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The map label for this gene is ycbL [H]

Identifier: 108762125

GI number: 108762125

Start: 6757957

End: 6759408

Strand: Reverse

Name: ycbL [H]

Synonym: MXAN_5428

Alternate gene names: 108762125

Gene position: 6759408-6757957 (Counterclockwise)

Preceding gene: 108759932

Following gene: 108760423

Centisome position: 73.96

GC content: 66.32

Gene sequence:

>1452_bases
ATGTACTTCCAGGCCATCAAGACCGCGGGCCTTGCCCAAATCACCTACATCCTGGGCAGTGAAGGCGAGGCGCTCGTCGT
CGACCCCCGGCGTGATGTCGACGTCTACCTGGACGTGTTGCGGCGGCAGGAGTTGCGGCTGCGCTACGTGCTCCAGACGC
ACCGCCAGGAAGACTTCGTTGAGGGTACTTCCGCGCTTGCCCGCCTTGCAGGCGCGCAGGTGGTGGCTGGCCGGCACCCC
ATCACCGGCCATGCCGACGTGCGGATGGGCGAGCGAGAGCGGCTACACCTGGGGGCCTTGACGCTGGTGGCGCTTCATAC
GCCGGGCCACACGCCAGAGAGCATGAGCTGGGCCGTCTACCTGGATCCCCACCATGCCCAGGCTTGGGGCGTCTTCACGG
GCGACGCGCTCTTGGCTGGAGAGACAGGGCGCACGGACCTGGCTGCGCCAGAGCGGGTCTACGAGAATGCCGCGCTCCTC
TTTGATTCGCTCCATCAGAAGGTCCTGCCCCTGGGCGACCAGACACTGGTCTTCCCGGCCCACGGAGCAGGCTCGGTGTG
TCGCAGCGGCATCGCGGACAGGGAGTTGACGACACTGGGCTTCGAGCGCCTGCACAACCCCGTGTTCACCTCCAGCCGGA
GCGACTTCATCCAGCGCAAGGTGCAGGAGCGGCTTCACCGGCCTTCGTATTTCTCGCGCATGGAGGAGGTGAACATACGC
GGTGGCGTGCCACTCTCCGCGGATTCATCCGCCATCCCCTTCCTGGAGCCGAAACGCTTTCAGTGGGAAAGTCACAGTGG
CCTTGTCCTGGACGTGCGTGAGCCCGAGTCCTTCGCTGGGGGGCACATCCCGGGCTCGCTGAATGTCTGGATGCAGGGGT
TGTCCGTGTTCGGTGGACAGATGGTACAGCCGGGCACGCCGCTGTTCCTCGTCCTGCCTGCGCACGTGGACTCGAAGGAG
GCCGTGCTGGCCCTGGCCCGCGTCGGCCTCGACCAGGTGGAGGGCATCCTCACAGGGGGATTCGGGGCATGGCGCAACGC
GGGGCTGCCTATCGAGAGCAGCGGCACGCTGACGCCCGAGGCGCTCTTTTCCCAGTGGGAGGGCTTCCAGGTGCTCGACG
TGCGCGAGCGCTCTGAGTTCGAGCGTGGCCACATCCTGAGCGCACGACATGCGTATGTGACAGAGCTGGAGGAGTGCCTC
TCCGAGCTGGGACTGCGCGAAGACCATCCGGTCGCGGTGGTGTGCAGCACGGGCCATCGCTCCGGACTTGCCACGAGCAT
CCTGCTCCGCAACGGCTTCCAGCAGGTCTCGAACGTGCTGGGCGGCATGTCGGCATGGCGGCGGCTGGAACTTCCGGTGC
GGACAGGCCCGCCGTCGGAGGTCGAGTTCGAACAAGCAACGCGCTCCATGGGGACAGAGGAGCAGGACGCTTCTCCACCG
TCGCCTTCGTGA

Upstream 100 bases:

>100_bases
CGCTCCTGGCCGGACTCCCGGCGGGCCATGCAGGCGGCAACGCGCCGTGCCCGTGATGCTCTTTCCCGTCATGGCGACCA
CCTTCAGCGGAGGAGGGGCC

Downstream 100 bases:

>100_bases
GCCGTCGACGATGTTGTCGTCGGATGAGGGCATCTCCACTTCGGGCGCGGGAAGGAGGCGGTCGTGGAGTCAGGTACGCA
TCAATTCGAACCGCACGTCA

Product: metallo-beta-lactamase family protein

Products: glutathione; 2-hydroxy carboxylate

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MYFQAIKTAGLAQITYILGSEGEALVVDPRRDVDVYLDVLRRQELRLRYVLQTHRQEDFVEGTSALARLAGAQVVAGRHP
ITGHADVRMGERERLHLGALTLVALHTPGHTPESMSWAVYLDPHHAQAWGVFTGDALLAGETGRTDLAAPERVYENAALL
FDSLHQKVLPLGDQTLVFPAHGAGSVCRSGIADRELTTLGFERLHNPVFTSSRSDFIQRKVQERLHRPSYFSRMEEVNIR
GGVPLSADSSAIPFLEPKRFQWESHSGLVLDVREPESFAGGHIPGSLNVWMQGLSVFGGQMVQPGTPLFLVLPAHVDSKE
AVLALARVGLDQVEGILTGGFGAWRNAGLPIESSGTLTPEALFSQWEGFQVLDVRERSEFERGHILSARHAYVTELEECL
SELGLREDHPVAVVCSTGHRSGLATSILLRNGFQQVSNVLGGMSAWRRLELPVRTGPPSEVEFEQATRSMGTEEQDASPP
SPS

Sequences:

>Translated_483_residues
MYFQAIKTAGLAQITYILGSEGEALVVDPRRDVDVYLDVLRRQELRLRYVLQTHRQEDFVEGTSALARLAGAQVVAGRHP
ITGHADVRMGERERLHLGALTLVALHTPGHTPESMSWAVYLDPHHAQAWGVFTGDALLAGETGRTDLAAPERVYENAALL
FDSLHQKVLPLGDQTLVFPAHGAGSVCRSGIADRELTTLGFERLHNPVFTSSRSDFIQRKVQERLHRPSYFSRMEEVNIR
GGVPLSADSSAIPFLEPKRFQWESHSGLVLDVREPESFAGGHIPGSLNVWMQGLSVFGGQMVQPGTPLFLVLPAHVDSKE
AVLALARVGLDQVEGILTGGFGAWRNAGLPIESSGTLTPEALFSQWEGFQVLDVRERSEFERGHILSARHAYVTELEECL
SELGLREDHPVAVVCSTGHRSGLATSILLRNGFQQVSNVLGGMSAWRRLELPVRTGPPSEVEFEQATRSMGTEEQDASPP
SPS
>Mature_483_residues
MYFQAIKTAGLAQITYILGSEGEALVVDPRRDVDVYLDVLRRQELRLRYVLQTHRQEDFVEGTSALARLAGAQVVAGRHP
ITGHADVRMGERERLHLGALTLVALHTPGHTPESMSWAVYLDPHHAQAWGVFTGDALLAGETGRTDLAAPERVYENAALL
FDSLHQKVLPLGDQTLVFPAHGAGSVCRSGIADRELTTLGFERLHNPVFTSSRSDFIQRKVQERLHRPSYFSRMEEVNIR
GGVPLSADSSAIPFLEPKRFQWESHSGLVLDVREPESFAGGHIPGSLNVWMQGLSVFGGQMVQPGTPLFLVLPAHVDSKE
AVLALARVGLDQVEGILTGGFGAWRNAGLPIESSGTLTPEALFSQWEGFQVLDVRERSEFERGHILSARHAYVTELEECL
SELGLREDHPVAVVCSTGHRSGLATSILLRNGFQQVSNVLGGMSAWRRLELPVRTGPPSEVEFEQATRSMGTEEQDASPP
SPS

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=241, Percent_Identity=29.4605809128631, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1787158, Length=233, Percent_Identity=28.3261802575107, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538952, Length=231, Percent_Identity=29.8701298701299, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221330176, Length=237, Percent_Identity=27.4261603375527, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: 3.1.2.6

Molecular weight: Translated: 52963; Mature: 52963

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYFQAIKTAGLAQITYILGSEGEALVVDPRRDVDVYLDVLRRQELRLRYVLQTHRQEDFV
CCHHHHHHCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGTSALARLAGAQVVAGRHPITGHADVRMGERERLHLGALTLVALHTPGHTPESMSWAVY
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHEEECEEEEEEEECCCCCCCCCEEEEE
LDPHHAQAWGVFTGDALLAGETGRTDLAAPERVYENAALLFDSLHQKVLPLGDQTLVFPA
ECCCCCCEEEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
HGAGSVCRSGIADRELTTLGFERLHNPVFTSSRSDFIQRKVQERLHRPSYFSRMEEVNIR
CCCHHHHHCCCCCCHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCC
GGVPLSADSSAIPFLEPKRFQWESHSGLVLDVREPESFAGGHIPGSLNVWMQGLSVFGGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCE
MVQPGTPLFLVLPAHVDSKEAVLALARVGLDQVEGILTGGFGAWRNAGLPIESSGTLTPE
EECCCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHH
ALFSQWEGFQVLDVRERSEFERGHILSARHAYVTELEECLSELGLREDHPVAVVCSTGHR
HHHHHCCCCEEEECHHHHCCCCCCEECHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCC
SGLATSILLRNGFQQVSNVLGGMSAWRRLELPVRTGPPSEVEFEQATRSMGTEEQDASPP
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCC
SPS
CCC
>Mature Secondary Structure
MYFQAIKTAGLAQITYILGSEGEALVVDPRRDVDVYLDVLRRQELRLRYVLQTHRQEDFV
CCHHHHHHCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGTSALARLAGAQVVAGRHPITGHADVRMGERERLHLGALTLVALHTPGHTPESMSWAVY
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHEEECEEEEEEEECCCCCCCCCEEEEE
LDPHHAQAWGVFTGDALLAGETGRTDLAAPERVYENAALLFDSLHQKVLPLGDQTLVFPA
ECCCCCCEEEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
HGAGSVCRSGIADRELTTLGFERLHNPVFTSSRSDFIQRKVQERLHRPSYFSRMEEVNIR
CCCHHHHHCCCCCCHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCC
GGVPLSADSSAIPFLEPKRFQWESHSGLVLDVREPESFAGGHIPGSLNVWMQGLSVFGGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCE
MVQPGTPLFLVLPAHVDSKEAVLALARVGLDQVEGILTGGFGAWRNAGLPIESSGTLTPE
EECCCCCEEEEEECCCCCHHHHHHHHHHCHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHH
ALFSQWEGFQVLDVRERSEFERGHILSARHAYVTELEECLSELGLREDHPVAVVCSTGHR
HHHHHCCCCEEEECHHHHCCCCCCEECHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCC
SGLATSILLRNGFQQVSNVLGGMSAWRRLELPVRTGPPSEVEFEQATRSMGTEEQDASPP
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCHHHHHHHHCCCCCCCCCCC
SPS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-(2-hydroxyacyl)glutathione; H2O

Specific reaction: S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]