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The map label for this gene is accC [H]

Identifier: 108758762

GI number: 108758762

Start: 6949050

End: 6950402

Strand: Reverse

Name: accC [H]

Synonym: MXAN_5595

Alternate gene names: 108758762

Gene position: 6950402-6949050 (Counterclockwise)

Preceding gene: 108759800

Following gene: 108762374

Centisome position: 76.05

GC content: 69.33

Gene sequence:

>1353_bases
ATGTTCCAGAAGCTGCTCATCGCCAACCGGGGAGAGATTGCCCGCCGCATCGGCGTGGTGGCCCGGGGCATGGGGCTCAA
GACGGTCGCCGTCTATTCGGACGCGGACGCTGAGCTGCCCTTCGTGAAGGAGGCCGACGAGGCGGTGCGCATCGGCCCCG
CGCCGGCCAAGGACAGCTACCTCAATACCGCCGCCATCCTGGAAGCCGCGAAGCAGACGGGTGCGCAGGCCATCCACCCG
GGCTACGGCTTCCTGTCGGAGAACGGCGAGTTCGCCCAGGCCTGCGCGGACGCGGGGCTCATCTTCGTGGGACCGCCGCC
GGAGGCCATGGCGCGGATGAAGGACAAGAGCCAGGCCCGAAAGTTGGTGTCCGCCGCGGGGGTCCCCGTGGTGCCCGGCA
GCGAGGGCGTGGTGCCCGACGTGGCCAGCGCGCTGGCGGAGGCCGAGCGCATCGGCTACCCGGTGCTCGTCAAGGCGGCC
AGCGGCGGCGGCGGCATTGGCATGGCGGTGGCCAGGAACGCCGCGGAGATGGAGAAGGTCTACCGCCAGTGCACGGACCG
GGCGAAGGCCGCCTTCGGCAAGGAAGGCGTGTACGTGGAGCGCTACTTCCCGGCGCCCCGGCACATCGAGGTCCAGATTC
TGGGGGACCAGCACGGCCACCTCATCCACTGTCTGGAGCGGGAATGTTCCATCCAGCGGCGCCACCAGAAGGTGGTGGAG
GAAGCCCCCTCCGTGCTGTTCGCGGACGGGCGCAACCCGGAGCTGGCGCAGAAGCTCTTCACGGCCGCGGTGGCCGCGGC
GAAGGCCTTTGGTTACGCCAACGCCGGCACGGTGGAGTTCCTCTACTCGGACGGTGAGGTCTACTTCATCGAGATGAACG
CCCGCCTCCAGGTGGAGCACCCGGTGACGGAGCTGACCACGGGGCTGGACCTCATCGGCTGGCAGCTGCGCATCGCCGCG
GGCGAGCGCCTCACGGTGAAGCAGGAGGACGTGAAGCGGCGCGGGGCGGCGCTGGAGTTCCGCATCTACGCCGAGGACCC
GGTGAAGTTCTTCCCGTCTCCCGGGCCGCTGAAGGTGTTCCAGCCGCCCACGGGCGAGGGCGTCCGGCTGGACGCGGGCT
ACGGCGAGGGCAACACCGTCACGCCGAACTACGACCCGATGATTGCCAAGCTCATCGTCACCGGTGAGACGCGGGCGCAG
GCGATTGAGCGCTCCGTGACGGCGCTCCAGTCGTTCCGCATCGAAGGCATCAAGACGAACATCCCGCTCCACCTGCGCAT
CGTGCAGGATGCGGCCTTCCAGGCCGGCGAGCTGGACACGAACTTCCTGGAGCACCACGCCAAGCCGGCGTAG

Upstream 100 bases:

>100_bases
ACTGTAGGGACCTGTTGCACGTCCGTTCGCACCCTTGTCTTGGGAGGGAGCGAGGGTTAGGTTCGCCGCCCTTTCGCACC
CGCACCCCAGGGGTTTCGCC

Downstream 100 bases:

>100_bases
CGGGGCCCGCTCCAGCCCCAACCACCCCTGAGGAGGCACGGATTCATGGCGGACGTAGCGGCGCACATCACCGGCACGGT
GTGGAAGATTGAGGTTCAGG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MFQKLLIANRGEIARRIGVVARGMGLKTVAVYSDADAELPFVKEADEAVRIGPAPAKDSYLNTAAILEAAKQTGAQAIHP
GYGFLSENGEFAQACADAGLIFVGPPPEAMARMKDKSQARKLVSAAGVPVVPGSEGVVPDVASALAEAERIGYPVLVKAA
SGGGGIGMAVARNAAEMEKVYRQCTDRAKAAFGKEGVYVERYFPAPRHIEVQILGDQHGHLIHCLERECSIQRRHQKVVE
EAPSVLFADGRNPELAQKLFTAAVAAAKAFGYANAGTVEFLYSDGEVYFIEMNARLQVEHPVTELTTGLDLIGWQLRIAA
GERLTVKQEDVKRRGAALEFRIYAEDPVKFFPSPGPLKVFQPPTGEGVRLDAGYGEGNTVTPNYDPMIAKLIVTGETRAQ
AIERSVTALQSFRIEGIKTNIPLHLRIVQDAAFQAGELDTNFLEHHAKPA

Sequences:

>Translated_450_residues
MFQKLLIANRGEIARRIGVVARGMGLKTVAVYSDADAELPFVKEADEAVRIGPAPAKDSYLNTAAILEAAKQTGAQAIHP
GYGFLSENGEFAQACADAGLIFVGPPPEAMARMKDKSQARKLVSAAGVPVVPGSEGVVPDVASALAEAERIGYPVLVKAA
SGGGGIGMAVARNAAEMEKVYRQCTDRAKAAFGKEGVYVERYFPAPRHIEVQILGDQHGHLIHCLERECSIQRRHQKVVE
EAPSVLFADGRNPELAQKLFTAAVAAAKAFGYANAGTVEFLYSDGEVYFIEMNARLQVEHPVTELTTGLDLIGWQLRIAA
GERLTVKQEDVKRRGAALEFRIYAEDPVKFFPSPGPLKVFQPPTGEGVRLDAGYGEGNTVTPNYDPMIAKLIVTGETRAQ
AIERSVTALQSFRIEGIKTNIPLHLRIVQDAAFQAGELDTNFLEHHAKPA
>Mature_450_residues
MFQKLLIANRGEIARRIGVVARGMGLKTVAVYSDADAELPFVKEADEAVRIGPAPAKDSYLNTAAILEAAKQTGAQAIHP
GYGFLSENGEFAQACADAGLIFVGPPPEAMARMKDKSQARKLVSAAGVPVVPGSEGVVPDVASALAEAERIGYPVLVKAA
SGGGGIGMAVARNAAEMEKVYRQCTDRAKAAFGKEGVYVERYFPAPRHIEVQILGDQHGHLIHCLERECSIQRRHQKVVE
EAPSVLFADGRNPELAQKLFTAAVAAAKAFGYANAGTVEFLYSDGEVYFIEMNARLQVEHPVTELTTGLDLIGWQLRIAA
GERLTVKQEDVKRRGAALEFRIYAEDPVKFFPSPGPLKVFQPPTGEGVRLDAGYGEGNTVTPNYDPMIAKLIVTGETRAQ
AIERSVTALQSFRIEGIKTNIPLHLRIVQDAAFQAGELDTNFLEHHAKPA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=448, Percent_Identity=47.5446428571429, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI189095269, Length=446, Percent_Identity=48.2062780269058, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI65506442, Length=446, Percent_Identity=48.2062780269058, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI295821183, Length=446, Percent_Identity=48.2062780269058, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI106049528, Length=451, Percent_Identity=44.1241685144124, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI106049295, Length=451, Percent_Identity=44.1241685144124, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI106049292, Length=451, Percent_Identity=44.1241685144124, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI38679977, Length=507, Percent_Identity=31.3609467455621, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI38679967, Length=507, Percent_Identity=31.3609467455621, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI38679974, Length=507, Percent_Identity=31.3609467455621, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI38679960, Length=507, Percent_Identity=31.3609467455621, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI38679971, Length=507, Percent_Identity=31.3609467455621, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=30.0589390962672, Blast_Score=217, Evalue=2e-56,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=52.8089887640449, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71987519, Length=450, Percent_Identity=48.4444444444444, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17567343, Length=446, Percent_Identity=48.2062780269058, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17562816, Length=452, Percent_Identity=43.141592920354, Blast_Score=356, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=26.6802443991853, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71997168, Length=443, Percent_Identity=27.765237020316, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71997163, Length=443, Percent_Identity=27.765237020316, Blast_Score=171, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6319685, Length=453, Percent_Identity=41.9426048565121, Blast_Score=348, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6319695, Length=452, Percent_Identity=43.3628318584071, Blast_Score=333, Evalue=5e-92,
Organism=Saccharomyces cerevisiae, GI6321376, Length=451, Percent_Identity=42.5720620842572, Blast_Score=317, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6323863, Length=467, Percent_Identity=30.8351177730193, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324343, Length=514, Percent_Identity=28.0155642023346, Blast_Score=198, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24651757, Length=449, Percent_Identity=46.1024498886414, Blast_Score=401, Evalue=1e-112,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=46.0591133004926, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI281363050, Length=453, Percent_Identity=44.3708609271523, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24652224, Length=453, Percent_Identity=44.3708609271523, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24652222, Length=453, Percent_Identity=44.3708609271523, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24652220, Length=453, Percent_Identity=44.3708609271523, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24652218, Length=453, Percent_Identity=44.3708609271523, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24652212, Length=453, Percent_Identity=44.3708609271523, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI24652210, Length=453, Percent_Identity=44.3708609271523, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI24652214, Length=453, Percent_Identity=44.3708609271523, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI19921944, Length=453, Percent_Identity=44.3708609271523, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI24652216, Length=453, Percent_Identity=44.3708609271523, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI161076407, Length=502, Percent_Identity=29.8804780876494, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24586460, Length=502, Percent_Identity=29.8804780876494, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI161076409, Length=502, Percent_Identity=29.8804780876494, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=29.8804780876494, Blast_Score=207, Evalue=9e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48499; Mature: 48499

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKLLIANRGEIARRIGVVARGMGLKTVAVYSDADAELPFVKEADEAVRIGPAPAKDSY
CCCCEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHCCCCEEEECCCCCCCCH
LNTAAILEAAKQTGAQAIHPGYGFLSENGEFAQACADAGLIFVGPPPEAMARMKDKSQAR
HHHHHHHHHHHHCCCCEECCCCCEECCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHH
KLVSAAGVPVVPGSEGVVPDVASALAEAERIGYPVLVKAASGGGGIGMAVARNAAEMEKV
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCHHHHHHH
YRQCTDRAKAAFGKEGVYVERYFPAPRHIEVQILGDQHGHLIHCLERECSIQRRHQKVVE
HHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHH
EAPSVLFADGRNPELAQKLFTAAVAAAKAFGYANAGTVEFLYSDGEVYFIEMNARLQVEH
HCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEEEECCEEEECC
PVTELTTGLDLIGWQLRIAAGERLTVKQEDVKRRGAALEFRIYAEDPVKFFPSPGPLKVF
CHHHHHCCHHHCCEEEEEECCCEEEEEHHHHHHCCCEEEEEEEECCCCEECCCCCCEEEE
QPPTGEGVRLDAGYGEGNTVTPNYDPMIAKLIVTGETRAQAIERSVTALQSFRIEGIKTN
CCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCEECC
IPLHLRIVQDAAFQAGELDTNFLEHHAKPA
CCEEEEEEECCCCCCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MFQKLLIANRGEIARRIGVVARGMGLKTVAVYSDADAELPFVKEADEAVRIGPAPAKDSY
CCCCEEECCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHCCCCEEEECCCCCCCCH
LNTAAILEAAKQTGAQAIHPGYGFLSENGEFAQACADAGLIFVGPPPEAMARMKDKSQAR
HHHHHHHHHHHHCCCCEECCCCCEECCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHHH
KLVSAAGVPVVPGSEGVVPDVASALAEAERIGYPVLVKAASGGGGIGMAVARNAAEMEKV
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHCCHHHHHHH
YRQCTDRAKAAFGKEGVYVERYFPAPRHIEVQILGDQHGHLIHCLERECSIQRRHQKVVE
HHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCCCCEEHHHHHHHHHHHHHHHHHH
EAPSVLFADGRNPELAQKLFTAAVAAAKAFGYANAGTVEFLYSDGEVYFIEMNARLQVEH
HCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEEEEEECCEEEECC
PVTELTTGLDLIGWQLRIAAGERLTVKQEDVKRRGAALEFRIYAEDPVKFFPSPGPLKVF
CHHHHHCCHHHCCEEEEEECCCEEEEEHHHHHHCCCEEEEEEEECCCCEECCCCCCEEEE
QPPTGEGVRLDAGYGEGNTVTPNYDPMIAKLIVTGETRAQAIERSVTALQSFRIEGIKTN
CCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCEECC
IPLHLRIVQDAAFQAGELDTNFLEHHAKPA
CCEEEEEEECCCCCCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]