Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 108563447

GI number: 108563447

Start: 1078005

End: 1079381

Strand: Direct

Name: accC [H]

Synonym: HPAG1_1022

Alternate gene names: 108563447

Gene position: 1078005-1079381 (Clockwise)

Preceding gene: 108563446

Following gene: 108563448

Centisome position: 67.53

GC content: 43.72

Gene sequence:

>1377_bases
ATGAATAAAGTGAATAAAGAAAATAAAAAGGTAGAAAAAAAAGAGCTTTCACGCATTTTGATCGCTAATAGAGGCGAGAT
CGCTTTAAGAGCGATCCAAACCATTCAAGAAATGGGTAAAGAATCCATAGCCATTTATTCTATCGCTGACAAGGACGCCC
ACTACCTCAATACGGCTAACGCAAAAGTGTGTATAGGGGGGGCCAAATCCAGCGAGAGTTACTTGAATATCCCTGCAATC
ATTAGCGCGGCGGAATTGTTTGAAGCGGATGCGATTTTCCCCGGGTATGGGTTTTTGAGTGAAAATCAGAATTTTGTAGA
GATTTGCTCGCACCATTCTTTAGAATTTATTGGCCCAAGCGCGAAAGTCATGGCTTTAATGAGCGATAAATCCAAAGCCA
AAAGCGTGATGAAAGAAGCCGGCATGCCTGTGATTGAGGGCAGTGATGGGTTGCTTAAAAGCTATCAAGAAGCTGAAGAA
ATCGCTGATAAAATCGGCTACCCTGTCATCATTAAAGCGGCCGCTGGTGGGGGCGGGAGAGGCATGCGTGTCGTAGAAGA
TAAATCCAAGCTTAAAAACCTTTATTTAGCCGCCGAAACGGAAGCTTTGAGCGCGTTTGGCGATGGGAGCGTGTATTTAG
AAAAATTCATCAACAAGCCTAAGCACATTGAAGTCCAGATTTTAGCCGATAAGCACGGCAATGTCATTCATGTGGGCGAA
AGGGATTGCTCGGTGCAAAGACGCCAGCAAAAGCTCATTGAAGAAACCCCGGCAGTGGTTTTAGAAGAGGGCGTTCGTAA
GCGTTTGCTAGAAACAGCGATCAAGGCCGCTAAATACATCGGCTATGTGGGGGCTGGGACTTTTGAATTTTTGCTCGATT
CCAACATGAAAGATTTTTATTTCATGGAGATGAACACTCGTTTGCAAGTGGAACACACCATTAGCGAAATGGTGAGCGGG
TTAAACCTCATTGAATGGATGATTAAAATCGCTCAAGGCGAAGAATTGCCCAAGCAAGAAAGCTTTTCTCTTAAAGGGCA
TGCGATAGAATGTAGAATCACTGCAGAAGATCCTAAAAAATTCTACCCAAGCCCGGGTAAAATCACCGAATGGATCGCCC
CTAGTGGGGTGAATGTGCGCCTTGATTCGCACGCGCATGCTCATTATGTCGTGCCTACGCACTATGATTCTATGATTGGC
AAGCTCATTGTGTGGGGTGAAAACAGAGAAAGAGCGATCGCTAAGATGAAAAGGGCTTTAAAGGAATTTAAAGTAGAAGG
CATTAAAACGACCATTCCTTTCCACCTTGAAATGCTTGAAAATGCGGATTTTAGGCAAGCAAAAATCCACACGAAGTATT
TAGAAGAAAATTTTTAA

Upstream 100 bases:

>100_bases
AAGTGGAATACCCTTGCAAGGTGGTTTCTGTTGAAGTGGGAGACGCTCAACCGGTAGAATACGGCACGAAACTCATCAAA
GTTGAAAAGCTTTAAAATCC

Downstream 100 bases:

>100_bases
GTTTTAAGGATTTTCTTAAGCATGATTTAAGGATTTTAAACGATCAGAAAAAGTCAGCGTTAAATTTTATGATTTTATAG
TAAAGTTTTTTCATGCAAAC

Product: biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MNKVNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKVCIGGAKSSESYLNIPAI
ISAAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEE
IADKIGYPVIIKAAAGGGGRGMRVVEDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGE
RDCSVQRRQQKLIEETPAVVLEEGVRKRLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFYFMEMNTRLQVEHTISEMVSG
LNLIEWMIKIAQGEELPKQESFSLKGHAIECRITAEDPKKFYPSPGKITEWIAPSGVNVRLDSHAHAHYVVPTHYDSMIG
KLIVWGENRERAIAKMKRALKEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF

Sequences:

>Translated_458_residues
MNKVNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKVCIGGAKSSESYLNIPAI
ISAAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEE
IADKIGYPVIIKAAAGGGGRGMRVVEDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGE
RDCSVQRRQQKLIEETPAVVLEEGVRKRLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFYFMEMNTRLQVEHTISEMVSG
LNLIEWMIKIAQGEELPKQESFSLKGHAIECRITAEDPKKFYPSPGKITEWIAPSGVNVRLDSHAHAHYVVPTHYDSMIG
KLIVWGENRERAIAKMKRALKEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF
>Mature_458_residues
MNKVNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTANAKVCIGGAKSSESYLNIPAI
ISAAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPSAKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEE
IADKIGYPVIIKAAAGGGGRGMRVVEDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGE
RDCSVQRRQQKLIEETPAVVLEEGVRKRLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFYFMEMNTRLQVEHTISEMVSG
LNLIEWMIKIAQGEELPKQESFSLKGHAIECRITAEDPKKFYPSPGKITEWIAPSGVNVRLDSHAHAHYVVPTHYDSMIG
KLIVWGENRERAIAKMKRALKEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=43.6241610738255, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI106049528, Length=456, Percent_Identity=43.640350877193, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049295, Length=456, Percent_Identity=43.640350877193, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049292, Length=456, Percent_Identity=43.640350877193, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI189095269, Length=449, Percent_Identity=42.7616926503341, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI65506442, Length=450, Percent_Identity=42.6666666666667, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI295821183, Length=450, Percent_Identity=42.6666666666667, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI38679971, Length=510, Percent_Identity=31.5686274509804, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679960, Length=516, Percent_Identity=31.7829457364341, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679977, Length=516, Percent_Identity=31.7829457364341, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679967, Length=516, Percent_Identity=31.7829457364341, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679974, Length=510, Percent_Identity=31.5686274509804, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=30.0589390962672, Blast_Score=242, Evalue=6e-64,
Organism=Homo sapiens, GI18105007, Length=238, Percent_Identity=24.3697478991597, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI170295797, Length=307, Percent_Identity=23.7785016286645, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI21361331, Length=307, Percent_Identity=23.7785016286645, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI169790915, Length=307, Percent_Identity=23.7785016286645, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=50.7865168539326, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17562816, Length=460, Percent_Identity=44.1304347826087, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI71987519, Length=447, Percent_Identity=43.4004474272931, Blast_Score=378, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17567343, Length=448, Percent_Identity=41.7410714285714, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133931226, Length=508, Percent_Identity=29.5275590551181, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI71997168, Length=512, Percent_Identity=29.296875, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=512, Percent_Identity=29.296875, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI193204318, Length=200, Percent_Identity=25.5, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=439, Percent_Identity=40.5466970387244, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=452, Percent_Identity=43.5840707964602, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6319695, Length=452, Percent_Identity=42.9203539823009, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6323863, Length=461, Percent_Identity=33.8394793926247, Blast_Score=248, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=31.3953488372093, Blast_Score=243, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6322569, Length=323, Percent_Identity=23.2198142414861, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24651757, Length=448, Percent_Identity=44.4196428571429, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI281363050, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652224, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652222, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652220, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652218, Length=460, Percent_Identity=43.2608695652174, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652212, Length=460, Percent_Identity=43.2608695652174, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652210, Length=460, Percent_Identity=43.2608695652174, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652214, Length=460, Percent_Identity=43.2608695652174, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19921944, Length=460, Percent_Identity=43.2608695652174, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652216, Length=460, Percent_Identity=43.2608695652174, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651759, Length=403, Percent_Identity=45.1612903225806, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=30.6163021868787, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=30.6163021868787, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=30.6163021868787, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=30.6163021868787, Blast_Score=239, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 51155; Mature: 51155

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTAN
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCC
AKVCIGGAKSSESYLNIPAIISAAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPS
CEEEEECCCCCCCEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCC
AKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIADKIGYPVIIKAAAGGGGR
HHEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
GMRVVEDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGE
CCEEECCHHHHHHEEEEECHHHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECC
RDCSVQRRQQKLIEETPAVVLEEGVRKRLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFY
CCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHCCCCCCCEE
FMEMNTRLQVEHTISEMVSGLNLIEWMIKIAQGEELPKQESFSLKGHAIECRITAEDPKK
EEEECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCHH
FYPSPGKITEWIAPSGVNVRLDSHAHAHYVVPTHYDSMIGKLIVWGENRERAIAKMKRAL
HCCCCCCEEHEECCCCCEEEECCCCCEEEEECCCHHHHHCEEEEECCCHHHHHHHHHHHH
KEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF
HHHHHCCCEEECCCHHEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKVNKENKKVEKKELSRILIANRGEIALRAIQTIQEMGKESIAIYSIADKDAHYLNTAN
CCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCC
AKVCIGGAKSSESYLNIPAIISAAELFEADAIFPGYGFLSENQNFVEICSHHSLEFIGPS
CEEEEECCCCCCCEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCC
AKVMALMSDKSKAKSVMKEAGMPVIEGSDGLLKSYQEAEEIADKIGYPVIIKAAAGGGGR
HHEEEECCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCC
GMRVVEDKSKLKNLYLAAETEALSAFGDGSVYLEKFINKPKHIEVQILADKHGNVIHVGE
CCEEECCHHHHHHEEEEECHHHHHHCCCCHHHHHHHCCCCCEEEEEEEECCCCCEEEECC
RDCSVQRRQQKLIEETPAVVLEEGVRKRLLETAIKAAKYIGYVGAGTFEFLLDSNMKDFY
CCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHCCCCCCCEE
FMEMNTRLQVEHTISEMVSGLNLIEWMIKIAQGEELPKQESFSLKGHAIECRITAEDPKK
EEEECCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCHH
FYPSPGKITEWIAPSGVNVRLDSHAHAHYVVPTHYDSMIGKLIVWGENRERAIAKMKRAL
HCCCCCCEEHEECCCCCEEEECCCCCEEEEECCCHHHHHCEEEEECCCHHHHHHHHHHHH
KEFKVEGIKTTIPFHLEMLENADFRQAKIHTKYLEENF
HHHHHCCCEEECCCHHEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]