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The map label for this gene is cobB [H]

Identifier: 108563628

GI number: 108563628

Start: 1265599

End: 1266303

Strand: Direct

Name: cobB [H]

Synonym: HPAG1_1203

Alternate gene names: 108563628

Gene position: 1265599-1266303 (Clockwise)

Preceding gene: 108563627

Following gene: 108563629

Centisome position: 79.28

GC content: 43.55

Gene sequence:

>705_bases
ATGAAAAATTTAGTGATTTTAAGCGGGGCTGGCATTTCAGCAGAAAGCGGGATTAAAACCTTTAGAGACGCTGATGGCTT
GTGGGAAGGGCATGACATCATGGAAGTTGCCTCGCCTTATGGCTGGAAAAAGAACCCGCAAAAGGTGTTGGATTTTTACA
ACCAAAGGCGCCGACAGCTTTTTGAAGTTTATCCTAACAAGGCTCATAAGGCTTTAGCGGAATTGGAAAAACACTATCAA
GTCCATATCATCACCCAAAATGTAGATGATTTGCATGAAAGAGCGGGTTCTTCTCGCATTTTGCACTTGCATGGGGAATT
GTTGAGCGTTCGCAGCGAGAAAGATCCTAATTTAGTTTATAGGTGGGAAAAGGACTTGAATTTAGGCGATCTCGCCCATG
ATGATTCGCAATTACGCCCCAATATTGTGTGGTTTGGCGAAGAGGTGCCTTTGCTTGAAGAAGCGATTTTTTTAGTCAAA
GAAGCGCACCTTTTAATCATCATTGGCACTTCTTTGCAAGTCTATCCGGCCGCTAGCCTCTACACGCATGCGCATAAAGA
TGCTCTCATTTATTACATTGACCCTAAGGCTAAAAACGCCCGTTTGCCCCAGAATGTCCAATGCATTAATGAAAGCGCGG
TGCATGCCATGCAAGATTTAATGCCCAAACTCATAGAAATGGCCTCTCAAGAGATGTTGAAATAA

Upstream 100 bases:

>100_bases
GCATGGGGTTACTCATAGGGTTTGTTACGCCTTTTATTTTTAAGTTTTTTTTGCATGACAAACTCAGCGGCACTCATATT
GAAATTATCAAGGAGGCAAC

Downstream 100 bases:

>100_bases
TTTTTATTTTTTCAGCTAACGATTAGCAAAAACATGGTTTAATTGGCTTCATCGTTTGCTGAAAGTAATAATTAAAGGAG
TCTGAGAGCCTAATGCAACA

Product: hypothetical protein

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKNLVILSGAGISAESGIKTFRDADGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQ
VHIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAHDDSQLRPNIVWFGEEVPLLEEAIFLVK
EAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNARLPQNVQCINESAVHAMQDLMPKLIEMASQEMLK

Sequences:

>Translated_234_residues
MKNLVILSGAGISAESGIKTFRDADGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQ
VHIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAHDDSQLRPNIVWFGEEVPLLEEAIFLVK
EAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNARLPQNVQCINESAVHAMQDLMPKLIEMASQEMLK
>Mature_234_residues
MKNLVILSGAGISAESGIKTFRDADGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQ
VHIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAHDDSQLRPNIVWFGEEVPLLEEAIFLVK
EAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNARLPQNVQCINESAVHAMQDLMPKLIEMASQEMLK

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=196, Percent_Identity=37.7551020408163, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI6912664, Length=208, Percent_Identity=35.5769230769231, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI13787215, Length=208, Percent_Identity=35.5769230769231, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI7657575, Length=206, Percent_Identity=30.0970873786408, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI308199517, Length=188, Percent_Identity=46.8085106382979, Blast_Score=164, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17541892, Length=196, Percent_Identity=26.530612244898, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26753; Mature: 26753

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLVILSGAGISAESGIKTFRDADGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQL
CCCEEEEECCCCCCHHCHHHHHCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
FEVYPNKAHKALAELEKHYQVHIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVY
HHHCCCHHHHHHHHHHHCEEEEEEECCHHHHHHHCCCCEEEEECHHHHHHCCCCCCCEEE
RWEKDLNLGDLAHDDSQLRPNIVWFGEEVPLLEEAIFLVKEAHLLIIIGTSLQVYPAASL
EECCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEEECCCEEEEECHHH
YTHAHKDALIYYIDPKAKNARLPQNVQCINESAVHAMQDLMPKLIEMASQEMLK
HHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNLVILSGAGISAESGIKTFRDADGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQL
CCCEEEEECCCCCCHHCHHHHHCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
FEVYPNKAHKALAELEKHYQVHIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVY
HHHCCCHHHHHHHHHHHCEEEEEEECCHHHHHHHCCCCEEEEECHHHHHHCCCCCCCEEE
RWEKDLNLGDLAHDDSQLRPNIVWFGEEVPLLEEAIFLVKEAHLLIIIGTSLQVYPAASL
EECCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEEEECCCEEEEECHHH
YTHAHKDALIYYIDPKAKNARLPQNVQCINESAVHAMQDLMPKLIEMASQEMLK
HHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]