Click here to switch to the map view.

The map label for this gene is aqpZ [H]

Identifier: 103485731

GI number: 103485731

Start: 241747

End: 242472

Strand: Direct

Name: aqpZ [H]

Synonym: Sala_0235

Alternate gene names: 103485731

Gene position: 241747-242472 (Clockwise)

Preceding gene: 103485730

Following gene: 103485738

Centisome position: 7.23

GC content: 64.88

Gene sequence:

>726_bases
ATGACGAATATCCAAAAGGGTTTGGCCGAGTTCATCGGCACATTCTGGCTCGTGTTCGGCGGCTGCGGCAGCGCGGTGCT
CGCGGCGGGTTTCCCCGACGTCGGGATCGGCCTGCTCGGCGTGTCGCTCGCTTTTGGCCTGACCGTGATCACGATGGCCT
ATGCGATCGGCCATATTTCAGGATGCCACCTCAACCCCGCGGTGACGGTCGGGCTGTGGGCCGGCGGGCGCTTCGGGGCG
CGCGACATTCCGCTCTATGTCGTTGCGCAGCTGCTGGGCGCGATCGTCGCCGCCTTCCTGCTCTTTTATATCGCGAGTGG
CAGTCCGACCTATGACCTTGCCACCAACGGCCTCGCCGCCAACGGCTTCGGCGAAGGATCGCCCGGCGGTTATGACATCT
GGTCGGCGCTGCTGATCGAGATCGTGCTGACGGCCTTCTTCCTGTGGATCATCATGGGGTCGACCGACGGGCGCGCGCCC
GCCGGTTTTGCGCCGATCGCGATCGGCCTTGCGCTGACGCTGATCCATCTGATTTCGATCCCGGTCACCAATACCTCGGT
CAATCCGGCACGCAGCACCGGCCCGGCGCTCGTCGTCGGCGGGCTCGCGATCCAGCAGCTCTGGCTGTTCTGGGTCGCGC
CGATCGTCGGCGGGATTATCGGCGGCGTGCTTTACAAGACGCTGGGCGCCGACAGCTTCCCGAAACCGAATATCGAGGGC
GAATGA

Upstream 100 bases:

>100_bases
ATTTTGCCGCGTTTCGCAAGGTCTTGCTCCATGACCCGGCGCTGGTAGGATGACATCGCGCCGGAGGCGTCTGAGGCCGT
CGGCGGGGAGGAGGGTCATC

Downstream 100 bases:

>100_bases
CGTATCGGCCGGTGGAAGCGCCCCGCCTCCGCCGGTCCTATTTGAGCAGGTCGATGGCGAAGGCGCGGACGTCGGCCGCA
ATGTCGGGGCGTTCGAGCGC

Product: MIP family channel protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MTNIQKGLAEFIGTFWLVFGGCGSAVLAAGFPDVGIGLLGVSLAFGLTVITMAYAIGHISGCHLNPAVTVGLWAGGRFGA
RDIPLYVVAQLLGAIVAAFLLFYIASGSPTYDLATNGLAANGFGEGSPGGYDIWSALLIEIVLTAFFLWIIMGSTDGRAP
AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGPALVVGGLAIQQLWLFWVAPIVGGIIGGVLYKTLGADSFPKPNIEG
E

Sequences:

>Translated_241_residues
MTNIQKGLAEFIGTFWLVFGGCGSAVLAAGFPDVGIGLLGVSLAFGLTVITMAYAIGHISGCHLNPAVTVGLWAGGRFGA
RDIPLYVVAQLLGAIVAAFLLFYIASGSPTYDLATNGLAANGFGEGSPGGYDIWSALLIEIVLTAFFLWIIMGSTDGRAP
AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGPALVVGGLAIQQLWLFWVAPIVGGIIGGVLYKTLGADSFPKPNIEG
E
>Mature_240_residues
TNIQKGLAEFIGTFWLVFGGCGSAVLAAGFPDVGIGLLGVSLAFGLTVITMAYAIGHISGCHLNPAVTVGLWAGGRFGAR
DIPLYVVAQLLGAIVAAFLLFYIASGSPTYDLATNGLAANGFGEGSPGGYDIWSALLIEIVLTAFFLWIIMGSTDGRAPA
GFAPIAIGLALTLIHLISIPVTNTSVNPARSTGPALVVGGLAIQQLWLFWVAPIVGGIIGGVLYKTLGADSFPKPNIEGE

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502179, Length=220, Percent_Identity=39.5454545454545, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI37694062, Length=227, Percent_Identity=38.7665198237885, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI4502183, Length=220, Percent_Identity=39.0909090909091, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI6912506, Length=230, Percent_Identity=35.2173913043478, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4502181, Length=222, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4755125, Length=222, Percent_Identity=33.3333333333333, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI86792455, Length=219, Percent_Identity=32.8767123287671, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI157266307, Length=255, Percent_Identity=30.9803921568627, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4502187, Length=256, Percent_Identity=29.6875, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4826645, Length=262, Percent_Identity=29.3893129770992, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI45446752, Length=217, Percent_Identity=30.8755760368664, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI22538420, Length=253, Percent_Identity=26.8774703557312, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787101, Length=224, Percent_Identity=70.0892857142857, Blast_Score=281, Evalue=3e-77,
Organism=Escherichia coli, GI1790362, Length=268, Percent_Identity=30.5970149253731, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71993722, Length=230, Percent_Identity=32.1739130434783, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17558372, Length=243, Percent_Identity=30.4526748971193, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71992966, Length=232, Percent_Identity=29.3103448275862, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32564052, Length=260, Percent_Identity=28.8461538461538, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17533613, Length=260, Percent_Identity=28.8461538461538, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24652747, Length=222, Percent_Identity=36.036036036036, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45551084, Length=222, Percent_Identity=36.036036036036, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24652751, Length=242, Percent_Identity=33.8842975206612, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI19922038, Length=242, Percent_Identity=33.8842975206612, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45550503, Length=248, Percent_Identity=28.6290322580645, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762346, Length=243, Percent_Identity=32.5102880658436, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24762348, Length=243, Percent_Identity=32.5102880658436, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20130305, Length=243, Percent_Identity=32.5102880658436, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136672, Length=220, Percent_Identity=29.5454545454545, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24762344, Length=243, Percent_Identity=32.5102880658436, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24762342, Length=191, Percent_Identity=27.7486910994764, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 24704; Mature: 24573

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIQKGLAEFIGTFWLVFGGCGSAVLAAGFPDVGIGLLGVSLAFGLTVITMAYAIGHIS
CCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVTVGLWAGGRFGARDIPLYVVAQLLGAIVAAFLLFYIASGSPTYDLATNGLAA
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEE
NGFGEGSPGGYDIWSALLIEIVLTAFFLWIIMGSTDGRAPAGFAPIAIGLALTLIHLISI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHC
PVTNTSVNPARSTGPALVVGGLAIQQLWLFWVAPIVGGIIGGVLYKTLGADSFPKPNIEG
CCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
E
C
>Mature Secondary Structure 
TNIQKGLAEFIGTFWLVFGGCGSAVLAAGFPDVGIGLLGVSLAFGLTVITMAYAIGHIS
CCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVTVGLWAGGRFGARDIPLYVVAQLLGAIVAAFLLFYIASGSPTYDLATNGLAA
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEE
NGFGEGSPGGYDIWSALLIEIVLTAFFLWIIMGSTDGRAPAGFAPIAIGLALTLIHLISI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHC
PVTNTSVNPARSTGPALVVGGLAIQQLWLFWVAPIVGGIIGGVLYKTLGADSFPKPNIEG
CCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]