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The map label for this gene is eccD1 [H]

Identifier: 108797054

GI number: 108797054

Start: 85580

End: 87109

Strand: Direct

Name: eccD1 [H]

Synonym: Mmcs_0073

Alternate gene names: 108797054

Gene position: 85580-87109 (Clockwise)

Preceding gene: 108797053

Following gene: 108797055

Centisome position: 1.5

GC content: 70.33

Gene sequence:

>1530_bases
TTGACCACCACCGCCGCGGCATCCACCACCTCGAGCGTCACGCCCGGGCGGCCGTCGACCACCCGGGTGACGATCCTGAC
CGGCCGGCGTATGACGGATCTCGTACTGCCCGCGGCGGCCCCCGTCGAGACCTACATCGACGAGACCGTCGCGGTGCTCG
CCGAGATCCTGGAGGACACCCCCAAGGATGTGCTGGCGGGCTTCGACTTCACCGCGCAGGGGGTGTGGGCGTTCGCGCGT
CCCGGGGCGCCGCCACTGAAGGCCGACGAGTCCCTCGACGACGCCGGGGTGGTCGACGGGTCGTTGCTGACGCTGGTCTC
GGTGAGCCGGACGGAACGCTACCGTCCGCTGGTCGAGGACGTGATCGACGCGATCGCGGTGCTCGACGAATCCCCGGAGT
TCGACCGCGCCGCGCTCAACCGCTTCGTCGGTGTGTCGATACCCCTTGTCTCCGTTGCGATCACGCTGATGTCCTTGGTC
TCGTGGGACCGCACCGGGCAGAGCCTGTGGTGGGCGCTGGCGCTGGCCGTGCTCGGCCTCGGACTGCTCGGCGGCAGCCT
GCTGGCGCAGAACCGCTACGCCAACCTGAACATGGCCGAAAGCCTGCTGATCGCCTCGATTCCGGCGCTCGCCGGAGGTG
CGGCGCTGGCCGTGCCGCTGCCCAACGGCGTCGGATCGCTGGGTGCGCCGCAGCTGGCGGGCGCGGGCGCCGTGGTGTTG
CTGCTGACATTGGCGACCAGGGGCGGGCCCCGGAAGCGGGCCGAGGTCGCGGCCTTCCTGGCGATCGCCACGGCGGCGCT
GACGGCGGCCGCGGTGGGGTACGGATACGGGTGGCAGTACTGGGTGCCCGCGGGTGCGGTCGCATTCGGCCTGATCGTGC
TGACCAACGCGGCGAAGCTGACCGTGGCGGTCGCCCGCATCGCCCTGCCGCCGATCCCCGCACCCGGTGAGACCGTCACC
AACGACGAACTGCTCGATCCGGTCACTTCGCGCGAAGGCGTCGACGAGGAATCGCCGACATGGCAGGCCATCATCGCCTC
GGTGCCCGAATCGGCCGCCCGCCTGCAGGAACGCAGCGTGCTGGCCAAGAAGCTGCTGATCGGCTTCCTCACGGCGGGCG
CGCTCATCCTCGCGGTCGGGGCGGTCGCGGTGGTGGTGCAGGGTCACTTCTTCGTCCACAGCCTGATCGTGGCCGGACTG
GTCGCCGCGATCTGCGGCTTCCGCTCCCGGTTGTACGCCGAGCGCTGGTGCGCGTGGGCGCTGCTTGCGGTGACCGTGAT
CGTGCCGACGGGTGTGATGGTCAGGCTGTGCCAGTGGTATCCCGACGACGCGTGGTTGGTGCTGGCGATCTACACCGCAC
TGGGCGCGGTGGCGTTGGTCGTCATCGGTGCCACCGACGGGGTGCGTCGCGTGTCGCCGGTGACCAAACGGATCCTCGAA
CTGGTCGACGGCGCGGCGATCGCGGCGGTCATCCCGCTGCTGCTGTGGATCGCCAGCGTGTACGACGTGCTGCGCAACCT
GCGTTTCTGA

Upstream 100 bases:

>100_bases
GCACGGAGATCCAGCTCGACCTGCTCGACAAGGTCTTCCAGCGGCGGATCACCGAGTTGGCGGCCGCCTTGTCTGACGAT
TTCGACAGGCTCGAACGGCG

Downstream 100 bases:

>100_bases
GGGGGACCGGTGAGTGGTGAAGTGCTGCAGGTGAATCCGCCCGCGCTGGCCGGCGCCGGGACGGCGTTCGGGCAGGCCGC
CTCGGGGGTCGCCGGCCTGC

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component D1; Type VII secretion system protein eccD1; T7SS protein eccD1 [H]

Number of amino acids: Translated: 509; Mature: 508

Protein sequence:

>509_residues
MTTTAAASTTSSVTPGRPSTTRVTILTGRRMTDLVLPAAAPVETYIDETVAVLAEILEDTPKDVLAGFDFTAQGVWAFAR
PGAPPLKADESLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRAALNRFVGVSIPLVSVAITLMSLV
SWDRTGQSLWWALALAVLGLGLLGGSLLAQNRYANLNMAESLLIASIPALAGGAALAVPLPNGVGSLGAPQLAGAGAVVL
LLTLATRGGPRKRAEVAAFLAIATAALTAAAVGYGYGWQYWVPAGAVAFGLIVLTNAAKLTVAVARIALPPIPAPGETVT
NDELLDPVTSREGVDEESPTWQAIIASVPESAARLQERSVLAKKLLIGFLTAGALILAVGAVAVVVQGHFFVHSLIVAGL
VAAICGFRSRLYAERWCAWALLAVTVIVPTGVMVRLCQWYPDDAWLVLAIYTALGAVALVVIGATDGVRRVSPVTKRILE
LVDGAAIAAVIPLLLWIASVYDVLRNLRF

Sequences:

>Translated_509_residues
MTTTAAASTTSSVTPGRPSTTRVTILTGRRMTDLVLPAAAPVETYIDETVAVLAEILEDTPKDVLAGFDFTAQGVWAFAR
PGAPPLKADESLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRAALNRFVGVSIPLVSVAITLMSLV
SWDRTGQSLWWALALAVLGLGLLGGSLLAQNRYANLNMAESLLIASIPALAGGAALAVPLPNGVGSLGAPQLAGAGAVVL
LLTLATRGGPRKRAEVAAFLAIATAALTAAAVGYGYGWQYWVPAGAVAFGLIVLTNAAKLTVAVARIALPPIPAPGETVT
NDELLDPVTSREGVDEESPTWQAIIASVPESAARLQERSVLAKKLLIGFLTAGALILAVGAVAVVVQGHFFVHSLIVAGL
VAAICGFRSRLYAERWCAWALLAVTVIVPTGVMVRLCQWYPDDAWLVLAIYTALGAVALVVIGATDGVRRVSPVTKRILE
LVDGAAIAAVIPLLLWIASVYDVLRNLRF
>Mature_508_residues
TTTAAASTTSSVTPGRPSTTRVTILTGRRMTDLVLPAAAPVETYIDETVAVLAEILEDTPKDVLAGFDFTAQGVWAFARP
GAPPLKADESLDDAGVVDGSLLTLVSVSRTERYRPLVEDVIDAIAVLDESPEFDRAALNRFVGVSIPLVSVAITLMSLVS
WDRTGQSLWWALALAVLGLGLLGGSLLAQNRYANLNMAESLLIASIPALAGGAALAVPLPNGVGSLGAPQLAGAGAVVLL
LTLATRGGPRKRAEVAAFLAIATAALTAAAVGYGYGWQYWVPAGAVAFGLIVLTNAAKLTVAVARIALPPIPAPGETVTN
DELLDPVTSREGVDEESPTWQAIIASVPESAARLQERSVLAKKLLIGFLTAGALILAVGAVAVVVQGHFFVHSLIVAGLV
AAICGFRSRLYAERWCAWALLAVTVIVPTGVMVRLCQWYPDDAWLVLAIYTALGAVALVVIGATDGVRRVSPVTKRILEL
VDGAAIAAVIPLLLWIASVYDVLRNLRF

Specific function: Part of a complex that is involved in secretion of ESX-1 substrates, such as esxA (ESAT-6) and esxB (CFP-10). Responsible for multiple suppressive effects on macrophages and required for bacterial replication after phagocytosis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eccD/snm4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006707 [H]

Pfam domain/function: PF04600 DUF571 [H]

EC number: NA

Molecular weight: Translated: 53113; Mature: 52982

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTAAASTTSSVTPGRPSTTRVTILTGRRMTDLVLPAAAPVETYIDETVAVLAEILEDT
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
PKDVLAGFDFTAQGVWAFARPGAPPLKADESLDDAGVVDGSLLTLVSVSRTERYRPLVED
HHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VIDAIAVLDESPEFDRAALNRFVGVSIPLVSVAITLMSLVSWDRTGQSLWWALALAVLGL
HHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GLLGGSLLAQNRYANLNMAESLLIASIPALAGGAALAVPLPNGVGSLGAPQLAGAGAVVL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHH
LLTLATRGGPRKRAEVAAFLAIATAALTAAAVGYGYGWQYWVPAGAVAFGLIVLTNAAKL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCHHH
TVAVARIALPPIPAPGETVTNDELLDPVTSREGVDEESPTWQAIIASVPESAARLQERSV
HHHHHHHHCCCCCCCCCCCCCHHHHCCHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHH
LAKKLLIGFLTAGALILAVGAVAVVVQGHFFVHSLIVAGLVAAICGFRSRLYAERWCAWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAVTVIVPTGVMVRLCQWYPDDAWLVLAIYTALGAVALVVIGATDGVRRVSPVTKRILE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LVDGAAIAAVIPLLLWIASVYDVLRNLRF
HHCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTTAAASTTSSVTPGRPSTTRVTILTGRRMTDLVLPAAAPVETYIDETVAVLAEILEDT
CCCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
PKDVLAGFDFTAQGVWAFARPGAPPLKADESLDDAGVVDGSLLTLVSVSRTERYRPLVED
HHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VIDAIAVLDESPEFDRAALNRFVGVSIPLVSVAITLMSLVSWDRTGQSLWWALALAVLGL
HHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GLLGGSLLAQNRYANLNMAESLLIASIPALAGGAALAVPLPNGVGSLGAPQLAGAGAVVL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHH
LLTLATRGGPRKRAEVAAFLAIATAALTAAAVGYGYGWQYWVPAGAVAFGLIVLTNAAKL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCHHH
TVAVARIALPPIPAPGETVTNDELLDPVTSREGVDEESPTWQAIIASVPESAARLQERSV
HHHHHHHHCCCCCCCCCCCCCHHHHCCHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHH
LAKKLLIGFLTAGALILAVGAVAVVVQGHFFVHSLIVAGLVAAICGFRSRLYAERWCAWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAVTVIVPTGVMVRLCQWYPDDAWLVLAIYTALGAVALVVIGATDGVRRVSPVTKRILE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LVDGAAIAAVIPLLLWIASVYDVLRNLRF
HHCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]