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The map label for this gene is ppe68 [H]

Identifier: 108797050

GI number: 108797050

Start: 82008

End: 83339

Strand: Direct

Name: ppe68 [H]

Synonym: Mmcs_0069

Alternate gene names: 108797050

Gene position: 82008-83339 (Clockwise)

Preceding gene: 108797049

Following gene: 108797051

Centisome position: 1.44

GC content: 71.17

Gene sequence:

>1332_bases
ATGGCACTGACGGGCATACCCCTTCCACCGACCTGGACGGCGCTGCCGCCCGAGGTCAACACCGGCCGGCTGATGGCCGG
AGCCGGTCCCGCGCCGATGCTGCAGGCCGCGGCCGGGTGGGAGGCGCTCGCCGTGCTGTTGGAGACCCAGGCCGACGAAC
TCGCCGCGAGCCTGGCGAACCTGTCGTCGATGTGGACGGGCACCGCGAGTGAACGGGCCGTGGCCGCGACCATGCCGATG
GTCCTCTGGTTGCGGACCACGTCGGCGCAGGCCATGAAGCGGGCGCTGCAGGCGGCCAACCAGGCAAACTCCTACACCCT
TGCAATGGCAACTACTCCGCCGTTGCCGGAGATCGAACAGAACCACATCACGCACGCGGTCCTCGAGGCGACGAACTTCC
TGGGCGTCAACACCGTGCCGATCGGGGTGAACGAGTTCGACTACTTCGTCCGGATGTGGAACCAGGCCGCCGGGGCGATG
GACGTGTACCAGGCCGAGACCCAGATGAACCTTCTGTTCGAACCGATTCCGCCGATGACGCCGATCGTCATCCCCGGCGT
CGGCGAGAGCACCGGCGCCGCCGCGGTGGCCCAGGCGGGCGCCCGCGCCCCGATGGGGGTGGCCCGCAACGGGCTCATCG
CCAAGGCCAGCGCCACCGCCAAGATGGAGTCCGTCGGCCTCAACGCCGGCCGGGCGATGGCCCAGGGCAACATGGCCGCG
CAACGCGCGCAGGGTGCGGTGCAGAAGGGGGAGCAGGCCGCACACCAGCAGCCGCAGGACCAGGTTATGCAGCAGGGCGT
CCAGATGGGTGTGCAGATGGCCGGCCAGGTGGGTTCCATGGTCGCGCAGGTACCGCAGCAGTTCGGCCAGATGGTGCAGA
CCCCGATGCAGATGCTGACCCAACCGCTGCAGCAGGTGTCGTCGATCTTCGGTCAGATGGGCGGCGGTCTCGGCGGCGAG
AAGGCCCAGATCGGCGTCATCGGTGCCGCACCGTTCTCCAACCATCCGCTCGCGGGTGGTTCCGGTGTGAGCTCGGGTGC
GGGTCTGGTCCGGGCGGCGTCGCTGCCCGGCGCCGGGGGGACCGCGGCGCGCACACCGCTGATGGCCAACCTCGTCGGCG
ACAAGATGGCGGCCGCACCCGTGCCCGTCGGGGCCGGCGCGGCGGCCGGAGCCACCGTCGGCGGTCTGGCGCCTGTCGGC
GGCGCGGGCGGTGGGATGGGCCCGATGGGGATGGCCGGACAGGGCGCCAAGGGCGGCGGTTCGAAGCCGGGGCTGACCGC
ACCCGCACCACTCGTCCACGACCTGGACGAGGACGACGGCGACGACTGGTGA

Upstream 100 bases:

>100_bases
TCTCCGGTATCTACGCCGCCGTCGACGCCGCCAACGCCAGCACCTTCTGAGCGGCGCGGCAGATTCCCCAGCGGATCCCT
AGCGGAGCCACCCACACACC

Downstream 100 bases:

>100_bases
GTCGCCGCAGGAACACAGACTTCCCGGTCACCTGACCGGAAGACTCGCCATTTCCCGTGGTGAGGACACAGGAAAAGAAG
GAATGTATCCACAATGGCAA

Product: PPE protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MALTGIPLPPTWTALPPEVNTGRLMAGAGPAPMLQAAAGWEALAVLLETQADELAASLANLSSMWTGTASERAVAATMPM
VLWLRTTSAQAMKRALQAANQANSYTLAMATTPPLPEIEQNHITHAVLEATNFLGVNTVPIGVNEFDYFVRMWNQAAGAM
DVYQAETQMNLLFEPIPPMTPIVIPGVGESTGAAAVAQAGARAPMGVARNGLIAKASATAKMESVGLNAGRAMAQGNMAA
QRAQGAVQKGEQAAHQQPQDQVMQQGVQMGVQMAGQVGSMVAQVPQQFGQMVQTPMQMLTQPLQQVSSIFGQMGGGLGGE
KAQIGVIGAAPFSNHPLAGGSGVSSGAGLVRAASLPGAGGTAARTPLMANLVGDKMAAAPVPVGAGAAAGATVGGLAPVG
GAGGGMGPMGMAGQGAKGGGSKPGLTAPAPLVHDLDEDDGDDW

Sequences:

>Translated_443_residues
MALTGIPLPPTWTALPPEVNTGRLMAGAGPAPMLQAAAGWEALAVLLETQADELAASLANLSSMWTGTASERAVAATMPM
VLWLRTTSAQAMKRALQAANQANSYTLAMATTPPLPEIEQNHITHAVLEATNFLGVNTVPIGVNEFDYFVRMWNQAAGAM
DVYQAETQMNLLFEPIPPMTPIVIPGVGESTGAAAVAQAGARAPMGVARNGLIAKASATAKMESVGLNAGRAMAQGNMAA
QRAQGAVQKGEQAAHQQPQDQVMQQGVQMGVQMAGQVGSMVAQVPQQFGQMVQTPMQMLTQPLQQVSSIFGQMGGGLGGE
KAQIGVIGAAPFSNHPLAGGSGVSSGAGLVRAASLPGAGGTAARTPLMANLVGDKMAAAPVPVGAGAAAGATVGGLAPVG
GAGGGMGPMGMAGQGAKGGGSKPGLTAPAPLVHDLDEDDGDDW
>Mature_442_residues
ALTGIPLPPTWTALPPEVNTGRLMAGAGPAPMLQAAAGWEALAVLLETQADELAASLANLSSMWTGTASERAVAATMPMV
LWLRTTSAQAMKRALQAANQANSYTLAMATTPPLPEIEQNHITHAVLEATNFLGVNTVPIGVNEFDYFVRMWNQAAGAMD
VYQAETQMNLLFEPIPPMTPIVIPGVGESTGAAAVAQAGARAPMGVARNGLIAKASATAKMESVGLNAGRAMAQGNMAAQ
RAQGAVQKGEQAAHQQPQDQVMQQGVQMGVQMAGQVGSMVAQVPQQFGQMVQTPMQMLTQPLQQVSSIFGQMGGGLGGEK
AQIGVIGAAPFSNHPLAGGSGVSSGAGLVRAASLPGAGGTAARTPLMANLVGDKMAAAPVPVGAGAAAGATVGGLAPVGG
AGGGMGPMGMAGQGAKGGGSKPGLTAPAPLVHDLDEDDGDDW

Specific function: Stimulates high levels of gamma interferon secretion in peripheral blood mononuclear cells isolated from tuberculosis patients, as well as from healthy tuberculin purified protein derivative-positive donors. Does not interfere with the secretion and prese

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall. Cell membrane. Note=Detected predominantly in the membrane and cell wall fractions [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mycobacterial PPE family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000030 [H]

Pfam domain/function: PF00823 PPE [H]

EC number: NA

Molecular weight: Translated: 44477; Mature: 44345

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTGIPLPPTWTALPPEVNTGRLMAGAGPAPMLQAAAGWEALAVLLETQADELAASLAN
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LSSMWTGTASERAVAATMPMVLWLRTTSAQAMKRALQAANQANSYTLAMATTPPLPEIEQ
HHHHHCCCCCCCHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHH
NHITHAVLEATNFLGVNTVPIGVNEFDYFVRMWNQAAGAMDVYQAETQMNLLFEPIPPMT
HHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
PIVIPGVGESTGAAAVAQAGARAPMGVARNGLIAKASATAKMESVGLNAGRAMAQGNMAA
CEEECCCCCCCCHHHHHHCCCCCCCCHHCCCCEEECHHHHHHHHHCCCCCHHHHHCHHHH
QRAQGAVQKGEQAAHQQPQDQVMQQGVQMGVQMAGQVGSMVAQVPQQFGQMVQTPMQMLT
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QPLQQVSSIFGQMGGGLGGEKAQIGVIGAAPFSNHPLAGGSGVSSGAGLVRAASLPGAGG
HHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCC
TAARTPLMANLVGDKMAAAPVPVGAGAAAGATVGGLAPVGGAGGGMGPMGMAGQGAKGGG
CHHHCCHHHHHHHCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SKPGLTAPAPLVHDLDEDDGDDW
CCCCCCCCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
ALTGIPLPPTWTALPPEVNTGRLMAGAGPAPMLQAAAGWEALAVLLETQADELAASLAN
CCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LSSMWTGTASERAVAATMPMVLWLRTTSAQAMKRALQAANQANSYTLAMATTPPLPEIEQ
HHHHHCCCCCCCHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHH
NHITHAVLEATNFLGVNTVPIGVNEFDYFVRMWNQAAGAMDVYQAETQMNLLFEPIPPMT
HHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCC
PIVIPGVGESTGAAAVAQAGARAPMGVARNGLIAKASATAKMESVGLNAGRAMAQGNMAA
CEEECCCCCCCCHHHHHHCCCCCCCCHHCCCCEEECHHHHHHHHHCCCCCHHHHHCHHHH
QRAQGAVQKGEQAAHQQPQDQVMQQGVQMGVQMAGQVGSMVAQVPQQFGQMVQTPMQMLT
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QPLQQVSSIFGQMGGGLGGEKAQIGVIGAAPFSNHPLAGGSGVSSGAGLVRAASLPGAGG
HHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCC
TAARTPLMANLVGDKMAAAPVPVGAGAAAGATVGGLAPVGGAGGGMGPMGMAGQGAKGGG
CHHHCCHHHHHHHCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SKPGLTAPAPLVHDLDEDDGDDW
CCCCCCCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]