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The map label for this gene is folE [H]

Identifier: 108563334

GI number: 108563334

Start: 957115

End: 957657

Strand: Direct

Name: folE [H]

Synonym: HPAG1_0909

Alternate gene names: 108563334

Gene position: 957115-957657 (Clockwise)

Preceding gene: 108563333

Following gene: 108563335

Centisome position: 59.96

GC content: 37.94

Gene sequence:

>543_bases
ATGGAAAATTTTTTCAACCAATTTTTTGAAAATATCGGCGAAGATAAGAATAGAGAAGGTCTAAAAGAGACGCCTAAAAG
GGTTCAAGAATTATGGAAATTCTTGTATAAAGGCTATAAAGAAGACCCTAGAGTGGCTTTAAAAAGCGCGTATTTTCAAG
GCGTTTGCGATGAAATGATAGTGGCTCAAAACATTGAATTTTACTCCACTTGCGAACACCATTTGCTCCCTTTTTTGGGG
AATATCAGTTTAGGATACATTCCTAAAGAAAAGATTGTAGGCATTAGCGCGATCGCCAAACTCATTGAAATTTATAGCAA
ACGCCTGCAAATCCAAGAAAGGCTGACCACTCAAATTACAGAAACCTTTGATGAAATCATAGAGCCAAGGGGCGTGATTG
TGGTTTGTGAAGCCAAGCATTTGTGCATGAGCATGCAGGGGGTGCAAAAGCAAAATGCGATCATTAAAACAAGTGTGTTA
AGAGGCCTCTTTAAAAAAGACCCTAAAACCAGAGCTGAATTTATGCAACTCTTAAAATCTTAG

Upstream 100 bases:

>100_bases
CTCCACCCGATCGGCGGCTTATCTTTTTAACGCTGAAATGTTTAGCACCCACCCTAGCATTAAAAATCGTATCCAATCTT
TATCAAGGCGCGTGATTTAA

Downstream 100 bases:

>100_bases
GTTATAATTCTGTGCATGAATAACCCTAATTTATCCTTTTATTATAATGAGTGCGAGCGTTTTGAAAGCTTTTTAAAAAA
CCATCATTTACACCTTGAAA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MENFFNQFFENIGEDKNREGLKETPKRVQELWKFLYKGYKEDPRVALKSAYFQGVCDEMIVAQNIEFYSTCEHHLLPFLG
NISLGYIPKEKIVGISAIAKLIEIYSKRLQIQERLTTQITETFDEIIEPRGVIVVCEAKHLCMSMQGVQKQNAIIKTSVL
RGLFKKDPKTRAEFMQLLKS

Sequences:

>Translated_180_residues
MENFFNQFFENIGEDKNREGLKETPKRVQELWKFLYKGYKEDPRVALKSAYFQGVCDEMIVAQNIEFYSTCEHHLLPFLG
NISLGYIPKEKIVGISAIAKLIEIYSKRLQIQERLTTQITETFDEIIEPRGVIVVCEAKHLCMSMQGVQKQNAIIKTSVL
RGLFKKDPKTRAEFMQLLKS
>Mature_180_residues
MENFFNQFFENIGEDKNREGLKETPKRVQELWKFLYKGYKEDPRVALKSAYFQGVCDEMIVAQNIEFYSTCEHHLLPFLG
NISLGYIPKEKIVGISAIAKLIEIYSKRLQIQERLTTQITETFDEIIEPRGVIVVCEAKHLCMSMQGVQKQNAIIKTSVL
RGLFKKDPKTRAEFMQLLKS

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=176, Percent_Identity=44.8863636363636, Blast_Score=181, Evalue=3e-46,
Organism=Homo sapiens, GI4503949, Length=176, Percent_Identity=44.8863636363636, Blast_Score=181, Evalue=3e-46,
Organism=Homo sapiens, GI66932970, Length=134, Percent_Identity=42.5373134328358, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI66932972, Length=134, Percent_Identity=42.5373134328358, Blast_Score=130, Evalue=5e-31,
Organism=Escherichia coli, GI1788476, Length=168, Percent_Identity=31.547619047619, Blast_Score=103, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=45.5056179775281, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321706, Length=168, Percent_Identity=46.4285714285714, Blast_Score=164, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24656782, Length=180, Percent_Identity=44.4444444444444, Blast_Score=166, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24656796, Length=180, Percent_Identity=44.4444444444444, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24656791, Length=180, Percent_Identity=44.4444444444444, Blast_Score=165, Evalue=1e-41,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 20900; Mature: 20900

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENFFNQFFENIGEDKNREGLKETPKRVQELWKFLYKGYKEDPRVALKSAYFQGVCDEMI
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VAQNIEFYSTCEHHLLPFLGNISLGYIPKEKIVGISAIAKLIEIYSKRLQIQERLTTQIT
HHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETFDEIIEPRGVIVVCEAKHLCMSMQGVQKQNAIIKTSVLRGLFKKDPKTRAEFMQLLKS
HHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
>Mature Secondary Structure
MENFFNQFFENIGEDKNREGLKETPKRVQELWKFLYKGYKEDPRVALKSAYFQGVCDEMI
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
VAQNIEFYSTCEHHLLPFLGNISLGYIPKEKIVGISAIAKLIEIYSKRLQIQERLTTQIT
HHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ETFDEIIEPRGVIVVCEAKHLCMSMQGVQKQNAIIKTSVLRGLFKKDPKTRAEFMQLLKS
HHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA