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The map label for this gene is qor [C]

Identifier: 158340509

GI number: 158340509

Start: 57675

End: 58619

Strand: Direct

Name: qor [C]

Synonym: AM1_C0054

Alternate gene names: 158340509

Gene position: 57675-58619 (Clockwise)

Preceding gene: 158340508

Following gene: 158340511

Centisome position: 21.12

GC content: 49.95

Gene sequence:

>945_bases
ATGCAACGCATCATCATGAACTCAGATCAAGAAGGCGGTCTTTCTTTTGTCGAAACCGATTCCCTCCAACCTTTACCGCA
CCAAAGTCTGATTAAGGTCACGGCCTTTTCTCTCAACCGTGGTGAGATCAATATTGCTCAATCTCCAACAAGCGGGGGTA
GAAGCATTGGCTGGGATTTCGTCGGCGTTATTGAGAACTCAGCGGCTGATGGCACCGGGCTAAAGAAGGGCACACGGGTC
GTCGGCTGGCGACCGGAAATGGATGCATTTGCTGAATATGTAATTGGAGAACACCAGTTCATTGCTCCTATTCCCGATGC
TGTTTCCGACGTCCAGGCTGCAACTTTGCCAGTTGCGGGCTTAACTGCCCTCGCAGCAGTGGATCAGGGAAATCGCCTAG
TGGGCAATTCAGCTCTCGTTACTGGAGTCACAGGTGGTGTTGGCTACTTTGCTCTACAACTCGCTAAGCTAAGTGGTGCA
AGAACGGTAGCTCAGGTTCGTCGATCCGAGCAAGCAACGTTCGCTAGCAATATTGGTGCAGATGCAGTGGTCGTAACAGA
AGATGGGTCAGGGCTAGAGGGAGAAGGACCTTATCATCTGGTTGTGGACGGCGTTGGCGGTCAACTATTTAGCTCATTGC
TGAGCGTCACAGCAAAGGGAGGCACTCTAGTATCCTATGGTTCCTCTGAGAGTCATGAATCGACTGTTAATCTCTATCCT
GCGCTTTTTGGTAACGGGGGACAACGTCGAATCTATGGTCTAACGCTCTACAGCGAAATTGAAAAGGAACCCTCGTCTGC
AGCTTTGACGCGGCTTCTGAATCTGGTTGAGCGAGATCTATTGAAATTGCCTGAAACTATAACTTCAGATTGGTCAGAAA
CCCCTCATCTTGCCGAAGACCTATTGGCGCGTAAGTTCACTGGCAAAGCTGTATTAACCCTCTGA

Upstream 100 bases:

>100_bases
GCGGAATTGACTTTTAACTGCACACCGAAAATTAGCAAAAACGTGGTGGCTTTGCCCACATCCAAAATTCATATTCACTT
CAATCAAGCGGAGAAGTCCT

Downstream 100 bases:

>100_bases
ACGACTGACTTTTCCTGTAGGAAATGCAGTAGTTGAAGCATGTCTGATAAGTTGAAATCTTTATTCTCTGGTTGGCTGTC
AAACCTTTGCTTCCGACATA

Product: oxidoreductase, zinc-binding dehydrogenase family protein

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MQRIIMNSDQEGGLSFVETDSLQPLPHQSLIKVTAFSLNRGEINIAQSPTSGGRSIGWDFVGVIENSAADGTGLKKGTRV
VGWRPEMDAFAEYVIGEHQFIAPIPDAVSDVQAATLPVAGLTALAAVDQGNRLVGNSALVTGVTGGVGYFALQLAKLSGA
RTVAQVRRSEQATFASNIGADAVVVTEDGSGLEGEGPYHLVVDGVGGQLFSSLLSVTAKGGTLVSYGSSESHESTVNLYP
ALFGNGGQRRIYGLTLYSEIEKEPSSAALTRLLNLVERDLLKLPETITSDWSETPHLAEDLLARKFTGKAVLTL

Sequences:

>Translated_314_residues
MQRIIMNSDQEGGLSFVETDSLQPLPHQSLIKVTAFSLNRGEINIAQSPTSGGRSIGWDFVGVIENSAADGTGLKKGTRV
VGWRPEMDAFAEYVIGEHQFIAPIPDAVSDVQAATLPVAGLTALAAVDQGNRLVGNSALVTGVTGGVGYFALQLAKLSGA
RTVAQVRRSEQATFASNIGADAVVVTEDGSGLEGEGPYHLVVDGVGGQLFSSLLSVTAKGGTLVSYGSSESHESTVNLYP
ALFGNGGQRRIYGLTLYSEIEKEPSSAALTRLLNLVERDLLKLPETITSDWSETPHLAEDLLARKFTGKAVLTL
>Mature_314_residues
MQRIIMNSDQEGGLSFVETDSLQPLPHQSLIKVTAFSLNRGEINIAQSPTSGGRSIGWDFVGVIENSAADGTGLKKGTRV
VGWRPEMDAFAEYVIGEHQFIAPIPDAVSDVQAATLPVAGLTALAAVDQGNRLVGNSALVTGVTGGVGYFALQLAKLSGA
RTVAQVRRSEQATFASNIGADAVVVTEDGSGLEGEGPYHLVVDGVGGQLFSSLLSVTAKGGTLVSYGSSESHESTVNLYP
ALFGNGGQRRIYGLTLYSEIEKEPSSAALTRLLNLVERDLLKLPETITSDWSETPHLAEDLLARKFTGKAVLTL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=184, Percent_Identity=27.1739130434783, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 33059; Mature: 33059

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRIIMNSDQEGGLSFVETDSLQPLPHQSLIKVTAFSLNRGEINIAQSPTSGGRSIGWDF
CCCEEECCCCCCCEEEEECCCCCCCCCHHHEEEEEEEECCCEEEEECCCCCCCCCCCCEE
VGVIENSAADGTGLKKGTRVVGWRPEMDAFAEYVIGEHQFIAPIPDAVSDVQAATLPVAG
EEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCHHH
LTALAAVDQGNRLVGNSALVTGVTGGVGYFALQLAKLSGARTVAQVRRSEQATFASNIGA
HHHHHHHCCCCEEECCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
DAVVVTEDGSGLEGEGPYHLVVDGVGGQLFSSLLSVTAKGGTLVSYGSSESHESTVNLYP
CEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEH
ALFGNGGQRRIYGLTLYSEIEKEPSSAALTRLLNLVERDLLKLPETITSDWSETPHLAED
HEECCCCCEEEEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHH
LLARKFTGKAVLTL
HHHHHCCCCEEEEC
>Mature Secondary Structure
MQRIIMNSDQEGGLSFVETDSLQPLPHQSLIKVTAFSLNRGEINIAQSPTSGGRSIGWDF
CCCEEECCCCCCCEEEEECCCCCCCCCHHHEEEEEEEECCCEEEEECCCCCCCCCCCCEE
VGVIENSAADGTGLKKGTRVVGWRPEMDAFAEYVIGEHQFIAPIPDAVSDVQAATLPVAG
EEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCHHH
LTALAAVDQGNRLVGNSALVTGVTGGVGYFALQLAKLSGARTVAQVRRSEQATFASNIGA
HHHHHHHCCCCEEECCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
DAVVVTEDGSGLEGEGPYHLVVDGVGGQLFSSLLSVTAKGGTLVSYGSSESHESTVNLYP
CEEEEECCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEH
ALFGNGGQRRIYGLTLYSEIEKEPSSAALTRLLNLVERDLLKLPETITSDWSETPHLAED
HEECCCCCEEEEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHH
LLARKFTGKAVLTL
HHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA