Click here to switch to the map view.

The map label for this gene is ffh [H]

Identifier: 108563516

GI number: 108563516

Start: 1144215

End: 1145561

Strand: Reverse

Name: ffh [H]

Synonym: HPAG1_1091

Alternate gene names: 108563516

Gene position: 1145561-1144215 (Counterclockwise)

Preceding gene: 108563517

Following gene: 108563515

Centisome position: 71.76

GC content: 41.65

Gene sequence:

>1347_bases
ATGTTTCAAGCGTTAAGCGATGGGTTTAAAAACGCGCTCAATAAAATCCGCTTTCAAGATGATGAAAAAGCGCTAGATCG
GGCGTTAGACGAATTGAAAAAAACGCTCTTAAAAAACGATGTGCATCATAAAGTGGCTAGAGAATTGCTCAAAAAAGTGG
AAAGCCAGACTAAAGCGAGTGGCATTGGTAAGCAGCAATTTTTAGACGCTTTAGAAAAGAGTTTGTTAGAAATTTTAAGC
GCTAAAGGGAGCAGTGGTTTCACTTTCGCTCAAACGCCCCCCACCGTGGTTTTAATGGCAGGTTTGCAAGGGAGCGGTAA
GACAACCACAACCGCTAAACTCGCTCATTATTTAAAAACCAAAAATAAAAAAGTGCTTTTATGCGCATGCGATTTGCAAC
GCTTAGCGGCAGTGGAGCAATTGAAGGTTTTGGGTGAACAAGTGGGCGTGGAAGTGTTTTATGAAGAAAATAAAAGCGTG
AAAGAAATCGCCAACAACGCTTTAAAAAGGGCTAAAGAAGCGCAATTTGATGTTTTACTCGTGGATAGCGCGGGGCGTTT
AGCCATTGATAAAGAGCTTATGCAAGAATTAAAAGAAGTCAAAGAAGTCTTAAACCCCCATGAAGTGCTGTATGTTGCAG
ACGCGTTGAGCGGGCAAGATGGGGTCAAAAGCGCGAACACCTTTAATGAAGAAATAGGCGTGAGCGGGGTGGTGTTAAGC
AAATTTGATAGCGATTCTAAAGGGGGTATCGCCTTAGGCATCACTTATCAATTAGGCTTACCCTTGCGTTTTATTGGGAG
CGGGGAAAAAATCCCTGATTTAGATGTGTTTGTGCCTGAAAGAATCGTGGGGCGTTTGATGGGGGCTGGAGATATTGTCT
CGCTCGCTGAAAAAACCGCCAGCGTTTTAAACCCTAATGAAGCCAAAGATTTGAGCAAAAAACTCAAAAAAGGGCAATTC
ACTTTCAATGACTTTTTAAACCAGATTGAAAAAGTGAAAAAATTAGGCTCTATGAGTTCTCTAATCTCTATGATTCCAGG
TTTAGGGAATATGGCAAACGCGCTGAAAGACACGGATTTAGAAAGCTCTTTAGAGGTGAAAAAAATCAAGGCTATGGTCA
ATTCCATGACCAAAAAAGAGCAAGAAAACCCCGAGATTTTAAACGGCAGCCGAAGAAAAAGGATCGCTTTAGGGAGCGGC
TTAGAAGTGTCTGAAATCAATCGCATCATCAAACGCTTTGATCAAGCGAGCAAAATGGCGAAACGCTTAACCAATAAAAA
GGGCATTAGCGATTTGATGAATTTAATGAGTCAGGCTAAAAATCAAACTCCCCCTAAAATGCGCTAA

Upstream 100 bases:

>100_bases
TAGAAAAAGCCAAAGAGAGTTTAAAAACGCTTTTAGAAAAAGAAAGTAAAATTAAGCAAGAATTGGATTTGTTAGAACAA
CCATAATAAAAGGATAGAAA

Downstream 100 bases:

>100_bases
GTTTTAAGCATGTTTTAGGTGCTTTTGTTGTATAATCTCAAATTTAATACGAATATTTTAGGAGATTTTTGTAATGACAG
TCATTAGACTCACTCGCATC

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKASGIGKQQFLDALEKSLLEILS
AKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSV
KEIANNALKRAKEAQFDVLLVDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIVSLAEKTASVLNPNEAKDLSKKLKKGQF
TFNDFLNQIEKVKKLGSMSSLISMIPGLGNMANALKDTDLESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSG
LEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR

Sequences:

>Translated_448_residues
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKASGIGKQQFLDALEKSLLEILS
AKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSV
KEIANNALKRAKEAQFDVLLVDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIVSLAEKTASVLNPNEAKDLSKKLKKGQF
TFNDFLNQIEKVKKLGSMSSLISMIPGLGNMANALKDTDLESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSG
LEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR
>Mature_448_residues
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKASGIGKQQFLDALEKSLLEILS
AKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSV
KEIANNALKRAKEAQFDVLLVDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIVSLAEKTASVLNPNEAKDLSKKLKKGQF
TFNDFLNQIEKVKKLGSMSSLISMIPGLGNMANALKDTDLESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSG
LEVSEINRIIKRFDQASKMAKRLTNKKGISDLMNLMSQAKNQTPPKMR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=447, Percent_Identity=31.3199105145414, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI226371618, Length=380, Percent_Identity=31.8421052631579, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI23308697, Length=301, Percent_Identity=29.5681063122924, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI295424842, Length=301, Percent_Identity=29.5681063122924, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI89061728, Length=157, Percent_Identity=34.3949044585987, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788963, Length=428, Percent_Identity=40.6542056074766, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1789874, Length=230, Percent_Identity=38.2608695652174, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=438, Percent_Identity=31.0502283105023, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI193206261, Length=280, Percent_Identity=30.3571428571429, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=426, Percent_Identity=31.4553990610329, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6320498, Length=273, Percent_Identity=30.7692307692308, Blast_Score=112, Evalue=9e-26,
Organism=Drosophila melanogaster, GI17647949, Length=440, Percent_Identity=30, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24641198, Length=299, Percent_Identity=30.4347826086957, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49147; Mature: 49147

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKAS
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIGKQQFLDALEKSLLEILSAKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKT
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHC
KNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSVKEIANNALKRAKEAQFDVLL
CCCEEEEEECCHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEE
VDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
ECCCCCHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHCCCCCCCCHHHHHHHHCCCCEEEE
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIVSLAEKTA
CCCCCCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
SVLNPNEAKDLSKKLKKGQFTFNDFLNQIEKVKKLGSMSSLISMIPGLGNMANALKDTDL
HHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCC
ESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSGLEVSEINRIIKRFDQASKMA
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
KRLTNKKGISDLMNLMSQAKNQTPPKMR
HHHHCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKAS
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIGKQQFLDALEKSLLEILSAKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKT
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHC
KNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFYEENKSVKEIANNALKRAKEAQFDVLL
CCCEEEEEECCHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEE
VDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLS
ECCCCCHHHHHHHHHHHHHHHHHHCCHHEEEEHHHHCCCCCCCCHHHHHHHHCCCCEEEE
KFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFVPERIVGRLMGAGDIVSLAEKTA
CCCCCCCCCEEEEEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHH
SVLNPNEAKDLSKKLKKGQFTFNDFLNQIEKVKKLGSMSSLISMIPGLGNMANALKDTDL
HHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCC
ESSLEVKKIKAMVNSMTKKEQENPEILNGSRRKRIALGSGLEVSEINRIIKRFDQASKMA
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHH
KRLTNKKGISDLMNLMSQAKNQTPPKMR
HHHHCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]