BacMap

Definition	Myxococcus xanthus DK 1622 chromosome, complete genome.
Accession	NC_008095
Length	9,139,763

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The map label for this gene is pkn6 [H]

Identifier: 108756948

GI number: 108756948

Start: 5377079

End: 5378248

Strand: Direct

Name: pkn6 [H]

Synonym: MXAN_4371

Alternate gene names: 108756948

Gene position: 5377079-5378248 (Clockwise)

Preceding gene: 108759132

Following gene: 108759332

Centisome position: 58.83

GC content: 69.23

Gene sequence:

>1170_bases
TTGGCCTCGCACCGCCTCACGACCACGCCCCAGGATGAACCTTCCATCTTCACGTTCGAACGGCGGCACGTTCTCTTCTC
GGTGGAGCACACGCGGTTCGAGTTCGTCCGCATGCTGGAGCGCCGGGCCAACGGCGAGGAGTTGCTCCTGGCCGACCGCT
ACCAGCGGCACGGGCTCGCCGGCCCCGTCGTCATCAAGCGCGTGCGCAGCCCCGCGAGCTCCGCGCGCCGACACCGGCTG
GTGGAGGAAGTGCAACTGGCCTACCGCCTCCACCACCCCACCATCGCCCAGGTGCACTACTTCAAGATTCACCGGGGCAA
GCCGTACATCATCATGGAGCACGTGGACGGGCCGTCGCTGGAGACCGTGCTGGACCTCATGGCCATGCGGGGGCAGCCCG
TGTCCCTGGCCTTCGCGCTCCACGTCGCCGCGGAGCTGGCGGACGCCCTGCACCATGCCCACTCGCTCAAGGACGCGCAG
GGCCGGTCCCTGGGACTGATTCATCGCGACGTCAGTCCCCGCAACGTGCGCGTGGCTCGCACGGGCGAGGTGAAGCTGAC
GCACTTTGGCGTGGCCTATTCGCACCTAGTCGGCCGGGAGGAGACGGCGGAGGCGCTGCTCAAGGGCGACGTGGCCTATG
CGTCTCCGGAGTACCTCGCGGGCAAGACACTGACCGCCGCCTCGGACCTCTTCTCGCTGGGGCTGGTGCTACTGGAGCTG
GCCACGGGGCGGCACCTGTTCGCGGCCGCGGCGGAGGCGCTGGAGCCACCGCGTGCGAAGTCGCATGAGCTGCGCCTGGA
GGAGCCCCCTTCCCTGCCGCTCACACAGATGCTGATGCTGCTCGAGGACCATGGTCCCCAGGACGTGGAGCGAGCCGCCG
CGAGCCTGCCGCCCAAGGTGCGCGCCGTCCTTCAAGGGATGCTGCACAAGGATGCGACGAAGCGCTTCGGCTCGGCGGAG
GCGCTGTGCGAAGCACTTCGGGAATGCATCGTCCAGGAAGTCCGTCGCACCGGCCGCCCCTTCGGCAGGGCCGACATGGC
CGCGGAGCTGACGCGGCTCATCAGCGACGCCAGCGCGGTACGCGACGAGGTCGAACTGCTCGACGAGAGCCTCTTCCCAT
CGGGCCTCGAGGCCCATGAACTGTCGGGGCGGGGCCCCAAGGACGCCTGA

Upstream 100 bases:

>100_bases
AATCCGCCCTGGCACCCCGCACCGGGGCCGGCTTCCTCCCCGCGCCCAATTTATGTTTACCTAAGCATAACCTTTTCCGG
TCTACATCAAGGAGTCGCCA

Downstream 100 bases:

>100_bases
AGCCGGGCCCTGGTGCTAGCGGGACAGGGCGCTCGCCATCACGACGAGCGCCTTGAGCTTCTCTTCGTCCAGCGCCTCCG
AAAGCGTCATCAGCCGGCGT

Product: serine/threonine kinase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MASHRLTTTPQDEPSIFTFERRHVLFSVEHTRFEFVRMLERRANGEELLLADRYQRHGLAGPVVIKRVRSPASSARRHRL
VEEVQLAYRLHHPTIAQVHYFKIHRGKPYIIMEHVDGPSLETVLDLMAMRGQPVSLAFALHVAAELADALHHAHSLKDAQ
GRSLGLIHRDVSPRNVRVARTGEVKLTHFGVAYSHLVGREETAEALLKGDVAYASPEYLAGKTLTAASDLFSLGLVLLEL
ATGRHLFAAAAEALEPPRAKSHELRLEEPPSLPLTQMLMLLEDHGPQDVERAAASLPPKVRAVLQGMLHKDATKRFGSAE
ALCEALRECIVQEVRRTGRPFGRADMAAELTRLISDASAVRDEVELLDESLFPSGLEAHELSGRGPKDA

Sequences:

>Translated_389_residues
MASHRLTTTPQDEPSIFTFERRHVLFSVEHTRFEFVRMLERRANGEELLLADRYQRHGLAGPVVIKRVRSPASSARRHRL
VEEVQLAYRLHHPTIAQVHYFKIHRGKPYIIMEHVDGPSLETVLDLMAMRGQPVSLAFALHVAAELADALHHAHSLKDAQ
GRSLGLIHRDVSPRNVRVARTGEVKLTHFGVAYSHLVGREETAEALLKGDVAYASPEYLAGKTLTAASDLFSLGLVLLEL
ATGRHLFAAAAEALEPPRAKSHELRLEEPPSLPLTQMLMLLEDHGPQDVERAAASLPPKVRAVLQGMLHKDATKRFGSAE
ALCEALRECIVQEVRRTGRPFGRADMAAELTRLISDASAVRDEVELLDESLFPSGLEAHELSGRGPKDA
>Mature_388_residues
ASHRLTTTPQDEPSIFTFERRHVLFSVEHTRFEFVRMLERRANGEELLLADRYQRHGLAGPVVIKRVRSPASSARRHRLV
EEVQLAYRLHHPTIAQVHYFKIHRGKPYIIMEHVDGPSLETVLDLMAMRGQPVSLAFALHVAAELADALHHAHSLKDAQG
RSLGLIHRDVSPRNVRVARTGEVKLTHFGVAYSHLVGREETAEALLKGDVAYASPEYLAGKTLTAASDLFSLGLVLLELA
TGRHLFAAAAEALEPPRAKSHELRLEEPPSLPLTQMLMLLEDHGPQDVERAAASLPPKVRAVLQGMLHKDATKRFGSAEA
LCEALRECIVQEVRRTGRPFGRADMAAELTRLISDASAVRDEVELLDESLFPSGLEAHELSGRGPKDA

Specific function: Pkn5 and pkn6 may have reciprocal roles in growth and development. Pkn6 may be a transmembrane sensor of external signals for development [H]

COG id: COG0515

COG function: function code RTKL; Serine/threonine protein kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI14589900, Length=297, Percent_Identity=26.2626262626263, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI5579478, Length=190, Percent_Identity=31.5789473684211, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI55743136, Length=215, Percent_Identity=28.3720930232558, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI19923570, Length=215, Percent_Identity=28.3720930232558, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI13489054, Length=189, Percent_Identity=31.7460317460317, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4759050, Length=218, Percent_Identity=28.8990825688073, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI21618349, Length=224, Percent_Identity=27.6785714285714, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI21618347, Length=224, Percent_Identity=27.6785714285714, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI7657526, Length=214, Percent_Identity=28.5046728971963, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4505373, Length=171, Percent_Identity=31.5789473684211, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI16936528, Length=290, Percent_Identity=26.2068965517241, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI225735561, Length=219, Percent_Identity=25.1141552511416, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI66932999, Length=190, Percent_Identity=30, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI20149547, Length=215, Percent_Identity=27.906976744186, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI55743134, Length=215, Percent_Identity=27.906976744186, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI156105707, Length=176, Percent_Identity=28.9772727272727, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI156105705, Length=176, Percent_Identity=28.9772727272727, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI62865639, Length=197, Percent_Identity=27.9187817258883, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI62865641, Length=197, Percent_Identity=27.9187817258883, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI62865643, Length=197, Percent_Identity=27.9187817258883, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI38327572, Length=217, Percent_Identity=28.110599078341, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI38327570, Length=217, Percent_Identity=28.110599078341, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI38327568, Length=217, Percent_Identity=28.110599078341, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI38327566, Length=217, Percent_Identity=28.110599078341, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI38327564, Length=217, Percent_Identity=28.110599078341, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI38327562, Length=217, Percent_Identity=28.110599078341, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI217330634, Length=181, Percent_Identity=27.0718232044199, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI19424132, Length=182, Percent_Identity=26.9230769230769, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI55953117, Length=225, Percent_Identity=26.2222222222222, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI20127541, Length=298, Percent_Identity=25.503355704698, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4506737, Length=187, Percent_Identity=26.7379679144385, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI25168261, Length=298, Percent_Identity=25.503355704698, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI4826878, Length=269, Percent_Identity=26.0223048327138, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI41872673, Length=189, Percent_Identity=30.6878306878307, Blast_Score=65, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71989905, Length=242, Percent_Identity=28.5123966942149, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71989911, Length=214, Percent_Identity=29.4392523364486, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71989893, Length=214, Percent_Identity=29.4392523364486, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193203107, Length=214, Percent_Identity=29.4392523364486, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71989900, Length=214, Percent_Identity=29.4392523364486, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508425, Length=177, Percent_Identity=30.5084745762712, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI25146880, Length=214, Percent_Identity=26.6355140186916, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17505246, Length=175, Percent_Identity=25.1428571428571, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32563673, Length=217, Percent_Identity=24.8847926267281, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17557200, Length=171, Percent_Identity=26.9005847953216, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71988230, Length=173, Percent_Identity=26.0115606936416, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994328, Length=228, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25145082, Length=212, Percent_Identity=25.4716981132075, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988215, Length=163, Percent_Identity=26.3803680981595, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17540892, Length=178, Percent_Identity=25.8426966292135, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319917, Length=180, Percent_Identity=28.8888888888889, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325117, Length=176, Percent_Identity=28.9772727272727, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324805, Length=146, Percent_Identity=30.8219178082192, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323394, Length=186, Percent_Identity=27.4193548387097, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322333, Length=194, Percent_Identity=30.4123711340206, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325047, Length=207, Percent_Identity=23.1884057971014, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17137200, Length=253, Percent_Identity=25.6916996047431, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17647993, Length=255, Percent_Identity=26.2745098039216, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17737298, Length=225, Percent_Identity=26.6666666666667, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI18858209, Length=174, Percent_Identity=28.1609195402299, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24642565, Length=248, Percent_Identity=25, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24643817, Length=219, Percent_Identity=28.310502283105, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24649791, Length=225, Percent_Identity=28, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24658719, Length=230, Percent_Identity=26.0869565217391, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24653590, Length=203, Percent_Identity=28.0788177339901, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24653588, Length=203, Percent_Identity=28.0788177339901, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24653592, Length=203, Percent_Identity=28.0788177339901, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24653586, Length=203, Percent_Identity=28.0788177339901, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136516, Length=225, Percent_Identity=27.1111111111111, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR013229
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR008266 [H]

Pfam domain/function: PF08308 PEGA; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 43144; Mature: 43013

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASHRLTTTPQDEPSIFTFERRHVLFSVEHTRFEFVRMLERRANGEELLLADRYQRHGLA
CCCCCCCCCCCCCCCEEEEECCEEEEEEHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCC
GPVVIKRVRSPASSARRHRLVEEVQLAYRLHHPTIAQVHYFKIHRGKPYIIMEHVDGPSL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEECCCCCCH
ETVLDLMAMRGQPVSLAFALHVAAELADALHHAHSLKDAQGRSLGLIHRDVSPRNVRVAR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEE
TGEVKLTHFGVAYSHLVGREETAEALLKGDVAYASPEYLAGKTLTAASDLFSLGLVLLEL
CCCEEEEEHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHH
ATGRHLFAAAAEALEPPRAKSHELRLEEPPSLPLTQMLMLLEDHGPQDVERAAASLPPKV
HCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHH
RAVLQGMLHKDATKRFGSAEALCEALRECIVQEVRRTGRPFGRADMAAELTRLISDASAV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RDEVELLDESLFPSGLEAHELSGRGPKDA
HHHHHHHHHHCCCCCCCHHHCCCCCCCCC
>Mature Secondary Structure 
ASHRLTTTPQDEPSIFTFERRHVLFSVEHTRFEFVRMLERRANGEELLLADRYQRHGLA
CCCCCCCCCCCCCCEEEEECCEEEEEEHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCC
GPVVIKRVRSPASSARRHRLVEEVQLAYRLHHPTIAQVHYFKIHRGKPYIIMEHVDGPSL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEEECCCCCCH
ETVLDLMAMRGQPVSLAFALHVAAELADALHHAHSLKDAQGRSLGLIHRDVSPRNVRVAR
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEE
TGEVKLTHFGVAYSHLVGREETAEALLKGDVAYASPEYLAGKTLTAASDLFSLGLVLLEL
CCCEEEEEHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHH
ATGRHLFAAAAEALEPPRAKSHELRLEEPPSLPLTQMLMLLEDHGPQDVERAAASLPPKV
HCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHH
RAVLQGMLHKDATKRFGSAEALCEALRECIVQEVRRTGRPFGRADMAAELTRLISDASAV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
RDEVELLDESLFPSGLEAHELSGRGPKDA
HHHHHHHHHHCCCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8733241 [H]