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The map label for this gene is hemL [H]

Identifier: 108762371

GI number: 108762371

Start: 4337885

End: 4339159

Strand: Reverse

Name: hemL [H]

Synonym: MXAN_3640

Alternate gene names: 108762371

Gene position: 4339159-4337885 (Counterclockwise)

Preceding gene: 108762504

Following gene: 108760569

Centisome position: 47.48

GC content: 69.1

Gene sequence:

>1275_bases
ATGGACACTCCCGTCAAGAAGCACCCTTCCCTGCCTCGTCCCATCCAGGGCGAGCTGAAGCTCGACCGCTCCAACCAGCT
CCTCGCCGAGGCGCGGCGGCTGGTCCCCGGCGTCACGCAGTCCATGATGAAGCGCCCGGAGATGTTCGCGCTCGGCGCCT
TCCCCGTGTTCCTGGCCAAGGGCAAGGGCGCGCTGGTGGAGGACGTGGACGGCCAGGAGTACATCGACTTCATCGGCGGC
CTGGGCGCCAACATGCTGGGCCACAATGACCCAGCCGTGGTGAACGCCATCCGGGAGCACCTGGAGGAAGGGGTCCTCCA
CTCGCTGCCCACGCCCGTGGAGGTCTCCGCCGCCCAGACGCTGGTGGACCTCATCCCCGGCGCGGAGATGGCGCGCTTCT
TCAAGACGGGCGCGGATGCCACGTCCGCCGCCGTGCGCCTGGCGCGCCACATCACCGGCAAGCAGAAGATCATCACCGTC
GGCTACAACGGCTGGCACGACCACTTCATGTTCGACACGCCGGGCGTCCCGGCCGCGCTGGCGGCGCTGACCCTTCGGAT
GCCGCTCTTCACGCCCCCGGACGAACCGGCCCTGCTGGCCAGCATCGAGAAGAACGCCAGCGAGCTCGCCCTGGTGCTGT
TGTCGGTGCCCTACAACCGGCCCCTCACCCCGGCCTTCCTGCAACAGGTGCGCGCCACGTGCACCGCGAACAACGTCCTG
TTCGCCCTGGACGAAGTCGTCACCGGCTTCCGGCTCGCCGTGGGCGGCGCCCAGGAGTTCTTCGACGTCCGCGCGGACTT
CGTCACGCTGTCCAAGAGCATCGCTGGCGGCATGCCGCTGTCGGCCATCGCCGGTCCGGCGAAGCACCTGAGCCGCCTGA
GCGAGCTCCAGGTGTCCACCACCTTCGGCGGTGAGCTGCTGTCGCTGTACGTGTGCGACGCGGTGCTGAAGGGCTACCGG
GATGGCGCCTACATCCAGCACCTGGCCCACCTGGGCCGCAAGCTGCGCGAGGGCGTCAACGCCCAGGCGGAGGCCGCGGG
CTCATCGTTGCGCGTGATTGGCTACGACGCGATTCCCTTCTTCCTGTTCGCCAAGGACCCGACGGAGCACGCGAAGCAGA
TGCAGCCCTTCCAGGCGGGCATGGCCCGCCGGGGCATCCTGCTGCGCCGCGACGTCACCTTCCTCAGCACGGCGCACACG
GAGGAGCAGATTGACTACGCCATCGAGATGACGGGCGAAGTCCTCCGCTCCCTCGCGCAGCCGGCGGCGGCCTAG

Upstream 100 bases:

>100_bases
TCATCCTCTGGACCTTTGGCCGTAGCGCCGTCCCGCTCAACGCGGCGCCCACGCCTCGGTGAATCGCAGTCTCCGTCTCG
ACCCACAGAAGGAAACGTCC

Downstream 100 bases:

>100_bases
CCCTTCGCGTCGTGGTGGTCCGAGGTGCCGCGCTTCCAATAGCCCGTCACCCGGACCCAGCTCTTGTTGGCGCCACGCTC
GTTGATGAGGTGGTCCTTGA

Product: siderophore biosynthesis aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MDTPVKKHPSLPRPIQGELKLDRSNQLLAEARRLVPGVTQSMMKRPEMFALGAFPVFLAKGKGALVEDVDGQEYIDFIGG
LGANMLGHNDPAVVNAIREHLEEGVLHSLPTPVEVSAAQTLVDLIPGAEMARFFKTGADATSAAVRLARHITGKQKIITV
GYNGWHDHFMFDTPGVPAALAALTLRMPLFTPPDEPALLASIEKNASELALVLLSVPYNRPLTPAFLQQVRATCTANNVL
FALDEVVTGFRLAVGGAQEFFDVRADFVTLSKSIAGGMPLSAIAGPAKHLSRLSELQVSTTFGGELLSLYVCDAVLKGYR
DGAYIQHLAHLGRKLREGVNAQAEAAGSSLRVIGYDAIPFFLFAKDPTEHAKQMQPFQAGMARRGILLRRDVTFLSTAHT
EEQIDYAIEMTGEVLRSLAQPAAA

Sequences:

>Translated_424_residues
MDTPVKKHPSLPRPIQGELKLDRSNQLLAEARRLVPGVTQSMMKRPEMFALGAFPVFLAKGKGALVEDVDGQEYIDFIGG
LGANMLGHNDPAVVNAIREHLEEGVLHSLPTPVEVSAAQTLVDLIPGAEMARFFKTGADATSAAVRLARHITGKQKIITV
GYNGWHDHFMFDTPGVPAALAALTLRMPLFTPPDEPALLASIEKNASELALVLLSVPYNRPLTPAFLQQVRATCTANNVL
FALDEVVTGFRLAVGGAQEFFDVRADFVTLSKSIAGGMPLSAIAGPAKHLSRLSELQVSTTFGGELLSLYVCDAVLKGYR
DGAYIQHLAHLGRKLREGVNAQAEAAGSSLRVIGYDAIPFFLFAKDPTEHAKQMQPFQAGMARRGILLRRDVTFLSTAHT
EEQIDYAIEMTGEVLRSLAQPAAA
>Mature_424_residues
MDTPVKKHPSLPRPIQGELKLDRSNQLLAEARRLVPGVTQSMMKRPEMFALGAFPVFLAKGKGALVEDVDGQEYIDFIGG
LGANMLGHNDPAVVNAIREHLEEGVLHSLPTPVEVSAAQTLVDLIPGAEMARFFKTGADATSAAVRLARHITGKQKIITV
GYNGWHDHFMFDTPGVPAALAALTLRMPLFTPPDEPALLASIEKNASELALVLLSVPYNRPLTPAFLQQVRATCTANNVL
FALDEVVTGFRLAVGGAQEFFDVRADFVTLSKSIAGGMPLSAIAGPAKHLSRLSELQVSTTFGGELLSLYVCDAVLKGYR
DGAYIQHLAHLGRKLREGVNAQAEAAGSSLRVIGYDAIPFFLFAKDPTEHAKQMQPFQAGMARRGILLRRDVTFLSTAHT
EEQIDYAIEMTGEVLRSLAQPAAA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI24119277, Length=304, Percent_Identity=26.6447368421053, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1786349, Length=431, Percent_Identity=32.7146171693735, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1789016, Length=319, Percent_Identity=27.5862068965517, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI145693181, Length=314, Percent_Identity=29.9363057324841, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788044, Length=283, Percent_Identity=28.9752650176678, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323470, Length=337, Percent_Identity=26.7062314540059, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 45755; Mature: 45755

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTPVKKHPSLPRPIQGELKLDRSNQLLAEARRLVPGVTQSMMKRPEMFALGAFPVFLAK
CCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHCCHHHHHHHCCCCCEEECCHHHHEEC
GKGALVEDVDGQEYIDFIGGLGANMLGHNDPAVVNAIREHLEEGVLHSLPTPVEVSAAQT
CCCCEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LVDLIPGAEMARFFKTGADATSAAVRLARHITGKQKIITVGYNGWHDHFMFDTPGVPAAL
HHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCHHHHH
AALTLRMPLFTPPDEPALLASIEKNASELALVLLSVPYNRPLTPAFLQQVRATCTANNVL
HHHHHHCCCCCCCCCCHHHHHHHCCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHCHHH
FALDEVVTGFRLAVGGAQEFFDVRADFVTLSKSIAGGMPLSAIAGPAKHLSRLSELQVST
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHEEC
TFGGELLSLYVCDAVLKGYRDGAYIQHLAHLGRKLREGVNAQAEAAGSSLRVIGYDAIPF
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEEECCCEE
FLFAKDPTEHAKQMQPFQAGMARRGILLRRDVTFLSTAHTEEQIDYAIEMTGEVLRSLAQ
EEEECCHHHHHHHCCHHHHHHHHCCEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
PAAA
CCCC
>Mature Secondary Structure
MDTPVKKHPSLPRPIQGELKLDRSNQLLAEARRLVPGVTQSMMKRPEMFALGAFPVFLAK
CCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHCCHHHHHHHCCCCCEEECCHHHHEEC
GKGALVEDVDGQEYIDFIGGLGANMLGHNDPAVVNAIREHLEEGVLHSLPTPVEVSAAQT
CCCCEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LVDLIPGAEMARFFKTGADATSAAVRLARHITGKQKIITVGYNGWHDHFMFDTPGVPAAL
HHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEECCCCHHHHH
AALTLRMPLFTPPDEPALLASIEKNASELALVLLSVPYNRPLTPAFLQQVRATCTANNVL
HHHHHHCCCCCCCCCCHHHHHHHCCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHCHHH
FALDEVVTGFRLAVGGAQEFFDVRADFVTLSKSIAGGMPLSAIAGPAKHLSRLSELQVST
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHEEC
TFGGELLSLYVCDAVLKGYRDGAYIQHLAHLGRKLREGVNAQAEAAGSSLRVIGYDAIPF
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEEECCCEE
FLFAKDPTEHAKQMQPFQAGMARRGILLRRDVTFLSTAHTEEQIDYAIEMTGEVLRSLAQ
EEEECCHHHHHHHCCHHHHHHHHCCEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
PAAA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]