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The map label for this gene is pbpA [H]

Identifier: 158340532

GI number: 158340532

Start: 75338

End: 75811

Strand: Reverse

Name: pbpA [H]

Synonym: AM1_C0077

Alternate gene names: 158340532

Gene position: 75811-75338 (Counterclockwise)

Preceding gene: 158340535

Following gene: 158340531

Centisome position: 27.76

GC content: 53.38

Gene sequence:

>474_bases
ATGCAATTGACAACCTCTGTCTACGTAATTGTCACTCAACTCAGGGGTTCACTTCAGGCCTCTGCCTACGCTACCTTTGC
CAATAATGGTTGGCAGTCTAAAACGACTGCTATCCTCCAAGTCACGGATCGCTCTGGCAAAGCCTTGATTGATAACCCCC
CACAACCCAAGTTAGTACTCAATCAATGGGCGGTGGCCTCCGTGAACAGCACGTTACAAACCGTCGTTCAGAGTGGGACG
GGCATTGCGGCCCAGATTGGCCGTCCGGCTGCGGGTAAGACAGGTACAACTTCATCTGAACGAGATGTTTGGTTTGTGGG
GTACGTTCCTCAACTGTCCGTAGCGGTGTGGGAAGGAAATGACAACTACGCCCGTATTGGAGCGGGGGCAACGGGGGGCG
GATGGATGGCACCCGTCTGGCGAGAGTTTATGAGTGAGGCCCTCAAGGATCTCAGTACAGGACAAAAAGCTTGA

Upstream 100 bases:

>100_bases
GTCTTTCCTGTATGGGGATATAAAAAATCGAAAGTGACTGATGCTCTCTCTGCAGATGTGATCTCTGGATTGAACTAGAT
CCTGATTCCTAGAGAAGACT

Downstream 100 bases:

>100_bases
AAGGTCTATAGAGGTGGGATTTCAATAGGATTACCACAATCCCTAGAAACCCCATGACTCAATATAGCGAACTCAAAAGT
GCTCTCCAACCCCACCTGAA

Product: 1A family penicillin-binding protein

Products: NA

Alternate protein names: PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MQLTTSVYVIVTQLRGSLQASAYATFANNGWQSKTTAILQVTDRSGKALIDNPPQPKLVLNQWAVASVNSTLQTVVQSGT
GIAAQIGRPAAGKTGTTSSERDVWFVGYVPQLSVAVWEGNDNYARIGAGATGGGWMAPVWREFMSEALKDLSTGQKA

Sequences:

>Translated_157_residues
MQLTTSVYVIVTQLRGSLQASAYATFANNGWQSKTTAILQVTDRSGKALIDNPPQPKLVLNQWAVASVNSTLQTVVQSGT
GIAAQIGRPAAGKTGTTSSERDVWFVGYVPQLSVAVWEGNDNYARIGAGATGGGWMAPVWREFMSEALKDLSTGQKA
>Mature_157_residues
MQLTTSVYVIVTQLRGSLQASAYATFANNGWQSKTTAILQVTDRSGKALIDNPPQPKLVLNQWAVASVNSTLQTVVQSGT
GIAAQIGRPAAGKTGTTSSERDVWFVGYVPQLSVAVWEGNDNYARIGAGATGGGWMAPVWREFMSEALKDLSTGQKA

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.1.129; 3.4.-.- [C]

Molecular weight: Translated: 16663; Mature: 16663

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLTTSVYVIVTQLRGSLQASAYATFANNGWQSKTTAILQVTDRSGKALIDNPPQPKLVL
CCCCHHHHHHEEHHHCCCCHHEEEEECCCCCCCCEEEEEEEECCCCCEEECCCCCCCEEE
NQWAVASVNSTLQTVVQSGTGIAAQIGRPAAGKTGTTSSERDVWFVGYVPQLSVAVWEGN
CCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECC
DNYARIGAGATGGGWMAPVWREFMSEALKDLSTGQKA
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQLTTSVYVIVTQLRGSLQASAYATFANNGWQSKTTAILQVTDRSGKALIDNPPQPKLVL
CCCCHHHHHHEEHHHCCCCHHEEEEECCCCCCCCEEEEEEEECCCCCEEECCCCCCCEEE
NQWAVASVNSTLQTVVQSGTGIAAQIGRPAAGKTGTTSSERDVWFVGYVPQLSVAVWEGN
CCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEECC
DNYARIGAGATGGGWMAPVWREFMSEALKDLSTGQKA
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]