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The map label for this gene is hemH [H]

Identifier: 158340560

GI number: 158340560

Start: 97176

End: 98336

Strand: Direct

Name: hemH [H]

Synonym: AM1_C0107

Alternate gene names: 158340560

Gene position: 97176-98336 (Clockwise)

Preceding gene: 158340558

Following gene: 158340561

Centisome position: 35.58

GC content: 43.58

Gene sequence:

>1161_bases
ATGAGCCGAGCAGGAATATTGCTGTTAAATTTGGGAGGGCCTGAGAGGCTAAGAGACGTCCGCCCCTTTCTATATAATCT
ATTTTCAGATCCAGAAATCATCCGTTTACGCTTTCCTGTTTTACAGGCTCCGCTTGCATGGTTAATTTCTGTATTAAGGT
CTAGTAAATCTGAGAAAAACTACCAAAAGATTGGTGGTTTTTCTCCCTTGCGCGAGATTACTGAGTCCCAGGCATTTGCA
TTACAACAGGCATTATGTTCAGCAGGCTATCCGATTAAAACCTATGTAGGGATGAGATATTGGCATCCCTTTACGGAAGA
AGCCATCGAGCAAATAAAGCGAGACAGAATCACCGATCTCGTCATTCTTCCCCTTTACCCGCAGTTTTCAATTAGTACCA
GTGGATCTAGCTTTCGCCAACTAGAGAAAATTTGGATGGCCGATCCAGGCTTGCAGACCATTAACTATACAATCATTCCT
TCTTGGCACGACTGCAAAGACTATATTCGAGCGATAGCTGATTTGATAGATGGCTGCATTGATCAGCAACCTGATGCCCA
TCAGGCCCATTTATTTTTTAGCGCTCATGGTGTACCCGTCAGCTATGTCGAAGAAGCTGGCGATCCTTATCAAGATGAGG
TTGAGAAATGTGTGGGTTTAATTATGAAGGCCCTAAACAGGGATATACCTTACACATTGGCTTACCAAAGCCGAGTAGGT
CCAATTGAATGGCTGAAGCCTTATACGGACGAGGCAATTGTCGAAGTTGCACAACAAGGGTATAAAGAGCTAGTTGTTGT
CCCCATTAGTTTTGTCTCAGACCATATTGAGACCCTCGAAGAAATTGACATAGAGTATCGGGAGATAGCGATCAATGCTG
GGATAGAAACTTTTATTAGAGTTCCTGCCCTCAACACAAATCCAGACTTTATTCAAGCCCTAGCCAAGTTGGTCATTCAA
GCCTTAAGTGAACGCCCTGTTTTATTTAGTGATGTTTGTCCAGAGAACGCAGTGAAATTGTATCCTCAAGAACAATGGGC
TTGGGGAATAACTCCCTCCGCAGAGGTCTGGAATGGGCGACTAGCTATGTTTGGGATGTTGGGAGTACTACTTGAATATT
TCGTAGGATCTGGACCGCTACATTTATTAGGCTTAATGTAG

Upstream 100 bases:

>100_bases
TGTAACAATATTTGATATCTTTACAATTGTAATGAAAAACTTGAAGATAGGCCTTGGTTTGACGGTATGTCTGAAAGTTG
AACTCATCTGAGCCATAGGT

Downstream 100 bases:

>100_bases
TCATGGTCATAGTGAGGATGTTTAACCTGCCTCTCTTATTGGACTATTAAGAAATTGTAATGGAAGGGTTGTTCAAATTA
ACCTAATGTAGCTAACAAGG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MSRAGILLLNLGGPERLRDVRPFLYNLFSDPEIIRLRFPVLQAPLAWLISVLRSSKSEKNYQKIGGFSPLREITESQAFA
LQQALCSAGYPIKTYVGMRYWHPFTEEAIEQIKRDRITDLVILPLYPQFSISTSGSSFRQLEKIWMADPGLQTINYTIIP
SWHDCKDYIRAIADLIDGCIDQQPDAHQAHLFFSAHGVPVSYVEEAGDPYQDEVEKCVGLIMKALNRDIPYTLAYQSRVG
PIEWLKPYTDEAIVEVAQQGYKELVVVPISFVSDHIETLEEIDIEYREIAINAGIETFIRVPALNTNPDFIQALAKLVIQ
ALSERPVLFSDVCPENAVKLYPQEQWAWGITPSAEVWNGRLAMFGMLGVLLEYFVGSGPLHLLGLM

Sequences:

>Translated_386_residues
MSRAGILLLNLGGPERLRDVRPFLYNLFSDPEIIRLRFPVLQAPLAWLISVLRSSKSEKNYQKIGGFSPLREITESQAFA
LQQALCSAGYPIKTYVGMRYWHPFTEEAIEQIKRDRITDLVILPLYPQFSISTSGSSFRQLEKIWMADPGLQTINYTIIP
SWHDCKDYIRAIADLIDGCIDQQPDAHQAHLFFSAHGVPVSYVEEAGDPYQDEVEKCVGLIMKALNRDIPYTLAYQSRVG
PIEWLKPYTDEAIVEVAQQGYKELVVVPISFVSDHIETLEEIDIEYREIAINAGIETFIRVPALNTNPDFIQALAKLVIQ
ALSERPVLFSDVCPENAVKLYPQEQWAWGITPSAEVWNGRLAMFGMLGVLLEYFVGSGPLHLLGLM
>Mature_385_residues
SRAGILLLNLGGPERLRDVRPFLYNLFSDPEIIRLRFPVLQAPLAWLISVLRSSKSEKNYQKIGGFSPLREITESQAFAL
QQALCSAGYPIKTYVGMRYWHPFTEEAIEQIKRDRITDLVILPLYPQFSISTSGSSFRQLEKIWMADPGLQTINYTIIPS
WHDCKDYIRAIADLIDGCIDQQPDAHQAHLFFSAHGVPVSYVEEAGDPYQDEVEKCVGLIMKALNRDIPYTLAYQSRVGP
IEWLKPYTDEAIVEVAQQGYKELVVVPISFVSDHIETLEEIDIEYREIAINAGIETFIRVPALNTNPDFIQALAKLVIQA
LSERPVLFSDVCPENAVKLYPQEQWAWGITPSAEVWNGRLAMFGMLGVLLEYFVGSGPLHLLGLM

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=322, Percent_Identity=40.6832298136646, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI60499021, Length=322, Percent_Identity=40.6832298136646, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1786681, Length=328, Percent_Identity=31.7073170731707, Blast_Score=136, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324750, Length=338, Percent_Identity=36.6863905325444, Blast_Score=186, Evalue=6e-48,
Organism=Drosophila melanogaster, GI17864156, Length=341, Percent_Identity=35.4838709677419, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=33.984375, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45552018, Length=136, Percent_Identity=43.3823529411765, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 43665; Mature: 43534

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00626 RCC1_2 ; PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRAGILLLNLGGPERLRDVRPFLYNLFSDPEIIRLRFPVLQAPLAWLISVLRSSKSEKN
CCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCH
YQKIGGFSPLREITESQAFALQQALCSAGYPIKTYVGMRYWHPFTEEAIEQIKRDRITDL
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHCCCHHHHHHHHHHHHCCCCE
VILPLYPQFSISTSGSSFRQLEKIWMADPGLQTINYTIIPSWHDCKDYIRAIADLIDGCI
EEEECCCCCEECCCCHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
DQQPDAHQAHLFFSAHGVPVSYVEEAGDPYQDEVEKCVGLIMKALNRDIPYTLAYQSRVG
CCCCCCCCEEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
PIEWLKPYTDEAIVEVAQQGYKELVVVPISFVSDHIETLEEIDIEYREIAINAGIETFIR
CHHHHCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHEECCCHHHHEE
VPALNTNPDFIQALAKLVIQALSERPVLFSDVCPENAVKLYPQEQWAWGITPSAEVWNGR
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHCCCCCCEECCCCCCCCCCCCCCHHHHCCH
LAMFGMLGVLLEYFVGSGPLHLLGLM
HHHHHHHHHHHHHHHCCCCHHHHCCC
>Mature Secondary Structure 
SRAGILLLNLGGPERLRDVRPFLYNLFSDPEIIRLRFPVLQAPLAWLISVLRSSKSEKN
CCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCH
YQKIGGFSPLREITESQAFALQQALCSAGYPIKTYVGMRYWHPFTEEAIEQIKRDRITDL
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHCCCHHHHHHHHHHHHCCCCE
VILPLYPQFSISTSGSSFRQLEKIWMADPGLQTINYTIIPSWHDCKDYIRAIADLIDGCI
EEEECCCCCEECCCCHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
DQQPDAHQAHLFFSAHGVPVSYVEEAGDPYQDEVEKCVGLIMKALNRDIPYTLAYQSRVG
CCCCCCCCEEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
PIEWLKPYTDEAIVEVAQQGYKELVVVPISFVSDHIETLEEIDIEYREIAINAGIETFIR
CHHHHCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHEECCCHHHHEE
VPALNTNPDFIQALAKLVIQALSERPVLFSDVCPENAVKLYPQEQWAWGITPSAEVWNGR
CCCCCCCHHHHHHHHHHHHHHHHCCCCEEHHCCCCCCEECCCCCCCCCCCCCCHHHHCCH
LAMFGMLGVLLEYFVGSGPLHLLGLM
HHHHHHHHHHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA