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The map label for this gene is pcoA [H]

Identifier: 108760866

GI number: 108760866

Start: 3990792

End: 3992162

Strand: Direct

Name: pcoA [H]

Synonym: MXAN_3432

Alternate gene names: 108760866

Gene position: 3990792-3992162 (Clockwise)

Preceding gene: 108757665

Following gene: 108758469

Centisome position: 43.66

GC content: 66.45

Gene sequence:

>1371_bases
ATGCTTGCCACGGCGGGAGCCACGCTCACGGGAGGCTCGCTGCTGCTGAGTGGCTCCGCTGCGCGCGCCCAGTCAGCCGT
CTCAGGCGCACGTGGGCCTCGCGAGGGCTCCGCGGCTGACACCGGCCAGCGGTATGCGCGGCAGGACTGGTTGCGCCCCG
GAATGCCCGACCGGGACTACCGGCCCGTGGTGGTGCCCAATGGCTCCAAGCTGCCGTGGAAGGTCGTGGACAACGTGAAG
GTCTTCCACCTGGTGGCCGAGGAGGTGGCGCATGAGTTTGCCCCGGGACTGAAAGCCTTCTGCTGGGGCTACAACGGTCG
AGTCCACGGGCCCACCATCGAAGCGGTGGAGGGGGACCGGGTGCGCATCTACGTCACGAACCGGCTACCCGCGGCCACCA
CCATCCACTGGCACGGACTCCTGGTGCCCAGCGGTATGGATGGCGTGGGCGGCCTCAGCCAGAAGTCCATCGCTCCTGGC
GAGACGTTTCGGTACGAGTTCACCCTGCGCCAGGCGAGTACGAACATGTATCACTCGCACCATGACGAGATGACGCAGAT
TGGCCTCGGGATGACGGGCATGTTCATCATCCACCCGCGCCGACCTGTGGGGCCCCGCGTCGACCGGGACTTCGTCATCC
TCCTGCATGAATGGCGCATCGATGTCGGCACGGAGCGACCCAATCCGAATGAGATGACGGACTTCAACGTGCTCACCATG
AACGCGAAGGCGTTCCCGGGCACGGAGTCGCTCGTGGTGCGCCAGGGTGAGCGGGTGCGCATCCGGTTGGGCAACCTGAG
CCCGCAGAACCATCACCCCATCCACCTGCACGGTTTCCACTTCCGTATCACCGAAACGGATGGCGGGCGCGTCCCCGAGT
CCGCGCAGCAGCCGGAGGGAACGGTGCTCGTCCCCGTGGGCAGCACACGTGTCATCGAGTTCGTGGCGGACGTGCCCGGG
GACTGGGCCCTGCACTGTCACATGACGCACCACATGATGAATCAGATGGGCCATGCGTTCCCCAATATGATTGGCGTGAA
GCCGGGGAGCCTGGACGCGAGGGTCCGCACGCTGCTACCGGGCTACATGACGATGGGCCAGACGGGGATGGCGGAGATGG
GCGAGATGGGGATGCCCATTCCGCCCAACTCCATTCCCATGCTGGGGGCCCAGGGCAAGCACGATTACATCACGGCGGGA
GGCATGTTCACCGTGCTCAAGGTTCGCGAACGGTTGGAGAGCTACGCGGACCCTGGCTGGTACGACAACCCACCTGGCAC
GCTGGCGGTGGCGGCCACCTCGGACGAGCTGCGCCGGGACGGTATCGACGTGAACGCCCCGGCCCTGGTCGATCCCGGCG
CACCGGCCTGA

Upstream 100 bases:

>100_bases
ACCGGGCCGTGAGGATGACGCCCCTGGAGCTCGGGAGCGCAGGGGGGCCCCTGGAAACTCTCCGGCGATTGGAGCCGAGG
GAACGCTGACGCGGCGGAGC

Downstream 100 bases:

>100_bases
CCCGAGCCCAACGCTGGAGACCTCCAGTGAGCCCGGGTGCTGCTAGAGGATCGCCTCGAGGGCCGACTGAAGTTCAGAGT
CGCCATAAAGCTGGTCTGAG

Product: multicopper oxidase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MLATAGATLTGGSLLLSGSAARAQSAVSGARGPREGSAADTGQRYARQDWLRPGMPDRDYRPVVVPNGSKLPWKVVDNVK
VFHLVAEEVAHEFAPGLKAFCWGYNGRVHGPTIEAVEGDRVRIYVTNRLPAATTIHWHGLLVPSGMDGVGGLSQKSIAPG
ETFRYEFTLRQASTNMYHSHHDEMTQIGLGMTGMFIIHPRRPVGPRVDRDFVILLHEWRIDVGTERPNPNEMTDFNVLTM
NAKAFPGTESLVVRQGERVRIRLGNLSPQNHHPIHLHGFHFRITETDGGRVPESAQQPEGTVLVPVGSTRVIEFVADVPG
DWALHCHMTHHMMNQMGHAFPNMIGVKPGSLDARVRTLLPGYMTMGQTGMAEMGEMGMPIPPNSIPMLGAQGKHDYITAG
GMFTVLKVRERLESYADPGWYDNPPGTLAVAATSDELRRDGIDVNAPALVDPGAPA

Sequences:

>Translated_456_residues
MLATAGATLTGGSLLLSGSAARAQSAVSGARGPREGSAADTGQRYARQDWLRPGMPDRDYRPVVVPNGSKLPWKVVDNVK
VFHLVAEEVAHEFAPGLKAFCWGYNGRVHGPTIEAVEGDRVRIYVTNRLPAATTIHWHGLLVPSGMDGVGGLSQKSIAPG
ETFRYEFTLRQASTNMYHSHHDEMTQIGLGMTGMFIIHPRRPVGPRVDRDFVILLHEWRIDVGTERPNPNEMTDFNVLTM
NAKAFPGTESLVVRQGERVRIRLGNLSPQNHHPIHLHGFHFRITETDGGRVPESAQQPEGTVLVPVGSTRVIEFVADVPG
DWALHCHMTHHMMNQMGHAFPNMIGVKPGSLDARVRTLLPGYMTMGQTGMAEMGEMGMPIPPNSIPMLGAQGKHDYITAG
GMFTVLKVRERLESYADPGWYDNPPGTLAVAATSDELRRDGIDVNAPALVDPGAPA
>Mature_456_residues
MLATAGATLTGGSLLLSGSAARAQSAVSGARGPREGSAADTGQRYARQDWLRPGMPDRDYRPVVVPNGSKLPWKVVDNVK
VFHLVAEEVAHEFAPGLKAFCWGYNGRVHGPTIEAVEGDRVRIYVTNRLPAATTIHWHGLLVPSGMDGVGGLSQKSIAPG
ETFRYEFTLRQASTNMYHSHHDEMTQIGLGMTGMFIIHPRRPVGPRVDRDFVILLHEWRIDVGTERPNPNEMTDFNVLTM
NAKAFPGTESLVVRQGERVRIRLGNLSPQNHHPIHLHGFHFRITETDGGRVPESAQQPEGTVLVPVGSTRVIEFVADVPG
DWALHCHMTHHMMNQMGHAFPNMIGVKPGSLDARVRTLLPGYMTMGQTGMAEMGEMGMPIPPNSIPMLGAQGKHDYITAG
GMFTVLKVRERLESYADPGWYDNPPGTLAVAATSDELRRDGIDVNAPALVDPGAPA

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=251, Percent_Identity=25.4980079681275, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1789394, Length=224, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323703, Length=125, Percent_Identity=40, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321067, Length=211, Percent_Identity=35.0710900473934, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI18859919, Length=193, Percent_Identity=29.0155440414508, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574104, Length=123, Percent_Identity=38.2113821138211, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 49721; Mature: 49721

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLATAGATLTGGSLLLSGSAARAQSAVSGARGPREGSAADTGQRYARQDWLRPGMPDRDY
CCCCCCCEEECCEEEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
RPVVVPNGSKLPWKVVDNVKVFHLVAEEVAHEFAPGLKAFCWGYNGRVHGPTIEAVEGDR
CCEEECCCCCCCEEECCCEEEEHHHHHHHHHHHCCCCEEEEECCCCEECCCEEEEECCCE
VRIYVTNRLPAATTIHWHGLLVPSGMDGVGGLSQKSIAPGETFRYEFTLRQASTNMYHSH
EEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHH
HDEMTQIGLGMTGMFIIHPRRPVGPRVDRDFVILLHEWRIDVGTERPNPNEMTDFNVLTM
HHHHHHHCCCEEEEEEEECCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCEEEEEE
NAKAFPGTESLVVRQGERVRIRLGNLSPQNHHPIHLHGFHFRITETDGGRVPESAQQPEG
ECCCCCCCCCEEEECCCEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCC
TVLVPVGSTRVIEFVADVPGDWALHCHMTHHMMNQMGHAFPNMIGVKPGSLDARVRTLLP
EEEEECCCCEEEHHHHCCCCCEEEEEEHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHCC
GYMTMGQTGMAEMGEMGMPIPPNSIPMLGAQGKHDYITAGGMFTVLKVRERLESYADPGW
HHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCC
YDNPPGTLAVAATSDELRRDGIDVNAPALVDPGAPA
CCCCCCCEEEEECHHHHHHCCCCCCCCEECCCCCCC
>Mature Secondary Structure
MLATAGATLTGGSLLLSGSAARAQSAVSGARGPREGSAADTGQRYARQDWLRPGMPDRDY
CCCCCCCEEECCEEEEECCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
RPVVVPNGSKLPWKVVDNVKVFHLVAEEVAHEFAPGLKAFCWGYNGRVHGPTIEAVEGDR
CCEEECCCCCCCEEECCCEEEEHHHHHHHHHHHCCCCEEEEECCCCEECCCEEEEECCCE
VRIYVTNRLPAATTIHWHGLLVPSGMDGVGGLSQKSIAPGETFRYEFTLRQASTNMYHSH
EEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCHHHHH
HDEMTQIGLGMTGMFIIHPRRPVGPRVDRDFVILLHEWRIDVGTERPNPNEMTDFNVLTM
HHHHHHHCCCEEEEEEEECCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCEEEEEE
NAKAFPGTESLVVRQGERVRIRLGNLSPQNHHPIHLHGFHFRITETDGGRVPESAQQPEG
ECCCCCCCCCEEEECCCEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCC
TVLVPVGSTRVIEFVADVPGDWALHCHMTHHMMNQMGHAFPNMIGVKPGSLDARVRTLLP
EEEEECCCCEEEHHHHCCCCCEEEEEEHHHHHHHHHHHHCCHHHCCCCCCCCHHHHHHCC
GYMTMGQTGMAEMGEMGMPIPPNSIPMLGAQGKHDYITAGGMFTVLKVRERLESYADPGW
HHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCC
YDNPPGTLAVAATSDELRRDGIDVNAPALVDPGAPA
CCCCCCCEEEEECHHHHHHCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]