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The map label for this gene is hup [H]

Identifier: 158340410

GI number: 158340410

Start: 234682

End: 234957

Strand: Direct

Name: hup [H]

Synonym: AM1_C0338

Alternate gene names: 158340410

Gene position: 234682-234957 (Clockwise)

Preceding gene: 158340409

Following gene: 158340411

Centisome position: 85.93

GC content: 51.09

Gene sequence:

>276_bases
ATGAACAAAGGCGAGTTAGTAGACGAGATTGCTGATAACGCTGGGGTCACAAAGAAGCAGGCCGACACTATCCTCACAGC
ACTAACAGAAACCATCATGGAGACCGTTAGCTCTGGCGATAAGGACTCTCTAGTGGGCTTTGGCAGCTTTGAGGCTAGGG
ACCGCAAAGCTAGAGATGGACGCAATCCAAGGACGGGAAAGAAGCTTAAAATCCCGGCGACCAAAGCACCCGTTTTCAGT
GCGGGCAAGGTCTTCAAGGAAAAGGTTAAGGGCTGA

Upstream 100 bases:

>100_bases
TTCCCGACATCCGCCTATGACCCATTGATATTGCCCTGATTCCCAAATAAATCCTCCAACCCCTGCTATACAATGCTCAT
AAGCACTTTGAGGCAAGACC

Downstream 100 bases:

>100_bases
TAGACTAAGAATATCGCTAAAGACTTAACCTCATTCCAACACCCAAGCTGGCGGATGCTCTGGTGATTCTGCCAGCTTCC
TTATGCTGACATCTTTTTCC

Product: DNA-binding protein HU

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 91; Mature: 91

Protein sequence:

>91_residues
MNKGELVDEIADNAGVTKKQADTILTALTETIMETVSSGDKDSLVGFGSFEARDRKARDGRNPRTGKKLKIPATKAPVFS
AGKVFKEKVKG

Sequences:

>Translated_91_residues
MNKGELVDEIADNAGVTKKQADTILTALTETIMETVSSGDKDSLVGFGSFEARDRKARDGRNPRTGKKLKIPATKAPVFS
AGKVFKEKVKG
>Mature_91_residues
MNKGELVDEIADNAGVTKKQADTILTALTETIMETVSSGDKDSLVGFGSFEARDRKARDGRNPRTGKKLKIPATKAPVFS
AGKVFKEKVKG

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. It is essential for heterocyst differentiation [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1786644, Length=89, Percent_Identity=46.0674157303371, Blast_Score=86, Evalue=6e-19,
Organism=Escherichia coli, GI1790433, Length=90, Percent_Identity=45.5555555555556, Blast_Score=83, Evalue=3e-18,
Organism=Escherichia coli, GI1788005, Length=90, Percent_Identity=32.2222222222222, Blast_Score=62, Evalue=6e-12,

Paralogues:

None

Copy number: 860 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). 2040 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 9768; Mature: 9768

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKGELVDEIADNAGVTKKQADTILTALTETIMETVSSGDKDSLVGFGSFEARDRKARDG
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHCCC
RNPRTGKKLKIPATKAPVFSAGKVFKEKVKG
CCCCCCCEEECCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNKGELVDEIADNAGVTKKQADTILTALTETIMETVSSGDKDSLVGFGSFEARDRKARDG
CCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCHHCCC
RNPRTGKKLKIPATKAPVFSAGKVFKEKVKG
CCCCCCCEEECCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655556; 7748931; 11759840 [H]