Click here to switch to the map view.

The map label for this gene is thrS

Identifier: 108758923

GI number: 108758923

Start: 4186172

End: 4188100

Strand: Direct

Name: thrS

Synonym: MXAN_3591

Alternate gene names: 108758923

Gene position: 4186172-4188100 (Clockwise)

Preceding gene: 108760152

Following gene: 108761640

Centisome position: 45.8

GC content: 66.46

Gene sequence:

>1929_bases
ATGTCCGACATCATCACGGTGACGCTCCCCGACGGCTCGCAGAAGCAGACGGCCCGGGGGACCACGATCGCGGACTTCGT
GCGGGAGAGCATCGGCCCCGGCCTGGCGAAGGCCGCCCTCTTCGCGCGCGTGAATGGCCAGGACATGGACCTGGCCCGCA
AGCTGGACGAGGACGTGAAGCTGCAGATCTTCACGCCCAAGAGCCCCGAGTCCCTGGAGTTGATCCGCCACGACGCCGCC
CACGTGGTGGCCAGCGCGGTGCAGAAGCTCTTCCCGGGCACGCAGGTGACCATCGGTCCCGCGACGGAGGAGGGCTTCTA
TTACGATTTCTTCCGCGAGAAGCCCTTCACGCCCGAGGACCTGGAGAAGATCGAGGCAGAGGCGAACGCCGAGCTGAAGC
GGGACATGGCCTTCGTCCGCACCGAAATCTCCATGGACGAGGCCGTGCGCCTGTTCGAGGAGAAGGGCGAGAAGTTCAAG
GTCGAGATCGTCAAGGACATCGCGGCCAAGGGCGCCAAGACGCTGACGCTCTACACGCACGGTGACTGGGTGGACTTCTG
CCTGGGGCCCCACGCGCCCAGCACGGGGAAGATCGGCATCATCAAGATCCTCTCCTCCAGCGGAGCGTACTGGAGGGGGG
ACCACCGCAACCCGATGCTCCAGCGCGTCTACGGCACTGCCTTCTTCGACAAGAAGCAACTGGCGGAGTACCTGACGCGC
ATCGAGGAGTCGAAGAAGCGCGACCACCGCAAGCTGGGCAAGGAGCTGGACCTCTTCCACTTCCACCCGTACTCGCCGGG
CTCCGCCTTCTGGACCCCGAAGGGCACCACGCTCTACACCACGCTGTCGAACTGGATGCGTCAGCTGACGCAGAACGACG
GCTACGTGGAGATCAAGACGCCCCTGATGTTCAACAAGGGGCTGTGGGAGACCAGCGGCCACTGGGGCAAGTACAAGGAG
AACATGTTCCTCGTGCTCGACAGCGAGTCGGGGGAGCATGACTTCTCGCTCAAGCCGATGAACTGCCCGTCGCACCACCT
GTTCTACGGCTTCAAGAAGCACAGCTACCGCGACCTGCCGCTGCGCTACCACACGCAGGACGTGCTGCACCGCAACGAGG
CGGCGGGCTCCCTGGGCGGCCTCACGCGCGTGCGCCAGTTCGCGCAGGACGACGCGCACATCTACTGCACGGAGGCGCAG
ATCACCGACGAGGTGCGGCGCTTCGTGAAGCTCCTGGACCACGTCTACAAGGCGGTGGGCCTCACCTACGCGGTGAAGCT
ATCCACGCGGCCCGAGCAGCGCCTGGGCGATGACTCCCTGTGGGATCGCGCCGAGGGCGGCCTCAAGGCCGCGCTGGAGT
CGCTGGGCCTCGAGTACGAGCTGGCCCCGGGTGACGGCGCGTTCTACGGCCCGAAGATCGACTTCGCGGTGTCGGACAGC
ATCGGCCGCCGGTGGCAGCTGGGCACCATGCAGCTGGACTACCTGGCGCCCGAGCGCTTCGACCTGACCTACGTGGGCGA
GGACAACGCCGAGCACCGCCCCGTGGTGCTCCACCGCGCCATCTTCGGCTCGTTCGAGCGCTTCACGGCCATCCTCATCG
AGCACTTCGCCGGCGCCTTCCCGGCCTGGCTGGCCCCCATCCAGGCGGTGCTGGTGACGGTGGCGGACCGGCAGAACGAC
TACGCTCGGAAGGTTCGGGACTCCTTGAGGGCGAAGGGCTACCGGGTGGAGTTCGACGAGCGCGGCCTGTCGATGAACGC
GAAGATCCGCGAAGCCCAGCTCCAGAAGGTGCCGTTCACCCTGGTGGTGGGCGACAACGAGGTGTCGGGCGAGGGCGTGT
CGCCGCGGCGGTATGGCGGCGAGGACCTCAAGACGATGAAGGTGACGGACTTCGAGGCCCTGCTGGCGAAGGAAGCGGCC
CTGCCGTGA

Upstream 100 bases:

>100_bases
TCAGTGGTTCGATCCCACTACGACCCATCATCAAAGAGTGACTTCAGCGGGCGGCACGGCTTTAAAAGAGCCTGCCGCCC
GTTTTTTTTCCGAGGTTCGC

Downstream 100 bases:

>100_bases
TCGGGAGTTCAGGACGCCTGTTGGCTTGCTGACGGGCCTTGACTCCCTGTTGCACCTAAGTATCTTTGCGCACTTTCGAG
GGGAGCCTGCCCAAGTTCCC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MSDIITVTLPDGSQKQTARGTTIADFVRESIGPGLAKAALFARVNGQDMDLARKLDEDVKLQIFTPKSPESLELIRHDAA
HVVASAVQKLFPGTQVTIGPATEEGFYYDFFREKPFTPEDLEKIEAEANAELKRDMAFVRTEISMDEAVRLFEEKGEKFK
VEIVKDIAAKGAKTLTLYTHGDWVDFCLGPHAPSTGKIGIIKILSSSGAYWRGDHRNPMLQRVYGTAFFDKKQLAEYLTR
IEESKKRDHRKLGKELDLFHFHPYSPGSAFWTPKGTTLYTTLSNWMRQLTQNDGYVEIKTPLMFNKGLWETSGHWGKYKE
NMFLVLDSESGEHDFSLKPMNCPSHHLFYGFKKHSYRDLPLRYHTQDVLHRNEAAGSLGGLTRVRQFAQDDAHIYCTEAQ
ITDEVRRFVKLLDHVYKAVGLTYAVKLSTRPEQRLGDDSLWDRAEGGLKAALESLGLEYELAPGDGAFYGPKIDFAVSDS
IGRRWQLGTMQLDYLAPERFDLTYVGEDNAEHRPVVLHRAIFGSFERFTAILIEHFAGAFPAWLAPIQAVLVTVADRQND
YARKVRDSLRAKGYRVEFDERGLSMNAKIREAQLQKVPFTLVVGDNEVSGEGVSPRRYGGEDLKTMKVTDFEALLAKEAA
LP

Sequences:

>Translated_642_residues
MSDIITVTLPDGSQKQTARGTTIADFVRESIGPGLAKAALFARVNGQDMDLARKLDEDVKLQIFTPKSPESLELIRHDAA
HVVASAVQKLFPGTQVTIGPATEEGFYYDFFREKPFTPEDLEKIEAEANAELKRDMAFVRTEISMDEAVRLFEEKGEKFK
VEIVKDIAAKGAKTLTLYTHGDWVDFCLGPHAPSTGKIGIIKILSSSGAYWRGDHRNPMLQRVYGTAFFDKKQLAEYLTR
IEESKKRDHRKLGKELDLFHFHPYSPGSAFWTPKGTTLYTTLSNWMRQLTQNDGYVEIKTPLMFNKGLWETSGHWGKYKE
NMFLVLDSESGEHDFSLKPMNCPSHHLFYGFKKHSYRDLPLRYHTQDVLHRNEAAGSLGGLTRVRQFAQDDAHIYCTEAQ
ITDEVRRFVKLLDHVYKAVGLTYAVKLSTRPEQRLGDDSLWDRAEGGLKAALESLGLEYELAPGDGAFYGPKIDFAVSDS
IGRRWQLGTMQLDYLAPERFDLTYVGEDNAEHRPVVLHRAIFGSFERFTAILIEHFAGAFPAWLAPIQAVLVTVADRQND
YARKVRDSLRAKGYRVEFDERGLSMNAKIREAQLQKVPFTLVVGDNEVSGEGVSPRRYGGEDLKTMKVTDFEALLAKEAA
LP
>Mature_641_residues
SDIITVTLPDGSQKQTARGTTIADFVRESIGPGLAKAALFARVNGQDMDLARKLDEDVKLQIFTPKSPESLELIRHDAAH
VVASAVQKLFPGTQVTIGPATEEGFYYDFFREKPFTPEDLEKIEAEANAELKRDMAFVRTEISMDEAVRLFEEKGEKFKV
EIVKDIAAKGAKTLTLYTHGDWVDFCLGPHAPSTGKIGIIKILSSSGAYWRGDHRNPMLQRVYGTAFFDKKQLAEYLTRI
EESKKRDHRKLGKELDLFHFHPYSPGSAFWTPKGTTLYTTLSNWMRQLTQNDGYVEIKTPLMFNKGLWETSGHWGKYKEN
MFLVLDSESGEHDFSLKPMNCPSHHLFYGFKKHSYRDLPLRYHTQDVLHRNEAAGSLGGLTRVRQFAQDDAHIYCTEAQI
TDEVRRFVKLLDHVYKAVGLTYAVKLSTRPEQRLGDDSLWDRAEGGLKAALESLGLEYELAPGDGAFYGPKIDFAVSDSI
GRRWQLGTMQLDYLAPERFDLTYVGEDNAEHRPVVLHRAIFGSFERFTAILIEHFAGAFPAWLAPIQAVLVTVADRQNDY
ARKVRDSLRAKGYRVEFDERGLSMNAKIREAQLQKVPFTLVVGDNEVSGEGVSPRRYGGEDLKTMKVTDFEALLAKEAAL
P

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=640, Percent_Identity=40.625, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI38202255, Length=613, Percent_Identity=42.5774877650897, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI20070344, Length=644, Percent_Identity=41.1490683229814, Blast_Score=446, Evalue=1e-125,
Organism=Escherichia coli, GI1788013, Length=634, Percent_Identity=44.794952681388, Blast_Score=571, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI71984184, Length=618, Percent_Identity=43.042071197411, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI71984192, Length=618, Percent_Identity=43.042071197411, Blast_Score=520, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6322112, Length=631, Percent_Identity=40.4120443740095, Blast_Score=482, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6322654, Length=388, Percent_Identity=40.7216494845361, Blast_Score=309, Evalue=9e-85,
Organism=Drosophila melanogaster, GI24583842, Length=614, Percent_Identity=41.85667752443, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI28574141, Length=614, Percent_Identity=41.85667752443, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24583839, Length=614, Percent_Identity=41.85667752443, Blast_Score=491, Evalue=1e-139,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_MYXXD (Q1D6E3)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631780.1
- ProteinModelPortal:   Q1D6E3
- SMR:   Q1D6E3
- STRING:   Q1D6E3
- GeneID:   4103762
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_3591
- TIGR:   MXAN_3591
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   FHPKGMV
- PhylomeDB:   Q1D6E3
- ProtClustDB:   PRK00413
- BioCyc:   MXAN246197:MXAN_3591-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 72538; Mature: 72407

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIITVTLPDGSQKQTARGTTIADFVRESIGPGLAKAALFARVNGQDMDLARKLDEDVK
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHCCCCCE
LQIFTPKSPESLELIRHDAAHVVASAVQKLFPGTQVTIGPATEEGFYYDFFREKPFTPED
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEHHCCCCCCHHH
LEKIEAEANAELKRDMAFVRTEISMDEAVRLFEEKGEKFKVEIVKDIAAKGAKTLTLYTH
HHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEHHHHHHHHCCCEEEEEEEC
GDWVDFCLGPHAPSTGKIGIIKILSSSGAYWRGDHRNPMLQRVYGTAFFDKKQLAEYLTR
CCEEEEECCCCCCCCCCEEEEEEEECCCCEEECCCCCHHHHHHHHHHHCCHHHHHHHHHH
IEESKKRDHRKLGKELDLFHFHPYSPGSAFWTPKGTTLYTTLSNWMRQLTQNDGYVEIKT
HHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCCCEEEHHHHHHHHHHHCCCCEEEEEC
PLMFNKGLWETSGHWGKYKENMFLVLDSESGEHDFSLKPMNCPSHHLFYGFKKHSYRDLP
CEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCEEEEECCCCCCCCC
LRYHTQDVLHRNEAAGSLGGLTRVRQFAQDDAHIYCTEAQITDEVRRFVKLLDHVYKAVG
CEECHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHC
LTYAVKLSTRPEQRLGDDSLWDRAEGGLKAALESLGLEYELAPGDGAFYGPKIDFAVSDS
CEEEEEECCCCHHHCCCCHHHHHHCCHHHHHHHHCCCEEEECCCCCCEECCEEEEEECCC
IGRRWQLGTMQLDYLAPERFDLTYVGEDNAEHRPVVLHRAIFGSFERFTAILIEHFAGAF
CCCEEEECCEEEEEECCCCEEEEEECCCCCCCCCEEEHHHHHCCHHHHHHHHHHHHHCCC
PAWLAPIQAVLVTVADRQNDYARKVRDSLRAKGYRVEFDERGLSMNAKIREAQLQKVPFT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCEE
LVVGDNEVSGEGVSPRRYGGEDLKTMKVTDFEALLAKEAALP
EEECCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHCCCC
>Mature Secondary Structure 
SDIITVTLPDGSQKQTARGTTIADFVRESIGPGLAKAALFARVNGQDMDLARKLDEDVK
CCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHCCCCCE
LQIFTPKSPESLELIRHDAAHVVASAVQKLFPGTQVTIGPATEEGFYYDFFREKPFTPED
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEHHCCCCCCHHH
LEKIEAEANAELKRDMAFVRTEISMDEAVRLFEEKGEKFKVEIVKDIAAKGAKTLTLYTH
HHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEHHHHHHHHCCCEEEEEEEC
GDWVDFCLGPHAPSTGKIGIIKILSSSGAYWRGDHRNPMLQRVYGTAFFDKKQLAEYLTR
CCEEEEECCCCCCCCCCEEEEEEEECCCCEEECCCCCHHHHHHHHHHHCCHHHHHHHHHH
IEESKKRDHRKLGKELDLFHFHPYSPGSAFWTPKGTTLYTTLSNWMRQLTQNDGYVEIKT
HHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCCCEEEHHHHHHHHHHHCCCCEEEEEC
PLMFNKGLWETSGHWGKYKENMFLVLDSESGEHDFSLKPMNCPSHHLFYGFKKHSYRDLP
CEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEECCCCCCCCCEEEEECCCCCCCCC
LRYHTQDVLHRNEAAGSLGGLTRVRQFAQDDAHIYCTEAQITDEVRRFVKLLDHVYKAVG
CEECHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHC
LTYAVKLSTRPEQRLGDDSLWDRAEGGLKAALESLGLEYELAPGDGAFYGPKIDFAVSDS
CEEEEEECCCCHHHCCCCHHHHHHCCHHHHHHHHCCCEEEECCCCCCEECCEEEEEECCC
IGRRWQLGTMQLDYLAPERFDLTYVGEDNAEHRPVVLHRAIFGSFERFTAILIEHFAGAF
CCCEEEECCEEEEEECCCCEEEEEECCCCCCCCCEEEHHHHHCCHHHHHHHHHHHHHCCC
PAWLAPIQAVLVTVADRQNDYARKVRDSLRAKGYRVEFDERGLSMNAKIREAQLQKVPFT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCEE
LVVGDNEVSGEGVSPRRYGGEDLKTMKVTDFEALLAKEAALP
EEECCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA