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The map label for this gene is metA

Identifier: 159185345

GI number: 159185345

Start: 2703611

End: 2704537

Strand: Direct

Name: metA

Synonym: Atu2718

Alternate gene names: 159185345

Gene position: 2703611-2704537 (Clockwise)

Preceding gene: 159185339

Following gene: 15889971

Centisome position: 95.14

GC content: 55.02

Gene sequence:

>927_bases
ATGCCGATCAAGATTCCCGATACCCTTCCCGCCTTTGAGACCCTCGTTCATGAGGGTGTGCGGGTCATGACCGAAACGGC
GGCCATCCGGCAGGATATTCGCCCGCTCCAGATCGGGCTTCTGAACCTCATGCCGAACAAGATCAAGACGGAAATCCAGA
TGGCGCGTCTTGTTGGCGCCTCGCCGCTGCAGGTGGAATTGTCGCTCATCCGCATCGGCGGTCACCGCGCCAAGAATACG
CCGGAAGAACATCTCCTCTCCTTCTACCAGACCTGGGAAGAGGTCCGTCACCGCAAGTTCGACGGCTTCATCATCACCGG
CGCACCGATCGAACTGCTAGATTATGAAGATGTGACTTACTGGAACGAGATGCAGCAGATTTTCGAATGGACGCAGACCA
ACGTCCATTCGACTCTGAATGTCTGCTGGGGCGCAATGGCCGCCATCTACCATTTCCACGGGGTGCCGAAATACGAGTTG
AAGGAAAAGGCTTTCGGGGTTTATCGCCACCGCAACCTTAGCCCCTCATCGATTTACCTTAACGGTTTTTCAGACGATTT
TCAGGTTCCGGTGTCGCGTTGGACGGAAGTGCGCCGCGCCGATATCGAAAAACACCCCGAGCTGGAAATCCTGATGGAGT
CCGACGAGATGGGCGTGTGCCTGGCGCATGAGAAAGCCGGAAATCGGCTCTATATGTTTAACCACGTTGAATATGATTCC
ACTTCGCTTGCGGATGAATATTTCCGTGATGTGAACTCCGGTGTCCCCATCAAGCTGCCGCATGATTATTTTCCCCACAA
TGATCCGGAGCTTGCCCCGCTGAACCGCTGGCGCAGCCACGCCCATCTGTTTTTCGGAAACTGGATCAACGAGATATACC
AGACGACGCCTTATGACCCCCAAGCCATCGGGAAACTGGCGGCGTAA

Upstream 100 bases:

>100_bases
GTCGAGGAAAAGGGCAATTTCCTGGGACCGGCCGCGATTTCGCTGCCGGTTTTTTTGTTTTCGCAACGTTCTTTACGTGA
TCCGGAAAAGAGAGTTCGAC

Downstream 100 bases:

>100_bases
ACTGCGGGATTGCGAATTGCCGGAAAATGACGCAACGTCCGCCCGGCAATTTGCGATACCAGGGAGAATGACGAGATGAG
CGACGGTGCGGCACGAGAAG

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MPIKIPDTLPAFETLVHEGVRVMTETAAIRQDIRPLQIGLLNLMPNKIKTEIQMARLVGASPLQVELSLIRIGGHRAKNT
PEEHLLSFYQTWEEVRHRKFDGFIITGAPIELLDYEDVTYWNEMQQIFEWTQTNVHSTLNVCWGAMAAIYHFHGVPKYEL
KEKAFGVYRHRNLSPSSIYLNGFSDDFQVPVSRWTEVRRADIEKHPELEILMESDEMGVCLAHEKAGNRLYMFNHVEYDS
TSLADEYFRDVNSGVPIKLPHDYFPHNDPELAPLNRWRSHAHLFFGNWINEIYQTTPYDPQAIGKLAA

Sequences:

>Translated_308_residues
MPIKIPDTLPAFETLVHEGVRVMTETAAIRQDIRPLQIGLLNLMPNKIKTEIQMARLVGASPLQVELSLIRIGGHRAKNT
PEEHLLSFYQTWEEVRHRKFDGFIITGAPIELLDYEDVTYWNEMQQIFEWTQTNVHSTLNVCWGAMAAIYHFHGVPKYEL
KEKAFGVYRHRNLSPSSIYLNGFSDDFQVPVSRWTEVRRADIEKHPELEILMESDEMGVCLAHEKAGNRLYMFNHVEYDS
TSLADEYFRDVNSGVPIKLPHDYFPHNDPELAPLNRWRSHAHLFFGNWINEIYQTTPYDPQAIGKLAA
>Mature_307_residues
PIKIPDTLPAFETLVHEGVRVMTETAAIRQDIRPLQIGLLNLMPNKIKTEIQMARLVGASPLQVELSLIRIGGHRAKNTP
EEHLLSFYQTWEEVRHRKFDGFIITGAPIELLDYEDVTYWNEMQQIFEWTQTNVHSTLNVCWGAMAAIYHFHGVPKYELK
EKAFGVYRHRNLSPSSIYLNGFSDDFQVPVSRWTEVRRADIEKHPELEILMESDEMGVCLAHEKAGNRLYMFNHVEYDST
SLADEYFRDVNSGVPIKLPHDYFPHNDPELAPLNRWRSHAHLFFGNWINEIYQTTPYDPQAIGKLAA

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family

Homologues:

Organism=Escherichia coli, GI1790443, Length=300, Percent_Identity=46, Blast_Score=286, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): META_AGRT5 (Q7CWE8)

Other databases:

- EMBL:   AE007869
- RefSeq:   NP_355651.2
- HSSP:   Q72X44
- ProteinModelPortal:   Q7CWE8
- SMR:   Q7CWE8
- STRING:   Q7CWE8
- GeneID:   1134756
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2718
- eggNOG:   COG1897
- HOGENOM:   HBG362506
- OMA:   QAGLYYH
- PhylomeDB:   Q7CWE8
- ProtClustDB:   PRK05368
- GO:   GO:0005737
- HAMAP:   MF_00295
- InterPro:   IPR005697
- PANTHER:   PTHR20919
- PIRSF:   PIRSF000450
- ProDom:   PD037892
- TIGRFAMs:   TIGR01001

Pfam domain/function: PF04204 HTS

EC number: =2.3.1.46

Molecular weight: Translated: 35691; Mature: 35560

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: ACT_SITE 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKIPDTLPAFETLVHEGVRVMTETAAIRQDIRPLQIGLLNLMPNKIKTEIQMARLVGA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCC
SPLQVELSLIRIGGHRAKNTPEEHLLSFYQTWEEVRHRKFDGFIITGAPIELLDYEDVTY
CCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCHH
WNEMQQIFEWTQTNVHSTLNVCWGAMAAIYHFHGVPKYELKEKAFGVYRHRNLSPSSIYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEE
NGFSDDFQVPVSRWTEVRRADIEKHPELEILMESDEMGVCLAHEKAGNRLYMFNHVEYDS
ECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCEEEEEEECCCCC
TSLADEYFRDVNSGVPIKLPHDYFPHNDPELAPLNRWRSHAHLFFGNWINEIYQTTPYDP
HHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
QAIGKLAA
HHHHHCCC
>Mature Secondary Structure 
PIKIPDTLPAFETLVHEGVRVMTETAAIRQDIRPLQIGLLNLMPNKIKTEIQMARLVGA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHCC
SPLQVELSLIRIGGHRAKNTPEEHLLSFYQTWEEVRHRKFDGFIITGAPIELLDYEDVTY
CCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCHH
WNEMQQIFEWTQTNVHSTLNVCWGAMAAIYHFHGVPKYELKEKAFGVYRHRNLSPSSIYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEE
NGFSDDFQVPVSRWTEVRRADIEKHPELEILMESDEMGVCLAHEKAGNRLYMFNHVEYDS
ECCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCEEEEEEECCCCC
TSLADEYFRDVNSGVPIKLPHDYFPHNDPELAPLNRWRSHAHLFFGNWINEIYQTTPYDP
HHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
QAIGKLAA
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743194; 11743193