Click here to switch to the map view.

The map label for this gene is fadE [H]

Identifier: 108761574

GI number: 108761574

Start: 6979616

End: 6981421

Strand: Reverse

Name: fadE [H]

Synonym: MXAN_5616

Alternate gene names: 108761574

Gene position: 6981421-6979616 (Counterclockwise)

Preceding gene: 108759741

Following gene: 108763594

Centisome position: 76.39

GC content: 69.21

Gene sequence:

>1806_bases
ATGGATGCCGCATCCAAGGCCACTTCGCAGCAGGGGCTTGCTCTCGGGGGCGCGTTCCTCTTCGAGGAGGTGGGCTCGGC
CCGCATCCTCACCCCGGAGACCTTCACGGAGGAGCAGCGCCTCTTCTTCAAGACGGCGCTCCAGTTCTCCCGTGAGCAGG
TCCTCCCCCTGTCCGAGCGAATCGAGGCCAAGGACAACGCGCTCCTGCGCCAGTTGCTGCGACAGGCCGGCGAGCTGGGC
CTGCTGAGCGTGGATATCCCCGAGGCCTACGGCGGCACCGGCCTGGACAAGACGACGTCGCTGCTGCTGGCGGAGGCCAT
GAGCCTCAACGGCTCCTGGTCGGTGACGTTCGGCGCGCACACCGGCATCGGTACGTTGCCCATCGTCTGGTTCGGCAACG
CCGAGCAGAAGGCGAAGTACCTGCCGAAGCTGGCCACGGGGGAATGGGTGGCGGCCTATGCGCTCACGGAGCAGGGCAGC
GGCAGTGACGCGCTGGGCGCGAAGACGAAGGCAGTCCTGTCCCCCGACGGCAAGCACTGGATTCTCAACGGCTCCAAGCT
CTACATCACCAACGCGGCCTTCGCGGACGTGTTTGTCGTCTTCGCCAAGGTGGACGGGGACAAGTTCACCGGCTTCATCG
TGGAGAAGGACACGCCCGGCCTCACCGTGGGGCCGGAGGAGCACAAGATGGGCATCCGGGGCTCTTCCACGTGCCCGCTC
TACTTCGAGGACGCGCGCGTCCCGGTGGAGAACCAGCTGGGCGAGGTGGGCAAGGGCCACAAGATTGCCTTCAACATCCT
CAACTACGGCCGTCTCAAGCTGGGCGCGGGCGTGCTGGGGGGCATGAAGCTCCAGCTCCAGAACGCGCTGCGCTTCACGC
AGGAGCGCAAGCAGTTCAACGCGCCCATCGTCCAGTTCCCGCTGTCACGCGAGAAGCTGGCCCGCATGGCCGCGCTCGTC
TACGCGGTGGAGAGCATGACGTACCGCACCGCCGGGCTCGTGGATGCGCGCCTGGGGCAGGGGGACAAGGACGCCCCGGA
CTACGAGGCGCGCCTCCTGGAGGCGGTGGAGGAGTACGCCATCGAGTCTTCCATCATGAAGGTGCACGGCTCGGAGTCCT
TCGGCCACCTCGTGGATGACGCCGTCCAGCTCCACGGCGGCGCGGGCTACATCGAGGAGTACCCGGTGGAGCGCTCGTAC
CGCGACGCGCGCATCAACCGCATCTTCGAGGGCACCAACGAAATCAACCGCATGCTCATCACCGGCATGCTCCTCAAGCG
CGCGGTGAGGGGGGACCTGCCGCTGTTCGCCATGGCCGGCAACGTGGCGGAGGAGCTGTCCCGGGGCGAGCGGCCCCGCG
CGCGCGTGCAGGACGCCCTGGCCCCGCAGGAGGTCGCCGCCGAGGCCGCCAAGCACCTGGCGCTCCACGGCCTGCGCGTG
GCGGCGGAGACGTTCGGCCCGGAACTGGAGCAGCACCAGGAGGTGCTCGCGGCCCTGTCGGACGTGGTGATGGACGCCTT
CGCCCTGGACTCCATGGTGACGCGCACGCGCCAGGCCGCCACGTCCGGCGCGTTGGACCCGGTGCGGGTGGCGATGACGC
AGCTCTACGCACTGGACGCCATCCCCCGCGCCTACGACAGGACGCGCCGCGCGCTGTGCGCCACGTTGAAGGGGGGCGCG
CTCGACCAGGAGCTCGAGCGCCTGGGCACGCTGGACGTCTTCACGCCATATGACCCGGCGGCGCTGCGGGAGACGGTGGT
GGCGGCCCTGGAGTCCGCGGGCGGCTACCCCCTGGGCGCGGTGTAG

Upstream 100 bases:

>100_bases
GGACTGGCGAGGACTCGCCGGGTCTTCGCGGGCGACTTCCAGCCGGAGGATTAGATTCAGGTCCCAGGGCGGGGTGCGCT
CGCCCGCTGGAGGGATACTC

Downstream 100 bases:

>100_bases
CCCGCGGGGGCCTCCGAGCCGTCACGGCATCCGCGCGACGGCCTCCATGCCGAAGCTCACCCGGGCCTTCCAGGGGACGG
GCGGCAGCGTGGCCAGGGAC

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MDAASKATSQQGLALGGAFLFEEVGSARILTPETFTEEQRLFFKTALQFSREQVLPLSERIEAKDNALLRQLLRQAGELG
LLSVDIPEAYGGTGLDKTTSLLLAEAMSLNGSWSVTFGAHTGIGTLPIVWFGNAEQKAKYLPKLATGEWVAAYALTEQGS
GSDALGAKTKAVLSPDGKHWILNGSKLYITNAAFADVFVVFAKVDGDKFTGFIVEKDTPGLTVGPEEHKMGIRGSSTCPL
YFEDARVPVENQLGEVGKGHKIAFNILNYGRLKLGAGVLGGMKLQLQNALRFTQERKQFNAPIVQFPLSREKLARMAALV
YAVESMTYRTAGLVDARLGQGDKDAPDYEARLLEAVEEYAIESSIMKVHGSESFGHLVDDAVQLHGGAGYIEEYPVERSY
RDARINRIFEGTNEINRMLITGMLLKRAVRGDLPLFAMAGNVAEELSRGERPRARVQDALAPQEVAAEAAKHLALHGLRV
AAETFGPELEQHQEVLAALSDVVMDAFALDSMVTRTRQAATSGALDPVRVAMTQLYALDAIPRAYDRTRRALCATLKGGA
LDQELERLGTLDVFTPYDPAALRETVVAALESAGGYPLGAV

Sequences:

>Translated_601_residues
MDAASKATSQQGLALGGAFLFEEVGSARILTPETFTEEQRLFFKTALQFSREQVLPLSERIEAKDNALLRQLLRQAGELG
LLSVDIPEAYGGTGLDKTTSLLLAEAMSLNGSWSVTFGAHTGIGTLPIVWFGNAEQKAKYLPKLATGEWVAAYALTEQGS
GSDALGAKTKAVLSPDGKHWILNGSKLYITNAAFADVFVVFAKVDGDKFTGFIVEKDTPGLTVGPEEHKMGIRGSSTCPL
YFEDARVPVENQLGEVGKGHKIAFNILNYGRLKLGAGVLGGMKLQLQNALRFTQERKQFNAPIVQFPLSREKLARMAALV
YAVESMTYRTAGLVDARLGQGDKDAPDYEARLLEAVEEYAIESSIMKVHGSESFGHLVDDAVQLHGGAGYIEEYPVERSY
RDARINRIFEGTNEINRMLITGMLLKRAVRGDLPLFAMAGNVAEELSRGERPRARVQDALAPQEVAAEAAKHLALHGLRV
AAETFGPELEQHQEVLAALSDVVMDAFALDSMVTRTRQAATSGALDPVRVAMTQLYALDAIPRAYDRTRRALCATLKGGA
LDQELERLGTLDVFTPYDPAALRETVVAALESAGGYPLGAV
>Mature_601_residues
MDAASKATSQQGLALGGAFLFEEVGSARILTPETFTEEQRLFFKTALQFSREQVLPLSERIEAKDNALLRQLLRQAGELG
LLSVDIPEAYGGTGLDKTTSLLLAEAMSLNGSWSVTFGAHTGIGTLPIVWFGNAEQKAKYLPKLATGEWVAAYALTEQGS
GSDALGAKTKAVLSPDGKHWILNGSKLYITNAAFADVFVVFAKVDGDKFTGFIVEKDTPGLTVGPEEHKMGIRGSSTCPL
YFEDARVPVENQLGEVGKGHKIAFNILNYGRLKLGAGVLGGMKLQLQNALRFTQERKQFNAPIVQFPLSREKLARMAALV
YAVESMTYRTAGLVDARLGQGDKDAPDYEARLLEAVEEYAIESSIMKVHGSESFGHLVDDAVQLHGGAGYIEEYPVERSY
RDARINRIFEGTNEINRMLITGMLLKRAVRGDLPLFAMAGNVAEELSRGERPRARVQDALAPQEVAAEAAKHLALHGLRV
AAETFGPELEQHQEVLAALSDVVMDAFALDSMVTRTRQAATSGALDPVRVAMTQLYALDAIPRAYDRTRRALCATLKGGA
LDQELERLGTLDVFTPYDPAALRETVVAALESAGGYPLGAV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=368, Percent_Identity=47.0108695652174, Blast_Score=314, Evalue=2e-85,
Organism=Homo sapiens, GI76496475, Length=407, Percent_Identity=42.014742014742, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI4557235, Length=407, Percent_Identity=42.014742014742, Blast_Score=280, Evalue=4e-75,
Organism=Homo sapiens, GI4557233, Length=395, Percent_Identity=35.4430379746835, Blast_Score=242, Evalue=7e-64,
Organism=Homo sapiens, GI4501859, Length=389, Percent_Identity=34.9614395886889, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI226958412, Length=394, Percent_Identity=34.7715736040609, Blast_Score=226, Evalue=6e-59,
Organism=Homo sapiens, GI4557231, Length=423, Percent_Identity=35.6973995271868, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI187960098, Length=423, Percent_Identity=35.6973995271868, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI226958414, Length=376, Percent_Identity=34.3085106382979, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI7656849, Length=395, Percent_Identity=32.1518987341772, Blast_Score=196, Evalue=7e-50,
Organism=Homo sapiens, GI4501857, Length=404, Percent_Identity=31.6831683168317, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI4503943, Length=403, Percent_Identity=29.7766749379653, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI7669494, Length=370, Percent_Identity=30.2702702702703, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI211971008, Length=430, Percent_Identity=23.7209302325581, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI48976061, Length=429, Percent_Identity=23.0769230769231, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI218563752, Length=241, Percent_Identity=27.8008298755187, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI156104866, Length=327, Percent_Identity=25.6880733944954, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI156104864, Length=327, Percent_Identity=25.9938837920489, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=28.3505154639175, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1786223, Length=376, Percent_Identity=27.3936170212766, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87082384, Length=285, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87081702, Length=502, Percent_Identity=24.3027888446215, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=399, Percent_Identity=38.3458646616541, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17569725, Length=399, Percent_Identity=35.5889724310777, Blast_Score=223, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17534899, Length=402, Percent_Identity=35.3233830845771, Blast_Score=218, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17570075, Length=401, Percent_Identity=35.1620947630923, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71985192, Length=348, Percent_Identity=36.4942528735632, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17538396, Length=393, Percent_Identity=33.8422391857506, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17506239, Length=399, Percent_Identity=33.0827067669173, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17508101, Length=397, Percent_Identity=31.7380352644836, Blast_Score=205, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17533517, Length=396, Percent_Identity=29.7979797979798, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=38.6100386100386, Blast_Score=175, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=235, Percent_Identity=38.7234042553192, Blast_Score=165, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71982178, Length=284, Percent_Identity=33.4507042253521, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17534353, Length=406, Percent_Identity=29.5566502463054, Blast_Score=148, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17551932, Length=363, Percent_Identity=28.9256198347107, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17505929, Length=357, Percent_Identity=28.8515406162465, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=250, Percent_Identity=28.4, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17540912, Length=330, Percent_Identity=24.8484848484848, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI86563383, Length=281, Percent_Identity=24.1992882562278, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI86563381, Length=281, Percent_Identity=24.1992882562278, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562446, Length=356, Percent_Identity=25, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI281363737, Length=420, Percent_Identity=39.0476190476191, Blast_Score=271, Evalue=7e-73,
Organism=Drosophila melanogaster, GI21356377, Length=387, Percent_Identity=36.6925064599483, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24660351, Length=395, Percent_Identity=37.9746835443038, Blast_Score=233, Evalue=3e-61,
Organism=Drosophila melanogaster, GI24666513, Length=401, Percent_Identity=34.1645885286783, Blast_Score=223, Evalue=4e-58,
Organism=Drosophila melanogaster, GI21355753, Length=392, Percent_Identity=34.9489795918367, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24646207, Length=407, Percent_Identity=32.9238329238329, Blast_Score=205, Evalue=8e-53,
Organism=Drosophila melanogaster, GI19920834, Length=406, Percent_Identity=29.3103448275862, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24652780, Length=309, Percent_Identity=26.8608414239482, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 65051; Mature: 65051

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAASKATSQQGLALGGAFLFEEVGSARILTPETFTEEQRLFFKTALQFSREQVLPLSER
CCCCCHHHCCCCCHHHHHHHHHHCCCCEEECCHHHCHHHHHHHHHHHHHHHHHCCCHHHH
IEAKDNALLRQLLRQAGELGLLSVDIPEAYGGTGLDKTTSLLLAEAMSLNGSWSVTFGAH
HCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCC
TGIGTLPIVWFGNAEQKAKYLPKLATGEWVAAYALTEQGSGSDALGAKTKAVLSPDGKHW
CCCCCEEEEEECCHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCEE
ILNGSKLYITNAAFADVFVVFAKVDGDKFTGFIVEKDTPGLTVGPEEHKMGIRGSSTCPL
EEECCEEEEECHHHHHEEEEEEEECCCCEEEEEEECCCCCCEECCHHHCCCCCCCCCCCE
YFEDARVPVENQLGEVGKGHKIAFNILNYGRLKLGAGVLGGMKLQLQNALRFTQERKQFN
EECCCCCCHHHHHHCCCCCCEEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHC
APIVQFPLSREKLARMAALVYAVESMTYRTAGLVDARLGQGDKDAPDYEARLLEAVEEYA
CCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHH
IESSIMKVHGSESFGHLVDDAVQLHGGAGYIEEYPVERSYRDARINRIFEGTNEINRMLI
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHCHHHHHHHHH
TGMLLKRAVRGDLPLFAMAGNVAEELSRGERPRARVQDALAPQEVAAEAAKHLALHGLRV
HHHHHHHHHHCCCCEEEHHCHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AAETFGPELEQHQEVLAALSDVVMDAFALDSMVTRTRQAATSGALDPVRVAMTQLYALDA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IPRAYDRTRRALCATLKGGALDQELERLGTLDVFTPYDPAALRETVVAALESAGGYPLGA
HHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCC
V
C
>Mature Secondary Structure
MDAASKATSQQGLALGGAFLFEEVGSARILTPETFTEEQRLFFKTALQFSREQVLPLSER
CCCCCHHHCCCCCHHHHHHHHHHCCCCEEECCHHHCHHHHHHHHHHHHHHHHHCCCHHHH
IEAKDNALLRQLLRQAGELGLLSVDIPEAYGGTGLDKTTSLLLAEAMSLNGSWSVTFGAH
HCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCC
TGIGTLPIVWFGNAEQKAKYLPKLATGEWVAAYALTEQGSGSDALGAKTKAVLSPDGKHW
CCCCCEEEEEECCHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCEE
ILNGSKLYITNAAFADVFVVFAKVDGDKFTGFIVEKDTPGLTVGPEEHKMGIRGSSTCPL
EEECCEEEEECHHHHHEEEEEEEECCCCEEEEEEECCCCCCEECCHHHCCCCCCCCCCCE
YFEDARVPVENQLGEVGKGHKIAFNILNYGRLKLGAGVLGGMKLQLQNALRFTQERKQFN
EECCCCCCHHHHHHCCCCCCEEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHC
APIVQFPLSREKLARMAALVYAVESMTYRTAGLVDARLGQGDKDAPDYEARLLEAVEEYA
CCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHHH
IESSIMKVHGSESFGHLVDDAVQLHGGAGYIEEYPVERSYRDARINRIFEGTNEINRMLI
HHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHCHHHHHHHHH
TGMLLKRAVRGDLPLFAMAGNVAEELSRGERPRARVQDALAPQEVAAEAAKHLALHGLRV
HHHHHHHHHHCCCCEEEHHCHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AAETFGPELEQHQEVLAALSDVVMDAFALDSMVTRTRQAATSGALDPVRVAMTQLYALDA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IPRAYDRTRRALCATLKGGALDQELERLGTLDVFTPYDPAALRETVVAALESAGGYPLGA
HHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]