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The map label for this gene is capL [H]

Identifier: 159185276

GI number: 159185276

Start: 2556795

End: 2558069

Strand: Reverse

Name: capL [H]

Synonym: Atu2582

Alternate gene names: 159185276

Gene position: 2558069-2556795 (Counterclockwise)

Preceding gene: 159185278

Following gene: 159185444

Centisome position: 90.02

GC content: 58.04

Gene sequence:

>1275_bases
GTGATCGGCCTCGGCTATGTCGGCCTGCCGCTTGCCATGACGGTCGCTAAGGCCGGTTTCAAGGTCGTCGGTTTCGACAT
CGACCCCGGTAAAATTACCGCGATCGAAGCGGGCCGCAGCTATATCGAGGCGGTTTCCGATGAGGTGCTGGCAAGTGTGC
GGCAGGATGACGGTTTCGTTGCCACCAGCGATTTTTTGAGGCTGGCCGAATGCGATGTGATCGCCATTTGCGTGCCGACG
CCGCTGACGAAATATCGCGAGCCGGACCTTTCTTATGTCGAAAAGACCTGCCGGGATATTGCCGCACATCTGCGCAAGGG
GCAGCTCGTGGTGCTGGAATCGACCACCTATCCTGGCACGACCGACGGGGTGGTGAAGACCATTCTGGAGAGCACCGGCC
TCGTCTCTGGCGTCGATTTCTTCATCGGCTTTTCGCCCGAGCGGGAAGATCCGGGCAATCGCGATTTCGAGACCTCGACC
ATTCCGAAGGTTGTCGCCGGTGACGGCGAGGCTGCCGGAAAGCTGATGGCCGCCTTCTACGGCTCAGTGGTGAAGAAGAT
CGTTCCGGTTTCGACCAATGCCACGGCCGAGGCGGTGAAAATCACCGAAAACGTCTTCCGTGCCGTCAATATCGCGCTCG
TCAACGAACTCAAGGTCGTCTACGAGGCGATGGGCATCGACATATGGGAAGTGATCGACGCGGCAAAAACCAAGCCGTTC
GGTTTCATGCCGTTTTATCCCGGTCCCGGTCTCGGCGGTCATTGCATACCGATCGACCCTTTCTACCTCACCTGGAAATC
GCGCGAATATGAATTGCCGACGCGGTTCATCGAGCTTGCCGGCGAAATCAATACCGGCATGCCGCGCCATGTCGTCGGGC
GGGTTGCTGAAGCGCTGGATATCCATTCGGGGAAGGCGCTCAGCCGCTCGAAAGTGCTGGTCGTCGGTCTCGCTTACAAG
AAAAACGTGCCCGACATTCGCGAAAGTCCGTCGCTGAAGCTCTTGGAGCTTATTCAGGAGCGCGGTGGCGATGCGGCCTA
TTTCGATCCCTATGTGGCGGAAATCCCGAAAACCCGGGAATATAGCCACCTTATGGGCATGAAATCCATATCCTGGGACA
GGGAGACCATCGGCAGCTTCGATGCCGTTCTTGTCGCGACGGATCACGACAATGTCGACTATGCCGCGCTTAGCGACTGG
GCGCCGCTGATCATCGATACACGAAATGTCTTCGCGCGCCGGGATATCGCCGCAAAACACATCATCAAGGCCTGA

Upstream 100 bases:

>100_bases
GCATCTTTTGCACATGCGCGGAGCGTGACACGCTTTGACTTCCCCAGACATTTCCCGGACCCTGCTTTCCAGCATCGAAA
ACAAAAGCGCCAAAGCGGGG

Downstream 100 bases:

>100_bases
TATTATGAGCAGACTGGACAGTTTCATTCGCCGTTTGAGCGCACAGCGCGATATCCTCAACCATGTCGAGGCCGATCTCG
ATCTGCCCGATCAGGGCGCG

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MIGLGYVGLPLAMTVAKAGFKVVGFDIDPGKITAIEAGRSYIEAVSDEVLASVRQDDGFVATSDFLRLAECDVIAICVPT
PLTKYREPDLSYVEKTCRDIAAHLRKGQLVVLESTTYPGTTDGVVKTILESTGLVSGVDFFIGFSPEREDPGNRDFETST
IPKVVAGDGEAAGKLMAAFYGSVVKKIVPVSTNATAEAVKITENVFRAVNIALVNELKVVYEAMGIDIWEVIDAAKTKPF
GFMPFYPGPGLGGHCIPIDPFYLTWKSREYELPTRFIELAGEINTGMPRHVVGRVAEALDIHSGKALSRSKVLVVGLAYK
KNVPDIRESPSLKLLELIQERGGDAAYFDPYVAEIPKTREYSHLMGMKSISWDRETIGSFDAVLVATDHDNVDYAALSDW
APLIIDTRNVFARRDIAAKHIIKA

Sequences:

>Translated_424_residues
MIGLGYVGLPLAMTVAKAGFKVVGFDIDPGKITAIEAGRSYIEAVSDEVLASVRQDDGFVATSDFLRLAECDVIAICVPT
PLTKYREPDLSYVEKTCRDIAAHLRKGQLVVLESTTYPGTTDGVVKTILESTGLVSGVDFFIGFSPEREDPGNRDFETST
IPKVVAGDGEAAGKLMAAFYGSVVKKIVPVSTNATAEAVKITENVFRAVNIALVNELKVVYEAMGIDIWEVIDAAKTKPF
GFMPFYPGPGLGGHCIPIDPFYLTWKSREYELPTRFIELAGEINTGMPRHVVGRVAEALDIHSGKALSRSKVLVVGLAYK
KNVPDIRESPSLKLLELIQERGGDAAYFDPYVAEIPKTREYSHLMGMKSISWDRETIGSFDAVLVATDHDNVDYAALSDW
APLIIDTRNVFARRDIAAKHIIKA
>Mature_424_residues
MIGLGYVGLPLAMTVAKAGFKVVGFDIDPGKITAIEAGRSYIEAVSDEVLASVRQDDGFVATSDFLRLAECDVIAICVPT
PLTKYREPDLSYVEKTCRDIAAHLRKGQLVVLESTTYPGTTDGVVKTILESTGLVSGVDFFIGFSPEREDPGNRDFETST
IPKVVAGDGEAAGKLMAAFYGSVVKKIVPVSTNATAEAVKITENVFRAVNIALVNELKVVYEAMGIDIWEVIDAAKTKPF
GFMPFYPGPGLGGHCIPIDPFYLTWKSREYELPTRFIELAGEINTGMPRHVVGRVAEALDIHSGKALSRSKVLVVGLAYK
KNVPDIRESPSLKLLELIQERGGDAAYFDPYVAEIPKTREYSHLMGMKSISWDRETIGSFDAVLVATDHDNVDYAALSDW
APLIIDTRNVFARRDIAAKHIIKA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=379, Percent_Identity=25.3298153034301, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI296040438, Length=291, Percent_Identity=24.0549828178694, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI296040443, Length=200, Percent_Identity=25.5, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI48994968, Length=405, Percent_Identity=33.0864197530864, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1788340, Length=365, Percent_Identity=25.7534246575342, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17560350, Length=369, Percent_Identity=26.5582655826558, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136908, Length=368, Percent_Identity=26.6304347826087, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46226; Mature: 46226

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGLGYVGLPLAMTVAKAGFKVVGFDIDPGKITAIEAGRSYIEAVSDEVLASVRQDDGFV
CCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEE
ATSDFLRLAECDVIAICVPTPLTKYREPDLSYVEKTCRDIAAHLRKGQLVVLESTTYPGT
EHHHHHHHHCCCEEEEECCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
TDGVVKTILESTGLVSGVDFFIGFSPEREDPGNRDFETSTIPKVVAGDGEAAGKLMAAFY
CHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHH
GSVVKKIVPVSTNATAEAVKITENVFRAVNIALVNELKVVYEAMGIDIWEVIDAAKTKPF
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
GFMPFYPGPGLGGHCIPIDPFYLTWKSREYELPTRFIELAGEINTGMPRHVVGRVAEALD
CCCCCCCCCCCCCCEEECCCEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IHSGKALSRSKVLVVGLAYKKNVPDIRESPSLKLLELIQERGGDAAYFDPYVAEIPKTRE
CCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEECCHHHHCCCCCH
YSHLMGMKSISWDRETIGSFDAVLVATDHDNVDYAALSDWAPLIIDTRNVFARRDIAAKH
HHHHHCCHHCCCCHHHHCCCCEEEEEECCCCCCEEECCCCCCEEEECCHHHHHHHHHHHH
IIKA
HHCC
>Mature Secondary Structure
MIGLGYVGLPLAMTVAKAGFKVVGFDIDPGKITAIEAGRSYIEAVSDEVLASVRQDDGFV
CCCCCCHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEE
ATSDFLRLAECDVIAICVPTPLTKYREPDLSYVEKTCRDIAAHLRKGQLVVLESTTYPGT
EHHHHHHHHCCCEEEEECCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCC
TDGVVKTILESTGLVSGVDFFIGFSPEREDPGNRDFETSTIPKVVAGDGEAAGKLMAAFY
CHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHH
GSVVKKIVPVSTNATAEAVKITENVFRAVNIALVNELKVVYEAMGIDIWEVIDAAKTKPF
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
GFMPFYPGPGLGGHCIPIDPFYLTWKSREYELPTRFIELAGEINTGMPRHVVGRVAEALD
CCCCCCCCCCCCCCEEECCCEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IHSGKALSRSKVLVVGLAYKKNVPDIRESPSLKLLELIQERGGDAAYFDPYVAEIPKTRE
CCCCCCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEECCHHHHCCCCCH
YSHLMGMKSISWDRETIGSFDAVLVATDHDNVDYAALSDWAPLIIDTRNVFARRDIAAKH
HHHHHCCHHCCCCHHHHCCCCEEEEEECCCCCCEEECCCCCCEEEECCHHHHHHHHHHHH
IIKA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]