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The map label for this gene is lysA [H]

Identifier: 108562717

GI number: 108562717

Start: 304268

End: 305485

Strand: Direct

Name: lysA [H]

Synonym: HPAG1_0292

Alternate gene names: 108562717

Gene position: 304268-305485 (Clockwise)

Preceding gene: 108562716

Following gene: 108562718

Centisome position: 19.06

GC content: 41.54

Gene sequence:

>1218_bases
ATGTTTAATTATGAAGAGCTGTTTCAAACTCACAAAACCCCTTTTTACCTCTATGATTTTGACAAAATCAAACAGGCTTT
TTTGAATTATAAAGAAGCGTTTAAGGGGCGTAAGTCTTTGATTTGCTACGCTTTAAAGGCGAATTCCAATTTAAGTATCC
TCTCTTTATTAGCCCATTTAGGGAGTGGGGCGGATTGCGTTTCCATAGGCGAGATATATAGGGCTTTAAAGGCTGGGATC
AAGCCTTATAGGATCGTGTTTAGTGGGGTGGGTAAGAGCGGATTTGAAATAGAACAAGCCCTAAAACTCAACATTTTATT
TTTGAATGTAGAAAGTTTTATGGAATTAACAACGATTGAGAAAATCGCCCAATCTTTAGGGATAAAGGCCAGGATTTCCA
TTAGAATCAACCCTAACATTGACGCTAAAACGCACCCCTATATTTCTACCGGTTTGAAAGAAAATAAGTTTGGCGTGGGA
GAAAAAGAAGCTTTAGAAATGTTTCTTTGGGCTAAAAAAAGCGCGTTTTTAGAGCCTGTTAGCGTGCATTTTCATATCGG
CTCACAGCTCTTAGATTTAGAGCCGATTATAGAAGCGAGCCAAAAGGTGGCCAAAATCGCTAAATCTTTGATAGCGCTAG
GGATAGATTTGCGTTTTTTTGATGTGGGCGGAGGGATTGGCGTGAGCTATGAAAATGAAGAGACTATCAAGCTTTATGAT
TACGCGCAAAAGATCTTAAATGCGCTTCAAGGCTTGGATTTGACTATTATTTGTGAGCCGGGCCGATCCATCGTGGCTGA
GAGTGGGGAATTGATCACGCAGGTTTTGTATGAAAAAAAGGCTCAAAACAAGCGCTTTGTGGTTGTGGATGCAGGCATGA
ATGATTTCTTGCGCCCCAGTTTGTATCATGCTAAGCATGCCATAAGGGTTATAACGCCCTCTAAGGGGCGTGAGATCTCG
CCTTGCGATGTGGTAGGGCCTGTGTGCGAGAGCAGCGACACTTTTTTAAAAGATGTCCATTTGCCAGAATTAGATCCAGG
CGATAAAATAGCGATTGAGAAGGTTGGAGCTTATGGCTCTAGCATGGCCAGTCAATACAATTCGCGCCCCAAACTCTTAG
AATTAGCCCTAGAAGATCACAAAATCAGAGTGATAAGAAAAAGAGAGGCTTTAGAAGATTTGTGGCGGTTAGAAGAAGAA
GGCTTAAAAGGGGTTTGA

Upstream 100 bases:

>100_bases
AATACCAAGACATTAATATAACTGGGAATGTGGGCATGCGAGTGGCGTTTTAGCTTTTTTGCTATAATGCTTCGTTCAAA
TTTTATAGTTAGGTTTTTCT

Downstream 100 bases:

>100_bases
TTAGATGCAAAAGAATTTGGATAGTCTTTTAGAAAATTTAAGGGCTGAAATTGATGCGTTGGATAATGAATTAAGCGATC
TTTTAGACAAACGCTTAGAA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MFNYEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHLGSGADCVSIGEIYRALKAGI
KPYRIVFSGVGKSGFEIEQALKLNILFLNVESFMELTTIEKIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVG
EKEALEMFLWAKKSAFLEPVSVHFHIGSQLLDLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
YAQKILNALQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVVVDAGMNDFLRPSLYHAKHAIRVITPSKGREIS
PCDVVGPVCESSDTFLKDVHLPELDPGDKIAIEKVGAYGSSMASQYNSRPKLLELALEDHKIRVIRKREALEDLWRLEEE
GLKGV

Sequences:

>Translated_405_residues
MFNYEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHLGSGADCVSIGEIYRALKAGI
KPYRIVFSGVGKSGFEIEQALKLNILFLNVESFMELTTIEKIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVG
EKEALEMFLWAKKSAFLEPVSVHFHIGSQLLDLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
YAQKILNALQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVVVDAGMNDFLRPSLYHAKHAIRVITPSKGREIS
PCDVVGPVCESSDTFLKDVHLPELDPGDKIAIEKVGAYGSSMASQYNSRPKLLELALEDHKIRVIRKREALEDLWRLEEE
GLKGV
>Mature_405_residues
MFNYEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHLGSGADCVSIGEIYRALKAGI
KPYRIVFSGVGKSGFEIEQALKLNILFLNVESFMELTTIEKIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVG
EKEALEMFLWAKKSAFLEPVSVHFHIGSQLLDLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
YAQKILNALQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVVVDAGMNDFLRPSLYHAKHAIRVITPSKGREIS
PCDVVGPVCESSDTFLKDVHLPELDPGDKIAIEKVGAYGSSMASQYNSRPKLLELALEDHKIRVIRKREALEDLWRLEEE
GLKGV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=388, Percent_Identity=25, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI22538418, Length=389, Percent_Identity=25.4498714652956, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI21361583, Length=389, Percent_Identity=25.4498714652956, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI16506287, Length=344, Percent_Identity=25.8720930232558, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1789203, Length=401, Percent_Identity=31.6708229426434, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789307, Length=281, Percent_Identity=24.5551601423488, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562780, Length=384, Percent_Identity=23.6979166666667, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322664, Length=379, Percent_Identity=27.9683377308707, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24586472, Length=337, Percent_Identity=24.9258160237389, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24586474, Length=338, Percent_Identity=23.9644970414201, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45263; Mature: 45263

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNYEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHL
CCCHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHH
GSGADCVSIGEIYRALKAGIKPYRIVFSGVGKSGFEIEQALKLNILFLNVESFMELTTIE
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHEEEEEEEEEEHHHHHHHHHHH
KIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVGEKEALEMFLWAKKSAFLEPV
HHHHHCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
SVHFHIGSQLLDLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
EEEEEECCHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEHHH
YAQKILNALQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVVVDAGMNDFLRPS
HHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHCHH
LYHAKHAIRVITPSKGREISPCDVVGPVCESSDTFLKDVHLPELDPGDKIAIEKVGAYGS
HHHHHCEEEEECCCCCCCCCCHHHCCCCCCCCCCHHHHCCCCCCCCCCEEEHEECCCCHH
SMASQYNSRPKLLELALEDHKIRVIRKREALEDLWRLEEEGLKGV
HHHHHHCCCCCEEHEECCCCCEEEHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFNYEELFQTHKTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHL
CCCHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHH
GSGADCVSIGEIYRALKAGIKPYRIVFSGVGKSGFEIEQALKLNILFLNVESFMELTTIE
CCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHEEEEEEEEEEHHHHHHHHHHH
KIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVGEKEALEMFLWAKKSAFLEPV
HHHHHCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
SVHFHIGSQLLDLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
EEEEEECCHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEHHH
YAQKILNALQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVVVDAGMNDFLRPS
HHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHCHH
LYHAKHAIRVITPSKGREISPCDVVGPVCESSDTFLKDVHLPELDPGDKIAIEKVGAYGS
HHHHHCEEEEECCCCCCCCCCHHHCCCCCCCCCCHHHHCCCCCCCCCCEEEHEECCCCHH
SMASQYNSRPKLLELALEDHKIRVIRKREALEDLWRLEEEGLKGV
HHHHHHCCCCCEEHEECCCCCEEEHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]