Click here to switch to the map view.

The map label for this gene is purC

Identifier: 103486077

GI number: 103486077

Start: 594302

End: 595078

Strand: Direct

Name: purC

Synonym: Sala_0584

Alternate gene names: 103486077

Gene position: 594302-595078 (Clockwise)

Preceding gene: 103486075

Following gene: 103486078

Centisome position: 17.77

GC content: 61.9

Gene sequence:

>777_bases
ATGGCCCGTCGCCGCCAGATCTACGAAGGCAAAGCCAAAATCCTGTATGAAGGCCCCGAACCGGGCACGCTGATCCAGTA
TTTCAAGGACGACGCGACCGCGTTCAACGCGCAGAAGCGCGGGACGATCAATGGCAAGGGCGTGCTCAACAACCGGATTT
CGGAGCATGTGTTCACCCTGCTCGGCAATATCGGGGTGCCGACGCATTTCATCCGCCGCCTCAACATGCGCGAGCAGCTC
ATCCGTCAGGTCGAGATCGTGCCGATCGAGGTGATCGTGCGCAACGTCGCGGCGGGCACGCTGTCGAAGCGGCTGGGGAT
CGAGGAGGGGACGCAGCTTCCCCGCACCCTCATCGAATATTGCTACAAGGACGACGCGCTCGGCGATCCGCTCGTCGCCG
AGGAGCATATCGCCTGCTTCAACTGGTGCAGCCAGGACGAGCTTCACGACATTCAGGACATGGCGATCCGTATCAATGAT
TTCATGTCGGGCATGTTCGCCGCGGTCGGCATCCGCCTCGTCGACTTCAAGCTGGAGTTCGGGCGGCTGTACGAGGGCGA
TTTCAGCCGCATCATCCTCGCCGACGAGATCAGCCCGGATGGTTGTCGCCTGTGGGACATGACGACGAACGAAAAGCTCG
ACAAGGACCGTTTCCGCCGCGACCTCGGCGGCGAGGTCGAAGCCTATCAGGAAGTCGCGCGCCGCCTCGGCCTGCTGCCC
GAAGGCGGCGACAATGCCGTGCTCGACCTCGAAAGCCACCGCAAGAAAAAGGGTTGA

Upstream 100 bases:

>100_bases
TTTGCCGCTATAGGCGCCGCAACCGCCCCGGCGCCGCGCCTCCCCCGTGAGTCGCCACCGCCGGGGCCATTCATTTGCTT
CCGACAGAAAGTTGACCGCC

Downstream 100 bases:

>100_bases
GTCCGCCTTATCCGTCATCCCGGCCTTCGCCGGGATGACGATAGGAGTATGTTCACCATCGTTGCCAAGGCCTCCGCCTT
GACGCGGACGCAATGATCGC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MARRRQIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKRGTINGKGVLNNRISEHVFTLLGNIGVPTHFIRRLNMREQL
IRQVEIVPIEVIVRNVAAGTLSKRLGIEEGTQLPRTLIEYCYKDDALGDPLVAEEHIACFNWCSQDELHDIQDMAIRIND
FMSGMFAAVGIRLVDFKLEFGRLYEGDFSRIILADEISPDGCRLWDMTTNEKLDKDRFRRDLGGEVEAYQEVARRLGLLP
EGGDNAVLDLESHRKKKG

Sequences:

>Translated_258_residues
MARRRQIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKRGTINGKGVLNNRISEHVFTLLGNIGVPTHFIRRLNMREQL
IRQVEIVPIEVIVRNVAAGTLSKRLGIEEGTQLPRTLIEYCYKDDALGDPLVAEEHIACFNWCSQDELHDIQDMAIRIND
FMSGMFAAVGIRLVDFKLEFGRLYEGDFSRIILADEISPDGCRLWDMTTNEKLDKDRFRRDLGGEVEAYQEVARRLGLLP
EGGDNAVLDLESHRKKKG
>Mature_257_residues
ARRRQIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKRGTINGKGVLNNRISEHVFTLLGNIGVPTHFIRRLNMREQLI
RQVEIVPIEVIVRNVAAGTLSKRLGIEEGTQLPRTLIEYCYKDDALGDPLVAEEHIACFNWCSQDELHDIQDMAIRINDF
MSGMFAAVGIRLVDFKLEFGRLYEGDFSRIILADEISPDGCRLWDMTTNEKLDKDRFRRDLGGEVEAYQEVARRLGLLPE
GGDNAVLDLESHRKKKG

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=226, Percent_Identity=31.4159292035398, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI5453539, Length=226, Percent_Identity=31.4159292035398, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI119220559, Length=233, Percent_Identity=30.0429184549356, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=43.2773109243698, Blast_Score=209, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17531275, Length=223, Percent_Identity=31.390134529148, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI18860083, Length=239, Percent_Identity=28.4518828451883, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24583917, Length=207, Percent_Identity=29.951690821256, Blast_Score=87, Evalue=9e-18,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_SPHAL (Q1GVL7)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_615638.1
- ProteinModelPortal:   Q1GVL7
- SMR:   Q1GVL7
- GeneID:   4082015
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_0584
- NMPDR:   fig|317655.9.peg.542
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   SALA317655:SALA_0584-MONOMER
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 29356; Mature: 29225

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRRQIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKRGTINGKGVLNNRISEHVFTL
CCCCCCHHCCCEEEEEECCCCCHHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LGNIGVPTHFIRRLNMREQLIRQVEIVPIEVIVRNVAAGTLSKRLGIEEGTQLPRTLIEY
HHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
CYKDDALGDPLVAEEHIACFNWCSQDELHDIQDMAIRINDFMSGMFAAVGIRLVDFKLEF
HHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEC
GRLYEGDFSRIILADEISPDGCRLWDMTTNEKLDKDRFRRDLGGEVEAYQEVARRLGLLP
CCEECCCCCEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
EGGDNAVLDLESHRKKKG
CCCCCCEEECHHHCCCCC
>Mature Secondary Structure 
ARRRQIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKRGTINGKGVLNNRISEHVFTL
CCCCCHHCCCEEEEEECCCCCHHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LGNIGVPTHFIRRLNMREQLIRQVEIVPIEVIVRNVAAGTLSKRLGIEEGTQLPRTLIEY
HHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
CYKDDALGDPLVAEEHIACFNWCSQDELHDIQDMAIRINDFMSGMFAAVGIRLVDFKLEF
HHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEC
GRLYEGDFSRIILADEISPDGCRLWDMTTNEKLDKDRFRRDLGGEVEAYQEVARRLGLLP
CCEECCCCCEEEEEECCCCCCCEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
EGGDNAVLDLESHRKKKG
CCCCCCEEECHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA