Click here to switch to the map view.

The map label for this gene is nhaA [H]

Identifier: 57238665

GI number: 57238665

Start: 1718619

End: 1719788

Strand: Reverse

Name: nhaA [H]

Synonym: CJE1826

Alternate gene names: 57238665

Gene position: 1719788-1718619 (Counterclockwise)

Preceding gene: 57238666

Following gene: 57238664

Centisome position: 96.74

GC content: 31.11

Gene sequence:

>1170_bases
ATGAATAATATAGTACATAAATTAAAAACTTTAGTTTTAAATGAGGCTTTTGGCGGCGTTTTACTTATAGTTTGTACTTT
GCTTGCTTTGCTTGTGCAAAATGGATCTTTTAGCGAACATTATCGAGAATTTCTAAATTTAAAAGTCGGATTTAGTGTAG
GTGAATTTGAGCTTAATAAGCCTTTTTTACTTTGGATAAATGATGGGCTTATATCTATATTTTTCTTTGCTATAGGGCTT
GAGCTTAAGAAGGAATTTTTGCACGGGGATTTTAAAAATCCTAAAAATATTGTTTTACCTTTTATGGCTGCTTTAGGGGG
TATACTTATACCTGCGATGTTGTTTGCTTTGGTAAATATAGGAGATGCTTATACTTTAAAAGGTTGGGCTATACCTACAG
CCACAGATACAGCGTTTGCCTTAGCGATTTTAATGATGTGTGGCAAGCACATTCCATCAAGTTTAAAAATTTTCTTACTT
TCTTTGGCTATTTTTGATGATGTGGGTGCTATTTTAATTATAGCTATTTTTTATACGACAAAATTATCAATAGTTGCTTT
TGTCGTTGCAGGACTTGCTATTTTGGCAATGCTTATTTTAAATCTTTTAGGGATAACAAGAAAGTCTTTTTATTTTATTT
GCTCAGTTATTCTTTGGATTAGTGTTTTAAAAAGTGGAGTACATGCAACTTTAGCTGGAATTGTAACAGCATTTTTTATA
CCGATGCAAACTAAAAATGGAGAAGCATTTTTAGAAGAAATTTATGAAAGCTTAAAATTTTGGATTGCTTTTATTATTTT
ACCTTTATTTGCTTTTGCTAACGCTGGAGTAAATTTATCCAATATCGATATAGGAGCAATTTTTTCAGGTGTAAGTATAG
GTATTTTCTTAGGGCTTTTTGTGGGTAAACAAGTGGGTGTATTTTTATTTTCTTATTTGGCAATCCGCTTTAAATTTGCA
GCTTTGCCCCAAGGTTCAAATTTGAAACAACTTTATGGGGTTTGCATACTTACAGGAATTGGTTTTACAATGAGTTTGTT
TATTGATGGATTGGCGTATGAAGTTAGTGATATTTTTAATTATGCAGATAACTTAGCTATTCTTATAGCCTCATTTTGTT
CTGGGATTTGGGGTTTTATTTATCTTAAATTCTTTACTACTCGATCTTAA

Upstream 100 bases:

>100_bases
ATAAAAATAGTGATATTTTTGAATATGCGGATAAACTTGCTATTTTAGTAGCTAGTTTTTTAAGTGCCATTGTTGGTTTT
ATTTATCTTAAGATTGTTAA

Downstream 100 bases:

>100_bases
GGGGATTGATGAGGCATATTTTTTTTATTATTACGATTATATTTTTTATAAGTGGATGTAGTTTTTATCAGAATCTAAAC
TATCGTCCTAGTTACAACAC

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA 1 [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNNIVHKLKTLVLNEAFGGVLLIVCTLLALLVQNGSFSEHYREFLNLKVGFSVGEFELNKPFLLWINDGLISIFFFAIGL
ELKKEFLHGDFKNPKNIVLPFMAALGGILIPAMLFALVNIGDAYTLKGWAIPTATDTAFALAILMMCGKHIPSSLKIFLL
SLAIFDDVGAILIIAIFYTTKLSIVAFVVAGLAILAMLILNLLGITRKSFYFICSVILWISVLKSGVHATLAGIVTAFFI
PMQTKNGEAFLEEIYESLKFWIAFIILPLFAFANAGVNLSNIDIGAIFSGVSIGIFLGLFVGKQVGVFLFSYLAIRFKFA
ALPQGSNLKQLYGVCILTGIGFTMSLFIDGLAYEVSDIFNYADNLAILIASFCSGIWGFIYLKFFTTRS

Sequences:

>Translated_389_residues
MNNIVHKLKTLVLNEAFGGVLLIVCTLLALLVQNGSFSEHYREFLNLKVGFSVGEFELNKPFLLWINDGLISIFFFAIGL
ELKKEFLHGDFKNPKNIVLPFMAALGGILIPAMLFALVNIGDAYTLKGWAIPTATDTAFALAILMMCGKHIPSSLKIFLL
SLAIFDDVGAILIIAIFYTTKLSIVAFVVAGLAILAMLILNLLGITRKSFYFICSVILWISVLKSGVHATLAGIVTAFFI
PMQTKNGEAFLEEIYESLKFWIAFIILPLFAFANAGVNLSNIDIGAIFSGVSIGIFLGLFVGKQVGVFLFSYLAIRFKFA
ALPQGSNLKQLYGVCILTGIGFTMSLFIDGLAYEVSDIFNYADNLAILIASFCSGIWGFIYLKFFTTRS
>Mature_389_residues
MNNIVHKLKTLVLNEAFGGVLLIVCTLLALLVQNGSFSEHYREFLNLKVGFSVGEFELNKPFLLWINDGLISIFFFAIGL
ELKKEFLHGDFKNPKNIVLPFMAALGGILIPAMLFALVNIGDAYTLKGWAIPTATDTAFALAILMMCGKHIPSSLKIFLL
SLAIFDDVGAILIIAIFYTTKLSIVAFVVAGLAILAMLILNLLGITRKSFYFICSVILWISVLKSGVHATLAGIVTAFFI
PMQTKNGEAFLEEIYESLKFWIAFIILPLFAFANAGVNLSNIDIGAIFSGVSIGIFLGLFVGKQVGVFLFSYLAIRFKFA
ALPQGSNLKQLYGVCILTGIGFTMSLFIDGLAYEVSDIFNYADNLAILIASFCSGIWGFIYLKFFTTRS

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=353, Percent_Identity=46.1756373937677, Blast_Score=313, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 42647; Mature: 42647

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNIVHKLKTLVLNEAFGGVLLIVCTLLALLVQNGSFSEHYREFLNLKVGFSVGEFELNK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCEECCC
PFLLWINDGLISIFFFAIGLELKKEFLHGDFKNPKNIVLPFMAALGGILIPAMLFALVNI
CEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GDAYTLKGWAIPTATDTAFALAILMMCGKHIPSSLKIFLLSLAIFDDVGAILIIAIFYTT
CCCEEECCEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLSIVAFVVAGLAILAMLILNLLGITRKSFYFICSVILWISVLKSGVHATLAGIVTAFFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PMQTKNGEAFLEEIYESLKFWIAFIILPLFAFANAGVNLSNIDIGAIFSGVSIGIFLGLF
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
VGKQVGVFLFSYLAIRFKFAALPQGSNLKQLYGVCILTGIGFTMSLFIDGLAYEVSDIFN
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YADNLAILIASFCSGIWGFIYLKFFTTRS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNIVHKLKTLVLNEAFGGVLLIVCTLLALLVQNGSFSEHYREFLNLKVGFSVGEFELNK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCEECCC
PFLLWINDGLISIFFFAIGLELKKEFLHGDFKNPKNIVLPFMAALGGILIPAMLFALVNI
CEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GDAYTLKGWAIPTATDTAFALAILMMCGKHIPSSLKIFLLSLAIFDDVGAILIIAIFYTT
CCCEEECCEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLSIVAFVVAGLAILAMLILNLLGITRKSFYFICSVILWISVLKSGVHATLAGIVTAFFI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PMQTKNGEAFLEEIYESLKFWIAFIILPLFAFANAGVNLSNIDIGAIFSGVSIGIFLGLF
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
VGKQVGVFLFSYLAIRFKFAALPQGSNLKQLYGVCILTGIGFTMSLFIDGLAYEVSDIFN
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YADNLAILIASFCSGIWGFIYLKFFTTRS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA