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The map label for this gene is lexA

Identifier: 108763097

GI number: 108763097

Start: 5507020

End: 5507688

Strand: Direct

Name: lexA

Synonym: MXAN_4446

Alternate gene names: 108763097

Gene position: 5507020-5507688 (Clockwise)

Preceding gene: 108757677

Following gene: 108758777

Centisome position: 60.25

GC content: 65.77

Gene sequence:

>669_bases
ATGGAAGAGCTCACGGAACGCCAGCGCGAGATTCTCAGCTTCATCGTCAAGGAGACGGAGACCCGGGGCTTCCCGCCGAC
GATTCGCGAAATCGGGGAGCACATGGACATCCGCTCGACGAACGGCGTCAACGACCACCTGAAGGCGCTGGAGCGCAAGG
GTTACCTGAACCGGGGCGAGCAGCAGAGCCGCTCCCTGGTGGCCACCAAGCGCGCGCGGTTGCTCCTCGGCCTGGGGGCG
CGCAAGGACTCCGGCATGGTGGAGATTCCCCTGCTGGGCAAGGTCGCCGCCGGCGCGCCGCTGCTGGCGCAGGAGAACAT
GGAGGACTCCGTCAAGATCGACAGCTTCCTGCTCGGAGGTGTGAATGGCCGCGAGGTCTTCGCCCTGCGCGTGAAGGGGC
AGTCGATGATTGACGACGGCATCCACGACGGGGACTACCTCTTCGTGAAGAAGACGCCATCCGCACAGCCGGGTGAAATC
GTGGTGGCCCTCATCGAGGACGAGGCCACGGTGAAGCGTTACTACCCGGAAGGGGACCGCATCCGCTTCCAGCCGGCCAA
CGCCACCATGCAGCCCATCTACGTGAGCCGCGCGGAGTTCCGGTCCACGATGATTCTGGGTCAGGTGGTGGGCGTGTACC
GCAAGCTCCAGGGCGGCCGCACCCCGTAG

Upstream 100 bases:

>100_bases
CGAGTTGACTCTACACGTCTGTTCAGGGAGAGTGACACTGAAAGCCTGTTGCCTGGGGGGAACGACTCCCCGGCAGGACG
GCAGACGAGTGAGGGAGCGC

Downstream 100 bases:

>100_bases
TCCACCCCACCCGTCCCGGGCCGTTTCCTGGCCCGGGCCTGACTCAAGGGCACTTCTTGAGGGTGGCGTCAGCCGCCGTC
GCCCGCGCGCAGGCGGCCTG

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MEELTERQREILSFIVKETETRGFPPTIREIGEHMDIRSTNGVNDHLKALERKGYLNRGEQQSRSLVATKRARLLLGLGA
RKDSGMVEIPLLGKVAAGAPLLAQENMEDSVKIDSFLLGGVNGREVFALRVKGQSMIDDGIHDGDYLFVKKTPSAQPGEI
VVALIEDEATVKRYYPEGDRIRFQPANATMQPIYVSRAEFRSTMILGQVVGVYRKLQGGRTP

Sequences:

>Translated_222_residues
MEELTERQREILSFIVKETETRGFPPTIREIGEHMDIRSTNGVNDHLKALERKGYLNRGEQQSRSLVATKRARLLLGLGA
RKDSGMVEIPLLGKVAAGAPLLAQENMEDSVKIDSFLLGGVNGREVFALRVKGQSMIDDGIHDGDYLFVKKTPSAQPGEI
VVALIEDEATVKRYYPEGDRIRFQPANATMQPIYVSRAEFRSTMILGQVVGVYRKLQGGRTP
>Mature_222_residues
MEELTERQREILSFIVKETETRGFPPTIREIGEHMDIRSTNGVNDHLKALERKGYLNRGEQQSRSLVATKRARLLLGLGA
RKDSGMVEIPLLGKVAAGAPLLAQENMEDSVKIDSFLLGGVNGREVFALRVKGQSMIDDGIHDGDYLFVKKTPSAQPGEI
VVALIEDEATVKRYYPEGDRIRFQPANATMQPIYVSRAEFRSTMILGQVVGVYRKLQGGRTP

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=214, Percent_Identity=40.1869158878505, Blast_Score=131, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_MYXXD (Q1D406)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_632617.1
- ProteinModelPortal:   Q1D406
- SMR:   Q1D406
- STRING:   Q1D406
- MEROPS:   S24.001
- GeneID:   4106851
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_4446
- TIGR:   MXAN_4446
- eggNOG:   COG1974
- HOGENOM:   HBG679610
- OMA:   IAENPDF
- PhylomeDB:   Q1D406
- ProtClustDB:   CLSK945819
- BioCyc:   MXAN246197:MXAN_4446-MONOMER
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 24713; Mature: 24713

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: ACT_SITE 135-135 ACT_SITE 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEELTERQREILSFIVKETETRGFPPTIREIGEHMDIRSTNGVNDHLKALERKGYLNRGE
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCH
QQSRSLVATKRARLLLGLGARKDSGMVEIPLLGKVAAGAPLLAQENMEDSVKIDSFLLGG
HHHHHHHHHHHHHHEEECCCCCCCCEEEECCCCHHHCCCCCHHHCCCCCHHEECCEEECC
VNGREVFALRVKGQSMIDDGIHDGDYLFVKKTPSAQPGEIVVALIEDEATVKRYYPEGDR
CCCCEEEEEEECCCHHHHCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHCCCCCCE
IRFQPANATMQPIYVSRAEFRSTMILGQVVGVYRKLQGGRTP
EEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEELTERQREILSFIVKETETRGFPPTIREIGEHMDIRSTNGVNDHLKALERKGYLNRGE
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCH
QQSRSLVATKRARLLLGLGARKDSGMVEIPLLGKVAAGAPLLAQENMEDSVKIDSFLLGG
HHHHHHHHHHHHHHEEECCCCCCCCEEEECCCCHHHCCCCCHHHCCCCCHHEECCEEECC
VNGREVFALRVKGQSMIDDGIHDGDYLFVKKTPSAQPGEIVVALIEDEATVKRYYPEGDR
CCCCEEEEEEECCCHHHHCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHCCCCCCE
IRFQPANATMQPIYVSRAEFRSTMILGQVVGVYRKLQGGRTP
EEEECCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA