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The map label for this gene is proC [H]

Identifier: 108563522

GI number: 108563522

Start: 1155770

End: 1156543

Strand: Direct

Name: proC [H]

Synonym: HPAG1_1097

Alternate gene names: 108563522

Gene position: 1155770-1156543 (Clockwise)

Preceding gene: 108563521

Following gene: 108563523

Centisome position: 72.4

GC content: 41.34

Gene sequence:

>774_bases
ATGGAAATCTTACAATTCATCGGCTATGGGAATATGGCTCAAGCGATCTTAGAAGGCTCTCATGAAATTTTATCCAAGCG
TTTTATTTTAGAAATCACCGGGAGAAACCCTGAAAAAATCGCCCCCTTTTTACAAGAAAAAAACATTCAAGCCCAAATTG
TGCCTTATAAAAACGCTATTGATATACACCAAAAATTCGTGTTTTTACTTTTTAAGCCTTACAACCTTAAGGATTTTAAT
TATCAAGGGCAAGCCAAGAGCGTTTTGAGCGCTTTAGCTGGCGTGGGTTTTAAAGCTTTAAGTGATGCGATAAATTCTTT
ACATTACCTTAAATGCATGCCCAATATTGCGAGCAAGTTCGCCCTTTCTTCTACGGCGGTGTGCGAAAAATCGCCCATGC
CCTTAATAAGCCAAAAGGCTTTGAGTGTTATTGAGAGTTTTGGGAATTGCGTGCGAGTGGGCAATGAAGAGCAGGTTGAT
TCTAGCGTAGCGACAAACGGGAGCGCGCTCGCGTTTTTAAGCTTGGTAGCGAGCAGTTTGAAAGATGCCGGTATTAGAGA
GGGCTTGAACGCTAAAGATTCTTTAGAATTGGTGAAGATGAGTTTTAAAGGCTTTGCCAAGCTGTTAGAAAAAGAACGCC
CTGAGATGATTATAGAGCAAATTTGCACCCCTAAAGGCGCAACGATTGAAGGCTTGAGCGTTTTAGAAAAAAAGGGGGTT
AGGGGAGCGTTTATAAAAGCATGCCATGAAAGCGTGAAAAAAATGCGCCTCTAA

Upstream 100 bases:

>100_bases
TCAAGCGTATTTGAGAAGTGCTGGGGCTGATGTGAGTTACAGGAGGCTTTATACTTTCTATATCAATTACATCATGGGGT
TTTAAAAAAGGGGTGCATCA

Downstream 100 bases:

>100_bases
AAATTGCACTTTTAAAAAATAAGCACGATGCATTTAGACAGACAGAGTTTAGAAAAAGCCAAGCATTTGATCCAAAGCGG
TCTGATTGACACCATAGAAG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MEILQFIGYGNMAQAILEGSHEILSKRFILEITGRNPEKIAPFLQEKNIQAQIVPYKNAIDIHQKFVFLLFKPYNLKDFN
YQGQAKSVLSALAGVGFKALSDAINSLHYLKCMPNIASKFALSSTAVCEKSPMPLISQKALSVIESFGNCVRVGNEEQVD
SSVATNGSALAFLSLVASSLKDAGIREGLNAKDSLELVKMSFKGFAKLLEKERPEMIIEQICTPKGATIEGLSVLEKKGV
RGAFIKACHESVKKMRL

Sequences:

>Translated_257_residues
MEILQFIGYGNMAQAILEGSHEILSKRFILEITGRNPEKIAPFLQEKNIQAQIVPYKNAIDIHQKFVFLLFKPYNLKDFN
YQGQAKSVLSALAGVGFKALSDAINSLHYLKCMPNIASKFALSSTAVCEKSPMPLISQKALSVIESFGNCVRVGNEEQVD
SSVATNGSALAFLSLVASSLKDAGIREGLNAKDSLELVKMSFKGFAKLLEKERPEMIIEQICTPKGATIEGLSVLEKKGV
RGAFIKACHESVKKMRL
>Mature_257_residues
MEILQFIGYGNMAQAILEGSHEILSKRFILEITGRNPEKIAPFLQEKNIQAQIVPYKNAIDIHQKFVFLLFKPYNLKDFN
YQGQAKSVLSALAGVGFKALSDAINSLHYLKCMPNIASKFALSSTAVCEKSPMPLISQKALSVIESFGNCVRVGNEEQVD
SSVATNGSALAFLSLVASSLKDAGIREGLNAKDSLELVKMSFKGFAKLLEKERPEMIIEQICTPKGATIEGLSVLEKKGV
RGAFIKACHESVKKMRL

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=272, Percent_Identity=26.1029411764706, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI24797097, Length=272, Percent_Identity=24.6323529411765, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI24797095, Length=272, Percent_Identity=24.6323529411765, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786585, Length=272, Percent_Identity=26.8382352941176, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540664, Length=273, Percent_Identity=23.8095238095238, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320861, Length=176, Percent_Identity=29.5454545454545, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648116, Length=274, Percent_Identity=25.1824817518248, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28187; Mature: 28187

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEILQFIGYGNMAQAILEGSHEILSKRFILEITGRNPEKIAPFLQEKNIQAQIVPYKNAI
CCHHHHHCCCHHHHHHHHCHHHHHHHHHEEEECCCCHHHHHHHHHHCCCCEEEECCCCHH
DIHQKFVFLLFKPYNLKDFNYQGQAKSVLSALAGVGFKALSDAINSLHYLKCMPNIASKF
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ALSSTAVCEKSPMPLISQKALSVIESFGNCVRVGNEEQVDSSVATNGSALAFLSLVASSL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCHHHHHHHHHHHHH
KDAGIREGLNAKDSLELVKMSFKGFAKLLEKERPEMIIEQICTPKGATIEGLSVLEKKGV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHCCC
RGAFIKACHESVKKMRL
CHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEILQFIGYGNMAQAILEGSHEILSKRFILEITGRNPEKIAPFLQEKNIQAQIVPYKNAI
CCHHHHHCCCHHHHHHHHCHHHHHHHHHEEEECCCCHHHHHHHHHHCCCCEEEECCCCHH
DIHQKFVFLLFKPYNLKDFNYQGQAKSVLSALAGVGFKALSDAINSLHYLKCMPNIASKF
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
ALSSTAVCEKSPMPLISQKALSVIESFGNCVRVGNEEQVDSSVATNGSALAFLSLVASSL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCHHHHHHHHHHHHH
KDAGIREGLNAKDSLELVKMSFKGFAKLLEKERPEMIIEQICTPKGATIEGLSVLEKKGV
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHCCC
RGAFIKACHESVKKMRL
CHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]