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The map label for this gene is cobA [H]

Identifier: 159185385

GI number: 159185385

Start: 2796348

End: 2797136

Strand: Reverse

Name: cobA [H]

Synonym: Atu2794

Alternate gene names: 159185385

Gene position: 2797136-2796348 (Counterclockwise)

Preceding gene: 15890043

Following gene: 15890040

Centisome position: 98.44

GC content: 60.08

Gene sequence:

>789_bases
ATGTCGATACCGCAGATTTTGAACAGCATCGCCGCAAAAGGTCCGGTCTTTGAAGCCGGCCACGTCTGGCTCGCGGGCGC
GGGGCCGGGCGATGTGCGGTATCTGACGCTCGAAGTGGCGCTCGCGCTGTCGCAGGCCGATATCATCGTGCGCGATGCGC
TGGTGAGCGATGATGTCGTGGCGCTCGGTCCGCAGGCGGAAGTCGTCTTTGCCGGCAAGCGTGGCGGCAAGCCCTCCGCG
ACGCAGGATGACATTACCGCGTCGCTGATCGATTTTGCTCTGCAGGGCAAAAAGGTGCTGCGACTGAAGGGCGGCGATCC
CTTTATTTTCGGGCGTGGCGGCGAAGAGGCGGAGGCGCTTGTCCATGCCGGCATTCCGTTTCGCATATTGCCGGGCATGA
CCTCGTCGTTTACCGCGCTCGCTTCGGCACGCATTCCTGCCACCATGCGCGGCATCAGCCGCGCCGTGACGCTCGCTACC
GGCCACGCGGCGGGCACAGAAGAGGATCTCGACTGGCTGGCACTGGCGAAAACGCAGGAACCTATCGTCGTTTATATGGG
GCTGAAGAATATCGGCACTATTGCCGGTCTTCTGATGCAGGGTGGACGTTCGGGAAAAACGCCGGTCGCCGTCATCATGT
CGGCAACTACTGCGAAAGAACGGATTTTCATCGGTACATTGCAAAGCATAGCTGACGATGCAAAACGGGAGAGCTTCGAA
GCGCCGGCTTTGATTATTATCGGCGAGATTGTTTCGATGCGGGATCGTCTTGGAGTGTCGGGCTCATGA

Upstream 100 bases:

>100_bases
CGTGGTCCAGCCGCGGCGAAGGGTCTTTCCATCCGTTTCCATATGCATTCCTATAGCCGGGACGGCTTTTTCCGTCATCG
TTAAAAAGCAGCCAAGAACA

Downstream 100 bases:

>100_bases
CGGCGCGGGCAATCATCATCGGTGCGCCGCGCTCGGGCTCCGGCAAGACCAGTGTGACCATCGGCCTGCTCCGGGCTTTT
GCGCGCCGCGGGGTGAAGGT

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MSIPQILNSIAAKGPVFEAGHVWLAGAGPGDVRYLTLEVALALSQADIIVRDALVSDDVVALGPQAEVVFAGKRGGKPSA
TQDDITASLIDFALQGKKVLRLKGGDPFIFGRGGEEAEALVHAGIPFRILPGMTSSFTALASARIPATMRGISRAVTLAT
GHAAGTEEDLDWLALAKTQEPIVVYMGLKNIGTIAGLLMQGGRSGKTPVAVIMSATTAKERIFIGTLQSIADDAKRESFE
APALIIIGEIVSMRDRLGVSGS

Sequences:

>Translated_262_residues
MSIPQILNSIAAKGPVFEAGHVWLAGAGPGDVRYLTLEVALALSQADIIVRDALVSDDVVALGPQAEVVFAGKRGGKPSA
TQDDITASLIDFALQGKKVLRLKGGDPFIFGRGGEEAEALVHAGIPFRILPGMTSSFTALASARIPATMRGISRAVTLAT
GHAAGTEEDLDWLALAKTQEPIVVYMGLKNIGTIAGLLMQGGRSGKTPVAVIMSATTAKERIFIGTLQSIADDAKRESFE
APALIIIGEIVSMRDRLGVSGS
>Mature_261_residues
SIPQILNSIAAKGPVFEAGHVWLAGAGPGDVRYLTLEVALALSQADIIVRDALVSDDVVALGPQAEVVFAGKRGGKPSAT
QDDITASLIDFALQGKKVLRLKGGDPFIFGRGGEEAEALVHAGIPFRILPGMTSSFTALASARIPATMRGISRAVTLATG
HAAGTEEDLDWLALAKTQEPIVVYMGLKNIGTIAGLLMQGGRSGKTPVAVIMSATTAKERIFIGTLQSIADDAKRESFEA
PALIIIGEIVSMRDRLGVSGS

Specific function: Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=245, Percent_Identity=44.4897959183673, Blast_Score=197, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6322922, Length=235, Percent_Identity=31.4893617021277, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 27259; Mature: 27128

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPQILNSIAAKGPVFEAGHVWLAGAGPGDVRYLTLEVALALSQADIIVRDALVSDDVV
CCHHHHHHHHHCCCCCEECCCEEEEECCCCCEEEEEEEEEEHHHHCCEEEEHHHCCCCEE
ALGPQAEVVFAGKRGGKPSATQDDITASLIDFALQGKKVLRLKGGDPFIFGRGGEEAEAL
EECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCHHHHH
VHAGIPFRILPGMTSSFTALASARIPATMRGISRAVTLATGHAAGTEEDLDWLALAKTQE
EECCCCEEECCCCCHHHHHHHHCCCCHHHHHHHHEEEEEECCCCCCCCCCCEEEEECCCC
PIVVYMGLKNIGTIAGLLMQGGRSGKTPVAVIMSATTAKERIFIGTLQSIADDAKRESFE
CEEEEECCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHCCC
APALIIIGEIVSMRDRLGVSGS
CCEEEEEHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SIPQILNSIAAKGPVFEAGHVWLAGAGPGDVRYLTLEVALALSQADIIVRDALVSDDVV
CHHHHHHHHHCCCCCEECCCEEEEECCCCCEEEEEEEEEEHHHHCCEEEEHHHCCCCEE
ALGPQAEVVFAGKRGGKPSATQDDITASLIDFALQGKKVLRLKGGDPFIFGRGGEEAEAL
EECCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCHHHHH
VHAGIPFRILPGMTSSFTALASARIPATMRGISRAVTLATGHAAGTEEDLDWLALAKTQE
EECCCCEEECCCCCHHHHHHHHCCCCHHHHHHHHEEEEEECCCCCCCCCCCEEEEECCCC
PIVVYMGLKNIGTIAGLLMQGGRSGKTPVAVIMSATTAKERIFIGTLQSIADDAKRESFE
CEEEEECCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHCCC
APALIIIGEIVSMRDRLGVSGS
CCEEEEEHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520; 2546914 [H]