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The map label for this gene is fabL [H]

Identifier: 108757037

GI number: 108757037

Start: 4030883

End: 4032388

Strand: Direct

Name: fabL [H]

Synonym: MXAN_3461

Alternate gene names: 108757037

Gene position: 4030883-4032388 (Clockwise)

Preceding gene: 108757471

Following gene: 108760552

Centisome position: 44.1

GC content: 69.46

Gene sequence:

>1506_bases
ATGACAACGCACGCATCTCATCAGGGCACCTACGCGGTCGAGCACGTTCTCCAGCGGATTCGCCGTTGTGCCGCTGACGT
CACGCGGTACCCCGTGGACATCCTGACGGCGGACGCGCAGCTCGAGGACGAGCTCGGCATTGACTCCGTCAAGCTGGCGG
AGATCGCCGCCGTGGTCGGGCGCGAGTTCAACATTCCGTCCGAGCGGCTGCCACGGGGCGCTCAGGCGCGTACGTTGGGT
GCGATGGCGGACGTGGTGGCGCGGCTGCTCGCGGACACGCAGCCCGCCGCCGTCGCGACGCCTCCACCGGCGCCTGTCGC
GGCTCCCGTACTCCAGGTGTCGTCAGCGGGCTCACCGGTGAAGGACCTGGAGGCGCGGGTCCGTGCCGTCTTCGCTCGGG
TGACGCGCTATCCGGAAGAGCTCTTGACGCCGGAGGCGGACCTGGAGGACGAGCTGGGCATCGACTCGGTCAAGCAGGCC
GAGGTGATGGCCGTGCTCATCAAGGAGCTGGGCCTGACCGATGCTCCGCAGCCTTCGCAGCGGCTGCGGACGATTTCCTC
TATCTGTGAGATGGCGCGCGCTCGGCTGGCGGTCGCGGCGCCCGTGCGCGAGGACCGAGCGCCGCGTCAGTCGCCGCCGC
CAGCCGTGCTGCCCTTCGCGGGGAAGGTCGCGTTCGTTACGGGCTCTGGGAAGGGGATTGGCAAGGTCATCGCGGCTCGC
CTGGCCGGCTCGGGGGCGACGGTGGTGGTGAACTCGTTCCACTCCCGTGACGAAGGAGAGCGGACGGTTCAGGAGATTGT
TGACGCAGGAGGGAAGGCGTTCCACGCCTGGGGCTCAGTCGCGCAGGAAGAGCACCTGGACCGGATGTTCGCCAGCATCG
AGGCGCAGTTCGGCGGGTTGGACTTCCTGGTGTGCAACGCGTCCAACGGCCTCATCGGACCGTTCGACCGGATTACTCCG
CGCGACTGGGACAAGGCGTTCCGCACCTGCATCACGGGGACCTATGAGTGCGCCATGCGCGCGCGGCCCCTGATGGCCCG
GCGTGGCGGCGGAAGCATCGTGACGATGTCCACCTCCATGTCCCAGCGGTACATGCACGACCTCGGCTGTCAGGGCGTGG
TGAAGGCCGGGGTGGAGTCCTTGACACGCTACCTGGCCGCGGAGCTGGCACCGGATGGCATCCGGACCAACTGCGTGTCC
GCGGGACCGGTGCATGGCGAGCTGCTGCGCATGTTCCCCGACGCCGCGAGCCGGGTCGCGCGCTGGGAGTCGGCGACGCC
GGGCGGGGAAATCTGCACTGCCGAGGATGTCGCCGACGTCACCGAGCTCCTCCTGGGGCCCAAGACGCGCCGGGTAAACG
GCGCCATCTGGGTGGTGGATGCGGGGCTCTCCGGCACGGTGGACGGGCTGCTGCCGGGCGCGTCGGAGGCACGGCGTTCC
GAGGCGCAGCGCGGGTCTCACCGCAGTGAGCACGACCTGCGAGCGCTCCTCGCGCTCGATTCCTGA

Upstream 100 bases:

>100_bases
GCTTCTTCGTGCGCTGAATGTGCGGCGACATCCGCCTCCGCAAGTCGTGTCAGACCCTTGATGCATTCATTGCCGCGAAC
CGGGAAACCAGGGGTCGGCA

Downstream 100 bases:

>100_bases
ACGTCGTACCGGAGCCAATTGCCATGGGTTACTTCGCGGTCCCGTACGACATTCATTTCGATGACACGATGGCCTACGGG
AGCCATCACTTCCTCACGAA

Product: short chain dehydrogenase/reductase family oxidoreductase

Products: NA

Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MTTHASHQGTYAVEHVLQRIRRCAADVTRYPVDILTADAQLEDELGIDSVKLAEIAAVVGREFNIPSERLPRGAQARTLG
AMADVVARLLADTQPAAVATPPPAPVAAPVLQVSSAGSPVKDLEARVRAVFARVTRYPEELLTPEADLEDELGIDSVKQA
EVMAVLIKELGLTDAPQPSQRLRTISSICEMARARLAVAAPVREDRAPRQSPPPAVLPFAGKVAFVTGSGKGIGKVIAAR
LAGSGATVVVNSFHSRDEGERTVQEIVDAGGKAFHAWGSVAQEEHLDRMFASIEAQFGGLDFLVCNASNGLIGPFDRITP
RDWDKAFRTCITGTYECAMRARPLMARRGGGSIVTMSTSMSQRYMHDLGCQGVVKAGVESLTRYLAAELAPDGIRTNCVS
AGPVHGELLRMFPDAASRVARWESATPGGEICTAEDVADVTELLLGPKTRRVNGAIWVVDAGLSGTVDGLLPGASEARRS
EAQRGSHRSEHDLRALLALDS

Sequences:

>Translated_501_residues
MTTHASHQGTYAVEHVLQRIRRCAADVTRYPVDILTADAQLEDELGIDSVKLAEIAAVVGREFNIPSERLPRGAQARTLG
AMADVVARLLADTQPAAVATPPPAPVAAPVLQVSSAGSPVKDLEARVRAVFARVTRYPEELLTPEADLEDELGIDSVKQA
EVMAVLIKELGLTDAPQPSQRLRTISSICEMARARLAVAAPVREDRAPRQSPPPAVLPFAGKVAFVTGSGKGIGKVIAAR
LAGSGATVVVNSFHSRDEGERTVQEIVDAGGKAFHAWGSVAQEEHLDRMFASIEAQFGGLDFLVCNASNGLIGPFDRITP
RDWDKAFRTCITGTYECAMRARPLMARRGGGSIVTMSTSMSQRYMHDLGCQGVVKAGVESLTRYLAAELAPDGIRTNCVS
AGPVHGELLRMFPDAASRVARWESATPGGEICTAEDVADVTELLLGPKTRRVNGAIWVVDAGLSGTVDGLLPGASEARRS
EAQRGSHRSEHDLRALLALDS
>Mature_500_residues
TTHASHQGTYAVEHVLQRIRRCAADVTRYPVDILTADAQLEDELGIDSVKLAEIAAVVGREFNIPSERLPRGAQARTLGA
MADVVARLLADTQPAAVATPPPAPVAAPVLQVSSAGSPVKDLEARVRAVFARVTRYPEELLTPEADLEDELGIDSVKQAE
VMAVLIKELGLTDAPQPSQRLRTISSICEMARARLAVAAPVREDRAPRQSPPPAVLPFAGKVAFVTGSGKGIGKVIAARL
AGSGATVVVNSFHSRDEGERTVQEIVDAGGKAFHAWGSVAQEEHLDRMFASIEAQFGGLDFLVCNASNGLIGPFDRITPR
DWDKAFRTCITGTYECAMRARPLMARRGGGSIVTMSTSMSQRYMHDLGCQGVVKAGVESLTRYLAAELAPDGIRTNCVSA
GPVHGELLRMFPDAASRVARWESATPGGEICTAEDVADVTELLLGPKTRRVNGAIWVVDAGLSGTVDGLLPGASEARRSE
AQRGSHRSEHDLRALLALDS

Specific function: 7-Alpha-Dehydroxylation Of Cholic Acid, Yielding Deoxycholic Acid And Lithocholic Acid, Respectively. Highest Affinity With Taurochenodeoxycholic Acid. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=31.7269076305221, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI5031737, Length=237, Percent_Identity=31.2236286919831, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=27.9693486590038, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI126723191, Length=198, Percent_Identity=34.3434343434343, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=32.4742268041237, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI209862901, Length=203, Percent_Identity=33.0049261083744, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI19923983, Length=203, Percent_Identity=33.0049261083744, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI7705925, Length=255, Percent_Identity=27.843137254902, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI10190704, Length=250, Percent_Identity=26.4, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI126723750, Length=204, Percent_Identity=29.9019607843137, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI4504505, Length=259, Percent_Identity=28.1853281853282, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI4503301, Length=270, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=28.6290322580645, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=32.1285140562249, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=25.2, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=23.7903225806452, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786812, Length=254, Percent_Identity=27.1653543307087, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI2367365, Length=250, Percent_Identity=27.2, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=26.0700389105058, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789378, Length=206, Percent_Identity=26.2135922330097, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788459, Length=193, Percent_Identity=28.4974093264249, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=25.7936507936508, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1787545, Length=254, Percent_Identity=24.4094488188976, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=26.3779527559055, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=30.1526717557252, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17561402, Length=230, Percent_Identity=28.695652173913, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17555612, Length=241, Percent_Identity=30.2904564315353, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=27.4436090225564, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=248, Percent_Identity=29.0322580645161, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17568967, Length=191, Percent_Identity=32.4607329842932, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17536651, Length=260, Percent_Identity=27.3076923076923, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=240, Percent_Identity=27.5, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508651, Length=248, Percent_Identity=27.4193548387097, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=29.4339622641509, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=271, Percent_Identity=28.4132841328413, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=259, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=259, Percent_Identity=27.4131274131274, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=243, Percent_Identity=28.3950617283951, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562908, Length=259, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=249, Percent_Identity=25.7028112449799, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322861, Length=195, Percent_Identity=29.2307692307692, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=30.6772908366534, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=31.3253012048193, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24644339, Length=186, Percent_Identity=29.0322580645161, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=30.1960784313725, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21357041, Length=193, Percent_Identity=29.5336787564767, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28571526, Length=187, Percent_Identity=29.4117647058824, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=26.7441860465116, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.10 [H]

Molecular weight: Translated: 53329; Mature: 53198

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS50075 ACP_DOMAIN ; PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHASHQGTYAVEHVLQRIRRCAADVTRYPVDILTADAQLEDELGIDSVKLAEIAAVVG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHCCCCHHHHHHHHHHHC
REFNIPSERLPRGAQARTLGAMADVVARLLADTQPAAVATPPPAPVAAPVLQVSSAGSPV
CCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCH
KDLEARVRAVFARVTRYPEELLTPEADLEDELGIDSVKQAEVMAVLIKELGLTDAPQPSQ
HHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
RLRTISSICEMARARLAVAAPVREDRAPRQSPPPAVLPFAGKVAFVTGSGKGIGKVIAAR
HHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCEEECCCEEEEEECCCCCHHHHHHHH
LAGSGATVVVNSFHSRDEGERTVQEIVDAGGKAFHAWGSVAQEEHLDRMFASIEAQFGGL
HCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCE
DFLVCNASNGLIGPFDRITPRDWDKAFRTCITGTYECAMRARPLMARRGGGSIVTMSTSM
EEEEEECCCCCCCCHHCCCCCCHHHHHHHHHCCHHHHHHHHCHHHHCCCCCCEEEEECHH
SQRYMHDLGCQGVVKAGVESLTRYLAAELAPDGIRTNCVSAGPVHGELLRMFPDAASRVA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RWESATPGGEICTAEDVADVTELLLGPKTRRVNGAIWVVDAGLSGTVDGLLPGASEARRS
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCEEEEEECCCCCCHHHCCCCCHHHHHH
EAQRGSHRSEHDLRALLALDS
HHHHCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TTHASHQGTYAVEHVLQRIRRCAADVTRYPVDILTADAQLEDELGIDSVKLAEIAAVVG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHCCCCHHHHHHHHHHHC
REFNIPSERLPRGAQARTLGAMADVVARLLADTQPAAVATPPPAPVAAPVLQVSSAGSPV
CCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCCCCCCH
KDLEARVRAVFARVTRYPEELLTPEADLEDELGIDSVKQAEVMAVLIKELGLTDAPQPSQ
HHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
RLRTISSICEMARARLAVAAPVREDRAPRQSPPPAVLPFAGKVAFVTGSGKGIGKVIAAR
HHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCEEECCCEEEEEECCCCCHHHHHHHH
LAGSGATVVVNSFHSRDEGERTVQEIVDAGGKAFHAWGSVAQEEHLDRMFASIEAQFGGL
HCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCE
DFLVCNASNGLIGPFDRITPRDWDKAFRTCITGTYECAMRARPLMARRGGGSIVTMSTSM
EEEEEECCCCCCCCHHCCCCCCHHHHHHHHHCCHHHHHHHHCHHHHCCCCCCEEEEECHH
SQRYMHDLGCQGVVKAGVESLTRYLAAELAPDGIRTNCVSAGPVHGELLRMFPDAASRVA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RWESATPGGEICTAEDVADVTELLLGPKTRRVNGAIWVVDAGLSGTVDGLLPGASEARRS
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCEEEEEECCCCCCHHHCCCCCHHHHHH
EAQRGSHRSEHDLRALLALDS
HHHHCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9202460; 9384377 [H]