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The map label for this gene is phoP [H]

Identifier: 158340539

GI number: 158340539

Start: 82752

End: 83498

Strand: Direct

Name: phoP [H]

Synonym: AM1_C0086

Alternate gene names: 158340539

Gene position: 82752-83498 (Clockwise)

Preceding gene: 158340534

Following gene: 158340540

Centisome position: 30.3

GC content: 44.44

Gene sequence:

>747_bases
ATGCCTGCATTTATGAGTACTCTGAACAATCATCAGCAATCAATTTTGGTAGCTGATGACGAAGTACCTATTCGTCGGAT
TTTAGGTACACGCCTATCCAAAATAGGTTACCAAGTCTACACCGCTGCTGATGGAGTGGAAGCACTCGATGTCTTCTATG
ATCAATGTCCCGACCTGATTATCTTAGATGTAATGATGCCCAAGCTCGATGGTTATGGGGTCTGTCAAGCAGTTCGCAAG
ACATCGAGAGTTCCGATTATTATGCTGACTGCATTGTCGGAAGTCAAAGATCGCATTACTGGCCTGGAAATGGGTGCTGA
TGATTATATGGTCAAGCCCTTTTCACCGAAGGAATTAGAATCCCGTGTGCGATGTATCCTAAGACGATTGAGTCCTCTTA
AAGCTTTCAATCATCAAATGACGGGTGTGATTGAAATCGGTTCAGTACAAATTGACACCGACAAGCGGCAGGTTTTCCGA
GACCATGAGCGAGTCTTCCTGACTTATAAAGAGTTCAACCTCCTAGCATTATTGGCGAGTCGTCCTGGAGAAACCGTTTC
TCGTCAAGAGCTGTTACAGAAGGTATGGGAGTATAACAAAGATTCCATCGTTGATACGCGAACTGTCGATGTTCACATGT
CTCGTCTGCGTCAAAAACTCAAGGAGAAACTAGGAGAAACTATTCTGATTCATACGGTTCGTGGAGTGGGTTTTACATTG
AAACATGGTGAGAGCGGGCCACTATAG

Upstream 100 bases:

>100_bases
TATAGATTCTTGCTAGCTATCTTAAGAATCTTGTCTCTCAAGCGTTTTAAGCATTATTGCTTAGGTATAAATGCTACTCT
GATTTGGAGCGGATCCAAAG

Downstream 100 bases:

>100_bases
AGAATTTCATCAAGTAGTAGACCATTAAAGGTGAGTTAGTACCCCTAAGTTAGGAAGCTTTCTATGCAAGCTAATGAATC
CATATCAATAAATCTCTTTT

Product: two-component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MPAFMSTLNNHQQSILVADDEVPIRRILGTRLSKIGYQVYTAADGVEALDVFYDQCPDLIILDVMMPKLDGYGVCQAVRK
TSRVPIIMLTALSEVKDRITGLEMGADDYMVKPFSPKELESRVRCILRRLSPLKAFNHQMTGVIEIGSVQIDTDKRQVFR
DHERVFLTYKEFNLLALLASRPGETVSRQELLQKVWEYNKDSIVDTRTVDVHMSRLRQKLKEKLGETILIHTVRGVGFTL
KHGESGPL

Sequences:

>Translated_248_residues
MPAFMSTLNNHQQSILVADDEVPIRRILGTRLSKIGYQVYTAADGVEALDVFYDQCPDLIILDVMMPKLDGYGVCQAVRK
TSRVPIIMLTALSEVKDRITGLEMGADDYMVKPFSPKELESRVRCILRRLSPLKAFNHQMTGVIEIGSVQIDTDKRQVFR
DHERVFLTYKEFNLLALLASRPGETVSRQELLQKVWEYNKDSIVDTRTVDVHMSRLRQKLKEKLGETILIHTVRGVGFTL
KHGESGPL
>Mature_247_residues
PAFMSTLNNHQQSILVADDEVPIRRILGTRLSKIGYQVYTAADGVEALDVFYDQCPDLIILDVMMPKLDGYGVCQAVRKT
SRVPIIMLTALSEVKDRITGLEMGADDYMVKPFSPKELESRVRCILRRLSPLKAFNHQMTGVIEIGSVQIDTDKRQVFRD
HERVFLTYKEFNLLALLASRPGETVSRQELLQKVWEYNKDSIVDTRTVDVHMSRLRQKLKEKLGETILIHTVRGVGFTLK
HGESGPL

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=226, Percent_Identity=39.8230088495575, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=39.2070484581498, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=38.2608695652174, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=36.8421052631579, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1790860, Length=232, Percent_Identity=37.9310344827586, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788394, Length=231, Percent_Identity=35.9307359307359, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=36, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=38.5964912280702, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=34.3612334801762, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1787229, Length=211, Percent_Identity=34.5971563981043, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1790552, Length=187, Percent_Identity=36.3636363636364, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=30.8370044052863, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=30.7017543859649, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI145693140, Length=240, Percent_Identity=29.5833333333333, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788550, Length=190, Percent_Identity=30, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI145693157, Length=108, Percent_Identity=37.962962962963, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788191, Length=126, Percent_Identity=31.7460317460317, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=31.3725490196078, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=101, Percent_Identity=30.6930693069307, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790437, Length=108, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788713, Length=103, Percent_Identity=39.8058252427184, Blast_Score=65, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322000, Length=108, Percent_Identity=35.1851851851852, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28204; Mature: 28073

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAFMSTLNNHQQSILVADDEVPIRRILGTRLSKIGYQVYTAADGVEALDVFYDQCPDLI
CCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHCCCEE
ILDVMMPKLDGYGVCQAVRKTSRVPIIMLTALSEVKDRITGLEMGADDYMVKPFSPKELE
EHHHHHHCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHH
SRVRCILRRLSPLKAFNHQMTGVIEIGSVQIDTDKRQVFRDHERVFLTYKEFNLLALLAS
HHHHHHHHHHHHHHHHCCCCCEEEEECEEEECCHHHHHHHCCCEEEEEEEHHHEEEHHHC
RPGETVSRQELLQKVWEYNKDSIVDTRTVDVHMSRLRQKLKEKLGETILIHTVRGVGFTL
CCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEE
KHGESGPL
ECCCCCCC
>Mature Secondary Structure 
PAFMSTLNNHQQSILVADDEVPIRRILGTRLSKIGYQVYTAADGVEALDVFYDQCPDLI
CHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHCCCEE
ILDVMMPKLDGYGVCQAVRKTSRVPIIMLTALSEVKDRITGLEMGADDYMVKPFSPKELE
EHHHHHHCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHH
SRVRCILRRLSPLKAFNHQMTGVIEIGSVQIDTDKRQVFRDHERVFLTYKEFNLLALLAS
HHHHHHHHHHHHHHHHCCCCCEEEEECEEEECCHHHHHHHCCCEEEEEEEHHHEEEHHHC
RPGETVSRQELLQKVWEYNKDSIVDTRTVDVHMSRLRQKLKEKLGETILIHTVRGVGFTL
CCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEE
KHGESGPL
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]