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The map label for this gene is ialA

Identifier: 159185373

GI number: 159185373

Start: 2777029

End: 2777541

Strand: Reverse

Name: ialA

Synonym: Atu2772

Alternate gene names: 159185373

Gene position: 2777541-2777029 (Counterclockwise)

Preceding gene: 15890022

Following gene: 159185370

Centisome position: 97.75

GC content: 57.89

Gene sequence:

>513_bases
ATGACAATCAAAGCAGAAGATTTGCCTTACCGTCCCTGTGCGGGAATAATGGTTTTGAACGCTCAGGGCCTCGTCTGGGC
CGGCCGGCGCATCAAGGAGGGCAACTCCGAATATGATGGCTCGCCGCAATTGTGGCAGATGCCGCAGGGTGGCATCGATG
ATGGCGAACGGCCTTTGACGGCTGCCATTCGTGAACTCTACGAAGAGACGGGCATGAAGACTGTGACCCTGCTTGCGGAG
GCGAGCGACTGGATTCACTATGATCTGCCGCCCGAACTGATCGGTATCGGCCTCAGGGGCAAATATCGCGGCCAGGCGCA
GCGCTGGTTCGCGTTCCGCTTTGAGGGTGATGAAAGCGAAATCCAGATCGATCCGCCGCCTACCGGGCATTCGGCCGAAT
TCGACGCCTGGGACTGGAAGCCGATGGAAAGTCTTCCGGAACTGATCGTGCCCTTCAAGCGGGCGGTCTATGAAAAGGTC
GTGGCAGAGTTCCAGCACCTTTCGGGCAAATAA

Upstream 100 bases:

>100_bases
GGCATCGAGATTGTCGGCGTTTCTGCGCTTGTTTCCGGGCAGGCGGGGCAGTAAACCTTGCCTGCGTCCATTTCCGGCGC
TGAGACAGTGCGGGTTTCCC

Downstream 100 bases:

>100_bases
AAAAGGCGGCCAAGGCCGCCTTTTTCGTTCTGGCGCCAGTGCTTATTCCGCTTCGTTGGCAGAATCGGCGTTGAGCTGGC
CGTATTTTTCCGCGCCGATC

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MTIKAEDLPYRPCAGIMVLNAQGLVWAGRRIKEGNSEYDGSPQLWQMPQGGIDDGERPLTAAIRELYEETGMKTVTLLAE
ASDWIHYDLPPELIGIGLRGKYRGQAQRWFAFRFEGDESEIQIDPPPTGHSAEFDAWDWKPMESLPELIVPFKRAVYEKV
VAEFQHLSGK

Sequences:

>Translated_170_residues
MTIKAEDLPYRPCAGIMVLNAQGLVWAGRRIKEGNSEYDGSPQLWQMPQGGIDDGERPLTAAIRELYEETGMKTVTLLAE
ASDWIHYDLPPELIGIGLRGKYRGQAQRWFAFRFEGDESEIQIDPPPTGHSAEFDAWDWKPMESLPELIVPFKRAVYEKV
VAEFQHLSGK
>Mature_169_residues
TIKAEDLPYRPCAGIMVLNAQGLVWAGRRIKEGNSEYDGSPQLWQMPQGGIDDGERPLTAAIRELYEETGMKTVTLLAEA
SDWIHYDLPPELIGIGLRGKYRGQAQRWFAFRFEGDESEIQIDPPPTGHSAEFDAWDWKPMESLPELIVPFKRAVYEKVV
AEFQHLSGK

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=161, Percent_Identity=36.6459627329193, Blast_Score=100, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_AGRT5 (Q8UBS8)

Other databases:

- EMBL:   AE007869
- PIR:   AC2917
- PIR:   F97691
- RefSeq:   NP_355702.2
- ProteinModelPortal:   Q8UBS8
- SMR:   Q8UBS8
- STRING:   Q8UBS8
- GeneID:   1134810
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2772
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   AGRAWKG
- PhylomeDB:   Q8UBS8
- ProtClustDB:   PRK00714
- BioCyc:   ATUM176299-1:ATU2772-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19264; Mature: 19133

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKAEDLPYRPCAGIMVLNAQGLVWAGRRIKEGNSEYDGSPQLWQMPQGGIDDGERPLT
CCCCCCCCCCCCCCCEEEECCCCEEECCCEECCCCCCCCCCCCEEECCCCCCCCCCCHHH
AAIRELYEETGMKTVTLLAEASDWIHYDLPPELIGIGLRGKYRGQAQRWFAFRFEGDESE
HHHHHHHHHCCCEEEEEEECCCCCEEECCCHHHEEECCCCCCCCCCEEEEEEEEECCCCE
IQIDPPPTGHSAEFDAWDWKPMESLPELIVPFKRAVYEKVVAEFQHLSGK
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIKAEDLPYRPCAGIMVLNAQGLVWAGRRIKEGNSEYDGSPQLWQMPQGGIDDGERPLT
CCCCCCCCCCCCCCEEEECCCCEEECCCEECCCCCCCCCCCCEEECCCCCCCCCCCHHH
AAIRELYEETGMKTVTLLAEASDWIHYDLPPELIGIGLRGKYRGQAQRWFAFRFEGDESE
HHHHHHHHHCCCEEEEEEECCCCCEEECCCHHHEEECCCCCCCCCCEEEEEEEEECCCCE
IQIDPPPTGHSAEFDAWDWKPMESLPELIVPFKRAVYEKVVAEFQHLSGK
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194