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The map label for this gene is pcrA [H]

Identifier: 108762524

GI number: 108762524

Start: 4052738

End: 4054816

Strand: Direct

Name: pcrA [H]

Synonym: MXAN_3472

Alternate gene names: 108762524

Gene position: 4052738-4054816 (Clockwise)

Preceding gene: 108757865

Following gene: 108758578

Centisome position: 44.34

GC content: 70.03

Gene sequence:

>2079_bases
ATGGCCTCCCGCACCGATACGCTCCAGGCTCCGGCCGTGACGCCCTCGCTGCGGATCGACTATGCCGCGCTCCTCAACGA
GGAGCAGTTGCGCGCGGTGGAGGCGGGGGAGGGGCCCGTGCTGGTGATTGCCGGCGCGGGCTCCGGCAAGACACGCACGC
TGACCTTCCGGGTGGCGCGCATGCTGGAGCGAGGTGTTCCGCCCGCGGGCATCCTCCTGCTCACCTTCACCAACAAGGCG
GCCCGGGAGATGACGCGCCGAGTGGAGGAGCTGGCCGGCGCCTTCGTGGACGTGCGGCGCATCCTCGGCGGCACCTTCCA
CCATGCCGCGCACGTGCTGCTGCGCCAGTACGCGGGCGTGCTGGGCTTCTCCACGAACTTCACCGTGCTGGACCGCGAGG
ACGCGCGGGACCTGATGGTGACGTGCATCGCCGAGCGCCGGCTCAAGAGCGACAAGCGCTTCCCCCGGCCAGACCTGGTG
TTGGACCTGGTTTCCCTGGCGGCCAACCTCCAGCAACCCGTGTCACACGTGCTGATGGACCGCCGGCCGCAGATGTTGCC
GCTGGCGCCCGAGGTGCTCGCCGCCGCCGCGCGCTTCCAGCAGCGCAAGGCGCAGATGCACCTGATGGACTTCGATGACC
TGCTGGTGCACCTCAAGCGCCTGCTGACGCATCACCCGGACGTGAAGGCGCAGCTCACCGAGCGCTTCCGCTGCGTGCTC
GTGGACGAGTACCAGGACACCAACCGGCTCCAGGGCGACCTGGTGGATTTGTTCGCCGGAGAGCGCAAGGACCTCACGGT
GGTGGGGGACGACTGCCAGTCCATCTACAGCTTCCGGGGCGCGGACTTCACCAACATCATCGGCTTCCCCGAACGCTACC
CGGGCTGCTCCGTCCATGCGCTGACGCGCAACTACCGCTCCACGCCGGAAATCCTGCGGCTGGCCAACACCTCCATCGCG
CTCAACACGAACCAGTTCCCCAAGGTGTTGACGGCGGCACGGTCCCCGGGCGTCAAGCCGCTCATCGTTCCCGCCCGGGA
CGCCGGGGAGCAGGCCGCCTACGTGGCCCAGCGCATCGGTGAGCTCCGCGACCAGGGCCTGTCCCTGGAGGCCATGGCCG
TGCTGTATCGGGCCCACAATCACTCGCTGGAGCTCCAACTGGAGTTGACCCGGCGCGGCATCCCTTTCCGGGTGCGCTCC
GGCGTCCGCTTCTTCGAGCAGTCCCACATCAAGGACGTGCTGGCCCACCTCCGGTTGGTGAACAACCCGGGGGATGAGCT
GGCCTTCAAGCGCGTCATCCGGCGCGTCCCAGGCGTGGGACCGGCGACGGCCGAGCACCTCTGGACCGCTCTGCGCGCAT
CGCCGGAGGGGACACCCCTGGCGGAGGGGCTGGCCCATGCGGACGTCCGCGCGCACCTGCCACGCAAGGCGCAGAAGGGA
TTCCAGGCCTTCAGTGACCTGATGGGGCGGCTGACCCAGCCGGAGGCGTCCCCCTCACCAGGGCGCCTCATCGAGGACGT
CCTCGCCGGGGGCTACGCGGACTTCCTCCGGGCGGAGTTCTCCGAGGAGGAGCACCGGGAGGACGACGTCCGCCAACTGG
CGGAGTTCGCCGGCCGCTTCGAGGACGTGGCGCGCTTCCTGTCGGAGATCGCCCTGGTGTCGGAGTTCGCGGCGGGGGAG
GCATTGAGGGAGGAGGGGCCGGAGGCGTGCCTGACGCTGTCCACCGTCCATCAGGCCAAGGGGCTTGAGTGGCGGGCCGT
CTTCGTCCTGTGGCTGGCCGACGGGCGGTTTCCGCTGTCATTGGCCACGCGCCTGCCCGAGGAGGAGGAAGAGGAGCGGC
GGCTGTTCTACGTGGCCCTGACCCGGGCGCGGGACACCCTGGCGCTGGTGTACCCCCAGTCGGTGCTGCCCCGGGACGGG
GAGCGGATCCTCCTGCGACCGTCCCGGTTCCTCCAGGAACTGCCCGGCGGGGAGGACGCACCGTTCGACCGGTGCATCCT
GTCCACCCTGGAGGCGGAGCCCGAGGCGTCCGTGGGGCAGGATGGTCCCCCTCCGGGTGGATCGGACCCGGTGGACTGA

Upstream 100 bases:

>100_bases
CCCAGGTCCGCGCGGCCGCGTCCGCCCGGCTGACCGCGCTCAAGCCGGTTCCCTGATCCGGGTGTCCCGGTGCGCCGGGC
CGGTTAGAGTCTGCGTCCCC

Downstream 100 bases:

>100_bases
CACCGTCGCCCAGAAACGCGCACTCCTGTGCGCGACGTGATAGACAGTGGAATCAGGGGCGGCGTCTTTTGGCACGAGCC
CCCTCACTTCATGGCGGACA

Product: ATP-dependent DNA helicase UvrD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MASRTDTLQAPAVTPSLRIDYAALLNEEQLRAVEAGEGPVLVIAGAGSGKTRTLTFRVARMLERGVPPAGILLLTFTNKA
AREMTRRVEELAGAFVDVRRILGGTFHHAAHVLLRQYAGVLGFSTNFTVLDREDARDLMVTCIAERRLKSDKRFPRPDLV
LDLVSLAANLQQPVSHVLMDRRPQMLPLAPEVLAAAARFQQRKAQMHLMDFDDLLVHLKRLLTHHPDVKAQLTERFRCVL
VDEYQDTNRLQGDLVDLFAGERKDLTVVGDDCQSIYSFRGADFTNIIGFPERYPGCSVHALTRNYRSTPEILRLANTSIA
LNTNQFPKVLTAARSPGVKPLIVPARDAGEQAAYVAQRIGELRDQGLSLEAMAVLYRAHNHSLELQLELTRRGIPFRVRS
GVRFFEQSHIKDVLAHLRLVNNPGDELAFKRVIRRVPGVGPATAEHLWTALRASPEGTPLAEGLAHADVRAHLPRKAQKG
FQAFSDLMGRLTQPEASPSPGRLIEDVLAGGYADFLRAEFSEEEHREDDVRQLAEFAGRFEDVARFLSEIALVSEFAAGE
ALREEGPEACLTLSTVHQAKGLEWRAVFVLWLADGRFPLSLATRLPEEEEEERRLFYVALTRARDTLALVYPQSVLPRDG
ERILLRPSRFLQELPGGEDAPFDRCILSTLEAEPEASVGQDGPPPGGSDPVD

Sequences:

>Translated_692_residues
MASRTDTLQAPAVTPSLRIDYAALLNEEQLRAVEAGEGPVLVIAGAGSGKTRTLTFRVARMLERGVPPAGILLLTFTNKA
AREMTRRVEELAGAFVDVRRILGGTFHHAAHVLLRQYAGVLGFSTNFTVLDREDARDLMVTCIAERRLKSDKRFPRPDLV
LDLVSLAANLQQPVSHVLMDRRPQMLPLAPEVLAAAARFQQRKAQMHLMDFDDLLVHLKRLLTHHPDVKAQLTERFRCVL
VDEYQDTNRLQGDLVDLFAGERKDLTVVGDDCQSIYSFRGADFTNIIGFPERYPGCSVHALTRNYRSTPEILRLANTSIA
LNTNQFPKVLTAARSPGVKPLIVPARDAGEQAAYVAQRIGELRDQGLSLEAMAVLYRAHNHSLELQLELTRRGIPFRVRS
GVRFFEQSHIKDVLAHLRLVNNPGDELAFKRVIRRVPGVGPATAEHLWTALRASPEGTPLAEGLAHADVRAHLPRKAQKG
FQAFSDLMGRLTQPEASPSPGRLIEDVLAGGYADFLRAEFSEEEHREDDVRQLAEFAGRFEDVARFLSEIALVSEFAAGE
ALREEGPEACLTLSTVHQAKGLEWRAVFVLWLADGRFPLSLATRLPEEEEEERRLFYVALTRARDTLALVYPQSVLPRDG
ERILLRPSRFLQELPGGEDAPFDRCILSTLEAEPEASVGQDGPPPGGSDPVD
>Mature_691_residues
ASRTDTLQAPAVTPSLRIDYAALLNEEQLRAVEAGEGPVLVIAGAGSGKTRTLTFRVARMLERGVPPAGILLLTFTNKAA
REMTRRVEELAGAFVDVRRILGGTFHHAAHVLLRQYAGVLGFSTNFTVLDREDARDLMVTCIAERRLKSDKRFPRPDLVL
DLVSLAANLQQPVSHVLMDRRPQMLPLAPEVLAAAARFQQRKAQMHLMDFDDLLVHLKRLLTHHPDVKAQLTERFRCVLV
DEYQDTNRLQGDLVDLFAGERKDLTVVGDDCQSIYSFRGADFTNIIGFPERYPGCSVHALTRNYRSTPEILRLANTSIAL
NTNQFPKVLTAARSPGVKPLIVPARDAGEQAAYVAQRIGELRDQGLSLEAMAVLYRAHNHSLELQLELTRRGIPFRVRSG
VRFFEQSHIKDVLAHLRLVNNPGDELAFKRVIRRVPGVGPATAEHLWTALRASPEGTPLAEGLAHADVRAHLPRKAQKGF
QAFSDLMGRLTQPEASPSPGRLIEDVLAGGYADFLRAEFSEEEHREDDVRQLAEFAGRFEDVARFLSEIALVSEFAAGEA
LREEGPEACLTLSTVHQAKGLEWRAVFVLWLADGRFPLSLATRLPEEEEEERRLFYVALTRARDTLALVYPQSVLPRDGE
RILLRPSRFLQELPGGEDAPFDRCILSTLEAEPEASVGQDGPPPGGSDPVD

Specific function: Essential helicase [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=658, Percent_Identity=33.2826747720365, Blast_Score=278, Evalue=8e-76,
Organism=Escherichia coli, GI48994965, Length=664, Percent_Identity=31.0240963855422, Blast_Score=236, Evalue=4e-63,
Organism=Escherichia coli, GI1787196, Length=365, Percent_Identity=27.3972602739726, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322369, Length=511, Percent_Identity=27.2015655577299, Blast_Score=143, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6324477, Length=673, Percent_Identity=22.1396731054978, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 76859; Mature: 76728

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASRTDTLQAPAVTPSLRIDYAALLNEEQLRAVEAGEGPVLVIAGAGSGKTRTLTFRVAR
CCCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHCCCCCCEEEEEECCCCCCEEHHHHHHH
MLERGVPPAGILLLTFTNKAAREMTRRVEELAGAFVDVRRILGGTFHHAAHVLLRQYAGV
HHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LGFSTNFTVLDREDARDLMVTCIAERRLKSDKRFPRPDLVLDLVSLAANLQQPVSHVLMD
HCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
RRPQMLPLAPEVLAAAARFQQRKAQMHLMDFDDLLVHLKRLLTHHPDVKAQLTERFRCVL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCEEEE
VDEYQDTNRLQGDLVDLFAGERKDLTVVGDDCQSIYSFRGADFTNIIGFPERYPGCSVHA
EECCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHCCCCHHHHCCCCCCCCCCEEEH
LTRNYRSTPEILRLANTSIALNTNQFPKVLTAARSPGVKPLIVPARDAGEQAAYVAQRIG
HHHCCCCCHHHHHHHCCEEEECCCCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
ELRDQGLSLEAMAVLYRAHNHSLELQLELTRRGIPFRVRSGVRFFEQSHIKDVLAHLRLV
HHHHCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
NNPGDELAFKRVIRRVPGVGPATAEHLWTALRASPEGTPLAEGLAHADVRAHLPRKAQKG
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHH
FQAFSDLMGRLTQPEASPSPGRLIEDVLAGGYADFLRAEFSEEEHREDDVRQLAEFAGRF
HHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
EDVARFLSEIALVSEFAAGEALREEGPEACLTLSTVHQAKGLEWRAVFVLWLADGRFPLS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEHHHHHHHCCCCEEEEEEEEEECCCCCHH
LATRLPEEEEEERRLFYVALTRARDTLALVYPQSVLPRDGERILLRPSRFLQELPGGEDA
HHHHCCCCCHHHHEEEEEEEECCCCEEEEEECHHHCCCCCCEEEECHHHHHHHCCCCCCC
PFDRCILSTLEAEPEASVGQDGPPPGGSDPVD
CHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASRTDTLQAPAVTPSLRIDYAALLNEEQLRAVEAGEGPVLVIAGAGSGKTRTLTFRVAR
CCCCCCCCCCCCCCCCCCHHHHHHCHHHHHHHCCCCCCEEEEEECCCCCCEEHHHHHHH
MLERGVPPAGILLLTFTNKAAREMTRRVEELAGAFVDVRRILGGTFHHAAHVLLRQYAGV
HHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LGFSTNFTVLDREDARDLMVTCIAERRLKSDKRFPRPDLVLDLVSLAANLQQPVSHVLMD
HCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
RRPQMLPLAPEVLAAAARFQQRKAQMHLMDFDDLLVHLKRLLTHHPDVKAQLTERFRCVL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCCEEEE
VDEYQDTNRLQGDLVDLFAGERKDLTVVGDDCQSIYSFRGADFTNIIGFPERYPGCSVHA
EECCCCCCHHHHHHHHHHCCCCCCEEEECCHHHHHHHHCCCCHHHHCCCCCCCCCCEEEH
LTRNYRSTPEILRLANTSIALNTNQFPKVLTAARSPGVKPLIVPARDAGEQAAYVAQRIG
HHHCCCCCHHHHHHHCCEEEECCCCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHH
ELRDQGLSLEAMAVLYRAHNHSLELQLELTRRGIPFRVRSGVRFFEQSHIKDVLAHLRLV
HHHHCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
NNPGDELAFKRVIRRVPGVGPATAEHLWTALRASPEGTPLAEGLAHADVRAHLPRKAQKG
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHH
FQAFSDLMGRLTQPEASPSPGRLIEDVLAGGYADFLRAEFSEEEHREDDVRQLAEFAGRF
HHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
EDVARFLSEIALVSEFAAGEALREEGPEACLTLSTVHQAKGLEWRAVFVLWLADGRFPLS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEHHHHHHHCCCCEEEEEEEEEECCCCCHH
LATRLPEEEEEERRLFYVALTRARDTLALVYPQSVLPRDGERILLRPSRFLQELPGGEDA
HHHHCCCCCHHHHEEEEEEEECCCCEEEEEECHHHCCCCCCEEEECHHHHHHHCCCCCCC
PFDRCILSTLEAEPEASVGQDGPPPGGSDPVD
CHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA