLRHSGFDVRVAANGKEALRLLSAESHDALVLDVQMPELDGVAVV
TALRALGNDIPICVLSARDTVNDRIAGLEAGADDYLTKPFDLGELVARLHALLRRAHHSDRPSDTMTVGPLTIDTARRLV
FVDGERVDLTKREFDLLAVLAENNGVVLSRQRLLELVWGYDFDVDTNVADVFISYLRRKLERDGLPRVIHTVRGIGYVLR
DEP

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=39.0909090909091, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=35.3211009174312, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=37.2727272727273, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=39.2070484581498, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=38.6363636363636, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=37.2727272727273, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=41.6666666666667, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=34.9775784753363, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=33.1818181818182, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=35.8407079646018, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=34.3478260869565, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=31.8777292576419, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=30.9734513274336, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=31.0344827586207, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1790299, Length=133, Percent_Identity=30.0751879699248, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790437, Length=128, Percent_Identity=34.375, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=34.9056603773585, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788713, Length=119, Percent_Identity=36.1344537815126, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1788905, Length=102, Percent_Identity=32.3529411764706, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=112, Percent_Identity=33.0357142857143, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=130, Percent_Identity=29.2307692307692, Blast_Score=61, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=131, Percent_Identity=31.2977099236641, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26810; Mature: 26810

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAETGEPEPAAQDTPGRTVLMVDDDPDVRTSVARGLRHSGFDVRVAANGKEALRLLSAE
CCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCC
SHDALVLDVQMPELDGVAVVTALRALGNDIPICVLSARDTVNDRIAGLEAGADDYLTKPF
CCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCCCHHCCCCC
DLGELVARLHALLRRAHHSDRPSDTMTVGPLTIDTARRLVFVDGERVDLTKREFDLLAVL
CHHHHHHHHHHHHHHHHCCCCCCCCEEECCEEECCCCEEEEECCCEEECHHHCEEEEEEE
AENNGVVLSRQRLLELVWGYDFDVDTNVADVFISYLRRKLERDGLPRVIHTVRGIGYVLR
ECCCCEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEE
DEP
CCC
>Mature Secondary Structure
MRAETGEPEPAAQDTPGRTVLMVDDDPDVRTSVARGLRHSGFDVRVAANGKEALRLLSAE
CCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCC
SHDALVLDVQMPELDGVAVVTALRALGNDIPICVLSARDTVNDRIAGLEAGADDYLTKPF
CCCEEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCCCHHCCCCC
DLGELVARLHALLRRAHHSDRPSDTMTVGPLTIDTARRLVFVDGERVDLTKREFDLLAVL
CHHHHHHHHHHHHHHHHCCCCCCCCEEECCEEECCCCEEEEECCCEEECHHHCEEEEEEE
AENNGVVLSRQRLLELVWGYDFDVDTNVADVFISYLRRKLERDGLPRVIHTVRGIGYVLR
ECCCCEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEE
DEP
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]