| Definition | Acidiphilium cryptum JF-5 plasmid pACRY01, complete sequence. |
|---|---|
| Accession | NC_009467 |
| Length | 203,589 |
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The map label for this gene is gdh [H]
Identifier: 148243665
GI number: 148243665
Start: 33803
End: 34612
Strand: Reverse
Name: gdh [H]
Synonym: Acry_3136
Alternate gene names: 148243665
Gene position: 34612-33803 (Counterclockwise)
Preceding gene: 148243667
Following gene: 148243664
Centisome position: 17.0
GC content: 59.88
Gene sequence:
>810_bases ATGTCCGATCGCAAGCTCTTGGCCAAACAGAAGGCGCTCGTTACCGGGGCCAACTCCGGCATCGGCGAGGGCGTCGCAAT TGCTCTCGGCCAGGCGGGCGCCGATGTAGTGGTGAATTATGTCGAGGGCGACGCCGCCGCGAACGCTGTGGTTGACAAGA TCAAGCAGTTCGGCGGCAACGCTATCACACACAAGGCCGATGTTTCGCATGAAGATGAGGTCGGCGACATGTTCGACCGA GCCGTACGCGAATTTGGCACGATCGACATCCTCGTCAACAATGCCGGTATGCAACGCGACTCTGCATTTTCTGACATGAC CCTGGAAAAGTGGAACAAAGTCCTTGGCGTCAATTTGACCGGCCAGTTTCTCTGCGCGCGGGCGGCCATACGCGAGTTCC TGCGCCGCGGCGTGGTCCCATCCGTGTCGCGCGCAGCCGGTAAGATCATTTGCATGAGTTCGGTGCACCAAGTGATCCCG TGGGCAGGTCACGCGAATTACGCCACCTCGAAGGGCGGCATCAAATTGATGATGGAGAGCATGGCGCAGGAGCTTGCCCC CAAGCGCATCCGCGTCAACGGCATCGCACCAGGCGCGATACAGACGCCAATCAATACCTCCGCCTGGGACACGCCGGAGG CCCTCAAGAGTCTGCTGACGCTAATTCCCTATGGAAGGATCGGACTGCCCGAAGATATCGCACGCGCCGCCGTTTGGCTG GCGTCTGACGATTCCGACTACGTCGTAGGCACCACACTCTTCGTTGACGGGGGCATGACGCTTTACCCCGGCTTCTCGAC CAACGGTTGA
Upstream 100 bases:
>100_bases AGTCCGGCAAGCACCGGACCGTCAAACTTGTCTCTTCAAGAGGTCGCCACCCTCTCGCAAGGGTTGCCCGACCTTTTGCG GTATTTGTGAAAGAACCCCC
Downstream 100 bases:
>100_bases AGACGATGACGCAGCATTACGACGTCATCATCATCGGAAGCGGCCCTGGTGGCGCATCTGTCGCGTATCGCCTCGCGCCA ACCGGCAAACGCATCTTGCT
Product: short-chain dehydrogenase/reductase SDR
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 269; Mature: 268
Protein sequence:
>269_residues MSDRKLLAKQKALVTGANSGIGEGVAIALGQAGADVVVNYVEGDAAANAVVDKIKQFGGNAITHKADVSHEDEVGDMFDR AVREFGTIDILVNNAGMQRDSAFSDMTLEKWNKVLGVNLTGQFLCARAAIREFLRRGVVPSVSRAAGKIICMSSVHQVIP WAGHANYATSKGGIKLMMESMAQELAPKRIRVNGIAPGAIQTPINTSAWDTPEALKSLLTLIPYGRIGLPEDIARAAVWL ASDDSDYVVGTTLFVDGGMTLYPGFSTNG
Sequences:
>Translated_269_residues MSDRKLLAKQKALVTGANSGIGEGVAIALGQAGADVVVNYVEGDAAANAVVDKIKQFGGNAITHKADVSHEDEVGDMFDR AVREFGTIDILVNNAGMQRDSAFSDMTLEKWNKVLGVNLTGQFLCARAAIREFLRRGVVPSVSRAAGKIICMSSVHQVIP WAGHANYATSKGGIKLMMESMAQELAPKRIRVNGIAPGAIQTPINTSAWDTPEALKSLLTLIPYGRIGLPEDIARAAVWL ASDDSDYVVGTTLFVDGGMTLYPGFSTNG >Mature_268_residues SDRKLLAKQKALVTGANSGIGEGVAIALGQAGADVVVNYVEGDAAANAVVDKIKQFGGNAITHKADVSHEDEVGDMFDRA VREFGTIDILVNNAGMQRDSAFSDMTLEKWNKVLGVNLTGQFLCARAAIREFLRRGVVPSVSRAAGKIICMSSVHQVIPW AGHANYATSKGGIKLMMESMAQELAPKRIRVNGIAPGAIQTPINTSAWDTPEALKSLLTLIPYGRIGLPEDIARAAVWLA SDDSDYVVGTTLFVDGGMTLYPGFSTNG
Specific function: Catalyzes A Reversible Reduction Of 5-Ketoglutanate To Form D-Gluconate. Dependent On Nadp, Almost Inactive With NAD. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=265, Percent_Identity=33.9622641509434, Blast_Score=125, Evalue=6e-29, Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=34.2412451361868, Blast_Score=122, Evalue=4e-28, Organism=Homo sapiens, GI7705925, Length=257, Percent_Identity=30.7392996108949, Blast_Score=112, Evalue=5e-25, Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=31.6, Blast_Score=108, Evalue=7e-24, Organism=Homo sapiens, GI19923817, Length=267, Percent_Identity=29.2134831460674, Blast_Score=102, Evalue=2e-22, Organism=Homo sapiens, GI4504505, Length=243, Percent_Identity=33.3333333333333, Blast_Score=101, Evalue=6e-22, Organism=Homo sapiens, GI126723750, Length=265, Percent_Identity=30.188679245283, Blast_Score=99, Evalue=5e-21, Organism=Homo sapiens, GI59889578, Length=235, Percent_Identity=28.5106382978723, Blast_Score=95, Evalue=6e-20, Organism=Homo sapiens, GI109715829, Length=245, Percent_Identity=29.3877551020408, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI4758504, Length=261, Percent_Identity=32.5670498084291, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI5031737, Length=264, Percent_Identity=30.3030303030303, Blast_Score=88, Evalue=7e-18, Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=27.734375, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI66933014, Length=204, Percent_Identity=28.4313725490196, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI126723191, Length=202, Percent_Identity=32.1782178217822, Blast_Score=77, Evalue=1e-14, Organism=Homo sapiens, GI83715985, Length=261, Percent_Identity=30.2681992337165, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI209862901, Length=203, Percent_Identity=29.064039408867, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI19923983, Length=203, Percent_Identity=29.064039408867, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI40254986, Length=212, Percent_Identity=27.3584905660377, Blast_Score=75, Evalue=9e-14, Organism=Homo sapiens, GI33667109, Length=206, Percent_Identity=31.0679611650485, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI31542939, Length=249, Percent_Identity=31.3253012048193, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI4503817, Length=199, Percent_Identity=26.6331658291457, Blast_Score=68, Evalue=1e-11, Organism=Homo sapiens, GI20149619, Length=202, Percent_Identity=26.2376237623762, Blast_Score=67, Evalue=1e-11, Organism=Escherichia coli, GI1790717, Length=260, Percent_Identity=38.0769230769231, Blast_Score=159, Evalue=3e-40, Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=32.5581395348837, Blast_Score=145, Evalue=3e-36, Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=35.2, Blast_Score=140, Evalue=6e-35, Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=37.007874015748, Blast_Score=140, Evalue=7e-35, Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=37.2, Blast_Score=140, Evalue=9e-35, Organism=Escherichia coli, GI1787905, Length=261, Percent_Identity=37.1647509578544, Blast_Score=134, Evalue=7e-33, Organism=Escherichia coli, GI87082100, Length=262, Percent_Identity=33.969465648855, Blast_Score=123, Evalue=1e-29, Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=31.6205533596838, Blast_Score=117, Evalue=1e-27, Organism=Escherichia coli, GI1789378, Length=257, Percent_Identity=31.9066147859922, Blast_Score=109, Evalue=2e-25, Organism=Escherichia coli, GI1786812, Length=256, Percent_Identity=28.90625, Blast_Score=96, Evalue=3e-21, Organism=Escherichia coli, GI2367365, Length=249, Percent_Identity=26.5060240963855, Blast_Score=82, Evalue=5e-17, Organism=Escherichia coli, GI1789057, Length=265, Percent_Identity=27.5471698113208, Blast_Score=79, Evalue=3e-16, Organism=Escherichia coli, GI1787526, Length=273, Percent_Identity=28.2051282051282, Blast_Score=68, Evalue=6e-13, Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=37.7431906614786, Blast_Score=136, Evalue=1e-32, Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=34.6303501945525, Blast_Score=130, Evalue=7e-31, Organism=Caenorhabditis elegans, GI115534694, Length=251, Percent_Identity=30.2788844621514, Blast_Score=121, Evalue=3e-28, Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=28.3464566929134, Blast_Score=106, Evalue=1e-23, Organism=Caenorhabditis elegans, GI17560676, Length=259, Percent_Identity=30.1158301158301, Blast_Score=104, Evalue=4e-23, Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=31.6602316602317, Blast_Score=103, Evalue=7e-23, Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=28.3464566929134, Blast_Score=101, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17562910, Length=275, Percent_Identity=29.0909090909091, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17551412, Length=279, Percent_Identity=30.1075268817204, Blast_Score=98, Evalue=5e-21, Organism=Caenorhabditis elegans, GI17562904, Length=278, Percent_Identity=29.4964028776978, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17568967, Length=196, Percent_Identity=34.1836734693878, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17560150, Length=280, Percent_Identity=27.8571428571429, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17560332, Length=278, Percent_Identity=28.4172661870504, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17559104, Length=284, Percent_Identity=27.4647887323944, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17538182, Length=260, Percent_Identity=32.6923076923077, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17538480, Length=277, Percent_Identity=28.5198555956679, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17562906, Length=278, Percent_Identity=26.978417266187, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17544670, Length=268, Percent_Identity=26.4925373134328, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI17562990, Length=276, Percent_Identity=28.2608695652174, Blast_Score=84, Evalue=8e-17, Organism=Caenorhabditis elegans, GI72000259, Length=272, Percent_Identity=26.8382352941176, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI193204405, Length=276, Percent_Identity=26.0869565217391, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17563726, Length=274, Percent_Identity=27.3722627737226, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17536025, Length=266, Percent_Identity=26.3157894736842, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17560220, Length=273, Percent_Identity=27.4725274725275, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI17565030, Length=271, Percent_Identity=29.1512915129151, Blast_Score=81, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17536651, Length=267, Percent_Identity=26.2172284644195, Blast_Score=80, Evalue=8e-16, Organism=Caenorhabditis elegans, GI17562908, Length=280, Percent_Identity=25.3571428571429, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17531453, Length=278, Percent_Identity=27.6978417266187, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI71997099, Length=216, Percent_Identity=30.0925925925926, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17538486, Length=271, Percent_Identity=28.4132841328413, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI71982365, Length=191, Percent_Identity=27.2251308900524, Blast_Score=77, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17555612, Length=217, Percent_Identity=29.9539170506912, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17508651, Length=259, Percent_Identity=24.7104247104247, Blast_Score=73, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17564282, Length=204, Percent_Identity=30.3921568627451, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI86565303, Length=226, Percent_Identity=27.8761061946903, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17558628, Length=212, Percent_Identity=27.8301886792453, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17561272, Length=243, Percent_Identity=26.3374485596708, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI32563809, Length=204, Percent_Identity=24.5098039215686, Blast_Score=66, Evalue=2e-11, Organism=Caenorhabditis elegans, GI17507613, Length=204, Percent_Identity=24.5098039215686, Blast_Score=66, Evalue=2e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=195, Percent_Identity=36.9230769230769, Blast_Score=104, Evalue=1e-23, Organism=Saccharomyces cerevisiae, GI6324126, Length=204, Percent_Identity=31.8627450980392, Blast_Score=95, Evalue=1e-20, Organism=Drosophila melanogaster, GI24639444, Length=256, Percent_Identity=32.8125, Blast_Score=114, Evalue=6e-26, Organism=Drosophila melanogaster, GI21355319, Length=257, Percent_Identity=29.5719844357977, Blast_Score=112, Evalue=3e-25, Organism=Drosophila melanogaster, GI23397609, Length=256, Percent_Identity=30.46875, Blast_Score=112, Evalue=3e-25, Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=29.4573643410853, Blast_Score=106, Evalue=2e-23, Organism=Drosophila melanogaster, GI21357041, Length=251, Percent_Identity=30.6772908366534, Blast_Score=105, Evalue=3e-23, Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=29.8804780876494, Blast_Score=101, Evalue=5e-22, Organism=Drosophila melanogaster, GI18859837, Length=196, Percent_Identity=33.6734693877551, Blast_Score=92, Evalue=2e-19, Organism=Drosophila melanogaster, GI24643142, Length=255, Percent_Identity=25.4901960784314, Blast_Score=87, Evalue=1e-17, Organism=Drosophila melanogaster, GI281364494, Length=207, Percent_Identity=32.8502415458937, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI281364892, Length=197, Percent_Identity=30.4568527918782, Blast_Score=78, Evalue=7e-15, Organism=Drosophila melanogaster, GI24641232, Length=245, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI17737361, Length=264, Percent_Identity=26.8939393939394, Blast_Score=75, Evalue=6e-14, Organism=Drosophila melanogaster, GI24644337, Length=180, Percent_Identity=29.4444444444444, Blast_Score=73, Evalue=2e-13, Organism=Drosophila melanogaster, GI24649181, Length=204, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI116007234, Length=254, Percent_Identity=31.1023622047244, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI21355631, Length=176, Percent_Identity=28.9772727272727, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI21357673, Length=210, Percent_Identity=27.1428571428571, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI28571387, Length=206, Percent_Identity=31.0679611650485, Blast_Score=71, Evalue=9e-13, Organism=Drosophila melanogaster, GI24648693, Length=240, Percent_Identity=30, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI21355889, Length=240, Percent_Identity=30, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI24663911, Length=245, Percent_Identity=28.9795918367347, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI116007236, Length=244, Percent_Identity=25.4098360655738, Blast_Score=66, Evalue=2e-11, Organism=Drosophila melanogaster, GI21358495, Length=213, Percent_Identity=25.3521126760563, Blast_Score=66, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.47 [H]
Molecular weight: Translated: 28536; Mature: 28405
Theoretical pI: Translated: 6.52; Mature: 6.52
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 3.3 %Met (Translated Protein) 4.1 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 3.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSDRKLLAKQKALVTGANSGIGEGVAIALGQAGADVVVNYVEGDAAANAVVDKIKQFGGN CCCHHHHHHHHHHEECCCCCCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHCCC AITHKADVSHEDEVGDMFDRAVREFGTIDILVNNAGMQRDSAFSDMTLEKWNKVLGVNLT EEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHEECCCCC GQFLCARAAIREFLRRGVVPSVSRAAGKIICMSSVHQVIPWAGHANYATSKGGIKLMMES HHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHH MAQELAPKRIRVNGIAPGAIQTPINTSAWDTPEALKSLLTLIPYGRIGLPEDIARAAVWL HHHHCCCCEEEECCCCCCCEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHEEEE ASDDSDYVVGTTLFVDGGMTLYPGFSTNG ECCCCCEEEEEEEEEECCEEEECCCCCCC >Mature Secondary Structure SDRKLLAKQKALVTGANSGIGEGVAIALGQAGADVVVNYVEGDAAANAVVDKIKQFGGN CCHHHHHHHHHHEECCCCCCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHCCC AITHKADVSHEDEVGDMFDRAVREFGTIDILVNNAGMQRDSAFSDMTLEKWNKVLGVNLT EEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHEECCCCC GQFLCARAAIREFLRRGVVPSVSRAAGKIICMSSVHQVIPWAGHANYATSKGGIKLMMES HHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHH MAQELAPKRIRVNGIAPGAIQTPINTSAWDTPEALKSLLTLIPYGRIGLPEDIARAAVWL HHHHCCCCEEEECCCCCCCEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHEEEE ASDDSDYVVGTTLFVDGGMTLYPGFSTNG ECCCCCEEEEEEEEEECCEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 3082854; 8969502; 9384377 [H]