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The map label for this gene is rotA [H]

Identifier: 103486037

GI number: 103486037

Start: 558688

End: 559392

Strand: Direct

Name: rotA [H]

Synonym: Sala_0544

Alternate gene names: 103486037

Gene position: 558688-559392 (Clockwise)

Preceding gene: 103486036

Following gene: 103486038

Centisome position: 16.7

GC content: 68.94

Gene sequence:

>705_bases
ATGGTCGGCACCATGCTGACGCTTGCCGCCGCCCTGATCCTCGCCATCCAGCCCGCCGCCGTCCCGCCGCAGGCGACGCA
ATTGCCGCCGCCCGTGCCGCCGGTCCCGGCGCCGGTTACGCCGGTGGTCGAGGCCGATACGCGCCCCTTTGTCGCGCTCA
CCACCGATCTGGGGACAATCACCGTGCGGATCGAGGACAAGCGCGCGCCGGTGACAGCCGCCAATTTCCTTCGCTATGTC
GACACGAAGCGGATGGACGGGTTCCAATTCTATCGTTCGACCCGAAGCTGGGGCCCGGCGAACCAGCTCATCCAGGCCGG
CAATCGCGGCGATGCGCGGCGCAATTATCCGCCGATCGCGCACGAACCGACGACCGCCACGGGCCTCACCCATTGCAAGG
GGGCGCTGTCGATGGCGCGGCTGAGTCCCGGCGATGCGACGACCGACTTTTTCCTGCTGCTCTCGGACATCAAGGGTTTC
GACGCCGATGCGCCGGGCGGCGACGGTGTGGGTTTTGCAGTGTTCGGGGAGGTCGTCGCGGGCGCGGACGTCGCCGCGGC
GATTTTCAACGCGCCGATCTCGCCGACCGCGGGCGAGGGGGTGATGGTGGGACAGATCCTCGACCCGCAGGTGACAATCC
GCACCGCGCGCCGCGTCCCCGCGCCTGCCGATGCGCCCAAGGGCTGCGTGGTCAAGGCACAATAG

Upstream 100 bases:

>100_bases
CCGGGTCTGCACGGGTTGCGCGCGGCCGGGTCCGGTTGCCGCCCGGCGGCATAGCCGGACATGATGTGAAAGCACTCGCA
TCGACGGCGCGGTTGCGGTT

Downstream 100 bases:

>100_bases
CTTTCTCTTGCAAGGCAAGGCCGAAACCCGACCGGGCGTGCCATCATTTATTTTGCGTTCATCCGCGCTGTGGCTATACC
GCGCGCATGACTCGTTTTGC

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MVGTMLTLAAALILAIQPAAVPPQATQLPPPVPPVPAPVTPVVEADTRPFVALTTDLGTITVRIEDKRAPVTAANFLRYV
DTKRMDGFQFYRSTRSWGPANQLIQAGNRGDARRNYPPIAHEPTTATGLTHCKGALSMARLSPGDATTDFFLLLSDIKGF
DADAPGGDGVGFAVFGEVVAGADVAAAIFNAPISPTAGEGVMVGQILDPQVTIRTARRVPAPADAPKGCVVKAQ

Sequences:

>Translated_234_residues
MVGTMLTLAAALILAIQPAAVPPQATQLPPPVPPVPAPVTPVVEADTRPFVALTTDLGTITVRIEDKRAPVTAANFLRYV
DTKRMDGFQFYRSTRSWGPANQLIQAGNRGDARRNYPPIAHEPTTATGLTHCKGALSMARLSPGDATTDFFLLLSDIKGF
DADAPGGDGVGFAVFGEVVAGADVAAAIFNAPISPTAGEGVMVGQILDPQVTIRTARRVPAPADAPKGCVVKAQ
>Mature_234_residues
MVGTMLTLAAALILAIQPAAVPPQATQLPPPVPPVPAPVTPVVEADTRPFVALTTDLGTITVRIEDKRAPVTAANFLRYV
DTKRMDGFQFYRSTRSWGPANQLIQAGNRGDARRNYPPIAHEPTTATGLTHCKGALSMARLSPGDATTDFFLLLSDIKGF
DADAPGGDGVGFAVFGEVVAGADVAAAIFNAPISPTAGEGVMVGQILDPQVTIRTARRVPAPADAPKGCVVKAQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789763, Length=148, Percent_Identity=33.7837837837838, Blast_Score=74, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 24363; Mature: 24363

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGTMLTLAAALILAIQPAAVPPQATQLPPPVPPVPAPVTPVVEADTRPFVALTTDLGTI
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCEEE
TVRIEDKRAPVTAANFLRYVDTKRMDGFQFYRSTRSWGPANQLIQAGNRGDARRNYPPIA
EEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCC
HEPTTATGLTHCKGALSMARLSPGDATTDFFLLLSDIKGFDADAPGGDGVGFAVFGEVVA
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
GADVAAAIFNAPISPTAGEGVMVGQILDPQVTIRTARRVPAPADAPKGCVVKAQ
CCHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEHHHCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MVGTMLTLAAALILAIQPAAVPPQATQLPPPVPPVPAPVTPVVEADTRPFVALTTDLGTI
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEEEECCEEE
TVRIEDKRAPVTAANFLRYVDTKRMDGFQFYRSTRSWGPANQLIQAGNRGDARRNYPPIA
EEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCC
HEPTTATGLTHCKGALSMARLSPGDATTDFFLLLSDIKGFDADAPGGDGVGFAVFGEVVA
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
GADVAAAIFNAPISPTAGEGVMVGQILDPQVTIRTARRVPAPADAPKGCVVKAQ
CCHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEHHHCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9418240 [H]