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The map label for this gene is nhaK [H]

Identifier: 108797084

GI number: 108797084

Start: 118065

End: 119672

Strand: Direct

Name: nhaK [H]

Synonym: Mmcs_0103

Alternate gene names: 108797084

Gene position: 118065-119672 (Clockwise)

Preceding gene: 108797076

Following gene: 108797085

Centisome position: 2.07

GC content: 70.83

Gene sequence:

>1608_bases
ATGGACACGTCTGACCCCACCTCTGACCGATGGAAGGATCACCCCGCCTTGGCCGCTCTCACCCTGTGCCTGGCTCTGTT
GGCGGCCACCGTCGTCCTCGCCCCCGCGGCGCAACGCCTCTCCGTGCCGTATCCGGCGGTGATGCTGGCGTTCGGGCTGG
CGCTGGCGTTCATCCCGGGCGTCCCGGTGCTGTCGCCGAATCCCGAATTGATCCTTCCGCTCGTCCTGCCGCCGCTGCTG
TTCGCCGCCGCCCGCCGCACCTCCTGGCGGGAGTTCCTCGACAATCGCCGCCCCATCGCGCTGCTGGCCGTCGCGCTGGT
CGGCGTCACCGCCGTCGCGGTCGGCGCGACGCTGCACGCCCTGGTGCCGACCGTCCCGCTGATCGCGGCGATCGCCCTCG
GCGCGGCCGTCGCCCCACCGGACGCCGTGGCCGCCACCGCGGTCGCCCAGAAGCTCGGCATCCCGCGACGGCTGCGCACG
ATCCTCGAGGGGGAGGGGCTGTCCAACGACGCCACCTCGCTGGTGCTCTACGAGGTGGCCGTCGCCGGCACGATGACCGG
CGCGTTCTCCGCCTGGGGCGCGGGTGAGGCACTCGGGCTCGCCGTCGTGCTCGGTGTCCTCGTTGGTCTTGCCATCGCCG
TCGCCACCCGCTGGCTGATCAACAAGCTGCCAGCGCACCCGGCGGGCAGCGGTCTGGTCCTGGTCGTGCCGTTCGCGGCC
TACGCCGCCGCGGACGCCGTCCACGGCAGCGGCGTGCTCGCGGTGGTCACGGTGGCCCTCGCGATGAGTCGCTACGGCGA
CACCCAGTCGTCGCAGACCCGACTGGCCACCGGGACGACATGGGAGATCGTCGAACTGCTGTTGACCGGTTCGGCATTCG
CGTTCGTGGGGCTGCAGATGCGGGCAGTCGCCGACAGCATCGACATGACCTTCTGGGAACTGCTCCAACAGGGGCTGATC
ATCACGCTGGTGGTGATCGTCGTGCGGTTCCTGTGGATCTTCCCGGTCGCCACCATCGACGAACGGATGCACCGGCGCAA
AGCGCACGTGGCCGAGCCGATCGGCTGGCGGGAGATGACCGTCTCGTCATGGGCGGGGATGCGGGGTGTCGTGACACTGG
CCGCCGTCCTCGCGCTGCCACCCCAGTTCCCCGAGCGTGAACGGCTGGTGTTCTACGCGTTCGTCGTCATCGTCGTCACC
CTGCTGCTGCAGGGCCTCTCGTTGCCGACCGTGGTGCGGCGGCTCGGCGTGCGCGCCTCTCCCCACGAAGAGGACGACGC
CGTGCAGGCGCTGATCCGGCGGGCCCGCGACGCCGGCTTCGAACGCCTCGACGAAATCCGCGCGCGCGAGGAAGCCGACC
CCGAGGTCATCGAACACGCCCGCGACAACGCCGAGCGGATGTGGCAGTCGGTCGGGTTCGCCCCGCCCGACGCCGAATCC
CACCACGCGCACACCGACCACGCGATGACGCTCAACGCGCTCAAGGACGAGATACTCGCGGCCGCCCGCGAAGCCGTCGT
CAAGGCGCGCTCGGAATCGGGCACGGATCCGACGGTCGTCGACCGGGTGTTGCGCCGCCTCGATACCCGCGGCAGCCAGC
CCGAATAA

Upstream 100 bases:

>100_bases
TACACCCGGATTAAGGAAGTTAAGGAAAAGATAAGGTAACGGTAAGGCAGCTTATGCTGCGGTTTTCTCGGCGGTGGTGC
GGCGGCCCGTCAGCGGGTAC

Downstream 100 bases:

>100_bases
ACTCACGCGGATCGCAAACATTTGCCGATCGCGACGGTGCCGGTAGCAATATCCCGGTGAACACCGCGCTGTCCGACGAC
TGCTGTCGCTGAAGCCTTCT

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MDTSDPTSDRWKDHPALAALTLCLALLAATVVLAPAAQRLSVPYPAVMLAFGLALAFIPGVPVLSPNPELILPLVLPPLL
FAAARRTSWREFLDNRRPIALLAVALVGVTAVAVGATLHALVPTVPLIAAIALGAAVAPPDAVAATAVAQKLGIPRRLRT
ILEGEGLSNDATSLVLYEVAVAGTMTGAFSAWGAGEALGLAVVLGVLVGLAIAVATRWLINKLPAHPAGSGLVLVVPFAA
YAAADAVHGSGVLAVVTVALAMSRYGDTQSSQTRLATGTTWEIVELLLTGSAFAFVGLQMRAVADSIDMTFWELLQQGLI
ITLVVIVVRFLWIFPVATIDERMHRRKAHVAEPIGWREMTVSSWAGMRGVVTLAAVLALPPQFPERERLVFYAFVVIVVT
LLLQGLSLPTVVRRLGVRASPHEEDDAVQALIRRARDAGFERLDEIRAREEADPEVIEHARDNAERMWQSVGFAPPDAES
HHAHTDHAMTLNALKDEILAAAREAVVKARSESGTDPTVVDRVLRRLDTRGSQPE

Sequences:

>Translated_535_residues
MDTSDPTSDRWKDHPALAALTLCLALLAATVVLAPAAQRLSVPYPAVMLAFGLALAFIPGVPVLSPNPELILPLVLPPLL
FAAARRTSWREFLDNRRPIALLAVALVGVTAVAVGATLHALVPTVPLIAAIALGAAVAPPDAVAATAVAQKLGIPRRLRT
ILEGEGLSNDATSLVLYEVAVAGTMTGAFSAWGAGEALGLAVVLGVLVGLAIAVATRWLINKLPAHPAGSGLVLVVPFAA
YAAADAVHGSGVLAVVTVALAMSRYGDTQSSQTRLATGTTWEIVELLLTGSAFAFVGLQMRAVADSIDMTFWELLQQGLI
ITLVVIVVRFLWIFPVATIDERMHRRKAHVAEPIGWREMTVSSWAGMRGVVTLAAVLALPPQFPERERLVFYAFVVIVVT
LLLQGLSLPTVVRRLGVRASPHEEDDAVQALIRRARDAGFERLDEIRAREEADPEVIEHARDNAERMWQSVGFAPPDAES
HHAHTDHAMTLNALKDEILAAAREAVVKARSESGTDPTVVDRVLRRLDTRGSQPE
>Mature_535_residues
MDTSDPTSDRWKDHPALAALTLCLALLAATVVLAPAAQRLSVPYPAVMLAFGLALAFIPGVPVLSPNPELILPLVLPPLL
FAAARRTSWREFLDNRRPIALLAVALVGVTAVAVGATLHALVPTVPLIAAIALGAAVAPPDAVAATAVAQKLGIPRRLRT
ILEGEGLSNDATSLVLYEVAVAGTMTGAFSAWGAGEALGLAVVLGVLVGLAIAVATRWLINKLPAHPAGSGLVLVVPFAA
YAAADAVHGSGVLAVVTVALAMSRYGDTQSSQTRLATGTTWEIVELLLTGSAFAFVGLQMRAVADSIDMTFWELLQQGLI
ITLVVIVVRFLWIFPVATIDERMHRRKAHVAEPIGWREMTVSSWAGMRGVVTLAAVLALPPQFPERERLVFYAFVVIVVT
LLLQGLSLPTVVRRLGVRASPHEEDDAVQALIRRARDAGFERLDEIRAREEADPEVIEHARDNAERMWQSVGFAPPDAES
HHAHTDHAMTLNALKDEILAAAREAVVKARSESGTDPTVVDRVLRRLDTRGSQPE

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=415, Percent_Identity=22.6506024096386, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI148727259, Length=381, Percent_Identity=23.8845144356955, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI41872703, Length=423, Percent_Identity=24.113475177305, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI194239733, Length=410, Percent_Identity=23.9024390243902, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI27734935, Length=413, Percent_Identity=21.7917675544794, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI14211919, Length=387, Percent_Identity=22.4806201550388, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4759144, Length=406, Percent_Identity=24.1379310344828, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI294997330, Length=333, Percent_Identity=22.5225225225225, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI5454070, Length=341, Percent_Identity=22.2873900293255, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI110227626, Length=333, Percent_Identity=22.5225225225225, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790501, Length=400, Percent_Identity=33.5, Blast_Score=170, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71980847, Length=395, Percent_Identity=22.0253164556962, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI25150332, Length=424, Percent_Identity=22.1698113207547, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71993590, Length=382, Percent_Identity=22.7748691099476, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71993582, Length=382, Percent_Identity=22.7748691099476, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71999817, Length=483, Percent_Identity=21.1180124223602, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71999819, Length=483, Percent_Identity=21.1180124223602, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71987537, Length=443, Percent_Identity=20.9932279909707, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71987535, Length=443, Percent_Identity=20.9932279909707, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71999821, Length=449, Percent_Identity=21.380846325167, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71990924, Length=399, Percent_Identity=22.3057644110276, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71990932, Length=395, Percent_Identity=22.2784810126582, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71987545, Length=364, Percent_Identity=22.2527472527473, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71987559, Length=364, Percent_Identity=22.2527472527473, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25147678, Length=412, Percent_Identity=20.3883495145631, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71992107, Length=343, Percent_Identity=22.1574344023324, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992101, Length=343, Percent_Identity=22.1574344023324, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320663, Length=378, Percent_Identity=22.4867724867725, Blast_Score=93, Evalue=9e-20,
Organism=Drosophila melanogaster, GI281360447, Length=431, Percent_Identity=22.2737819025522, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221510738, Length=416, Percent_Identity=24.7596153846154, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI221510734, Length=416, Percent_Identity=24.7596153846154, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI221510736, Length=455, Percent_Identity=24.8351648351648, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221510732, Length=455, Percent_Identity=24.8351648351648, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221510740, Length=455, Percent_Identity=24.8351648351648, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585580, Length=455, Percent_Identity=24.8351648351648, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24585578, Length=455, Percent_Identity=24.8351648351648, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221473212, Length=405, Percent_Identity=21.4814814814815, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221473215, Length=363, Percent_Identity=21.2121212121212, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221473222, Length=365, Percent_Identity=22.1917808219178, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281364513, Length=363, Percent_Identity=21.2121212121212, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 57029; Mature: 57029

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTSDPTSDRWKDHPALAALTLCLALLAATVVLAPAAQRLSVPYPAVMLAFGLALAFIPG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
VPVLSPNPELILPLVLPPLLFAAARRTSWREFLDNRRPIALLAVALVGVTAVAVGATLHA
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LVPTVPLIAAIALGAAVAPPDAVAATAVAQKLGIPRRLRTILEGEGLSNDATSLVLYEVA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHH
VAGTMTGAFSAWGAGEALGLAVVLGVLVGLAIAVATRWLINKLPAHPAGSGLVLVVPFAA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHH
YAAADAVHGSGVLAVVTVALAMSRYGDTQSSQTRLATGTTWEIVELLLTGSAFAFVGLQM
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHCCHHHHHHHHH
RAVADSIDMTFWELLQQGLIITLVVIVVRFLWIFPVATIDERMHRRKAHVAEPIGWREMT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VSSWAGMRGVVTLAAVLALPPQFPERERLVFYAFVVIVVTLLLQGLSLPTVVRRLGVRAS
HHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
PHEEDDAVQALIRRARDAGFERLDEIRAREEADPEVIEHARDNAERMWQSVGFAPPDAES
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
HHAHTDHAMTLNALKDEILAAAREAVVKARSESGTDPTVVDRVLRRLDTRGSQPE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDTSDPTSDRWKDHPALAALTLCLALLAATVVLAPAAQRLSVPYPAVMLAFGLALAFIPG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
VPVLSPNPELILPLVLPPLLFAAARRTSWREFLDNRRPIALLAVALVGVTAVAVGATLHA
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LVPTVPLIAAIALGAAVAPPDAVAATAVAQKLGIPRRLRTILEGEGLSNDATSLVLYEVA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHH
VAGTMTGAFSAWGAGEALGLAVVLGVLVGLAIAVATRWLINKLPAHPAGSGLVLVVPFAA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHHHH
YAAADAVHGSGVLAVVTVALAMSRYGDTQSSQTRLATGTTWEIVELLLTGSAFAFVGLQM
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHCCHHHHHHHHH
RAVADSIDMTFWELLQQGLIITLVVIVVRFLWIFPVATIDERMHRRKAHVAEPIGWREMT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VSSWAGMRGVVTLAAVLALPPQFPERERLVFYAFVVIVVTLLLQGLSLPTVVRRLGVRAS
HHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCC
PHEEDDAVQALIRRARDAGFERLDEIRAREEADPEVIEHARDNAERMWQSVGFAPPDAES
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
HHAHTDHAMTLNALKDEILAAAREAVVKARSESGTDPTVVDRVLRRLDTRGSQPE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA