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The map label for this gene is lysC [H]

Identifier: 108760667

GI number: 108760667

Start: 4044610

End: 4045887

Strand: Direct

Name: lysC [H]

Synonym: MXAN_3466

Alternate gene names: 108760667

Gene position: 4044610-4045887 (Clockwise)

Preceding gene: 108763979

Following gene: 108761686

Centisome position: 44.25

GC content: 66.51

Gene sequence:

>1278_bases
GTGGCACTCATCGTCCAGAAGTACGGCGGTACCTCTGTAGGTGACGTGGCCCGCATCAAGAGCGTGGCGCTGCGCTGCCT
GGCCGCCCAGGAGGCGGGGCATGACGTGGTCGTCGTCGTGTCCGCCATGTCCGGCGAGACGAACCGGCTGATGAAACTGG
TGGCGCAAATCACCGACCGGCCGGACGAGCGCGAGCAGGACGTGGTCGTCGCCACCGGTGAGCAGGTCTCCATCGGCCTG
CTGGCCATGGCCATCCACGCCCAGCAGGGGAAGGCGACCAGCTTCCTCGGCCAACAGGTGCGCATCGTCACCGACAGCAC
CTTCGCCAAAGCGCGAATCAAGAGCATCGACGCGCAGCCCATCCGCGCCGCGCTGGCCCGGGGCCACATCGTCGTGGTGG
CGGGCTTCCAGGGCGTGGACGAGTCCGGCAGCGTCACCACGCTGGGCCGTGGCGGATCCGACACCACCGCCGTGGCCCTG
GCCGCCGCGCTGAACGCGGACGCCTGTGAAATCTACACGGACGTGGACGGCGTCTACACCTCCGACCCCAACATGGTTCC
GTCCGCGCGCAAGCTGGACCGCATCACCTACGAGGAGATGCTGGAGCTGGCCAGCGTGGGCGCCAAGGTGTTGCAGATCC
GCTCGGTCGAGTTCGCCATGAAGTACAAAGTGCCGCTGTGGGTGAAGTCGTCCTTCACCGATGACCCCGGCACCCTCGTG
TGTGAGGAGGACAGTTCCATGGAGGATGTGCTGGTCCGCGGCGTCGCGTATGACCGCAACGAGGCGAAGATCACGGTGTG
CGGTGTGCCGGACGTCGCGGGCGCCGCGGCGAAGATCTTCGGACCGCTCGATGAGAAGCACATCGTGGTGGACCTCATCG
TGCAGAACCCGTCCAAGGACGGACGCACGGACGTGACCTTCACCGTGGGCAAGGCGGACTTCCTTACCGCGCAGGAAGTG
GTGCGGAAGGTCGCCGAGGAGATTGGCGCGTCCGGTATCGAGACGGACGGGGACATCGCGAAGGTGTCCATCGTGGGTGT
GGGCATGCGCAATCACTCGGGTGTGGCGGCGCGGATGTTCCGGGCGCTGTCCGCCGAGGGCATCAACATCCAGATGATCT
CCACGTCGGAGATCAAGGTGTCCTGCGTGGTCCAGGCCAAGTACACGGAGCTGGCCGTGCGCGCGTTGCACACCGCCTTC
GGGTTGGATCAGCCGATGCCGCCGGAAGGCGTCTCCGCCGTCTCCGAGATGGCGGCCCTGATGGGCGAGAAGGTCTGA

Upstream 100 bases:

>100_bases
CCCTAACGTAAACGGGTGCGGTGGTGCTGGCGGGCGCTTTACACCCGCCGGCCGGGCTCGTATAGCTCCCGCCCGTCTGA
AGAGGGAGGTTGCAGGCGCC

Downstream 100 bases:

>100_bases
GCGCGTGGCGAGCCGCACCGCCGCGCTCGCCGCCGTCGCGCTGGGGGTGTTGGGCGTGGGCGTCGTCGCGCGCCTGCGCT
GGCCGGATACGGCGCCCGCG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MALIVQKYGGTSVGDVARIKSVALRCLAAQEAGHDVVVVVSAMSGETNRLMKLVAQITDRPDEREQDVVVATGEQVSIGL
LAMAIHAQQGKATSFLGQQVRIVTDSTFAKARIKSIDAQPIRAALARGHIVVVAGFQGVDESGSVTTLGRGGSDTTAVAL
AAALNADACEIYTDVDGVYTSDPNMVPSARKLDRITYEEMLELASVGAKVLQIRSVEFAMKYKVPLWVKSSFTDDPGTLV
CEEDSSMEDVLVRGVAYDRNEAKITVCGVPDVAGAAAKIFGPLDEKHIVVDLIVQNPSKDGRTDVTFTVGKADFLTAQEV
VRKVAEEIGASGIETDGDIAKVSIVGVGMRNHSGVAARMFRALSAEGINIQMISTSEIKVSCVVQAKYTELAVRALHTAF
GLDQPMPPEGVSAVSEMAALMGEKV

Sequences:

>Translated_425_residues
MALIVQKYGGTSVGDVARIKSVALRCLAAQEAGHDVVVVVSAMSGETNRLMKLVAQITDRPDEREQDVVVATGEQVSIGL
LAMAIHAQQGKATSFLGQQVRIVTDSTFAKARIKSIDAQPIRAALARGHIVVVAGFQGVDESGSVTTLGRGGSDTTAVAL
AAALNADACEIYTDVDGVYTSDPNMVPSARKLDRITYEEMLELASVGAKVLQIRSVEFAMKYKVPLWVKSSFTDDPGTLV
CEEDSSMEDVLVRGVAYDRNEAKITVCGVPDVAGAAAKIFGPLDEKHIVVDLIVQNPSKDGRTDVTFTVGKADFLTAQEV
VRKVAEEIGASGIETDGDIAKVSIVGVGMRNHSGVAARMFRALSAEGINIQMISTSEIKVSCVVQAKYTELAVRALHTAF
GLDQPMPPEGVSAVSEMAALMGEKV
>Mature_424_residues
ALIVQKYGGTSVGDVARIKSVALRCLAAQEAGHDVVVVVSAMSGETNRLMKLVAQITDRPDEREQDVVVATGEQVSIGLL
AMAIHAQQGKATSFLGQQVRIVTDSTFAKARIKSIDAQPIRAALARGHIVVVAGFQGVDESGSVTTLGRGGSDTTAVALA
AALNADACEIYTDVDGVYTSDPNMVPSARKLDRITYEEMLELASVGAKVLQIRSVEFAMKYKVPLWVKSSFTDDPGTLVC
EEDSSMEDVLVRGVAYDRNEAKITVCGVPDVAGAAAKIFGPLDEKHIVVDLIVQNPSKDGRTDVTFTVGKADFLTAQEVV
RKVAEEIGASGIETDGDIAKVSIVGVGMRNHSGVAARMFRALSAEGINIQMISTSEIKVSCVVQAKYTELAVRALHTAFG
LDQPMPPEGVSAVSEMAALMGEKV

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=410, Percent_Identity=31.7073170731707, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1790455, Length=277, Percent_Identity=33.2129963898917, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1790376, Length=347, Percent_Identity=26.2247838616715, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=492, Percent_Identity=25.609756097561, Blast_Score=126, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44940; Mature: 44809

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVQKYGGTSVGDVARIKSVALRCLAAQEAGHDVVVVVSAMSGETNRLMKLVAQITDR
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHCC
PDEREQDVVVATGEQVSIGLLAMAIHAQQGKATSFLGQQVRIVTDSTFAKARIKSIDAQP
CCCCCCCEEEECCCCEEHHHEEEEEECCCCCHHHHCCCEEEEEECCHHHHHHHHCCCCHH
IRAALARGHIVVVAGFQGVDESGSVTTLGRGGSDTTAVALAAALNADACEIYTDVDGVYT
HHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCEEE
SDPNMVPSARKLDRITYEEMLELASVGAKVLQIRSVEFAMKYKVPLWVKSSFTDDPGTLV
CCCCCCCCHHHHHHCCHHHHHHHHHCCHHHEEEEEEEEEEEEECEEEEECCCCCCCCEEE
CEEDSSMEDVLVRGVAYDRNEAKITVCGVPDVAGAAAKIFGPLDEKHIVVDLIVQNPSKD
ECCCCCHHHHHHHHEEECCCCCEEEEECCCCCCCCHHHHHCCCCCCEEEEEEEEECCCCC
GRTDVTFTVGKADFLTAQEVVRKVAEEIGASGIETDGDIAKVSIVGVGMRNHSGVAARMF
CCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHH
RALSAEGINIQMISTSEIKVSCVVQAKYTELAVRALHTAFGLDQPMPPEGVSAVSEMAAL
HHHCCCCCEEEEEECCCEEEEEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MGEKV
HCCCC
>Mature Secondary Structure 
ALIVQKYGGTSVGDVARIKSVALRCLAAQEAGHDVVVVVSAMSGETNRLMKLVAQITDR
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHCC
PDEREQDVVVATGEQVSIGLLAMAIHAQQGKATSFLGQQVRIVTDSTFAKARIKSIDAQP
CCCCCCCEEEECCCCEEHHHEEEEEECCCCCHHHHCCCEEEEEECCHHHHHHHHCCCCHH
IRAALARGHIVVVAGFQGVDESGSVTTLGRGGSDTTAVALAAALNADACEIYTDVDGVYT
HHHHHHCCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCEEE
SDPNMVPSARKLDRITYEEMLELASVGAKVLQIRSVEFAMKYKVPLWVKSSFTDDPGTLV
CCCCCCCCHHHHHHCCHHHHHHHHHCCHHHEEEEEEEEEEEEECEEEEECCCCCCCCEEE
CEEDSSMEDVLVRGVAYDRNEAKITVCGVPDVAGAAAKIFGPLDEKHIVVDLIVQNPSKD
ECCCCCHHHHHHHHEEECCCCCEEEEECCCCCCCCHHHHHCCCCCCEEEEEEEEECCCCC
GRTDVTFTVGKADFLTAQEVVRKVAEEIGASGIETDGDIAKVSIVGVGMRNHSGVAARMF
CCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHH
RALSAEGINIQMISTSEIKVSCVVQAKYTELAVRALHTAFGLDQPMPPEGVSAVSEMAAL
HHHCCCCCEEEEEECCCEEEEEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MGEKV
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]