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The map label for this gene is fumC [H]

Identifier: 108563695

GI number: 108563695

Start: 1316393

End: 1317784

Strand: Reverse

Name: fumC [H]

Synonym: HPAG1_1270

Alternate gene names: 108563695

Gene position: 1317784-1316393 (Counterclockwise)

Preceding gene: 108563700

Following gene: 108563694

Centisome position: 82.55

GC content: 44.32

Gene sequence:

>1392_bases
ATGCAATTTAGAATTGAACATGACACGATGGGCGAAATCAAAGTAGATGATAGCCAATACTGGGGGGCTCAAACGCAACG
CAGTCTTGAAAACTTTAAAATCGGCACTGAAAAAATGCCTAAAGAACTCATTGCGGCATTTGCCAAACTCAAAAGGAGTT
TGGCGGTAGTCAATCATAAGTTAGGGAAATTAAGCCTAGAAAAATCACAAGCCATTATCAAGGCGTGCGATTGCATTTTA
AAAGGCGAGCTGTGCGGCGAGTTTCCCTTAGCGATATGGCAAACAGGGAGCGGGACTCAAACGAACATGAATCTCAATGA
AGTCATTGCCAATAAGGCTACCGAAATTTTAGGGGGTAATTTTAGGGAGAAAAAACTCATCCACCCTAACGATGATGTGA
ACATGTCTCAAAGCTCCAACGACACTTTCCCTACCGCAATGCACATTGTGAGCGTGCTAGAAATCACGTGCAAGTTACTG
CCCAGTTTAGAGAATCTGTTAAAGACTTTTAAAGACAAAAGCCAACAATTTAAAGAGATTGTCAAAATCGGGCGCACGCA
TTTACAAGACGCTACGCCTTTAACTTTGGGGCAAGAATTTAGCGGGTATGCGAGCATGCTAGAGCATTCCAAACAACAAA
TTTTAGAGAGTTTGGAGCATTTAAGAGAATTAGCCATAGGCGGGACGGCCGTAGGCACAGGGCTAAACGCTCATAAGGAA
TTGAGTGAAAAAGTGGCTGAAGAATTGAGCCAGTTTAGCGGCGTGAAATTCATTTCTGCGCCCAATAAATTCCACGCGCT
CACTAGCCATGACGCTATCGCTTATGCGCATGGGGCTTTTAAGGCTTTAGCGGCGAATTTAATGAAAATCGCTAACGATA
TTAGATGGCTTGCGAGCGGGCCGCGCTGTGGTCTGGGCGAGCTTAATATCCCTGAAAATGAGCCGGGCAGCTCTATTATG
CCCGGTAAAGTCAATCCCACGCAATGCGAAGCGATGACCATGGTGGCCGTGCAAGTGATGGGGAATGATACCGCTATTGG
CATTGCGGCCAGTCAGGGTAATTTTGAATTGAATGTGTTTAAACCGGTGATCATTTATAATTTCTTGCAAAGTTTGAGGC
TCTTAAGCGATAGCATGGAAAGTTTTAATACCCATTGCGCGAGCGGTATTGAGCCTAACAAAGAAAAAATTGATTATTAC
TTGCACCATTCTTTAATGCTAGTAACCGCCCTTAACCCGCATGTAGGCTATGAAAACGCCGCTAGAATCGCTAAAAACGC
CCACAAAAAAGGCATTTCTCTAAAAGAAAGCGCGCTGGAACTGAAACTCTTGAGCGCTGAAGATTTTGACCAATTCGTGG
TGCCTGAAAAGATGATCGGGCCTAAGGCTTAA

Upstream 100 bases:

>100_bases
TGTGGAAATGGTTTTTAAAAAAATTAGGGTTTTTAAGTAGAAGGTATAAGAGTTTATGCTATTTTTTTAAGGTTTTAAAA
TCAAATTTCAAAGGATTAGT

Downstream 100 bases:

>100_bases
AACCTTGGGCGGGCGTGCGAGATGAATCCTGAAAAAGCCACTCATTGCAAAGAGATTCGTAAGATCTTAAAAGAGGCATT
GCATGACAATAAAGATTTGA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MQFRIEHDTMGEIKVDDSQYWGAQTQRSLENFKIGTEKMPKELIAAFAKLKRSLAVVNHKLGKLSLEKSQAIIKACDCIL
KGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGNFREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITCKLL
PSLENLLKTFKDKSQQFKEIVKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASGPRCGLGELNIPENEPGSSIM
PGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVFKPVIIYNFLQSLRLLSDSMESFNTHCASGIEPNKEKIDYY
LHHSLMLVTALNPHVGYENAARIAKNAHKKGISLKESALELKLLSAEDFDQFVVPEKMIGPKA

Sequences:

>Translated_463_residues
MQFRIEHDTMGEIKVDDSQYWGAQTQRSLENFKIGTEKMPKELIAAFAKLKRSLAVVNHKLGKLSLEKSQAIIKACDCIL
KGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGNFREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITCKLL
PSLENLLKTFKDKSQQFKEIVKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASGPRCGLGELNIPENEPGSSIM
PGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVFKPVIIYNFLQSLRLLSDSMESFNTHCASGIEPNKEKIDYY
LHHSLMLVTALNPHVGYENAARIAKNAHKKGISLKESALELKLLSAEDFDQFVVPEKMIGPKA
>Mature_463_residues
MQFRIEHDTMGEIKVDDSQYWGAQTQRSLENFKIGTEKMPKELIAAFAKLKRSLAVVNHKLGKLSLEKSQAIIKACDCIL
KGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGNFREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITCKLL
PSLENLLKTFKDKSQQFKEIVKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASGPRCGLGELNIPENEPGSSIM
PGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVFKPVIIYNFLQSLRLLSDSMESFNTHCASGIEPNKEKIDYY
LHHSLMLVTALNPHVGYENAARIAKNAHKKGISLKESALELKLLSAEDFDQFVVPEKMIGPKA

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=58.2251082251082, Blast_Score=541, Evalue=1e-154,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=53.968253968254, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=62.882096069869, Blast_Score=597, Evalue=1e-172,
Organism=Escherichia coli, GI87082375, Length=462, Percent_Identity=38.0952380952381, Blast_Score=324, Evalue=7e-90,
Organism=Caenorhabditis elegans, GI17553882, Length=463, Percent_Identity=57.8833693304536, Blast_Score=559, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=60.0609756097561, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6324993, Length=462, Percent_Identity=59.5238095238095, Blast_Score=551, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=56.0344827586207, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=56.0344827586207, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=55.8189655172414, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=54.6236559139785, Blast_Score=515, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=48.3801295896328, Blast_Score=452, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50916; Mature: 50916

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFRIEHDTMGEIKVDDSQYWGAQTQRSLENFKIGTEKMPKELIAAFAKLKRSLAVVNHK
CCEEECCCCCCCEEECCCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGKLSLEKSQAIIKACDCILKGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGN
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
FREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITCKLLPSLENLLKTFKDKSQQFKEI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHH
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASG
HHHHHHHHHHHHCCCEEEECCCHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGLGELNIPENEPGSSIMPGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEEH
KPVIIYNFLQSLRLLSDSMESFNTHCASGIEPNKEKIDYYLHHSLMLVTALNPHVGYENA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEEECCCCCCHHHH
ARIAKNAHKKGISLKESALELKLLSAEDFDQFVVPEKMIGPKA
HHHHHHHHHCCCCHHHHHHHEEEECCCCCHHHCCCHHHCCCCC
>Mature Secondary Structure
MQFRIEHDTMGEIKVDDSQYWGAQTQRSLENFKIGTEKMPKELIAAFAKLKRSLAVVNHK
CCEEECCCCCCCEEECCCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LGKLSLEKSQAIIKACDCILKGELCGEFPLAIWQTGSGTQTNMNLNEVIANKATEILGGN
HCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
FREKKLIHPNDDVNMSQSSNDTFPTAMHIVSVLEITCKLLPSLENLLKTFKDKSQQFKEI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEFSGYASMLEHSKQQILESLEHLRELAIGGTAVGTGLNAHKE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHH
LSEKVAEELSQFSGVKFISAPNKFHALTSHDAIAYAHGAFKALAANLMKIANDIRWLASG
HHHHHHHHHHHHCCCEEEECCCHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRCGLGELNIPENEPGSSIMPGKVNPTQCEAMTMVAVQVMGNDTAIGIAASQGNFELNVF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEEH
KPVIIYNFLQSLRLLSDSMESFNTHCASGIEPNKEKIDYYLHHSLMLVTALNPHVGYENA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHEEEECCCCCCHHHH
ARIAKNAHKKGISLKESALELKLLSAEDFDQFVVPEKMIGPKA
HHHHHHHHHCCCCHHHHHHHEEEECCCCCHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]