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The map label for this gene is tesB [H]

Identifier: 108758168

GI number: 108758168

Start: 4601302

End: 4602171

Strand: Reverse

Name: tesB [H]

Synonym: MXAN_3828

Alternate gene names: 108758168

Gene position: 4602171-4601302 (Counterclockwise)

Preceding gene: 108762879

Following gene: 108758972

Centisome position: 50.35

GC content: 69.08

Gene sequence:

>870_bases
ATGAGCCGAGTCCTGGATGAGCTGTTGGCGCTCCTTAAACTGGAGAAAATCGAGGAAAATCTGTTTCGTGGCCGGAGTCA
AGACCTGGGGTTCCGCCAGCTCTTCGGCGGCCAGGTGCTGGGGCAGGCGTTGTCCGCGGGCAGCCAGACGGTGCCCGCCG
GCCGGCATGTCCACTCCCTGCACGGCTACTTCCTGCGCCCGGGCGACGCGACGCTTCCAGTCGTCTACACGGTGGACCGG
GTGCGGGACGGCGGCAGCATCACCACGCGCCGCGTCGTGGCCGTGCAGAAGGGCGAGCCCATCCTGACGATGATCGCCTC
CTTCCACGGGGACGAAGAGGGCTTTGCCCACCAGGCGCCCATGCCGGAGGTGCCAGGCCCGGAGGCGCTGGCCTCGGAGC
AGGAGCTGCTGAGCCGCGTGTCCGCCCGCATCCCGGAAGCCCTGCGGGAGAAGTTCCTGGGGGAGAAGCCGATTGAGATC
CGGCCCGTGGCGCCGGAGGATCCGTTCAACCCGGAGGCGCAGGCGCCCATCAAGCACGTGTGGTTCCGGGCCAACGGCGA
CCTGCCGGAGGATCCGCAGGTGCATCGGTACGTGCTGGCCTACGCGTCCGACTTCAACCTCATCAGCACCGCGCTCCTGC
CCCACGCGGCCAGCTTCTTCCAGCCCCGCATCCTGGGCGCCAGCCTGGACCATGCCCTGTGGTTCCACGGAGACCTGAAG
GTGAGCGACTGGCTGCTGTACTCCATGGACAGCCCGTGGGCGGGCAACGCGCGCGGCCTGTCGCGCGGCAGCGTCTACAC
GCGTGACGGCCGGCTGGTGGCCTCGGTGGCCCAGGAAGGGCTGCTGCGCATCCGCAAGCCCACGGCCTGA

Upstream 100 bases:

>100_bases
AACCGACACGGCTCCGCGGTCGGGCGGGACCCGGCAAGGGACCATGCACAGGGCGCCGCTTCCCGAGACACCGGTGCCCG
GGTCGATTACGACAGGGGCC

Downstream 100 bases:

>100_bases
GAAACGGGGACGACACCCCACACCGGCGTGTGGGGTCGAGCCCCCCGCCGCGCCCTCGGGAATCCACGAGGACTGCAACT
CTCCGGAATTCCTGGTGCTT

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSRVLDELLALLKLEKIEENLFRGRSQDLGFRQLFGGQVLGQALSAGSQTVPAGRHVHSLHGYFLRPGDATLPVVYTVDR
VRDGGSITTRRVVAVQKGEPILTMIASFHGDEEGFAHQAPMPEVPGPEALASEQELLSRVSARIPEALREKFLGEKPIEI
RPVAPEDPFNPEAQAPIKHVWFRANGDLPEDPQVHRYVLAYASDFNLISTALLPHAASFFQPRILGASLDHALWFHGDLK
VSDWLLYSMDSPWAGNARGLSRGSVYTRDGRLVASVAQEGLLRIRKPTA

Sequences:

>Translated_289_residues
MSRVLDELLALLKLEKIEENLFRGRSQDLGFRQLFGGQVLGQALSAGSQTVPAGRHVHSLHGYFLRPGDATLPVVYTVDR
VRDGGSITTRRVVAVQKGEPILTMIASFHGDEEGFAHQAPMPEVPGPEALASEQELLSRVSARIPEALREKFLGEKPIEI
RPVAPEDPFNPEAQAPIKHVWFRANGDLPEDPQVHRYVLAYASDFNLISTALLPHAASFFQPRILGASLDHALWFHGDLK
VSDWLLYSMDSPWAGNARGLSRGSVYTRDGRLVASVAQEGLLRIRKPTA
>Mature_288_residues
SRVLDELLALLKLEKIEENLFRGRSQDLGFRQLFGGQVLGQALSAGSQTVPAGRHVHSLHGYFLRPGDATLPVVYTVDRV
RDGGSITTRRVVAVQKGEPILTMIASFHGDEEGFAHQAPMPEVPGPEALASEQELLSRVSARIPEALREKFLGEKPIEIR
PVAPEDPFNPEAQAPIKHVWFRANGDLPEDPQVHRYVLAYASDFNLISTALLPHAASFFQPRILGASLDHALWFHGDLKV
SDWLLYSMDSPWAGNARGLSRGSVYTRDGRLVASVAQEGLLRIRKPTA

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=287, Percent_Identity=41.8118466898955, Blast_Score=219, Evalue=2e-57,
Organism=Escherichia coli, GI1786657, Length=283, Percent_Identity=50.8833922261484, Blast_Score=297, Evalue=5e-82,
Organism=Caenorhabditis elegans, GI17558508, Length=305, Percent_Identity=39.344262295082, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71988741, Length=290, Percent_Identity=36.8965517241379, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI115532456, Length=270, Percent_Identity=35.5555555555556, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17531889, Length=268, Percent_Identity=35.8208955223881, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17531885, Length=270, Percent_Identity=35.5555555555556, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71982224, Length=309, Percent_Identity=30.7443365695793, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI212645202, Length=294, Percent_Identity=30.952380952381, Blast_Score=126, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 31866; Mature: 31734

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRVLDELLALLKLEKIEENLFRGRSQDLGFRQLFGGQVLGQALSAGSQTVPAGRHVHSL
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHC
HGYFLRPGDATLPVVYTVDRVRDGGSITTRRVVAVQKGEPILTMIASFHGDEEGFAHQAP
CCEEECCCCCCEEEEEEEEHHCCCCCEEEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCC
MPEVPGPEALASEQELLSRVSARIPEALREKFLGEKPIEIRPVAPEDPFNPEAQAPIKHV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEE
WFRANGDLPEDPQVHRYVLAYASDFNLISTALLPHAASFFQPRILGASLDHALWFHGDLK
EEEECCCCCCCCHHHHEEHHHHCCCHHHHHHHHHHHHHHHCCHHHCCCCCCEEEEECCCE
VSDWLLYSMDSPWAGNARGLSRGSVYTRDGRLVASVAQEGLLRIRKPTA
EEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SRVLDELLALLKLEKIEENLFRGRSQDLGFRQLFGGQVLGQALSAGSQTVPAGRHVHSL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHC
HGYFLRPGDATLPVVYTVDRVRDGGSITTRRVVAVQKGEPILTMIASFHGDEEGFAHQAP
CCEEECCCCCCEEEEEEEEHHCCCCCEEEEEEEEEECCCHHHHHHHHHCCCCCCCCCCCC
MPEVPGPEALASEQELLSRVSARIPEALREKFLGEKPIEIRPVAPEDPFNPEAQAPIKHV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEE
WFRANGDLPEDPQVHRYVLAYASDFNLISTALLPHAASFFQPRILGASLDHALWFHGDLK
EEEECCCCCCCCHHHHEEHHHHCCCHHHHHHHHHHHHHHHCCHHHCCCCCCEEEEECCCE
VSDWLLYSMDSPWAGNARGLSRGSVYTRDGRLVASVAQEGLLRIRKPTA
EEEEEEEECCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]