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The map label for this gene is tesB [H]

Identifier: 159185364

GI number: 159185364

Start: 2756153

End: 2757037

Strand: Direct

Name: tesB [H]

Synonym: Atu2756

Alternate gene names: 159185364

Gene position: 2756153-2757037 (Clockwise)

Preceding gene: 15889999

Following gene: 15890006

Centisome position: 96.99

GC content: 59.77

Gene sequence:

>885_bases
ATGTCGCATCCTTCGCAAACGTCAGACCCGATGGTCAATCTCATTGCCACGCTCGATCTCGAGAAGCTGGAAGAGAACCT
CTATCGGGGCGAAAGCCCGCAGATCGGCTGGCAGCGGGTTTTTGGCGGCCAGGTCATCGCACAGGCCCTGATTGCCGCGC
AAAGAACCGTGGATGACGACCGTTTCGTGCATTCGCTGCATGCTTATTTCATGCGCCCCGGCGATCCGCTGGTGCCTATC
GTCTACCAGGTGGAGCGCATCCGCGACGGCGCAAGCTTCTGCACCCGCCGCGTGGTCGCCATCCAGCACGGCAAGGCGAT
TTTTTCCATGTCGGCGTCATTTCAGATCTTGGAGGACGGCTTCGACCATCAGATCAAGATGCCTGATGTGACGCCGCCTG
AAAAACTGATGAGCGAGGAGCAGATGCAGGCGGCCTTCCTCGCCAAGGCGCCCGCATCGATCCGTAAATACTGGAGCAAC
AAGCGGCCGATCGAGATAAGGCCGGTTTCGCTGACCCATTACATCTCGAAGGAAAAGCTGGAGCCGCAGCAGGATATCTG
GGTTCGCGCCGTCGGCGAGGTGCCTGCTGATCCGCGTCTGCAATCGGCCATTCTCGCCTACCTCTCGGACATGACGCTGC
TCGACACCTCGCTTTATGCCCATGGAACGACGATCTTCGATCCATCCATTCAGGTGGCGAGTCTCGACCACGCCATGTGG
TTCCACCGCCCCTGCCGGCTGGATGACTGGCTGCTCTACACCCAGGACAGCCCCAGCGCGTCCGGCGCACGGGGGCTCAC
CCGTGGCAATATTTTCACCAGGCAGGGTGAACTCGTCGCCTCCGTTGCGCAGGAGGGTTTGATCCGCAAAAGGGCAAATG
ATTAA

Upstream 100 bases:

>100_bases
ACCACGTCGAGCATCGCGCTTCTCCTCAAATCTTGTGCACACATCATCGGCACACTATAGACCATGTGACGTCTTCCTAC
AGCCGGAGCAGGCCGAAAAA

Downstream 100 bases:

>100_bases
ATAATACGCTTTTTTAAAAAATCGCACATTTTATAGACGCTTTTTTGGGCGACAAATGCCCCTTTTTCAGACGCCCGTCA
TATAATCTTTATATTTCAAT

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSHPSQTSDPMVNLIATLDLEKLEENLYRGESPQIGWQRVFGGQVIAQALIAAQRTVDDDRFVHSLHAYFMRPGDPLVPI
VYQVERIRDGASFCTRRVVAIQHGKAIFSMSASFQILEDGFDHQIKMPDVTPPEKLMSEEQMQAAFLAKAPASIRKYWSN
KRPIEIRPVSLTHYISKEKLEPQQDIWVRAVGEVPADPRLQSAILAYLSDMTLLDTSLYAHGTTIFDPSIQVASLDHAMW
FHRPCRLDDWLLYTQDSPSASGARGLTRGNIFTRQGELVASVAQEGLIRKRAND

Sequences:

>Translated_294_residues
MSHPSQTSDPMVNLIATLDLEKLEENLYRGESPQIGWQRVFGGQVIAQALIAAQRTVDDDRFVHSLHAYFMRPGDPLVPI
VYQVERIRDGASFCTRRVVAIQHGKAIFSMSASFQILEDGFDHQIKMPDVTPPEKLMSEEQMQAAFLAKAPASIRKYWSN
KRPIEIRPVSLTHYISKEKLEPQQDIWVRAVGEVPADPRLQSAILAYLSDMTLLDTSLYAHGTTIFDPSIQVASLDHAMW
FHRPCRLDDWLLYTQDSPSASGARGLTRGNIFTRQGELVASVAQEGLIRKRAND
>Mature_293_residues
SHPSQTSDPMVNLIATLDLEKLEENLYRGESPQIGWQRVFGGQVIAQALIAAQRTVDDDRFVHSLHAYFMRPGDPLVPIV
YQVERIRDGASFCTRRVVAIQHGKAIFSMSASFQILEDGFDHQIKMPDVTPPEKLMSEEQMQAAFLAKAPASIRKYWSNK
RPIEIRPVSLTHYISKEKLEPQQDIWVRAVGEVPADPRLQSAILAYLSDMTLLDTSLYAHGTTIFDPSIQVASLDHAMWF
HRPCRLDDWLLYTQDSPSASGARGLTRGNIFTRQGELVASVAQEGLIRKRAND

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=289, Percent_Identity=41.522491349481, Blast_Score=229, Evalue=3e-60,
Organism=Escherichia coli, GI1786657, Length=270, Percent_Identity=48.5185185185185, Blast_Score=281, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71988741, Length=302, Percent_Identity=39.4039735099338, Blast_Score=207, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17558508, Length=317, Percent_Identity=37.8548895899054, Blast_Score=183, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI115532456, Length=273, Percent_Identity=36.996336996337, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17531885, Length=273, Percent_Identity=36.996336996337, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17531889, Length=274, Percent_Identity=37.2262773722628, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI212645202, Length=287, Percent_Identity=33.7979094076655, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71982224, Length=298, Percent_Identity=33.5570469798658, Blast_Score=138, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322480, Length=304, Percent_Identity=27.3026315789474, Blast_Score=105, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 33130; Mature: 32999

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHPSQTSDPMVNLIATLDLEKLEENLYRGESPQIGWQRVFGGQVIAQALIAAQRTVDDD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
RFVHSLHAYFMRPGDPLVPIVYQVERIRDGASFCTRRVVAIQHGKAIFSMSASFQILEDG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHEECCCEEEEECCCHHHHHCC
FDHQIKMPDVTPPEKLMSEEQMQAAFLAKAPASIRKYWSNKRPIEIRPVSLTHYISKEKL
CCCEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEECHHHHHHHHHHC
EPQQDIWVRAVGEVPADPRLQSAILAYLSDMTLLDTSLYAHGTTIFDPSIQVASLDHAMW
CCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEECHHHHH
FHRPCRLDDWLLYTQDSPSASGARGLTRGNIFTRQGELVASVAQEGLIRKRAND
HCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SHPSQTSDPMVNLIATLDLEKLEENLYRGESPQIGWQRVFGGQVIAQALIAAQRTVDDD
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
RFVHSLHAYFMRPGDPLVPIVYQVERIRDGASFCTRRVVAIQHGKAIFSMSASFQILEDG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHEECCCEEEEECCCHHHHHCC
FDHQIKMPDVTPPEKLMSEEQMQAAFLAKAPASIRKYWSNKRPIEIRPVSLTHYISKEKL
CCCEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEECHHHHHHHHHHC
EPQQDIWVRAVGEVPADPRLQSAILAYLSDMTLLDTSLYAHGTTIFDPSIQVASLDHAMW
CCCHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEECHHHHH
FHRPCRLDDWLLYTQDSPSASGARGLTRGNIFTRQGELVASVAQEGLIRKRAND
HCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]