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The map label for this gene is gltA [H]

Identifier: 108762008

GI number: 108762008

Start: 4098860

End: 4100161

Strand: Reverse

Name: gltA [H]

Synonym: MXAN_3519

Alternate gene names: 108762008

Gene position: 4100161-4098860 (Counterclockwise)

Preceding gene: 108757763

Following gene: 108758485

Centisome position: 44.86

GC content: 63.59

Gene sequence:

>1302_bases
ATGGCCAAGGACACGCTGACGATCACCGACAATCGGACCGGGAAGACCTACGAGGTCCCGATCGAGAACGGCTGTATTCG
CACCAATGCTCTCCGCCAGATCAAAACGGGCGACGATGACTTTGGGTTGATGGGCTACGATCCGGCGTTCCTCAATACCG
CCAACTGCAAGAGCGCCATCACCTTCATCGACGGAGACAAGGGCATCCTGGAGTACCGGGGCTACCCCATCGAGCAGCTC
GCGGAGAAGTCGAGCTTCCTCGAGGTCGCCTACCTCCTGCTGAACGGTGAGCTTCCCTCCGAGAAGGAGCTGCAGCAGTT
CAACCACCTCGTCACGCACCACACCTACGTGCACGAGAACGTGAAGAGCTTCATGGACGGGTTCCGCTACGACGCGCACC
CCATGTCCATGGTGAGCTCCACGGTGGCGGCGCTGTCCAGCTTCTACCCCGACGCGAAGAACATCAAGGACCCGCTGAGC
CGCCGCATCCAGATCACGCGGCTCATCGCGAAGATGCCCACCATCGCCGCGTTCTCCTACCGGCACACGATGGGCCTGCC
GTACATCTACCCGGACAACGACCTGTCCTACGTCGCCAACTTCCTGGCGATGATCAAGCGCATCGGCACGTCGACCTACA
AGGTCCACCCGGTGCTCGAGCGCGCGCTCGACATCCTCTTCATCCTGCACGCGGACCACGAGCAGAACTGCTCCACCACG
TCCGTGCGCACGGTGGGCTCGTCCGAGGTGGATCCGTACTCGGCGGTCAGCGCGGGCATCGGCGCCCTCTACGGCCCGCT
GCACGGCGGCGCCAACGAGGCGGTGCTCCGCATGCTCCGCGACATCGGCCACGTCTCCAAGATCCCGGAGTTCATCAAGT
CGGTGAAGAGCGGCGAGGGTGAGAAGAAGCTGATGGGCTTCGGTCACCGCGTCTACAAGTCCTACGATCCGCGCGCCAAG
GTCATCAAGCGCGTGGCCGACGAGGTCTTCGAGGTGACGGGCAAGAACCCGCTGCTGGAGATCGCCGTCGAGCTGGAGCG
CATCGCGCTCGAGGACGAGTACTTCGTGAAGCGGAAGCTGTACCCGAACGTCGACTTCTACTCGGGCCTCATCTACGAGG
CGATGGGCTTCCAGGTCGAGATGTTCCCGGTGCTCTTCGCCATCCCCCGCACGGTGGGCTGGTGCGCGCAGTGGGAGGAG
ATGGTGACGGACAACGAGCAGAAGATTGCCCGTCCGCGCCAGGTGTTCACGGGCGCCCCGCGCCGCGACTACGTCCCCAT
GGACAAGCGCGCCGTCAAGTAG

Upstream 100 bases:

>100_bases
TTCGGATAACTGATGCAGGATGAGACCCCCAGTGTCCGTCCAGCAGACTTATCGTTCTTTTTTGTTGAAAGCACTCTCCC
CCCTGTGAAATCTCCGCCCC

Downstream 100 bases:

>100_bases
GCCGTGACCCAAGGCCCGCGCGTCTCGCGTGGGCCTGAAGCACGAAGGGGCGAGGAACCGCGAGGTTCCCCGCCCCTTTC
GCTTTCCCGCGGCGCCGGCA

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MAKDTLTITDNRTGKTYEVPIENGCIRTNALRQIKTGDDDFGLMGYDPAFLNTANCKSAITFIDGDKGILEYRGYPIEQL
AEKSSFLEVAYLLLNGELPSEKELQQFNHLVTHHTYVHENVKSFMDGFRYDAHPMSMVSSTVAALSSFYPDAKNIKDPLS
RRIQITRLIAKMPTIAAFSYRHTMGLPYIYPDNDLSYVANFLAMIKRIGTSTYKVHPVLERALDILFILHADHEQNCSTT
SVRTVGSSEVDPYSAVSAGIGALYGPLHGGANEAVLRMLRDIGHVSKIPEFIKSVKSGEGEKKLMGFGHRVYKSYDPRAK
VIKRVADEVFEVTGKNPLLEIAVELERIALEDEYFVKRKLYPNVDFYSGLIYEAMGFQVEMFPVLFAIPRTVGWCAQWEE
MVTDNEQKIARPRQVFTGAPRRDYVPMDKRAVK

Sequences:

>Translated_433_residues
MAKDTLTITDNRTGKTYEVPIENGCIRTNALRQIKTGDDDFGLMGYDPAFLNTANCKSAITFIDGDKGILEYRGYPIEQL
AEKSSFLEVAYLLLNGELPSEKELQQFNHLVTHHTYVHENVKSFMDGFRYDAHPMSMVSSTVAALSSFYPDAKNIKDPLS
RRIQITRLIAKMPTIAAFSYRHTMGLPYIYPDNDLSYVANFLAMIKRIGTSTYKVHPVLERALDILFILHADHEQNCSTT
SVRTVGSSEVDPYSAVSAGIGALYGPLHGGANEAVLRMLRDIGHVSKIPEFIKSVKSGEGEKKLMGFGHRVYKSYDPRAK
VIKRVADEVFEVTGKNPLLEIAVELERIALEDEYFVKRKLYPNVDFYSGLIYEAMGFQVEMFPVLFAIPRTVGWCAQWEE
MVTDNEQKIARPRQVFTGAPRRDYVPMDKRAVK
>Mature_432_residues
AKDTLTITDNRTGKTYEVPIENGCIRTNALRQIKTGDDDFGLMGYDPAFLNTANCKSAITFIDGDKGILEYRGYPIEQLA
EKSSFLEVAYLLLNGELPSEKELQQFNHLVTHHTYVHENVKSFMDGFRYDAHPMSMVSSTVAALSSFYPDAKNIKDPLSR
RIQITRLIAKMPTIAAFSYRHTMGLPYIYPDNDLSYVANFLAMIKRIGTSTYKVHPVLERALDILFILHADHEQNCSTTS
VRTVGSSEVDPYSAVSAGIGALYGPLHGGANEAVLRMLRDIGHVSKIPEFIKSVKSGEGEKKLMGFGHRVYKSYDPRAKV
IKRVADEVFEVTGKNPLLEIAVELERIALEDEYFVKRKLYPNVDFYSGLIYEAMGFQVEMFPVLFAIPRTVGWCAQWEEM
VTDNEQKIARPRQVFTGAPRRDYVPMDKRAVK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=414, Percent_Identity=28.0193236714976, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786939, Length=390, Percent_Identity=52.3076923076923, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1786527, Length=380, Percent_Identity=33.9473684210526, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17555174, Length=373, Percent_Identity=27.3458445040214, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319850, Length=354, Percent_Identity=27.1186440677966, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324328, Length=350, Percent_Identity=26.8571428571429, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=400, Percent_Identity=24.25, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24640124, Length=400, Percent_Identity=28.5, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24640126, Length=400, Percent_Identity=28.5, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21356863, Length=393, Percent_Identity=25.9541984732824, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48898; Mature: 48766

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDTLTITDNRTGKTYEVPIENGCIRTNALRQIKTGDDDFGLMGYDPAFLNTANCKSAI
CCCCCEEEECCCCCCEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCEE
TFIDGDKGILEYRGYPIEQLAEKSSFLEVAYLLLNGELPSEKELQQFNHLVTHHTYVHEN
EEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VKSFMDGFRYDAHPMSMVSSTVAALSSFYPDAKNIKDPLSRRIQITRLIAKMPTIAAFSY
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
RHTMGLPYIYPDNDLSYVANFLAMIKRIGTSTYKVHPVLERALDILFILHADHEQNCSTT
HHHCCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHEEEEEECCCCCCCCCC
SVRTVGSSEVDPYSAVSAGIGALYGPLHGGANEAVLRMLRDIGHVSKIPEFIKSVKSGEG
CEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EKKLMGFGHRVYKSYDPRAKVIKRVADEVFEVTGKNPLLEIAVELERIALEDEYFVKRKL
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHC
YPNVDFYSGLIYEAMGFQVEMFPVLFAIPRTVGWCAQWEEMVTDNEQKIARPRQVFTGAP
CCCCHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHCCCC
RRDYVPMDKRAVK
CCCCCCCCHHCCC
>Mature Secondary Structure 
AKDTLTITDNRTGKTYEVPIENGCIRTNALRQIKTGDDDFGLMGYDPAFLNTANCKSAI
CCCCEEEECCCCCCEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCEE
TFIDGDKGILEYRGYPIEQLAEKSSFLEVAYLLLNGELPSEKELQQFNHLVTHHTYVHEN
EEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
VKSFMDGFRYDAHPMSMVSSTVAALSSFYPDAKNIKDPLSRRIQITRLIAKMPTIAAFSY
HHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHH
RHTMGLPYIYPDNDLSYVANFLAMIKRIGTSTYKVHPVLERALDILFILHADHEQNCSTT
HHHCCCCEEECCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHEEEEEECCCCCCCCCC
SVRTVGSSEVDPYSAVSAGIGALYGPLHGGANEAVLRMLRDIGHVSKIPEFIKSVKSGEG
CEEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EKKLMGFGHRVYKSYDPRAKVIKRVADEVFEVTGKNPLLEIAVELERIALEDEYFVKRKL
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHC
YPNVDFYSGLIYEAMGFQVEMFPVLFAIPRTVGWCAQWEEMVTDNEQKIARPRQVFTGAP
CCCCHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHCCCC
RRDYVPMDKRAVK
CCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]