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The map label for this gene is cocE [H]

Identifier: 108757751

GI number: 108757751

Start: 4577070

End: 4579007

Strand: Reverse

Name: cocE [H]

Synonym: MXAN_3810

Alternate gene names: 108757751

Gene position: 4579007-4577070 (Counterclockwise)

Preceding gene: 108763029

Following gene: 108756990

Centisome position: 50.1

GC content: 66.98

Gene sequence:

>1938_bases
ATGCATCCCGTGACCCGATGCCTCGCGGCTGTCCTGCTGGCCACCGTCGCAGGCCCGGCGCAGGCGCAGTCCACCCCGCC
AGCCCCGAAGCGCCCTTACAGCATCTCTCCCGAGCGCACCGAACGCGTCCGCTCGCAGTACACCAAGTTCGAGTACCGCA
TTCCCATGCGGGACGGGACGCGCCTGTTCACCTCCGTCTACGTCCCCGCGGACGCGTCACCGGGGAAGCGCTATCCCATC
ATCCTGGTGCGCACGCCGTACAGCGTCGCACCCTATGGCGTGGACCGGTATCCCCCCGCGCTGGCCCCCACCGAGGCGTT
CGAGAAGGACGGCTTCATCTTTGCCTTCCAGGACGTGCGCGGCCGAAACATGTCCGAAGGCGAGTTCGTCAACGTACGCC
CCTACAAGCCGAAGAAGGCCGGGCCCAAGGACTTTGACGAGAGCACCGACACGTACGACACCATCGAGTGGCTGGTGAAG
CGCGTGGCGAACAACAACGGCCGCGTGGGCCAGTGGGGGATTTCGTACCCCGGCTTCTACGCGTCGGCGGGCGCCATTGA
TTCGCACCCGGCGCTCAAGGCGGTGTCACCGCAGGCCCCCATCGCCGACTGGTTCTGGGATGACATGCACCGCCACGGCG
CCTTCAACCTGGCGCTGGCGTTCAACTTCTTCTCCACGTTCGGCAAGCCCCGGCCCCACCCCACGGACAACGAGGAGTGG
CAGCGCTTCGAGCACGGCACGCCGGACGGCTACCAGTTCTTCCTGGACCTGGGCCCCCTGGGCAACGCGGACGCGAAGCA
CATGAAGGGGGACGTCGCCTTCTGGAAGGACGTCACCGCGCATCCCAACTACGACAGCTTCTGGCAGGCGCGGAACCTGC
TCCCGCACCTGAAGAACATCAAGGCGGCGGTGCTCACGGTGGGCGGCTGGTACGACACCGAGGACCTCTACGGCCCCCTG
CGGACCTACGCCGCCATCGAGAAGCAGAACCCCGGCATCTCCAACAGCCTCATCATGGGCCCGTGGCCGCACGGCGGCTG
GCAGCGCGGCGGTGGCGAGTCCCTGGGCGACGCGGACTTCGGCTTCGCCACCAGCGAGACCTACCAGACGTTGGCGCTGG
ACTTCTTCAAGCACCACCTCAAGGGCGGCGCGAAGCCGGACGTGCCGGAGGCCATGGTGTTCGAGACGGGCGCCAACCGC
TGGCGCCGCTTCGACACGTGGCCGCCCAAGGGGCTGCGCGAGACGCGGCTGTACTTCCAGCCCAAGGGTGGCTTGGCCAC
GACGGCGCCGAAGACGACGGGCGCATCCTTCGCCGAGTACGTGAGCGACCCCGCCAAGCCCGTGCCGTACACGCAGGAGA
TGATGACGGGCTGGAGCAAGGACTACATGACGGAGGACCAGCGCTTCGCCGCGCGCCGGCCGGACGTGCTGGTGTTCGAG
ACGGAGCCACTGGAGCGCGACCTCACGCTGGCGGGACCGCTGGAGGCGGAGTTGTGGGTTTCCACGACGGGCACCGACGC
GGACTGGGTGGTGAAGCTGGTGGACGTCAACCCGGGCAAGGTGCGCGGGTGGCGCAAGGGCGATGAAGAGAAGGGGCAGA
AGAACCGGGGCCATCAGCAGACGCTGGTGCGTGGCGAGCCCTTCCGCGGCCGGTTCCGCGACAGCTATAGCGAGCCCAAG
CCCTTCAAGCCCAACGAGGTGACGAAGGTGCGCTTCGTCATCAATGACGTGTTCCACACCTTCCAGCGTGGGCACCGCGT
GATGATTCAGGTCCAGTCGAGCTGGTTCCCGTTCATCGACCGCAATCCGCAGACCTACGTGCCCAACATCTTCGAGGCGA
AGGAGGAGCACTTCACGCGCGCCTTCCATCGCGTCTACCACTCCGCGGCGAACCCTAGTTTCATCCAGGTGGGCGTGCTG
CCCTCGTTGGACGAGTAG

Upstream 100 bases:

>100_bases
CTGGACGACGGCGGGGAAGAGCGGAGCTGATTCCGGGAACAAGCGGGCCGCTCGCGGTGTTGCGGGCCGGCCTTCCAGCG
TCATCGTTCCAGGAGCGTGC

Downstream 100 bases:

>100_bases
CGCGAGGGCCCCCACGCGGAGCCCTCCGTTCGCCGCCATCAGGGCTGCTTCTGTGCAGCGGCGAAGGGAAGGGTGTTCTC
GTGGGGGTGCCAGCCTTGCG

Product: CocE/NonD family hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 645; Mature: 645

Protein sequence:

>645_residues
MHPVTRCLAAVLLATVAGPAQAQSTPPAPKRPYSISPERTERVRSQYTKFEYRIPMRDGTRLFTSVYVPADASPGKRYPI
ILVRTPYSVAPYGVDRYPPALAPTEAFEKDGFIFAFQDVRGRNMSEGEFVNVRPYKPKKAGPKDFDESTDTYDTIEWLVK
RVANNNGRVGQWGISYPGFYASAGAIDSHPALKAVSPQAPIADWFWDDMHRHGAFNLALAFNFFSTFGKPRPHPTDNEEW
QRFEHGTPDGYQFFLDLGPLGNADAKHMKGDVAFWKDVTAHPNYDSFWQARNLLPHLKNIKAAVLTVGGWYDTEDLYGPL
RTYAAIEKQNPGISNSLIMGPWPHGGWQRGGGESLGDADFGFATSETYQTLALDFFKHHLKGGAKPDVPEAMVFETGANR
WRRFDTWPPKGLRETRLYFQPKGGLATTAPKTTGASFAEYVSDPAKPVPYTQEMMTGWSKDYMTEDQRFAARRPDVLVFE
TEPLERDLTLAGPLEAELWVSTTGTDADWVVKLVDVNPGKVRGWRKGDEEKGQKNRGHQQTLVRGEPFRGRFRDSYSEPK
PFKPNEVTKVRFVINDVFHTFQRGHRVMIQVQSSWFPFIDRNPQTYVPNIFEAKEEHFTRAFHRVYHSAANPSFIQVGVL
PSLDE

Sequences:

>Translated_645_residues
MHPVTRCLAAVLLATVAGPAQAQSTPPAPKRPYSISPERTERVRSQYTKFEYRIPMRDGTRLFTSVYVPADASPGKRYPI
ILVRTPYSVAPYGVDRYPPALAPTEAFEKDGFIFAFQDVRGRNMSEGEFVNVRPYKPKKAGPKDFDESTDTYDTIEWLVK
RVANNNGRVGQWGISYPGFYASAGAIDSHPALKAVSPQAPIADWFWDDMHRHGAFNLALAFNFFSTFGKPRPHPTDNEEW
QRFEHGTPDGYQFFLDLGPLGNADAKHMKGDVAFWKDVTAHPNYDSFWQARNLLPHLKNIKAAVLTVGGWYDTEDLYGPL
RTYAAIEKQNPGISNSLIMGPWPHGGWQRGGGESLGDADFGFATSETYQTLALDFFKHHLKGGAKPDVPEAMVFETGANR
WRRFDTWPPKGLRETRLYFQPKGGLATTAPKTTGASFAEYVSDPAKPVPYTQEMMTGWSKDYMTEDQRFAARRPDVLVFE
TEPLERDLTLAGPLEAELWVSTTGTDADWVVKLVDVNPGKVRGWRKGDEEKGQKNRGHQQTLVRGEPFRGRFRDSYSEPK
PFKPNEVTKVRFVINDVFHTFQRGHRVMIQVQSSWFPFIDRNPQTYVPNIFEAKEEHFTRAFHRVYHSAANPSFIQVGVL
PSLDE
>Mature_645_residues
MHPVTRCLAAVLLATVAGPAQAQSTPPAPKRPYSISPERTERVRSQYTKFEYRIPMRDGTRLFTSVYVPADASPGKRYPI
ILVRTPYSVAPYGVDRYPPALAPTEAFEKDGFIFAFQDVRGRNMSEGEFVNVRPYKPKKAGPKDFDESTDTYDTIEWLVK
RVANNNGRVGQWGISYPGFYASAGAIDSHPALKAVSPQAPIADWFWDDMHRHGAFNLALAFNFFSTFGKPRPHPTDNEEW
QRFEHGTPDGYQFFLDLGPLGNADAKHMKGDVAFWKDVTAHPNYDSFWQARNLLPHLKNIKAAVLTVGGWYDTEDLYGPL
RTYAAIEKQNPGISNSLIMGPWPHGGWQRGGGESLGDADFGFATSETYQTLALDFFKHHLKGGAKPDVPEAMVFETGANR
WRRFDTWPPKGLRETRLYFQPKGGLATTAPKTTGASFAEYVSDPAKPVPYTQEMMTGWSKDYMTEDQRFAARRPDVLVFE
TEPLERDLTLAGPLEAELWVSTTGTDADWVVKLVDVNPGKVRGWRKGDEEKGQKNRGHQQTLVRGEPFRGRFRDSYSEPK
PFKPNEVTKVRFVINDVFHTFQRGHRVMIQVQSSWFPFIDRNPQTYVPNIFEAKEEHFTRAFHRVYHSAANPSFIQVGVL
PSLDE

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 73002; Mature: 73002

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPVTRCLAAVLLATVAGPAQAQSTPPAPKRPYSISPERTERVRSQYTKFEYRIPMRDGT
CCHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCC
RLFTSVYVPADASPGKRYPIILVRTPYSVAPYGVDRYPPALAPTEAFEKDGFIFAFQDVR
EEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEEECCC
GRNMSEGEFVNVRPYKPKKAGPKDFDESTDTYDTIEWLVKRVANNNGRVGQWGISYPGFY
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCC
ASAGAIDSHPALKAVSPQAPIADWFWDDMHRHGAFNLALAFNFFSTFGKPRPHPTDNEEW
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCHHH
QRFEHGTPDGYQFFLDLGPLGNADAKHMKGDVAFWKDVTAHPNYDSFWQARNLLPHLKNI
HHHHCCCCCCEEEEEEECCCCCCCHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCC
KAAVLTVGGWYDTEDLYGPLRTYAAIEKQNPGISNSLIMGPWPHGGWQRGGGESLGDADF
EEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCC
GFATSETYQTLALDFFKHHLKGGAKPDVPEAMVFETGANRWRRFDTWPPKGLRETRLYFQ
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHEECCCCCCCCCCCCEEEEC
PKGGLATTAPKTTGASFAEYVSDPAKPVPYTQEMMTGWSKDYMTEDQRFAARRPDVLVFE
CCCCCEECCCCCCCCHHHHHHCCCCCCCCCHHHHHCCCCHHHCCCHHHHHHCCCCEEEEE
TEPLERDLTLAGPLEAELWVSTTGTDADWVVKLVDVNPGKVRGWRKGDEEKGQKNRGHQQ
CCCCCCCCEECCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCCCHH
TLVRGEPFRGRFRDSYSEPKPFKPNEVTKVRFVINDVFHTFQRGHRVMIQVQSSWFPFID
HHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
RNPQTYVPNIFEAKEEHFTRAFHRVYHSAANPSFIQVGVLPSLDE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MHPVTRCLAAVLLATVAGPAQAQSTPPAPKRPYSISPERTERVRSQYTKFEYRIPMRDGT
CCHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCC
RLFTSVYVPADASPGKRYPIILVRTPYSVAPYGVDRYPPALAPTEAFEKDGFIFAFQDVR
EEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEEECCC
GRNMSEGEFVNVRPYKPKKAGPKDFDESTDTYDTIEWLVKRVANNNGRVGQWGISYPGFY
CCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCC
ASAGAIDSHPALKAVSPQAPIADWFWDDMHRHGAFNLALAFNFFSTFGKPRPHPTDNEEW
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHCCCCCCCCCCCHHH
QRFEHGTPDGYQFFLDLGPLGNADAKHMKGDVAFWKDVTAHPNYDSFWQARNLLPHLKNI
HHHHCCCCCCEEEEEEECCCCCCCHHHHCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCC
KAAVLTVGGWYDTEDLYGPLRTYAAIEKQNPGISNSLIMGPWPHGGWQRGGGESLGDADF
EEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCC
GFATSETYQTLALDFFKHHLKGGAKPDVPEAMVFETGANRWRRFDTWPPKGLRETRLYFQ
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHEECCCCCCCCCCCCEEEEC
PKGGLATTAPKTTGASFAEYVSDPAKPVPYTQEMMTGWSKDYMTEDQRFAARRPDVLVFE
CCCCCEECCCCCCCCHHHHHHCCCCCCCCCHHHHHCCCCHHHCCCHHHHHHCCCCEEEEE
TEPLERDLTLAGPLEAELWVSTTGTDADWVVKLVDVNPGKVRGWRKGDEEKGQKNRGHQQ
CCCCCCCCEECCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCCCHH
TLVRGEPFRGRFRDSYSEPKPFKPNEVTKVRFVINDVFHTFQRGHRVMIQVQSSWFPFID
HHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
RNPQTYVPNIFEAKEEHFTRAFHRVYHSAANPSFIQVGVLPSLDE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]