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The map label for this gene is hemA [H]

Identifier: 229007178

GI number: 229007178

Start: 2592158

End: 2593375

Strand: Reverse

Name: hemA [H]

Synonym: Atu2613

Alternate gene names: 229007178

Gene position: 2593375-2592158 (Counterclockwise)

Preceding gene: 159185295

Following gene: 159185289

Centisome position: 91.27

GC content: 58.54

Gene sequence:

>1218_bases
ATGGACTTCGAGGCATTTTTTACGACGGAACTGCAAAGCCTGCATTCTGAGGGGCGTTATCGCGTTTTTGCGGATATCGA
ACGCCAGCAGGGCAATTTTCCCCGCGCGACACGGTACAATGCCAATGGCGATCGCAAGGACGTAACCGTCTGGTGCTCCA
ACGACTATCTCGGCATGGGCCAGAACCCGAAAGTCATCGAAGCCATGAAAGCCGCCATCGATCACTGTGGCGCGGGTGCG
GGAGGCACCCGGAACATTTCTGGCACCAACCATTATCATGTCCTGCTGGAGCAGGAACTCGCCGATCTGCACGGCAAGGA
ATCAGCCCTGATTTTCACGTCGGGTTATGTTTCGAACTGGGCAACCCTCGGCACTCTCGGCCAGAAAATTCCGGGCCTCA
TTATCTTCTCCGACGCGCTCAACCACGCATCGATGATCGAGGGCATTCGTTACGGTCGTTGCGAGCGGGTGATCTGGAAA
CACAACGATCTCGAAGATCTCGAAGCGAAGCTTAAGGCTGCCGATCCCAATGCGCCGAAGCTGATTGCCTTTGAATCCGT
CTATTCGATGGATGGCGATATCGCGCCGATCAGGGAAATCTGCGATCTGGCCGACCGTTACGGCGCCATGACCTATCTCG
ACGAAGTCCATGCCGTCGGCATGTACGGCCCGCGCGGTGGCGGCATTGCCGAGCGCGAAGGCCTGATGGATCGTCTGACG
ATCATCGAGGGTACACTTGGCAAAGCCTTCGGCGTGATGGGCGGTTATATCACCGGCTCCACCGCAGTCTGCGATTTCAT
CCGTTCTTTCGCATCCGGCTTCATCTTCACGACGGCCCTGCCACCGTCGCTTGCCGCCGGCGCTATCGCGTCGATCCAGC
ATCTGAAGGCTAGCCCCTTTGAGCGCGCGCGCCATCAGGATCGGGTCCGCAAGCTGCGCGGTCTTCTCGATGCCCGCGGC
ATTCCGCATATGGACAATCCAAGCCACATCGTGCCGGTCATGGTCGGCGATGCCGCCAAGTGCAAGTGGATTTCGGATAT
CCTGCTCGACAATCACGGCGTCTATGTGCAGCCGATCAATTACCCGACCGTGCCGCGCAAGACAGAGCGCCTGCGTATTA
CACCGACACCGCTGCACACTGATGCCGATATCGAGCAGCTTGTCGGTGCGCTGCATCAGCTCTGGTCGCATTGCGCACTG
GCGCGTGCGGTGGCTTAA

Upstream 100 bases:

>100_bases
AACAACGGCGAATTGACGCAGACGTGGTTAAAGTGGCCCGAAAGGGTTGACGGTCCCGGTGTCGGAGCGGAAAACGGTCT
GGTCAATTCTGGAGCATGGC

Downstream 100 bases:

>100_bases
GGCAACCGTTCAGATTGAAGAGGTCAGGGCCGCGTTCACGCGGCCTTTTCTTTTGTGGCGATGAGTTCCAGTGCATGGCG
GCGGGCCTCTTCGTCTGCCG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MDFEAFFTTELQSLHSEGRYRVFADIERQQGNFPRATRYNANGDRKDVTVWCSNDYLGMGQNPKVIEAMKAAIDHCGAGA
GGTRNISGTNHYHVLLEQELADLHGKESALIFTSGYVSNWATLGTLGQKIPGLIIFSDALNHASMIEGIRYGRCERVIWK
HNDLEDLEAKLKAADPNAPKLIAFESVYSMDGDIAPIREICDLADRYGAMTYLDEVHAVGMYGPRGGGIAEREGLMDRLT
IIEGTLGKAFGVMGGYITGSTAVCDFIRSFASGFIFTTALPPSLAAGAIASIQHLKASPFERARHQDRVRKLRGLLDARG
IPHMDNPSHIVPVMVGDAAKCKWISDILLDNHGVYVQPINYPTVPRKTERLRITPTPLHTDADIEQLVGALHQLWSHCAL
ARAVA

Sequences:

>Translated_405_residues
MDFEAFFTTELQSLHSEGRYRVFADIERQQGNFPRATRYNANGDRKDVTVWCSNDYLGMGQNPKVIEAMKAAIDHCGAGA
GGTRNISGTNHYHVLLEQELADLHGKESALIFTSGYVSNWATLGTLGQKIPGLIIFSDALNHASMIEGIRYGRCERVIWK
HNDLEDLEAKLKAADPNAPKLIAFESVYSMDGDIAPIREICDLADRYGAMTYLDEVHAVGMYGPRGGGIAEREGLMDRLT
IIEGTLGKAFGVMGGYITGSTAVCDFIRSFASGFIFTTALPPSLAAGAIASIQHLKASPFERARHQDRVRKLRGLLDARG
IPHMDNPSHIVPVMVGDAAKCKWISDILLDNHGVYVQPINYPTVPRKTERLRITPTPLHTDADIEQLVGALHQLWSHCAL
ARAVA
>Mature_405_residues
MDFEAFFTTELQSLHSEGRYRVFADIERQQGNFPRATRYNANGDRKDVTVWCSNDYLGMGQNPKVIEAMKAAIDHCGAGA
GGTRNISGTNHYHVLLEQELADLHGKESALIFTSGYVSNWATLGTLGQKIPGLIIFSDALNHASMIEGIRYGRCERVIWK
HNDLEDLEAKLKAADPNAPKLIAFESVYSMDGDIAPIREICDLADRYGAMTYLDEVHAVGMYGPRGGGIAEREGLMDRLT
IIEGTLGKAFGVMGGYITGSTAVCDFIRSFASGFIFTTALPPSLAAGAIASIQHLKASPFERARHQDRVRKLRGLLDARG
IPHMDNPSHIVPVMVGDAAKCKWISDILLDNHGVYVQPINYPTVPRKTERLRITPTPLHTDADIEQLVGALHQLWSHCAL
ARAVA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=403, Percent_Identity=48.6352357320099, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI83977440, Length=403, Percent_Identity=48.6352357320099, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI83977444, Length=403, Percent_Identity=48.6352357320099, Blast_Score=407, Evalue=1e-114,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=49.1315136476427, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=49.1315136476427, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI7657118, Length=386, Percent_Identity=35.4922279792746, Blast_Score=241, Evalue=8e-64,
Organism=Homo sapiens, GI284448556, Length=342, Percent_Identity=37.719298245614, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI4758668, Length=426, Percent_Identity=30.7511737089202, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI119220554, Length=420, Percent_Identity=27.6190476190476, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI5454084, Length=260, Percent_Identity=29.2307692307692, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1790046, Length=396, Percent_Identity=34.8484848484849, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI1786993, Length=359, Percent_Identity=32.033426183844, Blast_Score=163, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71994529, Length=392, Percent_Identity=35.7142857142857, Blast_Score=237, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=30.8108108108108, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560914, Length=377, Percent_Identity=28.6472148541114, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17560912, Length=377, Percent_Identity=28.6472148541114, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=272, Percent_Identity=26.8382352941176, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=272, Percent_Identity=26.8382352941176, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=424, Percent_Identity=48.8207547169811, Blast_Score=400, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6320267, Length=354, Percent_Identity=27.683615819209, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323954, Length=257, Percent_Identity=26.4591439688716, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17137420, Length=406, Percent_Identity=47.0443349753695, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24662918, Length=384, Percent_Identity=34.1145833333333, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17136286, Length=327, Percent_Identity=27.82874617737, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24653280, Length=278, Percent_Identity=26.2589928057554, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24653276, Length=278, Percent_Identity=26.2589928057554, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24653278, Length=278, Percent_Identity=26.2589928057554, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44459; Mature: 44459

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFEAFFTTELQSLHSEGRYRVFADIERQQGNFPRATRYNANGDRKDVTVWCSNDYLGMG
CCCHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCEEECCCCCCCEEEEEECCCCCCCC
QNPKVIEAMKAAIDHCGAGAGGTRNISGTNHYHVLLEQELADLHGKESALIFTSGYVSNW
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCCEEEEECCCHHHH
ATLGTLGQKIPGLIIFSDALNHASMIEGIRYGRCERVIWKHNDLEDLEAKLKAADPNAPK
HHHHHHHHHCCCEEEEHHHCCHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHCCCCCCCE
LIAFESVYSMDGDIAPIREICDLADRYGAMTYLDEVHAVGMYGPRGGGIAEREGLMDRLT
EEEEHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
IIEGTLGKAFGVMGGYITGSTAVCDFIRSFASGFIFTTALPPSLAAGAIASIQHLKASPF
HHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHCCCHH
ERARHQDRVRKLRGLLDARGIPHMDNPSHIVPVMVGDAAKCKWISDILLDNHGVYVQPIN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECC
YPTVPRKTERLRITPTPLHTDADIEQLVGALHQLWSHCALARAVA
CCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFEAFFTTELQSLHSEGRYRVFADIERQQGNFPRATRYNANGDRKDVTVWCSNDYLGMG
CCCHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCEEECCCCCCCEEEEEECCCCCCCC
QNPKVIEAMKAAIDHCGAGAGGTRNISGTNHYHVLLEQELADLHGKESALIFTSGYVSNW
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHCCCCCCEEEEECCCHHHH
ATLGTLGQKIPGLIIFSDALNHASMIEGIRYGRCERVIWKHNDLEDLEAKLKAADPNAPK
HHHHHHHHHCCCEEEEHHHCCHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHCCCCCCCE
LIAFESVYSMDGDIAPIREICDLADRYGAMTYLDEVHAVGMYGPRGGGIAEREGLMDRLT
EEEEHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
IIEGTLGKAFGVMGGYITGSTAVCDFIRSFASGFIFTTALPPSLAAGAIASIQHLKASPF
HHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHCCCHH
ERARHQDRVRKLRGLLDARGIPHMDNPSHIVPVMVGDAAKCKWISDILLDNHGVYVQPIN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEECC
YPTVPRKTERLRITPTPLHTDADIEQLVGALHQLWSHCALARAVA
CCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034217 [H]