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The map label for this gene is sdhA [H]

Identifier: 108761290

GI number: 108761290

Start: 4123745

End: 4125625

Strand: Direct

Name: sdhA [H]

Synonym: MXAN_3539

Alternate gene names: 108761290

Gene position: 4123745-4125625 (Clockwise)

Preceding gene: 108762306

Following gene: 108757195

Centisome position: 45.12

GC content: 67.25

Gene sequence:

>1881_bases
ATGATGGCACCAGCAGCGCGGTTCACGGTGGTGGGCGGCGGCCTCGCCGGGCTGATGACGACGATCAAGCTCGCGGAGGC
GGGCCACCAGGTGGATGTGCTCTCGCTCGTCCCGGTGAAGCGTTCCCACTCCGTTTGTGCCCAGGGCGGCATCAACGGCG
CGGTGAACACCAAGGGCGAAGGCGACCACCCGGATATCCACGTGAAGGACACGCTGCGCGGCGGCGACTTCCTCGCGGAG
CAGGTTTCGGTGAAGGGCATGTGTCATGCCGCGCCCGGCATCATCTACCTGTTGGACCGCATGGGCGTGACGTTCAACCG
CACGCCGGAAGGTCTGTTGGACTTCCGCCGCTTCGGCGGCACGCTGCACCACCGCACGGCCTTCGCCGGCGCCACCACCG
GCCAGCAGCTGCTCTACGCGCTGGACGAGCAGGTCCGCCGCTATGAGGCCGAGGGCAAGGTCACCAAGTACGAGTACTGG
GAGTGGCTCGGCACGGTGAAGGACGACAGCGGGCGCTGCATCGGCAGCGTGGCCGTCGACCTGCGCACCATGGAGATCCG
CACCTTCCCGGCCGAGGCCGTCTGCCTGGCCACGGGTGGTCCGGGCATCGTCTTCGGACGCTCCACCAACTCCATCATCA
ACACCGGCACCGCCGCGGGCCGCGCCTACATGGAGGGCGCGCACTACGCCAACGGTGAGTTCATCCAGGTGCACCCGACG
TCGATTCCGGGCGAGGACAAGCTCCGCCTGATGAGCGAGTCGGTGCGTGGCGAGGGCGGCCGCGTCTGGGTGCCCCGCAA
GAAGGGCGACACGCGGGCGCCTCAGCAGATCCCGGAGGCGGAGCGCTGGTACTTCCTGGAAGAGAAGTACCCCAAGTACA
AGAACCTGGTGCCGCGCGACGTGGCCACCCGCGAGATCTTCATGGTCTGCCGCGAGCTGGGCATGGGCATCAACGGCCGG
GACGGCGTGTACCTGGACGTCACGCACATCCCCGCGCCGGTGCTGGACGCCAAGATCAAGGGCGTCATGGAGATCTACGA
GAAGTTCGTCGGTGACGACCCGCGCAAGGTGCCCATGGTCATCTTCCCGGGCATGCACTACTCCATGGGCGGCCTGTACG
TGAACTTCGAGGCCGACCCGAAGACGCAGACGCCGGCCGAGGGCAGCCCGAAGAACCAGTCCACCACCATCCCCGGCCTC
TACGCCGCGGGCGAGGCGGACTACGCCTTCCACGGCGCGAACCGCCTGGGCGCCAACTCGCTGCTGTCGTGCATCTACTC
CGGCATGATCGGCGGCCCGGCCATGGTCTCCTTCGCCAAGAGCCAGGGCACCAGCGCCGCGGCGATGCCGGAGAAGCACT
TCCAGGCCGCCCGGCAGTACTGGCAGGACCGCTTCGCCACCATGCTCAAGATGAGTGGCACGGAGAACCCGTACGGGCTC
GCCAAGGAGCTGGGCGACACCATGACGGAGAACTGCACCGTCGTGCGCTACAACGACCGTCTGAAGAAGACGATCGAGAA
GATCCGCGAGCTCAAGGAGCGCTGGAAGAACGTCAACGTGCTGGACACGGGCAATGTGGCCAACCGCGCGCTGTCGTACA
CCAACCAGCTGTGGAACATGTTCGAGCTGGGCGAGGTCATCGCGACCAGCGCGCTGCTCCGCGACGAGAGCCGCGGCGCC
CACTACAAGCCGGACTTCTCGCTGCCCGAACCGAAGACGAAGGACCCGACGCAGGACCCGGAGTGGATGAGCCTGTGGCG
TGCGCGCCACGAGAAGTGGGCGAAGACGACCGTCGCGACGTACAGCGAGGCCGGCCCGAAGATCCACTACGAGGACATCC
CTACGCCCGTGCTGGACCCCGAGCCGCGCTGGTACGCCTGA

Upstream 100 bases:

>100_bases
ACTAGCCTGTAGAACTCGCACGGGACGTCCGGGCCCTGGCGCGCCACCTGGCGGGCCGGCTCAACCGAGCAGTGTCCGAC
GTCCGGCAGTCAAGGAGACG

Downstream 100 bases:

>100_bases
GACGGGAACCACTCAACCGATTTGGAAGTGAAGGGTCGAGCCACATGGACACTGCACAAGCATCCGCTGTCACCACCAAG
ACCATCACCTTCCGCATCTG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MMAPAARFTVVGGGLAGLMTTIKLAEAGHQVDVLSLVPVKRSHSVCAQGGINGAVNTKGEGDHPDIHVKDTLRGGDFLAE
QVSVKGMCHAAPGIIYLLDRMGVTFNRTPEGLLDFRRFGGTLHHRTAFAGATTGQQLLYALDEQVRRYEAEGKVTKYEYW
EWLGTVKDDSGRCIGSVAVDLRTMEIRTFPAEAVCLATGGPGIVFGRSTNSIINTGTAAGRAYMEGAHYANGEFIQVHPT
SIPGEDKLRLMSESVRGEGGRVWVPRKKGDTRAPQQIPEAERWYFLEEKYPKYKNLVPRDVATREIFMVCRELGMGINGR
DGVYLDVTHIPAPVLDAKIKGVMEIYEKFVGDDPRKVPMVIFPGMHYSMGGLYVNFEADPKTQTPAEGSPKNQSTTIPGL
YAAGEADYAFHGANRLGANSLLSCIYSGMIGGPAMVSFAKSQGTSAAAMPEKHFQAARQYWQDRFATMLKMSGTENPYGL
AKELGDTMTENCTVVRYNDRLKKTIEKIRELKERWKNVNVLDTGNVANRALSYTNQLWNMFELGEVIATSALLRDESRGA
HYKPDFSLPEPKTKDPTQDPEWMSLWRARHEKWAKTTVATYSEAGPKIHYEDIPTPVLDPEPRWYA

Sequences:

>Translated_626_residues
MMAPAARFTVVGGGLAGLMTTIKLAEAGHQVDVLSLVPVKRSHSVCAQGGINGAVNTKGEGDHPDIHVKDTLRGGDFLAE
QVSVKGMCHAAPGIIYLLDRMGVTFNRTPEGLLDFRRFGGTLHHRTAFAGATTGQQLLYALDEQVRRYEAEGKVTKYEYW
EWLGTVKDDSGRCIGSVAVDLRTMEIRTFPAEAVCLATGGPGIVFGRSTNSIINTGTAAGRAYMEGAHYANGEFIQVHPT
SIPGEDKLRLMSESVRGEGGRVWVPRKKGDTRAPQQIPEAERWYFLEEKYPKYKNLVPRDVATREIFMVCRELGMGINGR
DGVYLDVTHIPAPVLDAKIKGVMEIYEKFVGDDPRKVPMVIFPGMHYSMGGLYVNFEADPKTQTPAEGSPKNQSTTIPGL
YAAGEADYAFHGANRLGANSLLSCIYSGMIGGPAMVSFAKSQGTSAAAMPEKHFQAARQYWQDRFATMLKMSGTENPYGL
AKELGDTMTENCTVVRYNDRLKKTIEKIRELKERWKNVNVLDTGNVANRALSYTNQLWNMFELGEVIATSALLRDESRGA
HYKPDFSLPEPKTKDPTQDPEWMSLWRARHEKWAKTTVATYSEAGPKIHYEDIPTPVLDPEPRWYA
>Mature_626_residues
MMAPAARFTVVGGGLAGLMTTIKLAEAGHQVDVLSLVPVKRSHSVCAQGGINGAVNTKGEGDHPDIHVKDTLRGGDFLAE
QVSVKGMCHAAPGIIYLLDRMGVTFNRTPEGLLDFRRFGGTLHHRTAFAGATTGQQLLYALDEQVRRYEAEGKVTKYEYW
EWLGTVKDDSGRCIGSVAVDLRTMEIRTFPAEAVCLATGGPGIVFGRSTNSIINTGTAAGRAYMEGAHYANGEFIQVHPT
SIPGEDKLRLMSESVRGEGGRVWVPRKKGDTRAPQQIPEAERWYFLEEKYPKYKNLVPRDVATREIFMVCRELGMGINGR
DGVYLDVTHIPAPVLDAKIKGVMEIYEKFVGDDPRKVPMVIFPGMHYSMGGLYVNFEADPKTQTPAEGSPKNQSTTIPGL
YAAGEADYAFHGANRLGANSLLSCIYSGMIGGPAMVSFAKSQGTSAAAMPEKHFQAARQYWQDRFATMLKMSGTENPYGL
AKELGDTMTENCTVVRYNDRLKKTIEKIRELKERWKNVNVLDTGNVANRALSYTNQLWNMFELGEVIATSALLRDESRGA
HYKPDFSLPEPKTKDPTQDPEWMSLWRARHEKWAKTTVATYSEAGPKIHYEDIPTPVLDPEPRWYA

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=608, Percent_Identity=29.6052631578947, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI1786942, Length=593, Percent_Identity=32.2091062394604, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1790597, Length=602, Percent_Identity=32.2259136212625, Blast_Score=246, Evalue=4e-66,
Organism=Escherichia coli, GI1788928, Length=576, Percent_Identity=28.125, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17505833, Length=554, Percent_Identity=33.0324909747292, Blast_Score=238, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17550100, Length=558, Percent_Identity=31.3620071684588, Blast_Score=222, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6322701, Length=574, Percent_Identity=31.184668989547, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6322416, Length=613, Percent_Identity=30.1794453507341, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI17137288, Length=584, Percent_Identity=29.9657534246575, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24655642, Length=584, Percent_Identity=29.9657534246575, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24655647, Length=584, Percent_Identity=29.9657534246575, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24663005, Length=627, Percent_Identity=30.622009569378, Blast_Score=209, Evalue=4e-54,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 69245; Mature: 69245

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAPAARFTVVGGGLAGLMTTIKLAEAGHQVDVLSLVPVKRSHSVCAQGGINGAVNTKGE
CCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCC
GDHPDIHVKDTLRGGDFLAEQVSVKGMCHAAPGIIYLLDRMGVTFNRTPEGLLDFRRFGG
CCCCCEEEEECCCCCHHHHHHHHHCCHHHCCCCHHHHHHHCCCEECCCCHHHHHHHHHCC
TLHHRTAFAGATTGQQLLYALDEQVRRYEAEGKVTKYEYWEWLGTVKDDSGRCIGSVAVD
CHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCCCEEEEEEEE
LRTMEIRTFPAEAVCLATGGPGIVFGRSTNSIINTGTAAGRAYMEGAHYANGEFIQVHPT
EEEEEEEECCCCEEEEEECCCEEEEECCCCCCEECCCHHCHHHHCCCCCCCCCEEEEECC
SIPGEDKLRLMSESVRGEGGRVWVPRKKGDTRAPQQIPEAERWYFLEEKYPKYKNLVPRD
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHCCCCHHEEEECCCCCHHHCCCCCH
VATREIFMVCRELGMGINGRDGVYLDVTHIPAPVLDAKIKGVMEIYEKFVGDDPRKVPMV
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEE
IFPGMHYSMGGLYVNFEADPKTQTPAEGSPKNQSTTIPGLYAAGEADYAFHGANRLGANS
EECCCCEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCHHH
LLSCIYSGMIGGPAMVSFAKSQGTSAAAMPEKHFQAARQYWQDRFATMLKMSGTENPYGL
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
AKELGDTMTENCTVVRYNDRLKKTIEKIRELKERWKNVNVLDTGNVANRALSYTNQLWNM
HHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHH
FELGEVIATSALLRDESRGAHYKPDFSLPEPKTKDPTQDPEWMSLWRARHEKWAKTTVAT
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YSEAGPKIHYEDIPTPVLDPEPRWYA
HHCCCCEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMAPAARFTVVGGGLAGLMTTIKLAEAGHQVDVLSLVPVKRSHSVCAQGGINGAVNTKGE
CCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCC
GDHPDIHVKDTLRGGDFLAEQVSVKGMCHAAPGIIYLLDRMGVTFNRTPEGLLDFRRFGG
CCCCCEEEEECCCCCHHHHHHHHHCCHHHCCCCHHHHHHHCCCEECCCCHHHHHHHHHCC
TLHHRTAFAGATTGQQLLYALDEQVRRYEAEGKVTKYEYWEWLGTVKDDSGRCIGSVAVD
CHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCCCEEEEEEEE
LRTMEIRTFPAEAVCLATGGPGIVFGRSTNSIINTGTAAGRAYMEGAHYANGEFIQVHPT
EEEEEEEECCCCEEEEEECCCEEEEECCCCCCEECCCHHCHHHHCCCCCCCCCEEEEECC
SIPGEDKLRLMSESVRGEGGRVWVPRKKGDTRAPQQIPEAERWYFLEEKYPKYKNLVPRD
CCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHCCCCHHEEEECCCCCHHHCCCCCH
VATREIFMVCRELGMGINGRDGVYLDVTHIPAPVLDAKIKGVMEIYEKFVGDDPRKVPMV
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEE
IFPGMHYSMGGLYVNFEADPKTQTPAEGSPKNQSTTIPGLYAAGEADYAFHGANRLGANS
EECCCCEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCHHH
LLSCIYSGMIGGPAMVSFAKSQGTSAAAMPEKHFQAARQYWQDRFATMLKMSGTENPYGL
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
AKELGDTMTENCTVVRYNDRLKKTIEKIRELKERWKNVNVLDTGNVANRALSYTNQLWNM
HHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHH
FELGEVIATSALLRDESRGAHYKPDFSLPEPKTKDPTQDPEWMSLWRARHEKWAKTTVAT
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YSEAGPKIHYEDIPTPVLDPEPRWYA
HHCCCCEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]