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The map label for this gene is acs

Identifier: 159185358

GI number: 159185358

Start: 2742305

End: 2744260

Strand: Reverse

Name: acs

Synonym: Atu2745

Alternate gene names: 159185358

Gene position: 2744260-2742305 (Counterclockwise)

Preceding gene: 15889996

Following gene: 15889987

Centisome position: 96.58

GC content: 59.41

Gene sequence:

>1956_bases
ATGTCTGCCAAAATCTACCCGGTGCTCAAATCGGCGAAAGCCCGCACGCTCATCGACAATGAGCGTTACCAGAAATGGTA
TCAGGAGAGCGTCGAGGATCCGGAAAAATTCTGGGACAAGCACGGCCGGCGGATCGACTGGTTCAAGCCCTATACCAAGG
TCAAGAACACCTCATTCAAGGGGCGTGTGCCGATCAAATGGTTCGAAGACGGCCTGACGAACGTCTCCTATAACTGTATC
GACCGGCATTTGAAGACGCATGGCGAGCGCACGGCGATCATCTGGGAAGGCGACAATCCCTATATCGACAAGAAGATCAC
CTATAACCAGCTCTATGATTATGTCTGCCGTCTGGCCAATGTGCTGAAGAAGCACGGCGTTAAGAAGGGTGACCGCGTCA
CCATCTACATGCCGATGATTCCCGAGGCGGCCTATGCCATGCTTGCCTGCGCCCGCATCGGTGCCGTGCATTCCGTCGTC
TTTGGCGGCTTCTCGCCCGAAGCGCTGGCCGGTCGTATCGTTGACTGCGAATCGACCTTCGTCATCACCTGCGATGAAGG
CGTTCGCGGCGGCAAGCCGATCCCGCTCAAGGAAAATACCGACAAGGCGATCGATATCGCCGCCAAGCAATATGTCATCG
TCAACAAGGTTCTGGTCGTGCGCCGCACCGGCGGCAAGACCGGCTGGGCGCCGGGCCGCGACATCTGGTATCATCAGGAA
ATTGCGACCGTGAAGCCGGATTGCCCGCCGGTGAAGATGCGGGCGGAAGATCCGCTGTTCATCCTCTACACTTCAGGCTC
CACCGGCAAGCCCAAGGGTGTGTTGCACACCACGGGCGGCTATCTCGTCTATACGTCGATGACGCATGAATATGTGTTCG
ATTACAAGGATGGTGAAGTCTTCTGGTGTACGGCCGATGTTGGCTGGGTTACCGGCCATTCCTACATCGTCTACGGGCCA
CTCGCCAATTGTGCGACAACGCTGATGTTCGAGGGTGTTCCCAACTTCCCGGATCAGGGGCGTTTCTGGGAGGTCATCGA
CAAGCACAAGGTCAATATCTTCTATACCGCGCCGACGGCGCTCCGATCGCTGATGGGGGCGGGCGACCAGTTCGTTCAGC
GCTCGTCGCGCGAAAGCCTGCGGCTTCTCGGAACGGTGGGTGAGCCGATCAATCCGGAAGCGTGGGAGTGGTATTACCAT
GTGGTCGGCGAGGACAAGAGCCCGATCGTAGACACCTGGTGGCAGACGGAAACGGGCGGCATTCTCATCTCGCCGTTGCC
GGGTGCGACCGATCTGAAGCCAGGGTCGGCAACAAGGCCGTTCTTCGGCGTGCAGCCGCAGCTTGTCGATGCCGAGGGCA
ATGTGCTGGAAGGGCCGGCGGACGGCAATCTCTGCATCATCGACAGCTGGCCGGGCCAGTCGCGGTCCGTTTATGGGGAT
CACCAGCGATTCGTCGACACCTACTTCTCGACCTACAAGGGCAAGTACTTCACCGGTGACGGCTGCCGGCGCGACGAGGA
CGGTTATTACTGGATCACAGGTCGCGTCGATGACGTGCTCAACGTCTCCGGCCACCGCCTAGGCACGGCCGAGGTAGAAT
CGGCACTGGTCTCGCATCATCAGGTTTCGGAAGCGGCGGTGGTCGGTTATCCGCACCCCATCAAGGGGCAGGGCATTTAT
TGTTATGTCACGCTGATGGCGGGGCAGAGTGGCGATTATGCGCTGCGCGAGGAGCTGGTAAAGCATGTGCGCAACGAGAT
CGGACCGGTTGCGACGCCCGACAAGATCCAGTTTGCGCCCGGCCTGCCGAAGACCCGCTCAGGCAAGATCATGCGGCGCA
TTCTGCGCAAAATCGCCGAGGACGATTTCGGTGCGCTTGGGGATACGTCGACGCTTGCCGATCCGGCGGTGGTGGAAGAT
CTCATCGCCAACCGCCAGAACCGCACGGCGTCCTGA

Upstream 100 bases:

>100_bases
TCTAATTGCCGTCAGTCATTGACCTGCTATGAATTCACCACATGCCTGAGGTGGGAGTCTCAAGGCGCGCAACAAGACAT
ACTTGGTTCAGGAGGAGTTC

Downstream 100 bases:

>100_bases
TCTTCTGGAAAGGCTGCTTCGGCAGCCTTTTCTTTCCGCAAACGAAAACACCCGGAAGCAAACTTCCGGGTGTTTTTTAT
TCAATACAGATAGGCTTACT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MSAKIYPVLKSAKARTLIDNERYQKWYQESVEDPEKFWDKHGRRIDWFKPYTKVKNTSFKGRVPIKWFEDGLTNVSYNCI
DRHLKTHGERTAIIWEGDNPYIDKKITYNQLYDYVCRLANVLKKHGVKKGDRVTIYMPMIPEAAYAMLACARIGAVHSVV
FGGFSPEALAGRIVDCESTFVITCDEGVRGGKPIPLKENTDKAIDIAAKQYVIVNKVLVVRRTGGKTGWAPGRDIWYHQE
IATVKPDCPPVKMRAEDPLFILYTSGSTGKPKGVLHTTGGYLVYTSMTHEYVFDYKDGEVFWCTADVGWVTGHSYIVYGP
LANCATTLMFEGVPNFPDQGRFWEVIDKHKVNIFYTAPTALRSLMGAGDQFVQRSSRESLRLLGTVGEPINPEAWEWYYH
VVGEDKSPIVDTWWQTETGGILISPLPGATDLKPGSATRPFFGVQPQLVDAEGNVLEGPADGNLCIIDSWPGQSRSVYGD
HQRFVDTYFSTYKGKYFTGDGCRRDEDGYYWITGRVDDVLNVSGHRLGTAEVESALVSHHQVSEAAVVGYPHPIKGQGIY
CYVTLMAGQSGDYALREELVKHVRNEIGPVATPDKIQFAPGLPKTRSGKIMRRILRKIAEDDFGALGDTSTLADPAVVED
LIANRQNRTAS

Sequences:

>Translated_651_residues
MSAKIYPVLKSAKARTLIDNERYQKWYQESVEDPEKFWDKHGRRIDWFKPYTKVKNTSFKGRVPIKWFEDGLTNVSYNCI
DRHLKTHGERTAIIWEGDNPYIDKKITYNQLYDYVCRLANVLKKHGVKKGDRVTIYMPMIPEAAYAMLACARIGAVHSVV
FGGFSPEALAGRIVDCESTFVITCDEGVRGGKPIPLKENTDKAIDIAAKQYVIVNKVLVVRRTGGKTGWAPGRDIWYHQE
IATVKPDCPPVKMRAEDPLFILYTSGSTGKPKGVLHTTGGYLVYTSMTHEYVFDYKDGEVFWCTADVGWVTGHSYIVYGP
LANCATTLMFEGVPNFPDQGRFWEVIDKHKVNIFYTAPTALRSLMGAGDQFVQRSSRESLRLLGTVGEPINPEAWEWYYH
VVGEDKSPIVDTWWQTETGGILISPLPGATDLKPGSATRPFFGVQPQLVDAEGNVLEGPADGNLCIIDSWPGQSRSVYGD
HQRFVDTYFSTYKGKYFTGDGCRRDEDGYYWITGRVDDVLNVSGHRLGTAEVESALVSHHQVSEAAVVGYPHPIKGQGIY
CYVTLMAGQSGDYALREELVKHVRNEIGPVATPDKIQFAPGLPKTRSGKIMRRILRKIAEDDFGALGDTSTLADPAVVED
LIANRQNRTAS
>Mature_650_residues
SAKIYPVLKSAKARTLIDNERYQKWYQESVEDPEKFWDKHGRRIDWFKPYTKVKNTSFKGRVPIKWFEDGLTNVSYNCID
RHLKTHGERTAIIWEGDNPYIDKKITYNQLYDYVCRLANVLKKHGVKKGDRVTIYMPMIPEAAYAMLACARIGAVHSVVF
GGFSPEALAGRIVDCESTFVITCDEGVRGGKPIPLKENTDKAIDIAAKQYVIVNKVLVVRRTGGKTGWAPGRDIWYHQEI
ATVKPDCPPVKMRAEDPLFILYTSGSTGKPKGVLHTTGGYLVYTSMTHEYVFDYKDGEVFWCTADVGWVTGHSYIVYGPL
ANCATTLMFEGVPNFPDQGRFWEVIDKHKVNIFYTAPTALRSLMGAGDQFVQRSSRESLRLLGTVGEPINPEAWEWYYHV
VGEDKSPIVDTWWQTETGGILISPLPGATDLKPGSATRPFFGVQPQLVDAEGNVLEGPADGNLCIIDSWPGQSRSVYGDH
QRFVDTYFSTYKGKYFTGDGCRRDEDGYYWITGRVDDVLNVSGHRLGTAEVESALVSHHQVSEAAVVGYPHPIKGQGIYC
YVTLMAGQSGDYALREELVKHVRNEIGPVATPDKIQFAPGLPKTRSGKIMRRILRKIAEDDFGALGDTSTLADPAVVEDL
IANRQNRTAS

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

Homologues:

Organism=Homo sapiens, GI8923896, Length=666, Percent_Identity=53.003003003003, Blast_Score=703, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=679, Percent_Identity=51.9882179675994, Blast_Score=699, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=630, Percent_Identity=50.1587301587302, Blast_Score=644, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=637, Percent_Identity=38.1475667189953, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI38505220, Length=553, Percent_Identity=30.1989150090416, Blast_Score=199, Evalue=9e-51,
Organism=Homo sapiens, GI42544132, Length=515, Percent_Identity=29.3203883495146, Blast_Score=197, Evalue=3e-50,
Organism=Homo sapiens, GI115511026, Length=525, Percent_Identity=28.1904761904762, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI122937307, Length=535, Percent_Identity=27.8504672897196, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI31982927, Length=637, Percent_Identity=25.1177394034537, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI58082049, Length=515, Percent_Identity=27.1844660194175, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI157311624, Length=517, Percent_Identity=26.1121856866538, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI157311622, Length=517, Percent_Identity=26.1121856866538, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI187761345, Length=388, Percent_Identity=27.8350515463918, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI187761343, Length=388, Percent_Identity=27.8350515463918, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI195947378, Length=437, Percent_Identity=25.4004576659039, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI42544134, Length=335, Percent_Identity=25.0746268656716, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI156151445, Length=591, Percent_Identity=22.165820642978, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1790505, Length=633, Percent_Identity=64.4549763033175, Blast_Score=860, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=636, Percent_Identity=37.7358490566038, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1788107, Length=541, Percent_Identity=24.3992606284658, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI221142682, Length=539, Percent_Identity=21.1502782931354, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI145693145, Length=532, Percent_Identity=22.9323308270677, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71982997, Length=656, Percent_Identity=50.4573170731707, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71983001, Length=656, Percent_Identity=50.4573170731707, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=654, Percent_Identity=21.5596330275229, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17558820, Length=524, Percent_Identity=24.618320610687, Blast_Score=110, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17538037, Length=128, Percent_Identity=33.59375, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=648, Percent_Identity=49.537037037037, Blast_Score=629, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=662, Percent_Identity=45.9214501510574, Blast_Score=568, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319699, Length=376, Percent_Identity=25.2659574468085, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24667955, Length=643, Percent_Identity=54.1213063763608, Blast_Score=701, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=56.7615658362989, Blast_Score=643, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=56.9230769230769, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI21355225, Length=632, Percent_Identity=36.0759493670886, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI21355181, Length=550, Percent_Identity=23.2727272727273, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18859661, Length=544, Percent_Identity=24.2647058823529, Blast_Score=87, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24581924, Length=376, Percent_Identity=22.6063829787234, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356947, Length=411, Percent_Identity=22.6277372262774, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24656500, Length=527, Percent_Identity=21.0626185958254, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACSA_AGRT5 (Q8UBV5)

Other databases:

- EMBL:   AE007869
- PIR:   AH2913
- PIR:   C97688
- RefSeq:   NP_355675.2
- ProteinModelPortal:   Q8UBV5
- SMR:   Q8UBV5
- STRING:   Q8UBV5
- GeneID:   1134783
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2745
- HOGENOM:   HBG547964
- OMA:   ILACTRI
- PhylomeDB:   Q8UBV5
- ProtClustDB:   PRK00174
- BioCyc:   ATUM176299-1:ATU2745-MONOMER
- HAMAP:   MF_01123
- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873
- TIGRFAMs:   TIGR02188

Pfam domain/function: PF00501 AMP-binding

EC number: =6.2.1.1

Molecular weight: Translated: 72844; Mature: 72713

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS00455 AMP_BINDING

Important sites: ACT_SITE 517-517

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKIYPVLKSAKARTLIDNERYQKWYQESVEDPEKFWDKHGRRIDWFKPYTKVKNTSFK
CCCEEEHHHHCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCEEECCCCHHHHCCCCCC
GRVPIKWFEDGLTNVSYNCIDRHLKTHGERTAIIWEGDNPYIDKKITYNQLYDYVCRLAN
CCCCHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCEECCEEEHHHHHHHHHHHHH
VLKKHGVKKGDRVTIYMPMIPEAAYAMLACARIGAVHSVVFGGFSPEALAGRIVDCESTF
HHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEECCCEE
VITCDEGVRGGKPIPLKENTDKAIDIAAKQYVIVNKVLVVRRTGGKTGWAPGRDIWYHQE
EEEECCCCCCCCCCCCCCCCCCCEEHHHHEEEEEEEEEEEEECCCCCCCCCCCCEEEECE
IATVKPDCPPVKMRAEDPLFILYTSGSTGKPKGVLHTTGGYLVYTSMTHEYVFDYKDGEV
ECCCCCCCCCEEEECCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCEEEEEEECCCEE
FWCTADVGWVTGHSYIVYGPLANCATTLMFEGVPNFPDQGRFWEVIDKHKVNIFYTAPTA
EEEECCCCEEECCCEEEEECHHHHHHHHHCCCCCCCCCCCCHHHHHCCCEEEEEEECHHH
LRSLMGAGDQFVQRSSRESLRLLGTVGEPINPEAWEWYYHVVGEDKSPIVDTWWQTETGG
HHHHHCCCHHHHHHHCHHHEEEEECCCCCCCCCCEEEEEEEECCCCCCCEECCEEECCCC
ILISPLPGATDLKPGSATRPFFGVQPQLVDAEGNVLEGPADGNLCIIDSWPGQSRSVYGD
EEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCEEEEECCCCCCCCCCCH
HQRFVDTYFSTYKGKYFTGDGCRRDEDGYYWITGRVDDVLNVSGHRLGTAEVESALVSHH
HHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
QVSEAAVVGYPHPIKGQGIYCYVTLMAGQSGDYALREELVKHVRNEIGPVATPDKIQFAP
HHCCEEEECCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECC
GLPKTRSGKIMRRILRKIAEDDFGALGDTSTLADPAVVEDLIANRQNRTAS
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SAKIYPVLKSAKARTLIDNERYQKWYQESVEDPEKFWDKHGRRIDWFKPYTKVKNTSFK
CCEEEHHHHCCCHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCEEECCCCHHHHCCCCCC
GRVPIKWFEDGLTNVSYNCIDRHLKTHGERTAIIWEGDNPYIDKKITYNQLYDYVCRLAN
CCCCHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCEECCEEEHHHHHHHHHHHHH
VLKKHGVKKGDRVTIYMPMIPEAAYAMLACARIGAVHSVVFGGFSPEALAGRIVDCESTF
HHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEECCCEE
VITCDEGVRGGKPIPLKENTDKAIDIAAKQYVIVNKVLVVRRTGGKTGWAPGRDIWYHQE
EEEECCCCCCCCCCCCCCCCCCCEEHHHHEEEEEEEEEEEEECCCCCCCCCCCCEEEECE
IATVKPDCPPVKMRAEDPLFILYTSGSTGKPKGVLHTTGGYLVYTSMTHEYVFDYKDGEV
ECCCCCCCCCEEEECCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCEEEEEEECCCEE
FWCTADVGWVTGHSYIVYGPLANCATTLMFEGVPNFPDQGRFWEVIDKHKVNIFYTAPTA
EEEECCCCEEECCCEEEEECHHHHHHHHHCCCCCCCCCCCCHHHHHCCCEEEEEEECHHH
LRSLMGAGDQFVQRSSRESLRLLGTVGEPINPEAWEWYYHVVGEDKSPIVDTWWQTETGG
HHHHHCCCHHHHHHHCHHHEEEEECCCCCCCCCCEEEEEEEECCCCCCCEECCEEECCCC
ILISPLPGATDLKPGSATRPFFGVQPQLVDAEGNVLEGPADGNLCIIDSWPGQSRSVYGD
EEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCEEEEECCCCCCCCCCCH
HQRFVDTYFSTYKGKYFTGDGCRRDEDGYYWITGRVDDVLNVSGHRLGTAEVESALVSHH
HHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
QVSEAAVVGYPHPIKGQGIYCYVTLMAGQSGDYALREELVKHVRNEIGPVATPDKIQFAP
HHCCEEEECCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEECC
GLPKTRSGKIMRRILRKIAEDDFGALGDTSTLADPAVVEDLIANRQNRTAS
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194