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The map label for this gene is rpfC [H]

Identifier: 158340469

GI number: 158340469

Start: 10624

End: 12657

Strand: Reverse

Name: rpfC [H]

Synonym: AM1_C0014

Alternate gene names: 158340469

Gene position: 12657-10624 (Counterclockwise)

Preceding gene: 158340470

Following gene: 158340466

Centisome position: 4.63

GC content: 44.94

Gene sequence:

>2034_bases
ATGACAGAGAAGTTTGAGGCTGATTCTCTTCAACTTTTACAGACCTGGCAACAAACCATTTTGGATAGTGCCGATTTCAT
TGTCATTTCAACAGATATCAACGGGGTGGTTCAAACCCTAAATGCAGGGGCATTAAAACAATTTGGCTATTCATCTGAAG
AAATCATTGGTAGAGTCACCCCGATCATCTTTCATGACTCAGCAGAAATCGTGCTGCGGGCGCAAGTACTCTCTAAAGAG
TTGGGTCGCGTTATTGAAGCAGACGTGGAGACCCTTATTGTCAAAGCCCGTATGGGGATGGCCGATGAAAATATCTGGAC
CTTAATTCGCAAAGACCACAGTCAGTTTATGGTCTGTCTATCCGTGAAAGCATTGAGGGATGCCTCAGGTCAGTTGAAGG
GGTTTTTAGGAATTGGCAAAGATGTCACTGCTCAACAGGAGACTGAAGCTGCCCTCCGATGCCTCAATGCCAATCTGGAA
CAACTTGTTGAGGAACGGACGAGCCAACTCAACACAGCGATTGAAACGGCTGAAATCGCGAATCAAGCCAAAAGCAAATT
CATCGCCAATATGAGCCATGAATTCCGAACCCCTCTCAACGCCATCATGGGCTTTAGTCAACTCCTGCTCCGAGATCGGC
GCATCACACCAGATCAACAATCAAGGCTCGATGTCATTTATCGCAGTGGTGAGCACTTGCTCTCACTGGTCAACGAAGTC
ATTACCCTCTCCAAAATTGAGGACGGGGTGCTTACGTATGAGCCCAAGGATGTCAATCTCTACCATCTTTGTGAGGGGGT
TAAAGAATTATTTTCATTGCAGGCTAGCTCCAAAGATATACAGCTTCAACTCCGTATCGCCCCTGATGTTCCCCGATTCA
TCAGAACCGATGCTCAAAAACTCAGACAGATTCTCATCAACTTACTAGGTAATGCTCTCAAATATACAAAGCGAGGTAGT
GTTGAGTGCCGCGTTCAATGGCGTCCCCCTCGCACTGAGACTTTACCCCACCACATAGAATTCTCCATCCAAGATACAGG
ACCTGGGATTCCCCAGCATTTGCTCCCTAAACTGTTTGAACACTTTGTCCAAGACCCTTTAACACGCGATAAGTTTGGCG
GCATTGGATTAGGGCTATGCATTTGCCAAAGGTTCGTTCACCTGATGGGGGGAGACATATCCATCGAGAGTACTGAAGAC
CATGGAACGATCGTGGATTTTTATATTCAGGTTGACCTGGGTGAATCCTTTCAAGAACCGATAGTGACCCAAGCCACCGT
CGTTGGGATCGAAGAGCCTCAATCCTCTTTGAGAGTCCTCGTTGTAGAGGATCATCAAGATACTCAGGAAATGCTCGTGA
ATTTATTAGAAACAGTTGGCTTCATCGTGCGCTCTGCACGGGGAGGTCTGCAGGCTATTTCTCTCTGGCAAGAATGGTGC
CCTCATCTCATTCTAATGGACTGGCAAATGCCGGAAATGAATGGATATCAAACAACCCAGAGAATCCGACAACTCGAATC
GGAGAATGATTCGTCTTGTCTTCGAGTATCTGGTGAATATCCCCTTCTTGCAGACAAAGCAGCAGCAGATCCGATTGTCG
TAGAGGGTAGAACTGCCATAATTGCTTTGACTGCAAGTGTATTTGAAGATACAAAAAAAGAGTCGAAAGAATCTGGATGT
GATGGCTTCCTATGCAAACCTTTTCAAGAAAGTCTCCTATTCAAGATCATAGCTGAGCATTTAGAGGTCAAGTACACATA
TCAAAAACCAGATTTTATGAACGGTCATTCAGACCCCGTTAAAGTTTCCAATCCTAGATCATCTAAGGAGTTGTTGGAAG
AGGTGTCCCAATTATCCGAAGATTGGTTACTTTCTTTCGAGCAAGCTGCATTGGAGTTGGATGAAGAAGTACTTCATAAT
ATGTTGTCTGATATATCTAGCCAGCATCCACTCTTAACCGAAGAACTTAATCGGCTCCTTACTAATTTGAGGTTTGATAT
TATCCTAGACTTAGTTCAACAGGCCATAAATTAG

Upstream 100 bases:

>100_bases
TAGAAAACCTAACTTCATTACATTTTGGGAAAGCCTGAAACATAATGGACACACTAAATTCTGCTATAAAAACTCAAACA
AAAAGCAAGGTCGAAATTAT

Downstream 100 bases:

>100_bases
CTTAAAAACGAGTAGCATTTAGACAGAATTACCAGTATTCGAATAATTCTTATACATCGCATTTTTTTAATAGAATTAGG
GATTATAGGCCAAAAATATT

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 677; Mature: 676

Protein sequence:

>677_residues
MTEKFEADSLQLLQTWQQTILDSADFIVISTDINGVVQTLNAGALKQFGYSSEEIIGRVTPIIFHDSAEIVLRAQVLSKE
LGRVIEADVETLIVKARMGMADENIWTLIRKDHSQFMVCLSVKALRDASGQLKGFLGIGKDVTAQQETEAALRCLNANLE
QLVEERTSQLNTAIETAEIANQAKSKFIANMSHEFRTPLNAIMGFSQLLLRDRRITPDQQSRLDVIYRSGEHLLSLVNEV
ITLSKIEDGVLTYEPKDVNLYHLCEGVKELFSLQASSKDIQLQLRIAPDVPRFIRTDAQKLRQILINLLGNALKYTKRGS
VECRVQWRPPRTETLPHHIEFSIQDTGPGIPQHLLPKLFEHFVQDPLTRDKFGGIGLGLCICQRFVHLMGGDISIESTED
HGTIVDFYIQVDLGESFQEPIVTQATVVGIEEPQSSLRVLVVEDHQDTQEMLVNLLETVGFIVRSARGGLQAISLWQEWC
PHLILMDWQMPEMNGYQTTQRIRQLESENDSSCLRVSGEYPLLADKAAADPIVVEGRTAIIALTASVFEDTKKESKESGC
DGFLCKPFQESLLFKIIAEHLEVKYTYQKPDFMNGHSDPVKVSNPRSSKELLEEVSQLSEDWLLSFEQAALELDEEVLHN
MLSDISSQHPLLTEELNRLLTNLRFDIILDLVQQAIN

Sequences:

>Translated_677_residues
MTEKFEADSLQLLQTWQQTILDSADFIVISTDINGVVQTLNAGALKQFGYSSEEIIGRVTPIIFHDSAEIVLRAQVLSKE
LGRVIEADVETLIVKARMGMADENIWTLIRKDHSQFMVCLSVKALRDASGQLKGFLGIGKDVTAQQETEAALRCLNANLE
QLVEERTSQLNTAIETAEIANQAKSKFIANMSHEFRTPLNAIMGFSQLLLRDRRITPDQQSRLDVIYRSGEHLLSLVNEV
ITLSKIEDGVLTYEPKDVNLYHLCEGVKELFSLQASSKDIQLQLRIAPDVPRFIRTDAQKLRQILINLLGNALKYTKRGS
VECRVQWRPPRTETLPHHIEFSIQDTGPGIPQHLLPKLFEHFVQDPLTRDKFGGIGLGLCICQRFVHLMGGDISIESTED
HGTIVDFYIQVDLGESFQEPIVTQATVVGIEEPQSSLRVLVVEDHQDTQEMLVNLLETVGFIVRSARGGLQAISLWQEWC
PHLILMDWQMPEMNGYQTTQRIRQLESENDSSCLRVSGEYPLLADKAAADPIVVEGRTAIIALTASVFEDTKKESKESGC
DGFLCKPFQESLLFKIIAEHLEVKYTYQKPDFMNGHSDPVKVSNPRSSKELLEEVSQLSEDWLLSFEQAALELDEEVLHN
MLSDISSQHPLLTEELNRLLTNLRFDIILDLVQQAIN
>Mature_676_residues
TEKFEADSLQLLQTWQQTILDSADFIVISTDINGVVQTLNAGALKQFGYSSEEIIGRVTPIIFHDSAEIVLRAQVLSKEL
GRVIEADVETLIVKARMGMADENIWTLIRKDHSQFMVCLSVKALRDASGQLKGFLGIGKDVTAQQETEAALRCLNANLEQ
LVEERTSQLNTAIETAEIANQAKSKFIANMSHEFRTPLNAIMGFSQLLLRDRRITPDQQSRLDVIYRSGEHLLSLVNEVI
TLSKIEDGVLTYEPKDVNLYHLCEGVKELFSLQASSKDIQLQLRIAPDVPRFIRTDAQKLRQILINLLGNALKYTKRGSV
ECRVQWRPPRTETLPHHIEFSIQDTGPGIPQHLLPKLFEHFVQDPLTRDKFGGIGLGLCICQRFVHLMGGDISIESTEDH
GTIVDFYIQVDLGESFQEPIVTQATVVGIEEPQSSLRVLVVEDHQDTQEMLVNLLETVGFIVRSARGGLQAISLWQEWCP
HLILMDWQMPEMNGYQTTQRIRQLESENDSSCLRVSGEYPLLADKAAADPIVVEGRTAIIALTASVFEDTKKESKESGCD
GFLCKPFQESLLFKIIAEHLEVKYTYQKPDFMNGHSDPVKVSNPRSSKELLEEVSQLSEDWLLSFEQAALELDEEVLHNM
LSDISSQHPLLTEELNRLLTNLRFDIILDLVQQAIN

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=274, Percent_Identity=38.3211678832117, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI48994928, Length=469, Percent_Identity=28.1449893390192, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI87081816, Length=513, Percent_Identity=29.4346978557505, Blast_Score=169, Evalue=8e-43,
Organism=Escherichia coli, GI1788713, Length=334, Percent_Identity=32.3353293413174, Blast_Score=152, Evalue=9e-38,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=32.7800829875519, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=29.2576419213974, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1788393, Length=227, Percent_Identity=30.3964757709251, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=291, Percent_Identity=29.2096219931272, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1788549, Length=412, Percent_Identity=25.2427184466019, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=25.5144032921811, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=25.974025974026, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790861, Length=252, Percent_Identity=24.6031746031746, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=174, Percent_Identity=36.7816091954023, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323034, Length=143, Percent_Identity=30.0699300699301, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76301; Mature: 76170

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKFEADSLQLLQTWQQTILDSADFIVISTDINGVVQTLNAGALKQFGYSSEEIIGRVT
CCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHC
PIIFHDSAEIVLRAQVLSKELGRVIEADVETLIVKARMGMADENIWTLIRKDHSQFMVCL
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHEEHHH
SVKALRDASGQLKGFLGIGKDVTAQQETEAALRCLNANLEQLVEERTSQLNTAIETAEIA
HHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
NQAKSKFIANMSHEFRTPLNAIMGFSQLLLRDRRITPDQQSRLDVIYRSGEHLLSLVNEV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHH
ITLSKIEDGVLTYEPKDVNLYHLCEGVKELFSLQASSKDIQLQLRIAPDVPRFIRTDAQK
HHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHH
LRQILINLLGNALKYTKRGSVECRVQWRPPRTETLPHHIEFSIQDTGPGIPQHLLPKLFE
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
HFVQDPLTRDKFGGIGLGLCICQRFVHLMGGDISIESTEDHGTIVDFYIQVDLGESFQEP
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEEECCCCCCCC
IVTQATVVGIEEPQSSLRVLVVEDHQDTQEMLVNLLETVGFIVRSARGGLQAISLWQEWC
CHHHHEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
PHLILMDWQMPEMNGYQTTQRIRQLESENDSSCLRVSGEYPLLADKAAADPIVVEGRTAI
CCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCEECCCCCCCEEECCCEEE
IALTASVFEDTKKESKESGCDGFLCKPFQESLLFKIIAEHLEVKYTYQKPDFMNGHSDPV
EEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCC
KVSNPRSSKELLEEVSQLSEDWLLSFEQAALELDEEVLHNMLSDISSQHPLLTEELNRLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
TNLRFDIILDLVQQAIN
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEKFEADSLQLLQTWQQTILDSADFIVISTDINGVVQTLNAGALKQFGYSSEEIIGRVT
CCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHC
PIIFHDSAEIVLRAQVLSKELGRVIEADVETLIVKARMGMADENIWTLIRKDHSQFMVCL
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHEEHHH
SVKALRDASGQLKGFLGIGKDVTAQQETEAALRCLNANLEQLVEERTSQLNTAIETAEIA
HHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
NQAKSKFIANMSHEFRTPLNAIMGFSQLLLRDRRITPDQQSRLDVIYRSGEHLLSLVNEV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHH
ITLSKIEDGVLTYEPKDVNLYHLCEGVKELFSLQASSKDIQLQLRIAPDVPRFIRTDAQK
HHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHH
LRQILINLLGNALKYTKRGSVECRVQWRPPRTETLPHHIEFSIQDTGPGIPQHLLPKLFE
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
HFVQDPLTRDKFGGIGLGLCICQRFVHLMGGDISIESTEDHGTIVDFYIQVDLGESFQEP
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEEECCCCCCCC
IVTQATVVGIEEPQSSLRVLVVEDHQDTQEMLVNLLETVGFIVRSARGGLQAISLWQEWC
CHHHHEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
PHLILMDWQMPEMNGYQTTQRIRQLESENDSSCLRVSGEYPLLADKAAADPIVVEGRTAI
CCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCCEECCCCCCCEEECCCEEE
IALTASVFEDTKKESKESGCDGFLCKPFQESLLFKIIAEHLEVKYTYQKPDFMNGHSDPV
EEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCC
KVSNPRSSKELLEEVSQLSEDWLLSFEQAALELDEEVLHNMLSDISSQHPLLTEELNRLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
TNLRFDIILDLVQQAIN
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]