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The map label for this gene is cutC

Identifier: 159185284

GI number: 159185284

Start: 2570912

End: 2571652

Strand: Reverse

Name: cutC

Synonym: Atu2593

Alternate gene names: 159185284

Gene position: 2571652-2570912 (Counterclockwise)

Preceding gene: 15889851

Following gene: 159185278

Centisome position: 90.5

GC content: 63.02

Gene sequence:

>741_bases
ATGATTCTCGAAATTTGCGTGGACGATGTGGCCGGTCTGGAAGCGGCTGTCAGGGGCGGGGCCGACCGGATCGAGCTTTG
TGCGGCGCTGTCCGGCGGCGGCGTGACGCCATCGGCGGGGTTCATGCAGCGGGCTGCGACCTATGGATTGCCGGTGAGTG
TCATGATCAGGCCGCGCGCCGGGGATTTCGTGTTCACGCACGACGAGGCCGATGTGATGAAACGCGATATCGATGCGGCG
CGCGCGGCGGGGCTTTCCGGCGTTGTACTCGGCGCATCGCGTGGCGATGGCTCGCTTGATATGGCTTTGCTTGAAGACTT
GCGCCGTCACGCCGACGGAATGGATGCGACGCTGCACCGGGCGTTTGATGTCGCGCCGGATATGGAAGAGGCCCTGGAGG
CTGCCATTTCGCTTGGCTTTCCACGCATCCTGACCTCCGGCGGCGCGCGTTCGGCGCTAGAGGGCGTAAAGACGCTGGCG
CGCCTATCGGAGCTTGCCAAAGGCCGGATCGTCATCATGCCCGGAGCGGGTGTGCGTCCGCAAAGCGTTCAGGCTTTGCT
GGATAGCTTTCCGATTACGGAAATCCATGCCTCCTGTTCCGCAGTTCCGCTTTATGATCCGGAAAGCAGGGTGGCTAAGC
TCGGTTTCACCGGCGCTGGGCGCAAGGCGACGGATGAGGCCGCCGTGCGCGAACTAAAGACGATCCTCAGCGCTCATCAT
AAAGGCGGTGCAACGCTCTAG

Upstream 100 bases:

>100_bases
TACTGGGTGCGATCGTCGGTCTGGGCGGTGTTTACATGCTCTACACGCTTGATGGGACCGGCCGCCGCAGGTAACGGCCA
CCCTGATGAAAGAGGTACCA

Downstream 100 bases:

>100_bases
CAGTGCCGGCCGCCCCATCGAGATCGAGGTGGATCTTGTCCGGTTCCGGCAGCGCCAATGCCGCCTTGATGGCATCGGCC
ATGGATTGCGCGGAGATGTG

Product: copper homeostasis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MILEICVDDVAGLEAAVRGGADRIELCAALSGGGVTPSAGFMQRAATYGLPVSVMIRPRAGDFVFTHDEADVMKRDIDAA
RAAGLSGVVLGASRGDGSLDMALLEDLRRHADGMDATLHRAFDVAPDMEEALEAAISLGFPRILTSGGARSALEGVKTLA
RLSELAKGRIVIMPGAGVRPQSVQALLDSFPITEIHASCSAVPLYDPESRVAKLGFTGAGRKATDEAAVRELKTILSAHH
KGGATL

Sequences:

>Translated_246_residues
MILEICVDDVAGLEAAVRGGADRIELCAALSGGGVTPSAGFMQRAATYGLPVSVMIRPRAGDFVFTHDEADVMKRDIDAA
RAAGLSGVVLGASRGDGSLDMALLEDLRRHADGMDATLHRAFDVAPDMEEALEAAISLGFPRILTSGGARSALEGVKTLA
RLSELAKGRIVIMPGAGVRPQSVQALLDSFPITEIHASCSAVPLYDPESRVAKLGFTGAGRKATDEAAVRELKTILSAHH
KGGATL
>Mature_246_residues
MILEICVDDVAGLEAAVRGGADRIELCAALSGGGVTPSAGFMQRAATYGLPVSVMIRPRAGDFVFTHDEADVMKRDIDAA
RAAGLSGVVLGASRGDGSLDMALLEDLRRHADGMDATLHRAFDVAPDMEEALEAAISLGFPRILTSGGARSALEGVKTLA
RLSELAKGRIVIMPGAGVRPQSVQALLDSFPITEIHASCSAVPLYDPESRVAKLGFTGAGRKATDEAAVRELKTILSAHH
KGGATL

Specific function: Involved in copper homeostasis

COG id: COG3142

COG function: function code P; Uncharacterized protein involved in copper resistance

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CutC family

Homologues:

Organism=Homo sapiens, GI148596990, Length=244, Percent_Identity=43.8524590163934, Blast_Score=176, Evalue=1e-44,
Organism=Escherichia coli, GI87081995, Length=248, Percent_Identity=35.0806451612903, Blast_Score=125, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17556905, Length=237, Percent_Identity=39.662447257384, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21355415, Length=200, Percent_Identity=37.5, Blast_Score=127, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CUTC_AGRT5 (Q8UCA5)

Other databases:

- EMBL:   AE007869
- PIR:   AH2894
- PIR:   C97670
- RefSeq:   NP_355531.2
- ProteinModelPortal:   Q8UCA5
- SMR:   Q8UCA5
- STRING:   Q8UCA5
- GeneID:   1134631
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu2593
- eggNOG:   COG3142
- HOGENOM:   HBG535337
- OMA:   PVYAMIR
- PhylomeDB:   Q8UCA5
- BioCyc:   ATUM176299-1:ATU2593-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00795
- InterPro:   IPR005627
- Gene3D:   G3DSA:3.20.20.380
- PANTHER:   PTHR12598

Pfam domain/function: PF03932 CutC; SSF110395 CutC

EC number: NA

Molecular weight: Translated: 25559; Mature: 25559

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILEICVDDVAGLEAAVRGGADRIELCAALSGGGVTPSAGFMQRAATYGLPVSVMIRPRA
CEEEEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCC
GDFVFTHDEADVMKRDIDAARAAGLSGVVLGASRGDGSLDMALLEDLRRHADGMDATLHR
CCEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHH
AFDVAPDMEEALEAAISLGFPRILTSGGARSALEGVKTLARLSELAKGRIVIMPGAGVRP
HHCCCCCHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCH
QSVQALLDSFPITEIHASCSAVPLYDPESRVAKLGFTGAGRKATDEAAVRELKTILSAHH
HHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHC
KGGATL
CCCCCC
>Mature Secondary Structure
MILEICVDDVAGLEAAVRGGADRIELCAALSGGGVTPSAGFMQRAATYGLPVSVMIRPRA
CEEEEEHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCC
GDFVFTHDEADVMKRDIDAARAAGLSGVVLGASRGDGSLDMALLEDLRRHADGMDATLHR
CCEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHH
AFDVAPDMEEALEAAISLGFPRILTSGGARSALEGVKTLARLSELAKGRIVIMPGAGVRP
HHCCCCCHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCH
QSVQALLDSFPITEIHASCSAVPLYDPESRVAKLGFTGAGRKATDEAAVRELKTILSAHH
HHHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHC
KGGATL
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194