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The map label for this gene is pdhA [H]

Identifier: 103486018

GI number: 103486018

Start: 539985

End: 541055

Strand: Direct

Name: pdhA [H]

Synonym: Sala_0525

Alternate gene names: 103486018

Gene position: 539985-541055 (Clockwise)

Preceding gene: 103486017

Following gene: 103486019

Centisome position: 16.14

GC content: 63.4

Gene sequence:

>1071_bases
TTGGCCAAAGCACCCGCGCGTAAGACTGCCGCGCCAAAAAAAGTCGCTGCCACCCCAGCTCCCGCATCCAATCGCGAAGG
GCCGCGCGATCCGGTCCCCTATGACGCGACCCCGCAAGAACTCGAAAAATTCTATCGCGACATGCTGCTCATCCGCCGCT
TCGAGGAAAAGGCGGGGCAGCTCTACGGTCTGGGGCTGATCGGCGGTTTCTGCCACCTCTATATCGGTCAGGAAGCCGTG
GCGGTCGGCCTGCAATCGGCGCTGGACGGGGACAAGGACAGCGTCATCACCGGATATCGCGACCATGGCCACATGCTCGC
CTACGGCATCGACCCCAAGGTCATCATGGCCGAGCTGACCGGCCGCGCCGCGGGCATTTCGAAGGGCAAGGGCGGCTCGA
TGCACATGTTCAGCGTCGAGCACAAGTTCTACGGCGGTCACGGTATCGTCGGCGCGCAGGTCTCGCTCGGCACGGGCCTT
GCCTTCGCGCACAAATATCGCGGCGACGGCGGTGTGGCGATGGCCTATTTCGGCGACGGCGCCGCGAACCAGGGTCAGGT
CTACGAAAGCTTCAACATGGCCGAGCTGTGGAAGCTGCCGATTATCTTCGTGATCGAGAACAACCAGTACGCCATGGGCA
CGTCGGTCAACCGCGCGTCGGCGGAGGACCAGCTCTATCGCCGCGGCGAAAGTTTCCGCATTCCGGGGATGCAGGTCGAC
GGCATGGACGTGCTCGCGGTGCGCGGCGCGGCTGAGGCGGCGCTCGAATGGGTGCGCGCAGGCAGGGGGCCGGTGCTGAT
GGAACTCAAGACCTATCGCTACCGCGGACACTCGATGTCCGACCCCGCAAAATATCGCAGCCGCGAGGAAGTGCAGGCGG
TGCGCGACAAATCGGACGCGATCGAGCATCTGAAAAAGCTGATGGAGGGCGCCGGGATCGGCGAGGACCGGATCAAGGAT
ATCGACAAGGAAATCCGTGCGATCGTCGCCGAATCGGCCGACTTTGCCGAGAGCGCGCCCGAACCCGACTTGTCCGAACT
CTATACCGACGTGCTGGTGGAGCAATATTGA

Upstream 100 bases:

>100_bases
AAGTCGGCCTTGCCCGCCGTCATGGCAGACGTTGCCAAACCCGCTGCGCCGCTCCTATAGGGAGCCTTGCCGTAACGGCT
AATCGCAAAGGAAATCCGCC

Downstream 100 bases:

>100_bases
GATGGCCATCGAACTGAAGATGCCGGCGCTGTCGCCGACGATGGAAGAGGGCACGCTCGCCAAGTGGCTCGTCAAGGAAG
GCGACATTGTGAAGTCGGGC

Product: pyruvate dehydrogenase (lipoamide)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MAKAPARKTAAPKKVAATPAPASNREGPRDPVPYDATPQELEKFYRDMLLIRRFEEKAGQLYGLGLIGGFCHLYIGQEAV
AVGLQSALDGDKDSVITGYRDHGHMLAYGIDPKVIMAELTGRAAGISKGKGGSMHMFSVEHKFYGGHGIVGAQVSLGTGL
AFAHKYRGDGGVAMAYFGDGAANQGQVYESFNMAELWKLPIIFVIENNQYAMGTSVNRASAEDQLYRRGESFRIPGMQVD
GMDVLAVRGAAEAALEWVRAGRGPVLMELKTYRYRGHSMSDPAKYRSREEVQAVRDKSDAIEHLKKLMEGAGIGEDRIKD
IDKEIRAIVAESADFAESAPEPDLSELYTDVLVEQY

Sequences:

>Translated_356_residues
MAKAPARKTAAPKKVAATPAPASNREGPRDPVPYDATPQELEKFYRDMLLIRRFEEKAGQLYGLGLIGGFCHLYIGQEAV
AVGLQSALDGDKDSVITGYRDHGHMLAYGIDPKVIMAELTGRAAGISKGKGGSMHMFSVEHKFYGGHGIVGAQVSLGTGL
AFAHKYRGDGGVAMAYFGDGAANQGQVYESFNMAELWKLPIIFVIENNQYAMGTSVNRASAEDQLYRRGESFRIPGMQVD
GMDVLAVRGAAEAALEWVRAGRGPVLMELKTYRYRGHSMSDPAKYRSREEVQAVRDKSDAIEHLKKLMEGAGIGEDRIKD
IDKEIRAIVAESADFAESAPEPDLSELYTDVLVEQY
>Mature_355_residues
AKAPARKTAAPKKVAATPAPASNREGPRDPVPYDATPQELEKFYRDMLLIRRFEEKAGQLYGLGLIGGFCHLYIGQEAVA
VGLQSALDGDKDSVITGYRDHGHMLAYGIDPKVIMAELTGRAAGISKGKGGSMHMFSVEHKFYGGHGIVGAQVSLGTGLA
FAHKYRGDGGVAMAYFGDGAANQGQVYESFNMAELWKLPIIFVIENNQYAMGTSVNRASAEDQLYRRGESFRIPGMQVDG
MDVLAVRGAAEAALEWVRAGRGPVLMELKTYRYRGHSMSDPAKYRSREEVQAVRDKSDAIEHLKKLMEGAGIGEDRIKDI
DKEIRAIVAESADFAESAPEPDLSELYTDVLVEQY

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=324, Percent_Identity=52.4691358024691, Blast_Score=326, Evalue=2e-89,
Organism=Homo sapiens, GI291084742, Length=324, Percent_Identity=53.0864197530864, Blast_Score=315, Evalue=5e-86,
Organism=Homo sapiens, GI4505685, Length=324, Percent_Identity=53.0864197530864, Blast_Score=315, Evalue=6e-86,
Organism=Homo sapiens, GI291084744, Length=331, Percent_Identity=51.963746223565, Blast_Score=308, Evalue=6e-84,
Organism=Homo sapiens, GI291084757, Length=324, Percent_Identity=47.8395061728395, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI11386135, Length=318, Percent_Identity=30.8176100628931, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI258645172, Length=318, Percent_Identity=30.8176100628931, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32564172, Length=328, Percent_Identity=49.0853658536585, Blast_Score=303, Evalue=7e-83,
Organism=Caenorhabditis elegans, GI17536047, Length=328, Percent_Identity=49.0853658536585, Blast_Score=303, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI86563357, Length=289, Percent_Identity=32.8719723183391, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI86563355, Length=289, Percent_Identity=32.8719723183391, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6321026, Length=327, Percent_Identity=48.9296636085627, Blast_Score=319, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24639744, Length=328, Percent_Identity=52.7439024390244, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI28571106, Length=328, Percent_Identity=52.7439024390244, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI24639740, Length=328, Percent_Identity=52.7439024390244, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=54.2483660130719, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24639748, Length=310, Percent_Identity=52.258064516129, Blast_Score=297, Evalue=8e-81,
Organism=Drosophila melanogaster, GI21355903, Length=318, Percent_Identity=28.9308176100629, Blast_Score=117, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38844; Mature: 38712

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKAPARKTAAPKKVAATPAPASNREGPRDPVPYDATPQELEKFYRDMLLIRRFEEKAGQ
CCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
LYGLGLIGGFCHLYIGQEAVAVGLQSALDGDKDSVITGYRDHGHMLAYGIDPKVIMAELT
EEEHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEECCCCCEEEEECC
GRAAGISKGKGGSMHMFSVEHKFYGGHGIVGAQVSLGTGLAFAHKYRGDGGVAMAYFGDG
CCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEEEECCCCCHHHHEECCCCCEEEEEECCC
AANQGQVYESFNMAELWKLPIIFVIENNQYAMGTSVNRASAEDQLYRRGESFRIPGMQVD
CCCCCCHHHCCCHHHHHCCCEEEEEECCCEEECCCCCCCCHHHHHHHCCCCEECCCEEEC
GMDVLAVRGAAEAALEWVRAGRGPVLMELKTYRYRGHSMSDPAKYRSREEVQAVRDKSDA
CCEEEEECCHHHHHHHHHHCCCCCEEEEEEEHEECCCCCCCHHHHCCHHHHHHHHHHHHH
IEHLKKLMEGAGIGEDRIKDIDKEIRAIVAESADFAESAPEPDLSELYTDVLVEQY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AKAPARKTAAPKKVAATPAPASNREGPRDPVPYDATPQELEKFYRDMLLIRRFEEKAGQ
CCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
LYGLGLIGGFCHLYIGQEAVAVGLQSALDGDKDSVITGYRDHGHMLAYGIDPKVIMAELT
EEEHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEECCCCCEEEEECC
GRAAGISKGKGGSMHMFSVEHKFYGGHGIVGAQVSLGTGLAFAHKYRGDGGVAMAYFGDG
CCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEEEECCCCCHHHHEECCCCCEEEEEECCC
AANQGQVYESFNMAELWKLPIIFVIENNQYAMGTSVNRASAEDQLYRRGESFRIPGMQVD
CCCCCCHHHCCCHHHHHCCCEEEEEECCCEEECCCCCCCCHHHHHHHCCCCEECCCEEEC
GMDVLAVRGAAEAALEWVRAGRGPVLMELKTYRYRGHSMSDPAKYRSREEVQAVRDKSDA
CCEEEEECCHHHHHHHHHHCCCCCEEEEEEEHEECCCCCCCHHHHCCHHHHHHHHHHHHH
IEHLKKLMEGAGIGEDRIKDIDKEIRAIVAESADFAESAPEPDLSELYTDVLVEQY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]