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The map label for this gene is purH

Identifier: 159185400

GI number: 159185400

Start: 2826329

End: 2827945

Strand: Reverse

Name: purH

Synonym: Atu2823

Alternate gene names: 159185400

Gene position: 2827945-2826329 (Counterclockwise)

Preceding gene: 159185401

Following gene: 159185398

Centisome position: 99.52

GC content: 60.05

Gene sequence:

>1617_bases
ATGGCCGTGGTGTCCAAGAAAATTCCCGCCCCCGATAAGGTCAAGATTCGCACGGCGCTTCTTTCCGTGTCCGACAAGAC
CGATATTATCGAGTTGGCAACGGTACTCTCCAAGCTCGGCGTCAAGCTCCTGTCGACCGGCGGTACGGCAAAGGCGATTG
CCGAAGCGGGTCTTGCCGTCACAGATGTCTCCGACGTCACCAATTTTCCCGAGATCATGGATGGCCGCGTCAAGACGCTG
CATCCCAATGTTCATGGCGGGCTTCTGGCAATCCGCGACGATGCCGAGCATGTCGAGGCCATGAAGGCACATGGTATCGA
GGCGATCGATCTTTCCGTGATCAATCTCTATCCGTTCGAGGAAGTGCGCGCCAAGGGCGGCGATTATCCGACGACGGTTG
AGAATATCGATATTGGCGGCCCGGCGATGATCCGCGCTTCCGCCAAGAACCATGCCTATGTCACCGTTGTTACCGACCCT
TCCGACTACCCTGCGCTGGTGGAAGCCCTGCAGGCCGATGACGGACAGACCTCCTATGCGCTGCGCCAGCGTTTTGCCGC
CAAGGCCTATGCCCGCACGGCTGCTTATGATGCCGTGATTTCCAACTGGTTTGCCGAAGCACTGGCGATCGAGACGCCTC
ATTACCGCGCCATCGGCGGTGTGCTGAAAGAAAAGATGCGTTATGGTGAAAACCCGCATCAGAGCGCCGGTTTCTACCTG
ACCGGTGAAAAGCGCCCCGGCGTTGCAACGGCGACGCTTCTCCAGGGCAAGCAGCTCTCCTACAACAACATCAATGATAC
CGATGCGGCTTACGAGCTGGTGGCGGAGTTCCTGCCGGAAAATGCGCCGGCCGTTGCCATCGTCAAACACGCCAATCCCT
GTGGCGTTGCGACCGGCCCTACCCTTGCAGAAGCCTATCGGCGGGCGCTGGCATGCGATTCCGTTTCCGCCTTTGGCGGC
GTCATTGCGCTCAACCGCACGCTCGATGCGGAAACGGCGGAAGAGATCGTCAAGCTCTTCACCGAAGTCATCATCGCGCC
TGACGTGACCGAAGAGGCCAAGTCCATCATCGCCCGCAAGCCGAACCTGCGCCTTCTGGCCGCCGGCGGCCTGCCAGACC
CGCGTGCGGCTGGCCTCACGGCGAAGACCGTTTCCGGTGGCCTGCTGGTGCAGAGCCGTGACAATGGCATGGTCGAGGAT
CTCGAACTCAAGGTCGTAACCAAGCGTGCACCGACGGCGCAAGAGCTTGAGGACATGAAGTTCGCTTTCAAGATCGCCAA
GCATGTGAAATCCAATGCCGTGATCTATGCGAAGGACGGTCAGACGGCGGGTATCGGCGCTGGCCAGATGAGCCGTGTGG
ATTCCGCCCGCATCGCCGCCCAGAAGGCGGAAGATGCAGCCAAGGCTCTTGGCCTTGCCGAACCATTGACGCGCGGCTCT
GCCGTTGCGTCGGAAGCCTTTTATCCGTTTGCGGATGGTTTGCTTGCTGCAATCGCTGCGGGCGCCACCGCTGTCATCCA
GCCGGGTGGCTCCATGCGCGATCAGGACGTGATCGACGCTGCAAACGAGCATAATGTGGCTATGGTCTTCACCGGCATGC
GCCACTTCCGCCATTAA

Upstream 100 bases:

>100_bases
TCCCCGCTGTTTATTAATGCGGTAAGCTGTGTTAACGCGGCGGCAATCGCTGGATCATTCCCCTTCCAGCCTGTCCTCCC
TATTATACGGAGTATGCCCG

Downstream 100 bases:

>100_bases
GCGCGCGATATAGACAGAAATGACGAAGGCCCGGAAAGTGATTTCCGGGCCTTTTGTTTCACGTGGGACAGTCGGTATTG
CGCTTCAGGTCACTGCGCCG

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 538; Mature: 537

Protein sequence:

>538_residues
MAVVSKKIPAPDKVKIRTALLSVSDKTDIIELATVLSKLGVKLLSTGGTAKAIAEAGLAVTDVSDVTNFPEIMDGRVKTL
HPNVHGGLLAIRDDAEHVEAMKAHGIEAIDLSVINLYPFEEVRAKGGDYPTTVENIDIGGPAMIRASAKNHAYVTVVTDP
SDYPALVEALQADDGQTSYALRQRFAAKAYARTAAYDAVISNWFAEALAIETPHYRAIGGVLKEKMRYGENPHQSAGFYL
TGEKRPGVATATLLQGKQLSYNNINDTDAAYELVAEFLPENAPAVAIVKHANPCGVATGPTLAEAYRRALACDSVSAFGG
VIALNRTLDAETAEEIVKLFTEVIIAPDVTEEAKSIIARKPNLRLLAAGGLPDPRAAGLTAKTVSGGLLVQSRDNGMVED
LELKVVTKRAPTAQELEDMKFAFKIAKHVKSNAVIYAKDGQTAGIGAGQMSRVDSARIAAQKAEDAAKALGLAEPLTRGS
AVASEAFYPFADGLLAAIAAGATAVIQPGGSMRDQDVIDAANEHNVAMVFTGMRHFRH

Sequences:

>Translated_538_residues
MAVVSKKIPAPDKVKIRTALLSVSDKTDIIELATVLSKLGVKLLSTGGTAKAIAEAGLAVTDVSDVTNFPEIMDGRVKTL
HPNVHGGLLAIRDDAEHVEAMKAHGIEAIDLSVINLYPFEEVRAKGGDYPTTVENIDIGGPAMIRASAKNHAYVTVVTDP
SDYPALVEALQADDGQTSYALRQRFAAKAYARTAAYDAVISNWFAEALAIETPHYRAIGGVLKEKMRYGENPHQSAGFYL
TGEKRPGVATATLLQGKQLSYNNINDTDAAYELVAEFLPENAPAVAIVKHANPCGVATGPTLAEAYRRALACDSVSAFGG
VIALNRTLDAETAEEIVKLFTEVIIAPDVTEEAKSIIARKPNLRLLAAGGLPDPRAAGLTAKTVSGGLLVQSRDNGMVED
LELKVVTKRAPTAQELEDMKFAFKIAKHVKSNAVIYAKDGQTAGIGAGQMSRVDSARIAAQKAEDAAKALGLAEPLTRGS
AVASEAFYPFADGLLAAIAAGATAVIQPGGSMRDQDVIDAANEHNVAMVFTGMRHFRH
>Mature_537_residues
AVVSKKIPAPDKVKIRTALLSVSDKTDIIELATVLSKLGVKLLSTGGTAKAIAEAGLAVTDVSDVTNFPEIMDGRVKTLH
PNVHGGLLAIRDDAEHVEAMKAHGIEAIDLSVINLYPFEEVRAKGGDYPTTVENIDIGGPAMIRASAKNHAYVTVVTDPS
DYPALVEALQADDGQTSYALRQRFAAKAYARTAAYDAVISNWFAEALAIETPHYRAIGGVLKEKMRYGENPHQSAGFYLT
GEKRPGVATATLLQGKQLSYNNINDTDAAYELVAEFLPENAPAVAIVKHANPCGVATGPTLAEAYRRALACDSVSAFGGV
IALNRTLDAETAEEIVKLFTEVIIAPDVTEEAKSIIARKPNLRLLAAGGLPDPRAAGLTAKTVSGGLLVQSRDNGMVEDL
ELKVVTKRAPTAQELEDMKFAFKIAKHVKSNAVIYAKDGQTAGIGAGQMSRVDSARIAAQKAEDAAKALGLAEPLTRGSA
VASEAFYPFADGLLAAIAAGATAVIQPGGSMRDQDVIDAANEHNVAMVFTGMRHFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=605, Percent_Identity=35.5371900826446, Blast_Score=285, Evalue=6e-77,
Organism=Escherichia coli, GI1790439, Length=538, Percent_Identity=54.8327137546468, Blast_Score=528, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI71985564, Length=603, Percent_Identity=33.665008291874, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71985574, Length=303, Percent_Identity=31.3531353135314, Blast_Score=99, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323056, Length=601, Percent_Identity=33.6106489184692, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6323768, Length=473, Percent_Identity=37.2093023255814, Blast_Score=264, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24649832, Length=474, Percent_Identity=37.3417721518987, Blast_Score=257, Evalue=1e-68,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_AGRT5 (Q8UBM8)

Other databases:

- EMBL:   AE007869
- PIR:   AF2923
- PIR:   F97697
- RefSeq:   NP_355750.2
- ProteinModelPortal:   Q8UBM8
- SMR:   Q8UBM8
- STRING:   Q8UBM8
- GeneID:   1134861
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2823
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- PhylomeDB:   Q8UBM8
- ProtClustDB:   PRK00881
- BioCyc:   ATUM176299-1:ATU2823-MONOMER
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 56891; Mature: 56760

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVVSKKIPAPDKVKIRTALLSVSDKTDIIELATVLSKLGVKLLSTGGTAKAIAEAGLAV
CCCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCHHEECCCCCHHHHHHCCCEE
TDVSDVTNFPEIMDGRVKTLHPNVHGGLLAIRDDAEHVEAMKAHGIEAIDLSVINLYPFE
EEHHHHCCCHHHHCCCEEEECCCCCCCEEEEECCHHHHHHHHHCCCEEEEEEEEEECCHH
EVRAKGGDYPTTVENIDIGGPAMIRASAKNHAYVTVVTDPSDYPALVEALQADDGQTSYA
HHHHCCCCCCCCCCEECCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHCCCCCHHHH
LRQRFAAKAYARTAAYDAVISNWFAEALAIETPHYRAIGGVLKEKMRYGENPHQSAGFYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEE
TGEKRPGVATATLLQGKQLSYNNINDTDAAYELVAEFLPENAPAVAIVKHANPCGVATGP
ECCCCCCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
TLAEAYRRALACDSVSAFGGVIALNRTLDAETAEEIVKLFTEVIIAPDVTEEAKSIIARK
HHHHHHHHHHHHCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
PNLRLLAAGGLPDPRAAGLTAKTVSGGLLVQSRDNGMVEDLELKVVTKRAPTAQELEDMK
CCEEEEEECCCCCCCCCCCEEEECCCCEEEEECCCCCEEEEEEEEEECCCCCHHHHHHHH
FAFKIAKHVKSNAVIYAKDGQTAGIGAGQMSRVDSARIAAQKAEDAAKALGLAEPLTRGS
HHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
AVASEAFYPFADGLLAAIAAGATAVIQPGGSMRDQDVIDAANEHNVAMVFTGMRHFRH
HHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHCCCCCCEEEEEECHHHHCC
>Mature Secondary Structure 
AVVSKKIPAPDKVKIRTALLSVSDKTDIIELATVLSKLGVKLLSTGGTAKAIAEAGLAV
CCCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCHHEECCCCCHHHHHHCCCEE
TDVSDVTNFPEIMDGRVKTLHPNVHGGLLAIRDDAEHVEAMKAHGIEAIDLSVINLYPFE
EEHHHHCCCHHHHCCCEEEECCCCCCCEEEEECCHHHHHHHHHCCCEEEEEEEEEECCHH
EVRAKGGDYPTTVENIDIGGPAMIRASAKNHAYVTVVTDPSDYPALVEALQADDGQTSYA
HHHHCCCCCCCCCCEECCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHCCCCCHHHH
LRQRFAAKAYARTAAYDAVISNWFAEALAIETPHYRAIGGVLKEKMRYGENPHQSAGFYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEE
TGEKRPGVATATLLQGKQLSYNNINDTDAAYELVAEFLPENAPAVAIVKHANPCGVATGP
ECCCCCCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCC
TLAEAYRRALACDSVSAFGGVIALNRTLDAETAEEIVKLFTEVIIAPDVTEEAKSIIARK
HHHHHHHHHHHHCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
PNLRLLAAGGLPDPRAAGLTAKTVSGGLLVQSRDNGMVEDLELKVVTKRAPTAQELEDMK
CCEEEEEECCCCCCCCCCCEEEECCCCEEEEECCCCCEEEEEEEEEECCCCCHHHHHHHH
FAFKIAKHVKSNAVIYAKDGQTAGIGAGQMSRVDSARIAAQKAEDAAKALGLAEPLTRGS
HHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCC
AVASEAFYPFADGLLAAIAAGATAVIQPGGSMRDQDVIDAANEHNVAMVFTGMRHFRH
HHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHCCCCCCEEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194