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The map label for this gene is cya [H]

Identifier: 158340439

GI number: 158340439

Start: 254196

End: 257027

Strand: Direct

Name: cya [H]

Synonym: AM1_C0367

Alternate gene names: 158340439

Gene position: 254196-257027 (Clockwise)

Preceding gene: 158340438

Following gene: 158340446

Centisome position: 93.07

GC content: 44.35

Gene sequence:

>2832_bases
ATGACTATTGAAGCAAGATATGACATCGACCCCGACCTAACTGGAATCTCTCGTATTACTGATGATTCTCCCATTCAGTT
CCTATCGAATCGCCTCGATCATTGGAAGGGATTGAAACATTATCGATTTGACTTAACCGTTCGCAATTCTTACCAGTTTG
CTACTGCACCTAATCATGATGGCAAGCACGGTGGTTCGCTAGAACTCACCAGATTTAATAAGAAGTGGACTAATCAGAAA
CAGGACTACTATCAGTATAAAACCCTCTTTGGTACTGATTCAAGAGACGTTATTTACGAAACCCAAGACTATAGATACTT
GGGGGGTTGGGGTGAATACCTTGACGAAACATTGAAACCTGTTTCACAAAACATATACGGTGGTGGCGGTAATGACACCA
TTATTGCTCATGATTTGCAAGGTTATAGCGACAGCGTAAAGAGTTATTTAAACGGTGATCCAAGTAGTATTAATCAATTT
CATGGTGAAGCTGGAAATGACATTTTGAAAGGTAACGCGTTCCAGAACCTCCTGTATGGAGGGACTGGCAACGATACGCT
AGATGGTGGCGGAGGCGATGATTTTCTCTCAGGCAATGAAGATAATGACAAACTATGGGGTGGAGATGGAGAAGATCAAC
TCTTTGGCGGAATAGGAAATGACATTCTGGTTGGTGGAGACGGATACGATGAAATAGACGCTGGTGATGGTGATGACACG
ATTTTTCTGGATGTTCCAATTGAGGGTAACAATAAGGGTGACTATGTAATTGGTGGAACAGGTGCTGACACCTTCGTCAT
TGGTGGCACGACAATGACTACTACTACTACCACCACCACCACACCCTATGACTGGAAGGGGACAGGTTTAGGTGCCACTA
CTGATGTAATGGGTGCTGTCATTGATGGTACTGGTTTAGGTGTCGCCTCGAAAGTTACCAAAGGTGTTGTTGGTGCTGTT
ATTGATATTTTTAAGGGTGCTGAAAGCAAAAATGTTGAAACAACCACAGTGGAATCAGTACCTGGCAACATAGCAACAGG
AAATTATATCCAAATCACTGATTTTAATCCTAGAGAAGATGTCATTGTTATTCCTATAAGTGCTGAACTGTCTAATGTTG
GGCGTACTATCACAGATGATAATTTGCGTACGCTAGAACTCTACTACAAAGACAGCGGGCGAGTTTTTGCCGAAATCAAG
CTTGAAGAACTCTATAAACTTTACAACAACGACGAAGTTGCTCTGAATATCAACAACCGTGATGAGTTGGAGAGCGTTTG
GGAATCTGTTCTAGACAGCTCACTCTATCTTGGTACATATGATGCCAATGACTCTAGTCCCACCATTAAGTTAGGTACAA
CAACAGAAAACTTTAAAAATGCTGATGGCAGTCTTACCGAAATCAAAACCACTGTATCTGAGCTAGATGCTAACTACATG
GTTATTGGCGCTTATGCAGGAGCTAATATTCTTACTTCAGGTAAGGACGATGATCTCTGGGGAACTGACTATAATGACGT
TCTCGTAGCCTATCCCACAGCTTCCAATAAAGAACCTCAGCATAATGAGATCAATAAGCTATACGGTTTCAACGGGGATG
ACATTTTAGCTGGTGGTGCTGGTGCCGATTATTACTTTGGTGGTGACGGTACTGATATTGTGTCTTATGCTGACGATAGA
TTTGACGATAACGATTCTAATGGCATCACAGTTAATCTTGCAGACTCGCTTGAAGGAAATAAAGAAGACTATGCCTACTT
AGACCCTGAAAGTGAAAAAGCAATTTTTTCTTGGGCTTGGGATGTTTATGCAGATCCTCTGGACCCAGATCAGGCTGACA
AGCTATTCAGTATTGAGGGCATTATTGGTTCCAAATGGGATGACAGTATTAAAGGAGATAAGTGGAACAACATATTCAAT
GGTGGTGACGGAAATGACACCCTAGAGGGTGGCGCCGGAAATGATACTCTCATTGGTGGTGAGGGTGAGGATACCCTAGA
GGGTGGCGGCGGAAATGATACCCTCATTGGTGGTGCTGGTAGCGATACTCTAATCGGCGATGTTGTTGCTGGTAACGATA
CTCTAATCGTCGATGCTGGTGCAGATACTTTTGTGTTAGATACCACTGAAGGTGGCATCGACACGATCAGAGGCTTTAGC
CTTGCAGAAAATGATGTGCTCTTGATTGACAATAAGAGCCTAGGTACTAGTCATGCGAAAGCCCGGAACTTGAATGGAAT
GCTCTCCGCTACGGGCCTTAAGCTTCAGTTAGGCAACGTAGGAATTGCGACTATCGAAAACGTCGATAGCTCTAACGTTC
ATCGAGTGCTGGGTCGTGTCGAATTCACCACTAGCTCACACATCAACACACCACTTGGCCTCGGCGATGATTTGCTGGCA
ACAGGTGACGGCAATGATAGGCTCACGGGAGGATCGGGTGACGACCTTCTCAGTGGTGGTGCTGGAAATGACACTCTGCT
AGGCGGCACGCACAAAGACCTTTTACTGGGTGGTCGTGGGGATGATTTACTCGACGGGGGAAAGGGCATTGACCGTCTCT
ATGGCGGCAGTGGTGCGGACACCTTCGTCATCAACAACACGGTATCAGGCCTCAACAAGAGATCAGGCATCGATGTTATC
CAAGACTTCAGTGTGGATGAATTCGATCACATTCAGATTGATGCTTCTGTCTTCGGTATCGGGATTAACGATCACCATTT
AGTTCAGCTTGGCAATGACAGTTTCTTACGAGTGAACAACAGAAAAATTGCACAGCTTACCGGTGTGGATGTGAATACTT
TCGTCACCGACGAACATGTTAACTTGGTCTAA

Upstream 100 bases:

>100_bases
AATCCCACAGCCAGTCTCAACAAATCTGAGGTGCCGATCTAAATACTGGTTGGTATCAAGAGCAAGAAGCTCAACTTACC
CACAAAAAGGAGCAAGGACA

Downstream 100 bases:

>100_bases
TCCCAAGGGGGTGGGTGTTGACCACCGCATTGGAAACGCAATAAACCAGGCAGTACCCACTAATTACTTGAATGTTCATT
CCCTAGCAATGACTGTATAA

Product: hemolysin-type calcium-binding region protein

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 943; Mature: 942

Protein sequence:

>943_residues
MTIEARYDIDPDLTGISRITDDSPIQFLSNRLDHWKGLKHYRFDLTVRNSYQFATAPNHDGKHGGSLELTRFNKKWTNQK
QDYYQYKTLFGTDSRDVIYETQDYRYLGGWGEYLDETLKPVSQNIYGGGGNDTIIAHDLQGYSDSVKSYLNGDPSSINQF
HGEAGNDILKGNAFQNLLYGGTGNDTLDGGGGDDFLSGNEDNDKLWGGDGEDQLFGGIGNDILVGGDGYDEIDAGDGDDT
IFLDVPIEGNNKGDYVIGGTGADTFVIGGTTMTTTTTTTTTPYDWKGTGLGATTDVMGAVIDGTGLGVASKVTKGVVGAV
IDIFKGAESKNVETTTVESVPGNIATGNYIQITDFNPREDVIVIPISAELSNVGRTITDDNLRTLELYYKDSGRVFAEIK
LEELYKLYNNDEVALNINNRDELESVWESVLDSSLYLGTYDANDSSPTIKLGTTTENFKNADGSLTEIKTTVSELDANYM
VIGAYAGANILTSGKDDDLWGTDYNDVLVAYPTASNKEPQHNEINKLYGFNGDDILAGGAGADYYFGGDGTDIVSYADDR
FDDNDSNGITVNLADSLEGNKEDYAYLDPESEKAIFSWAWDVYADPLDPDQADKLFSIEGIIGSKWDDSIKGDKWNNIFN
GGDGNDTLEGGAGNDTLIGGEGEDTLEGGGGNDTLIGGAGSDTLIGDVVAGNDTLIVDAGADTFVLDTTEGGIDTIRGFS
LAENDVLLIDNKSLGTSHAKARNLNGMLSATGLKLQLGNVGIATIENVDSSNVHRVLGRVEFTTSSHINTPLGLGDDLLA
TGDGNDRLTGGSGDDLLSGGAGNDTLLGGTHKDLLLGGRGDDLLDGGKGIDRLYGGSGADTFVINNTVSGLNKRSGIDVI
QDFSVDEFDHIQIDASVFGIGINDHHLVQLGNDSFLRVNNRKIAQLTGVDVNTFVTDEHVNLV

Sequences:

>Translated_943_residues
MTIEARYDIDPDLTGISRITDDSPIQFLSNRLDHWKGLKHYRFDLTVRNSYQFATAPNHDGKHGGSLELTRFNKKWTNQK
QDYYQYKTLFGTDSRDVIYETQDYRYLGGWGEYLDETLKPVSQNIYGGGGNDTIIAHDLQGYSDSVKSYLNGDPSSINQF
HGEAGNDILKGNAFQNLLYGGTGNDTLDGGGGDDFLSGNEDNDKLWGGDGEDQLFGGIGNDILVGGDGYDEIDAGDGDDT
IFLDVPIEGNNKGDYVIGGTGADTFVIGGTTMTTTTTTTTTPYDWKGTGLGATTDVMGAVIDGTGLGVASKVTKGVVGAV
IDIFKGAESKNVETTTVESVPGNIATGNYIQITDFNPREDVIVIPISAELSNVGRTITDDNLRTLELYYKDSGRVFAEIK
LEELYKLYNNDEVALNINNRDELESVWESVLDSSLYLGTYDANDSSPTIKLGTTTENFKNADGSLTEIKTTVSELDANYM
VIGAYAGANILTSGKDDDLWGTDYNDVLVAYPTASNKEPQHNEINKLYGFNGDDILAGGAGADYYFGGDGTDIVSYADDR
FDDNDSNGITVNLADSLEGNKEDYAYLDPESEKAIFSWAWDVYADPLDPDQADKLFSIEGIIGSKWDDSIKGDKWNNIFN
GGDGNDTLEGGAGNDTLIGGEGEDTLEGGGGNDTLIGGAGSDTLIGDVVAGNDTLIVDAGADTFVLDTTEGGIDTIRGFS
LAENDVLLIDNKSLGTSHAKARNLNGMLSATGLKLQLGNVGIATIENVDSSNVHRVLGRVEFTTSSHINTPLGLGDDLLA
TGDGNDRLTGGSGDDLLSGGAGNDTLLGGTHKDLLLGGRGDDLLDGGKGIDRLYGGSGADTFVINNTVSGLNKRSGIDVI
QDFSVDEFDHIQIDASVFGIGINDHHLVQLGNDSFLRVNNRKIAQLTGVDVNTFVTDEHVNLV
>Mature_942_residues
TIEARYDIDPDLTGISRITDDSPIQFLSNRLDHWKGLKHYRFDLTVRNSYQFATAPNHDGKHGGSLELTRFNKKWTNQKQ
DYYQYKTLFGTDSRDVIYETQDYRYLGGWGEYLDETLKPVSQNIYGGGGNDTIIAHDLQGYSDSVKSYLNGDPSSINQFH
GEAGNDILKGNAFQNLLYGGTGNDTLDGGGGDDFLSGNEDNDKLWGGDGEDQLFGGIGNDILVGGDGYDEIDAGDGDDTI
FLDVPIEGNNKGDYVIGGTGADTFVIGGTTMTTTTTTTTTPYDWKGTGLGATTDVMGAVIDGTGLGVASKVTKGVVGAVI
DIFKGAESKNVETTTVESVPGNIATGNYIQITDFNPREDVIVIPISAELSNVGRTITDDNLRTLELYYKDSGRVFAEIKL
EELYKLYNNDEVALNINNRDELESVWESVLDSSLYLGTYDANDSSPTIKLGTTTENFKNADGSLTEIKTTVSELDANYMV
IGAYAGANILTSGKDDDLWGTDYNDVLVAYPTASNKEPQHNEINKLYGFNGDDILAGGAGADYYFGGDGTDIVSYADDRF
DDNDSNGITVNLADSLEGNKEDYAYLDPESEKAIFSWAWDVYADPLDPDQADKLFSIEGIIGSKWDDSIKGDKWNNIFNG
GDGNDTLEGGAGNDTLIGGEGEDTLEGGGGNDTLIGGAGSDTLIGDVVAGNDTLIVDAGADTFVLDTTEGGIDTIRGFSL
AENDVLLIDNKSLGTSHAKARNLNGMLSATGLKLQLGNVGIATIENVDSSNVHRVLGRVEFTTSSHINTPLGLGDDLLAT
GDGNDRLTGGSGDDLLSGGAGNDTLLGGTHKDLLLGGRGDDLLDGGKGIDRLYGGSGADTFVINNTVSGLNKRSGIDVIQ
DFSVDEFDHIQIDASVFGIGINDHHLVQLGNDSFLRVNNRKIAQLTGVDVNTFVTDEHVNLV

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 100721; Mature: 100590

Theoretical pI: Translated: 3.95; Mature: 3.95

Prosite motif: PS00583 PFKB_KINASES_1 ; PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEARYDIDPDLTGISRITDDSPIQFLSNRLDHWKGLKHYRFDLTVRNSYQFATAPNHD
CEEEEECCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCEEEEECCCCC
GKHGGSLELTRFNKKWTNQKQDYYQYKTLFGTDSRDVIYETQDYRYLGGWGEYLDETLKP
CCCCCEEEEEECCCHHCCCCHHHEEEEEEECCCCCCEEEECCCCEEECCHHHHHHHHHHH
VSQNIYGGGGNDTIIAHDLQGYSDSVKSYLNGDPSSINQFHGEAGNDILKGNAFQNLLYG
HHHHCCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHCCCCCCCEECCCCHHHHEEC
GTGNDTLDGGGGDDFLSGNEDNDKLWGGDGEDQLFGGIGNDILVGGDGYDEIDAGDGDDT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCEEECCCCCCCCCCCCCCCE
IFLDVPIEGNNKGDYVIGGTGADTFVIGGTTMTTTTTTTTTPYDWKGTGLGATTDVMGAV
EEEEEEECCCCCCCEEEECCCCCEEEECCEEEEEEEEECCCCCCCCCCCCCCHHHHHHEE
IDGTGLGVASKVTKGVVGAVIDIFKGAESKNVETTTVESVPGNIATGNYIQITDFNPRED
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCC
VIVIPISAELSNVGRTITDDNLRTLELYYKDSGRVFAEIKLEELYKLYNNDEVALNINNR
EEEEEECHHHHHCCCEEECCCCEEEEEEEECCCCEEEEEEHHHHHHHHCCCEEEEEECCH
DELESVWESVLDSSLYLGTYDANDSSPTIKLGTTTENFKNADGSLTEIKTTVSELDANYM
HHHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEE
VIGAYAGANILTSGKDDDLWGTDYNDVLVAYPTASNKEPQHNEINKLYGFNGDDILAGGA
EEEEECCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCEEEECCC
GADYYFGGDGTDIVSYADDRFDDNDSNGITVNLADSLEGNKEDYAYLDPESEKAIFSWAW
CCCEEECCCCCEEEEECCCCCCCCCCCCEEEEEHHCCCCCCCCEEEECCCCCCEEEEEEE
DVYADPLDPDQADKLFSIEGIIGSKWDDSIKGDKWNNIFNGGDGNDTLEGGAGNDTLIGG
EHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECC
EGEDTLEGGGGNDTLIGGAGSDTLIGDVVAGNDTLIVDAGADTFVLDTTEGGIDTIRGFS
CCCCCCCCCCCCCEEEECCCCCCEEEEEEECCCEEEEECCCCEEEEECCCCCHHHHCCCE
LAENDVLLIDNKSLGTSHAKARNLNGMLSATGLKLQLGNVGIATIENVDSSNVHRVLGRV
ECCCCEEEEECCCCCCCHHHHCCCCCEEEECCEEEEECCCCEEEEECCCCCCHHHHHHEE
EFTTSSHINTPLGLGDDLLATGDGNDRLTGGSGDDLLSGGAGNDTLLGGTHKDLLLGGRG
EEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEECCC
DDLLDGGKGIDRLYGGSGADTFVINNTVSGLNKRSGIDVIQDFSVDEFDHIQIDASVFGI
CCCCCCCCCHHHHCCCCCCCEEEEECCHHCCCCCCCCCCEECCCCCCCCEEEEEEEEEEE
GINDHHLVQLGNDSFLRVNNRKIAQLTGVDVNTFVTDEHVNLV
CCCCCEEEEECCCCEEEECCCEEEEEECCCEEEEEECCCEECC
>Mature Secondary Structure 
TIEARYDIDPDLTGISRITDDSPIQFLSNRLDHWKGLKHYRFDLTVRNSYQFATAPNHD
EEEEECCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCEEEEECCCCC
GKHGGSLELTRFNKKWTNQKQDYYQYKTLFGTDSRDVIYETQDYRYLGGWGEYLDETLKP
CCCCCEEEEEECCCHHCCCCHHHEEEEEEECCCCCCEEEECCCCEEECCHHHHHHHHHHH
VSQNIYGGGGNDTIIAHDLQGYSDSVKSYLNGDPSSINQFHGEAGNDILKGNAFQNLLYG
HHHHCCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHCCCCCCCEECCCCHHHHEEC
GTGNDTLDGGGGDDFLSGNEDNDKLWGGDGEDQLFGGIGNDILVGGDGYDEIDAGDGDDT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCEEECCCCCCCCCCCCCCCE
IFLDVPIEGNNKGDYVIGGTGADTFVIGGTTMTTTTTTTTTPYDWKGTGLGATTDVMGAV
EEEEEEECCCCCCCEEEECCCCCEEEECCEEEEEEEEECCCCCCCCCCCCCCHHHHHHEE
IDGTGLGVASKVTKGVVGAVIDIFKGAESKNVETTTVESVPGNIATGNYIQITDFNPRED
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCC
VIVIPISAELSNVGRTITDDNLRTLELYYKDSGRVFAEIKLEELYKLYNNDEVALNINNR
EEEEEECHHHHHCCCEEECCCCEEEEEEEECCCCEEEEEEHHHHHHHHCCCEEEEEECCH
DELESVWESVLDSSLYLGTYDANDSSPTIKLGTTTENFKNADGSLTEIKTTVSELDANYM
HHHHHHHHHHHCCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEE
VIGAYAGANILTSGKDDDLWGTDYNDVLVAYPTASNKEPQHNEINKLYGFNGDDILAGGA
EEEEECCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCEEEECCC
GADYYFGGDGTDIVSYADDRFDDNDSNGITVNLADSLEGNKEDYAYLDPESEKAIFSWAW
CCCEEECCCCCEEEEECCCCCCCCCCCCEEEEEHHCCCCCCCCEEEECCCCCCEEEEEEE
DVYADPLDPDQADKLFSIEGIIGSKWDDSIKGDKWNNIFNGGDGNDTLEGGAGNDTLIGG
EHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECC
EGEDTLEGGGGNDTLIGGAGSDTLIGDVVAGNDTLIVDAGADTFVLDTTEGGIDTIRGFS
CCCCCCCCCCCCCEEEECCCCCCEEEEEEECCCEEEEECCCCEEEEECCCCCHHHHCCCE
LAENDVLLIDNKSLGTSHAKARNLNGMLSATGLKLQLGNVGIATIENVDSSNVHRVLGRV
ECCCCEEEEECCCCCCCHHHHCCCCCEEEECCEEEEECCCCEEEEECCCCCCHHHHHHEE
EFTTSSHINTPLGLGDDLLATGDGNDRLTGGSGDDLLSGGAGNDTLLGGTHKDLLLGGRG
EEECCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHCCCCCCCCCEECCCCCEEEEECCC
DDLLDGGKGIDRLYGGSGADTFVINNTVSGLNKRSGIDVIQDFSVDEFDHIQIDASVFGI
CCCCCCCCCHHHHCCCCCCCEEEEECCHHCCCCCCCCCCEECCCCCCCCEEEEEEEEEEE
GINDHHLVQLGNDSFLRVNNRKIAQLTGVDVNTFVTDEHVNLV
CCCCCEEEEECCCCEEEECCCEEEEEECCCEEEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]